Infant fungal communities: current knowledge and research opportunities.

abstract：BACKGROUND:Clinical decision support systems assist physicians in interpreting complex patient data. However, they typically operate on a per-patient basis and do not exploit the extensive latent medical knowledge in electronic health records (EHRs). The emergence of large EHR systems offers the opportunity to integrat...

journal_title：BMC medicine

authors： Gottlieb A,Stein GY,Ruppin E,Altman RB,Sharan R

更新日期：2013-09-02 00:00:00

abstract：BACKGROUND:Observational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomisation study to investigate whether serum magnesium levels may be causally associated with coronary art...

journal_title：BMC medicine

authors： Larsson SC,Burgess S,Michaëlsson K

更新日期：2018-05-17 00:00:00

abstract：:Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and control to discuss the ways in which malaria mig...

journal_title：BMC medicine

authors： Tanner M,Greenwood B,Whitty CJ,Ansah EK,Price RN,Dondorp AM,von Seidlein L,Baird JK,Beeson JG,Fowkes FJ,Hemingway J,Marsh K,Osier F

更新日期：2015-07-25 00:00:00

abstract：BACKGROUND:The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines Agency (EMA) concerning human papillomavirus (HPV) vaccines during a European Union (EU) referral pro...

journal_title：BMC medicine

authors： Bahri P,Fogd J,Morales D,Kurz X,ADVANCE consortium.

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Obesity is common in young women, increasing insulin resistance (IR) and worsening pregnancy complications, including gestational diabetes (GDM). Women with polycystic ovary syndrome (PCOS) are commonly obese, which aggravates the severity of PCOS clinical expression. Relationships between these common insul...

journal_title：BMC medicine

authors： Kakoly NS,Earnest A,Moran LJ,Teede HJ,Joham AE

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. METHODS:To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal ...

journal_title：BMC medicine

authors： Xu X,Chow EPF,Ong JJ,Hoebe CJPA,Zou Z,Hocking JS,Fairley CK,Zhang L

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:All rigorous primary cardiovascular disease (CVD) prevention guidelines recommend absolute CVD risk scores to identify high- and low-risk patients, but laboratory testing can be impractical in low- and middle-income countries. The purpose of this study was to compare the ranking performance of a simple, non-...

journal_title：BMC medicine

authors： Gaziano TA,Pandya A,Steyn K,Levitt N,Mollentze W,Joubert G,Walsh CM,Motala AA,Kruger A,Schutte AE,Naidoo DP,Prakaschandra DR,Laubscher R

更新日期：2013-07-24 00:00:00

abstract：:Breast cancer is the most common cause of cancer and cancer death worldwide. Although most patients present with localized breast cancer and may be rendered disease-free with local therapy, distant recurrence is common and is the primary cause of death from the disease. Adjuvant systemic therapies are effective in red...

journal_title：BMC medicine

authors： Anampa J,Makower D,Sparano JA

更新日期：2015-08-17 00:00:00

abstract：BACKGROUND:Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomized controlled trial (RCT) investigating the impact of fatty fish on cognition in preschool children....

journal_title：BMC medicine

authors： Øyen J,Kvestad I,Midtbø LK,Graff IE,Hysing M,Stormark KM,Markhus MW,Baste V,Frøyland L,Koletzko B,Demmelmair H,Dahl L,Lie Ø,Kjellevold M

更新日期：2018-03-12 00:00:00

abstract：:In this video Q&A, we talk to Associate Professor Felice Jacka about population health approaches to the primary prevention of mental disorders across the lifespan. These include addressing lifestyle factors, such as diet, smoking and physical activity. Latest strategies are being developed through epidemiological stu...

journal_title：BMC medicine

authors： Jacka FN

更新日期：2015-10-14 00:00:00

abstract：BACKGROUND:Adiposity is associated with many adverse health outcomes but little direct evidence exists about its impact on the use of health care services. We aim to describe the relationship between body mass index (BMI) and rates of hospital admission in middle-aged UK women. METHODS:Among 1,251,619 Million Women St...

journal_title：BMC medicine

authors： Reeves GK,Balkwill A,Cairns BJ,Green J,Beral V,Million Women Study Collaborators.

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:Ineffective risk stratification can delay diagnosis of serious disease in patients with hematuria. We applied a systems biology approach to analyze clinical, demographic and biomarker measurements (n = 29) collected from 157 hematuric patients: 80 urothelial cancer (UC) and 77 controls with confounding patho...

journal_title：BMC medicine

authors： Emmert-Streib F,Abogunrin F,de Matos Simoes R,Duggan B,Ruddock MW,Reid CN,Roddy O,White L,O'Kane HF,O'Rourke D,Anderson NH,Nambirajan T,Williamson KE

更新日期：2013-01-17 00:00:00

abstract：BACKGROUND:The placebo response in patients with diabetes mellitus is very common. A systematic evaluation needs to be updated with the current evidence about the placebo response in diabetes mellitus and the associated factors in clinical trials of anti-diabetic medicine. METHODS:Literature research was conducted in ...

journal_title：BMC medicine

authors： Lin C,Cai X,Yang W,Lv F,Nie L,Ji L

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease...

journal_title：BMC medicine

authors： Ferreira JP,Girerd N,Pellicori P,Duarte K,Girerd S,Pfeffer MA,McMurray JJ,Pitt B,Dickstein K,Jacobs L,Staessen JA,Butler J,Latini R,Masson S,Mebazaa A,Rocca HP,Delles C,Heymans S,Sattar N,Jukema JW,Cleland JG,Za

更新日期：2016-11-10 00:00:00

abstract：:Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic A...

journal_title：BMC medicine

authors： Munshi R,Hsu C,Himmelfarb J

更新日期：2011-02-02 00:00:00

abstract：:In recent years, the introduction and Federal Drug Administration approval of immune checkpoint inhibitor antibodies has dramatically improved the clinical outcomes for patients with advanced melanoma. These antagonist monoclonal antibodies are capable of unleashing dormant or exhausted antitumor immunity, which has l...

journal_title：BMC medicine

authors： Redman JM,Gibney GT,Atkins MB

更新日期：2016-02-06 00:00:00

abstract：:Primary care clinicians and researchers are growing increasingly aware of the prevalence of multimorbidity among long-term conditions, and the impact on patient experience, health, and utilisation of care. The correspondence paper by Muth et al. entitled 'The Ariadne principles: how to handle multimorbidity in primary...

journal_title：BMC medicine

authors： Bower P

更新日期：2014-12-08 00:00:00

abstract：BACKGROUND:The declining efficacy of dihydroartemisinin-piperaquine against Plasmodium falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests resistance to both artemisinin and piperaquine. Available in vitro piperaquine susceptibility assays do not correlate with treatment outcome. A nov...

journal_title：BMC medicine

authors： Duru V,Khim N,Leang R,Kim S,Domergue A,Kloeung N,Ke S,Chy S,Eam R,Khean C,Loch K,Ken M,Lek D,Beghain J,Ariey F,Guerin PJ,Huy R,Mercereau-Puijalon O,Witkowski B,Menard D

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Participation in randomized controlled trials (RCTs) may be quite demanding and could represent an important burden for patients. We aimed to explore this research burden (i.e., the psychological, physical, and financial burdens) experienced by patients through their participation in a RCT. METHODS:We condu...

journal_title：BMC medicine

authors： Naidoo N,Nguyen VT,Ravaud P,Young B,Amiel P,Schanté D,Clarke M,Boutron I

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease (COPD). Our aim was to externally validate and concurrently compare prognostic scores for 3-year...

journal_title：BMC medicine

authors： Guerra B,Haile SR,Lamprecht B,Ramírez AS,Martinez-Camblor P,Kaiser B,Alfageme I,Almagro P,Casanova C,Esteban-González C,Soler-Cataluña JJ,de-Torres JP,Miravitlles M,Celli BR,Marin JM,Ter Riet G,Sobradillo P,Lange P,Ga

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:Wide implementation of mammography screening has resulted in increased numbers of women diagnosed with breast carcinoma in situ. We aimed to determine the risk of invasive breast cancer in relatives of patients with breast carcinoma in situ in comparison to the risk in relatives of patients with invasive bre...

journal_title：BMC medicine

authors： Mukama T,Fallah M,Brenner H,Xu X,Sundquist K,Sundquist J,Kharazmi E

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:The World Health Organisation estimates that by 2030 there will be approximately 350 million people with type 2 diabetes. Associated with renal complications, heart disease, stroke and peripheral vascular disease, early identification of patients with undiagnosed type 2 diabetes or those at an increased risk...

journal_title：BMC medicine

authors： Collins GS,Mallett S,Omar O,Yu LM

更新日期：2011-09-08 00:00:00

abstract：BACKGROUND:The treatment of patients with haematological malignancies by means of haematopoietic stem cell transplantation (HSCT) is often accompanied by life threatening infections. With emerging antimicrobial resistance there is an increased need for new agents, with a beneficial safety profile. Therefore we evaluate...

journal_title：BMC medicine

authors： Velden WJ,van Iersel TM,Blijlevens NM,Donnelly JP

更新日期：2009-09-08 00:00:00

abstract：:Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an obvious and attractive therapeutic strategy. After concerted effort...

journal_title：BMC medicine

authors： Quashie PK,Sloan RD,Wainberg MA

更新日期：2012-04-12 00:00:00

abstract：BACKGROUND:The Diagnostic and Statistical Manual fifth edition (DSM-5) provides new criteria for delirium diagnosis. We examined delirium diagnosis using these new criteria compared with the Diagnostic and Statistical Manual fourth edition (DSM-IV) in a large dataset of patients assessed for delirium and related presen...

journal_title：BMC medicine

authors： Meagher DJ,Morandi A,Inouye SK,Ely W,Adamis D,Maclullich AJ,Rudolph JL,Neufeld K,Leonard M,Bellelli G,Davis D,Teodorczuk A,Kreisel S,Thomas C,Hasemann W,Timmons S,O'Regan N,Grover S,Jabbar F,Cullen W,Dunne C,Kam

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:The major psychoactive cannabinoid compound of marijuana, delta-9 tetrahydrocannabinol (THC), has been shown to modulate immune responses and lymphocyte function. After primary infection the viral DNA genome of gamma herpesviruses persists in lymphoid cell nuclei in a latent episomal circular form. In respon...

journal_title：BMC medicine

authors： Medveczky MM,Sherwood TA,Klein TW,Friedman H,Medveczky PG

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Iron deficiency without anemia is related to adverse symptoms that can be relieved by supplementation. Since a blood donation can induce such an iron deficiency, we investigated the clinical impact of iron treatment after a blood donation. METHODS:One week after donation, we randomly assigned 154 female don...

journal_title：BMC medicine

authors： Waldvogel S,Pedrazzini B,Vaucher P,Bize R,Cornuz J,Tissot JD,Favrat B

更新日期：2012-01-24 00:00:00

abstract：BACKGROUND:Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss. Clinical management and outcomes are challenged by current limited immunosuppressive and immunomodulating regimens. METHODS...

journal_title：BMC medicine

authors： Li Y,Yan B,Wang H,Li H,Li Q,Zhao D,Chen Y,Zhang Y,Li W,Zhang J,Wang S,Shen J,Li Y,Guindi E,Zhao Y

更新日期：2015-04-20 00:00:00

abstract：BACKGROUND:The prognostic significance of tumor-associated macrophages (TAM) in adult classical Hodgkin lymphoma (cHL) remains controversial. Here, we report a meta-analysis of the association of CD68 and CD163 infiltration on the clinical outcome of adult cHL. METHODS:A comprehensive search to identify relevant artic...

journal_title：BMC medicine

authors： Guo B,Cen H,Tan X,Ke Q

更新日期：2016-10-17 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring involves therapeutic modifications based on the measurement of drug levels and antidrug antibodies. The viability of therapeutic drug monitoring in vedolizumab-treated patients with inflammatory bowel disease remains questioned. MAIN BODY:Accumulating evidence from clinical trial...

journal_title：BMC medicine

authors： Pouillon L,Vermeire S,Bossuyt P

更新日期：2019-05-08 00:00:00