Abstract:
BACKGROUND:It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. METHODS:To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal sex and calibrated these models to the observed rates of Chlamydia trachomatis infection at three anatomical sites from 4888 men who have sex with men (MSM) in Melbourne Sexual Health Centre during 2018-2019. RESULTS:A model that included only oral and anal sex could replicate the observed rates of single-site infection at the oropharynx, urethra and rectum alone, but could not replicate infection at more than one of these sites (multisite). However, if we included transmission from sexual practices that followed one another in the same sexual episode (e.g. saliva contamination of the penis from oral sex transmitting chlamydia to the rectum by anal sex), we significantly improved the calibration of multisite infection rates substantially. CONCLUSIONS:Our modelling study suggests that transmission routes other than just oral and anal sex are necessary to explain the high rate of Chlamydia trachomatis infection at more than one site.
journal_name
BMC Medjournal_title
BMC medicineauthors
Xu X,Chow EPF,Ong JJ,Hoebe CJPA,Zou Z,Hocking JS,Fairley CK,Zhang Ldoi
10.1186/s12916-020-01796-3subject
Has Abstractpub_date
2020-11-17 00:00:00pages
326issue
1issn
1741-7015pii
10.1186/s12916-020-01796-3journal_volume
18pub_type
杂志文章相关文献
BMC Medicine文献大全abstract:BACKGROUND:Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many cases of diagnosed dystroglycanopathies, only a small fraction can be linked directly to mutations ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1478-3
更新日期:2020-01-21 00:00:00
abstract:BACKGROUND:Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between comorbidities and to investigate the association between comorbidity groups and outcomes. METHODS:Lat...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01881-7
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake. METHODS:We followed-up 5,505 h...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1741-7015-11-192
更新日期:2013-08-30 00:00:00
abstract::Verotoxigenic Escherichia coli (VTEC) are a specialized group of E. coli that can cause severe colonic disease and renal failure. Their pathogenicity derives from virulence factors that enable the bacteria to colonize the colon and deliver extremely powerful toxins known as verotoxins (VT) or Shiga toxins (Stx) to the...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-12
更新日期:2012-02-02 00:00:00
abstract:BACKGROUND:Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on pregnancy or birth outcomes. A limited number of studies have examined iodine status and birth outco...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01602-0
更新日期:2020-06-11 00:00:00
abstract:BACKGROUND:Strategies in many countries have sought to improve palliative care and reduce hospital deaths for non-cancer patients, but their effects are not evaluated. We aimed to determine the trends and factors associated with dying in hospital in two common progressive respiratory diseases, and the impact of a natio...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-016-0776-2
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Clinicians have known for centuries that there is substantial variability between patients in their response to medications-some individuals exhibit a miraculous recovery while others fail to respond at all. Still others experience dangerous side effects. The hunt for the factors responsible for this variati...
journal_title:BMC medicine
pub_type: 社论
doi:10.1186/s12916-016-0622-6
更新日期:2016-05-04 00:00:00
abstract:BACKGROUND:Studies addressing the effects of aerobic exercise and a prudent diet on lipid and lipoprotein concentrations in adults have reached conflicting conclusions. The purpose of this study was to determine the effects of aerobic exercise combined with a prudent diet on lipid and lipoprotein concentrations in adul...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析
doi:10.1186/1741-7015-9-74
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:In childhood, attention deficit/hyperactivity disorder (ADHD) is characterized by age-inappropriate levels of inattentiveness/disorganization, hyperactivity/impulsiveness, or a combination thereof. Although the criteria for ADHD are well defined, the long-term consequences in adults and children need to be m...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1741-7015-10-99
更新日期:2012-09-04 00:00:00
abstract::Post-traumatic stress disorder (PTSD) can be caused by life threatening illness, such as cancer and coronary events. The study by Forbes et al. made the unexpected finding that military personnel evacuation with medical illness have similar rates of PTSD to those evacuated with combat injuries. It may be that the illn...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-126
更新日期:2012-10-24 00:00:00
abstract::The lack of formal training programs for peer reviewers places the scientific quality of biomedical publications at risk, as the introduction of 'hidden' bias may not be easily recognized by the reader. The exponential increase in the number of manuscripts submitted for publication worldwide, estimated in the millions...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0179-1
更新日期:2014-09-26 00:00:00
abstract:BACKGROUND:Multiple treatments are frequently available for a given condition, and clinicians and patients need a comprehensive, up-to-date synthesis of evidence for all competing treatments. We aimed to quantify the waste of research related to the failure of systematic reviews to provide a complete and up-to-date evi...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-016-0555-0
更新日期:2016-01-20 00:00:00
abstract::In a climate of economic uncertainty, cost effectiveness analysis is a potentially important tool for making choices about health care interventions. Methods for such analyses are well established, but the results need to be interpreted carefully and are subject to bias. Making decisions based on results of cost-effec...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-10
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based study aimed at exploring factors associated with survival in patients with resected TNM stage I-II PaC r...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1304-y
更新日期:2019-03-25 00:00:00
abstract::Singapore is endemic for Dengue virus, with approximately 10,000 to 20,000 annual cases reported in recent years. In 2012, Chikungunya was introduced, although the numbers of cases reported is much fewer. The current Zika virus pandemic originating in Brazil represents a threat to all regions with Aedes mosquitoes, pa...
journal_title:BMC medicine
pub_type: 社论
doi:10.1186/s12916-016-0737-9
更新日期:2016-11-21 00:00:00
abstract:BACKGROUND:Comorbidity between depressive and anxiety disorders is common. A hypothesis of the network perspective on psychopathology is that comorbidity arises due to the interplay of symptoms shared by both disorders, with overlapping symptoms acting as so-called bridges, funneling symptom activation between symptom ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01738-z
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:We update a previous systematic review to inform new World Health Organization HIV self-testing (HIVST) recommendations. We compared the effects of HIVST to standard HIV testing services to understand which service delivery models are effective for key populations. METHODS:We did a systematic review of rand...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01835-z
更新日期:2020-12-03 00:00:00
abstract:BACKGROUND:The placebo response in patients with diabetes mellitus is very common. A systematic evaluation needs to be updated with the current evidence about the placebo response in diabetes mellitus and the associated factors in clinical trials of anti-diabetic medicine. METHODS:Literature research was conducted in ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01787-4
更新日期:2020-11-16 00:00:00
abstract::Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed better than 50% improvement in 50% of patients in a clinical trial....
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-015-0522-1
更新日期:2015-11-10 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD). The current evidence on platelet activation levels in patients with HIV remains inconclusive. We therefore aimed to systematically synthesise ev...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01801-9
更新日期:2020-11-18 00:00:00
abstract:BACKGROUND:Use of fenfluramines for weight loss has been associated with the development of characteristic plaques on cardiac valves causing regurgitation. However, previously published studies of exposure to fenfluramines have been limited by relatively small sample size, short duration of follow-up, and the lack of a...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-6-34
更新日期:2008-11-06 00:00:00
abstract:BACKGROUND:Predicting treatment benefit and/or outcome before any therapeutic intervention has taken place would be clinically very useful. Herein, we evaluate the ability of the intrinsic subtypes and the risk of relapse score at diagnosis to predict survival and response following neoadjuvant chemotherapy. In additio...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0540-z
更新日期:2015-12-18 00:00:00
abstract:BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-1505-4
更新日期:2020-03-03 00:00:00
abstract:BACKGROUND:Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of key antigens, the im...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0183-5
更新日期:2014-10-16 00:00:00
abstract::The Ebola virus disease (EVD) outbreak in the three West Africa countries of Guinea, Liberia, and Sierra Leone, was declared by the World Health Organization (WHO) as a public health event of international concern in August 2014. The disease, which has caused more than 10,000 deaths from over 25,000 cases, has thrived...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0359-7
更新日期:2015-05-14 00:00:00
abstract:BACKGROUND:Migraine aura may be difficult to differentiate from transient ischemic attacks and other transient neurological disorders in pregnant women. The aims of the present study were to investigate and diagnose all pregnant women with transient neurological disorders of suspected central nervous system origin, and...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-5-19
更新日期:2007-07-17 00:00:00
abstract:BACKGROUND:Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sensitive behavioral assays in low-income settings, which has hindered researchers' ability to explain h...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1431-5
更新日期:2019-11-25 00:00:00
abstract:BACKGROUND:Diarrhea is a leading cause of morbidity and mortality among children under five years of age. The Lives Saved Tool (LiST) is a model used to calculate deaths averted or lives saved by past interventions and for the purposes of program planning when costly and time consuming impact studies are not possible. ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-12-70
更新日期:2014-04-29 00:00:00
abstract:BACKGROUND:Interventions to promote positive parenting are often reported to offer good outcomes for children but they can consume substantial resources and they require rigorous appraisal. METHODS:Evaluations of the Triple P parenting program were subjected to systematic review and meta-analysis with analysis of bias...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1741-7015-10-130
更新日期:2012-11-02 00:00:00
abstract::The Mediterranean diet has been linked to a number of health benefits, including reduced mortality risk and lower incidence of cardiovascular disease. Definitions of the Mediterranean diet vary across some settings, and scores are increasingly being employed to define Mediterranean diet adherence in epidemiological st...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-12-112
更新日期:2014-07-24 00:00:00