Advances in understanding ischemic acute kidney injury.

abstract：BACKGROUND:Thymic size in early infancy predicts subsequent survival in low-income settings. The human thymus develops from early gestation, is most active in early life and is highly sensitive to malnutrition. Our objective was to test whether thymic size in infancy could be increased by maternal and/or infant nutriti...

journal_title：BMC medicine

authors： Moore SE,Fulford AJC,Sosseh F,Nshe P,Darboe MK,Prentice AM

更新日期：2019-02-18 00:00:00

abstract：BACKGROUND:Managing hearing communication for residents living with hearing loss and dementia in long-term care settings is challenging. This paper explores how care can be effective in optimising hearing communication for residents living with dementia. We argue that the underlying notion of permission or authorisatio...

journal_title：BMC medicine

authors： Crosbie B,Ferguson M,Wong G,Walker DM,Vanhegan S,Dening T

更新日期：2019-03-04 00:00:00

abstract：:Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an obvious and attractive therapeutic strategy. After concerted effort...

journal_title：BMC medicine

authors： Quashie PK,Sloan RD,Wainberg MA

更新日期：2012-04-12 00:00:00

abstract：BACKGROUND:The term 'lower value services' concerns healthcare that is of little or no value to the patient and consequently should not be provided routinely, or not be provided at all. De-adoption of lower value care may occur through explicit recommendations in clinical guidelines. The present study aimed to generate...

journal_title：BMC medicine

authors： Wammes JJ,van den Akker-van Marle ME,Verkerk EW,van Dulmen SA,Westert GP,van Asselt AD,Kool RB

更新日期：2016-11-25 00:00:00

abstract：BACKGROUND:Multiple-arm randomized trials can be more complex in their design, data analysis, and result reporting than two-arm trials. We conducted a systematic review to assess the reporting of analyses in reports of randomized controlled trials (RCTs) with multiple arms. METHODS:The literature in the MEDLINE databa...

journal_title：BMC medicine

authors： Baron G,Perrodeau E,Boutron I,Ravaud P

更新日期：2013-03-27 00:00:00

abstract：BACKGROUND:The prognostic significance of tumor-associated macrophages (TAM) in adult classical Hodgkin lymphoma (cHL) remains controversial. Here, we report a meta-analysis of the association of CD68 and CD163 infiltration on the clinical outcome of adult cHL. METHODS:A comprehensive search to identify relevant artic...

journal_title：BMC medicine

authors： Guo B,Cen H,Tan X,Ke Q

更新日期：2016-10-17 00:00:00

abstract：BACKGROUND:Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake. METHODS:We followed-up 5,505 h...

journal_title：BMC medicine

authors： Gea A,Beunza JJ,Estruch R,Sánchez-Villegas A,Salas-Salvadó J,Buil-Cosiales P,Gómez-Gracia E,Covas MI,Corella D,Fiol M,Arós F,Lapetra J,Lamuela-Raventós RM,Wärnberg J,Pintó X,Serra-Majem L,Martínez-González MA,PREDIMED G

更新日期：2013-08-30 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial Parkinson's disease (PD). Variation around the LRRK2 locus also contributes to the risk of sporadic PD. The LRRK2 protein contains a central catalytic region, and pathogenic mutations cluster in the Ras of complex protein C termi...

journal_title：BMC medicine

authors： Rudenko IN,Chia R,Cookson MR

更新日期：2012-02-23 00:00:00

abstract：BACKGROUND:Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol trafficking characterized by increased plasma plant sterol levels. Based upo...

journal_title：BMC medicine

authors： Klett EL,Lu K,Kosters A,Vink E,Lee MH,Altenburg M,Shefer S,Batta AK,Yu H,Chen J,Klein R,Looije N,Oude-Elferink R,Groen AK,Maeda N,Salen G,Patel SB

更新日期：2004-03-24 00:00:00

abstract：BACKGROUND:Contrast-induced nephropathy is an important cause of acute renal failure. We assess the efficacy of acetylcysteine for prevention of contrast-induced nephropathy among patients undergoing intravascular angiography. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials c...

journal_title：BMC medicine

authors： Bagshaw SM,Ghali WA

更新日期：2004-10-22 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of the three leading causes of cancer-related deaths worldwide. Growing evidence suggests that a subset of cells exists among cancer stem cells. This distinct subpopulation is thought to contribute to liver metastasis; however, it ha...

journal_title：BMC medicine

authors： Zhang SS,Han ZP,Jing YY,Tao SF,Li TJ,Wang H,Wang Y,Li R,Yang Y,Zhao X,Xu XD,Yu ED,Rui YC,Liu HJ,Zhang L,Wei LX

更新日期：2012-08-07 00:00:00

abstract：BACKGROUND:Migraine aura may be difficult to differentiate from transient ischemic attacks and other transient neurological disorders in pregnant women. The aims of the present study were to investigate and diagnose all pregnant women with transient neurological disorders of suspected central nervous system origin, and...

journal_title：BMC medicine

authors： Ertresvg JM,Stovner LJ,Kvavik LE,Johnsen HJ,Zwart JA,Helde G,Bovim G

更新日期：2007-07-17 00:00:00

abstract：BACKGROUND:Inflammatory cytokines play a crucial role in coronary artery disease (CAD). We investigated the association between 48 coding and three non-coding single nucleotide polymorphisms (SNPs) from 35 inflammatory genes and the development of CAD, using a large discordant sibship collection (2699 individuals in 89...

journal_title：BMC medicine

authors： Brown BD,Nsengimana J,Barrett JH,Lawrence RA,Steiner L,Cheng S,Bishop DT,Samani NJ,Ball SG,Balmforth AJ,Hall AS

更新日期：2010-01-13 00:00:00

abstract：BACKGROUND:Pendred syndrome, an autosomal-recessive disorder characterized by deafness and goiter, is caused by a mutation of SLC26A4, which codes for the anion exchanger pendrin. We investigated the relationship between pendrin expression and deafness using mice that have (Slc26a4+/+ or Slc26a4+/-) or lack (Slc26a4-/-...

journal_title：BMC medicine

authors： Jabba SV,Oelke A,Singh R,Maganti RJ,Fleming S,Wall SM,Everett LA,Green ED,Wangemann P

更新日期：2006-12-22 00:00:00

abstract：:There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquitoes. The Worldwide ...

journal_title：BMC medicine

authors： Karunajeewa HA,Mueller I

更新日期：2016-06-18 00:00:00

abstract：BACKGROUND:The treatment of patients with haematological malignancies by means of haematopoietic stem cell transplantation (HSCT) is often accompanied by life threatening infections. With emerging antimicrobial resistance there is an increased need for new agents, with a beneficial safety profile. Therefore we evaluate...

journal_title：BMC medicine

authors： Velden WJ,van Iersel TM,Blijlevens NM,Donnelly JP

更新日期：2009-09-08 00:00:00

abstract：BACKGROUND:Associations between type 2 diabetes (T2D) and amyotrophic lateral sclerosis (ALS) were discovered in observational studies in both European and East Asian populations. However, whether such associations are causal remains largely unknown. METHODS:We employed a two-sample Mendelian randomization approach to...

journal_title：BMC medicine

authors： Zeng P,Wang T,Zheng J,Zhou X

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:Fetal and neonatal mortality rates in low-income countries are at least 10-fold greater than in high-income countries. These differences have been related to poor access to and poor quality of obstetric and neonatal care. METHODS:This trial tested the hypothesis that teams of health care providers, administ...

journal_title：BMC medicine

authors： Pasha O,McClure EM,Wright LL,Saleem S,Goudar SS,Chomba E,Patel A,Esamai F,Garces A,Althabe F,Kodkany B,Mabeya H,Manasyan A,Carlo WA,Derman RJ,Hibberd PL,Liechty EK,Krebs N,Hambidge KM,Buekens P,Moore J,Jobe AH,

更新日期：2013-10-03 00:00:00

abstract：BACKGROUND:Multiple treatments are frequently available for a given condition, and clinicians and patients need a comprehensive, up-to-date synthesis of evidence for all competing treatments. We aimed to quantify the waste of research related to the failure of systematic reviews to provide a complete and up-to-date evi...

journal_title：BMC medicine

authors： Créquit P,Trinquart L,Yavchitz A,Ravaud P

更新日期：2016-01-20 00:00:00

abstract：BACKGROUND:There are widespread concerns about communication and support for patients and families, especially when they face clinical uncertainty, a situation most marked in intensive care units (ICUs). Therefore, we aimed to develop and evaluate an interventional tool to improve communication and palliative care, usi...

journal_title：BMC medicine

authors： Higginson IJ,Koffman J,Hopkins P,Prentice W,Burman R,Leonard S,Rumble C,Noble J,Dampier O,Bernal W,Hall S,Morgan M,Shipman C

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The likelihood of recurrence in patients with breast cancer who have HER2-positive tumors is relatively high, although trastuzumab is a remarkably effective drug in this setting. Signal transducer and activator of transcription 3 protein (STAT3), a transcription factor that is persistently tyrosine-705 phosp...

journal_title：BMC medicine

authors： Sonnenblick A,Brohée S,Fumagalli D,Vincent D,Venet D,Ignatiadis M,Salgado R,Van den Eynden G,Rothé F,Desmedt C,Neven P,Loibl S,Denkert C,Joensuu H,Loi S,Sirtaine N,Kellokumpu-Lehtinen PL,Piccart M,Sotiriou C

更新日期：2015-08-03 00:00:00

abstract：BACKGROUND:Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. The utility of the new quantitative PCR test (Xpert MTB/RIF) for the diagnosis...

journal_title：BMC medicine

authors： Pandie S,Peter JG,Kerbelker ZS,Meldau R,Theron G,Govender U,Ntsekhe M,Dheda K,Mayosi BM

更新日期：2014-06-18 00:00:00

abstract：BACKGROUND:Adiposity is associated with many adverse health outcomes but little direct evidence exists about its impact on the use of health care services. We aim to describe the relationship between body mass index (BMI) and rates of hospital admission in middle-aged UK women. METHODS:Among 1,251,619 Million Women St...

journal_title：BMC medicine

authors： Reeves GK,Balkwill A,Cairns BJ,Green J,Beral V,Million Women Study Collaborators.

更新日期：2014-03-15 00:00:00

abstract：BACKGROUND:The World Health Organisation estimates that by 2030 there will be approximately 350 million people with type 2 diabetes. Associated with renal complications, heart disease, stroke and peripheral vascular disease, early identification of patients with undiagnosed type 2 diabetes or those at an increased risk...

journal_title：BMC medicine

authors： Collins GS,Mallett S,Omar O,Yu LM

更新日期：2011-09-08 00:00:00

abstract：BACKGROUND:The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines Agency (EMA) concerning human papillomavirus (HPV) vaccines during a European Union (EU) referral pro...

journal_title：BMC medicine

authors： Bahri P,Fogd J,Morales D,Kurz X,ADVANCE consortium.

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Armed conflicts are associated with a wide range of impacts on the mental health of children and adolescents. We evaluated the effectiveness of a school-based intervention aimed at reducing symptoms of posttraumatic stress disorder, depression, and anxiety (treatment aim); and improving a sense of hope and f...

journal_title：BMC medicine

authors： Tol WA,Komproe IH,Jordans MJ,Ndayisaba A,Ntamutumba P,Sipsma H,Smallegange ES,Macy RD,de Jong JT

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence of impaired glucose metabolism on the relation between dietary intake of n-3 LCPUFAs and risk of a...

journal_title：BMC medicine

authors： Strand E,Pedersen ER,Svingen GF,Schartum-Hansen H,Rebnord EW,Bjørndal B,Seifert R,Bohov P,Meyer K,Hiltunen JK,Nordrehaug JE,Nilsen DW,Berge RK,Nygård O

更新日期：2013-10-08 00:00:00

abstract：:Migraine is a highly prevalent neurological disorder imparting a major burden on health care around the world. The primary pathology may be a state of hyperresponsiveness of the nervous system, but the molecular mechanisms are yet to be fully elucidated. We could now be at a watershed moment in this respect, as the ge...

journal_title：BMC medicine

authors： Weir GA,Cader MZ

更新日期：2011-10-25 00:00:00

abstract：:Singapore is endemic for Dengue virus, with approximately 10,000 to 20,000 annual cases reported in recent years. In 2012, Chikungunya was introduced, although the numbers of cases reported is much fewer. The current Zika virus pandemic originating in Brazil represents a threat to all regions with Aedes mosquitoes, pa...

journal_title：BMC medicine

authors： Fisher D,Cutter J

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they present mild diseases on admission. METHODS:A multicenter nested case-control study was conducted in four...

journal_title：BMC medicine

authors： Shi J,Li Y,Zhou X,Zhang Q,Ye X,Wu Z,Jiang X,Yu H,Shao L,Ai JW,Zhang H,Xu B,Sun F,Zhang W

更新日期：2020-06-03 00:00:00