Reporting of analyses from randomized controlled trials with multiple arms: a systematic review.

abstract：BACKGROUND:Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomized controlled trial (RCT) investigating the impact of fatty fish on cognition in preschool children....

journal_title：BMC medicine

authors： Øyen J,Kvestad I,Midtbø LK,Graff IE,Hysing M,Stormark KM,Markhus MW,Baste V,Frøyland L,Koletzko B,Demmelmair H,Dahl L,Lie Ø,Kjellevold M

更新日期：2018-03-12 00:00:00

abstract：:The approval of sorafenib and active development of many other molecularly targeted agents in hepatocellular carcinoma (HCC) have presented a challenge to understand the mechanism of action of sorafenib and identify predictive biomarkers to select patients more likely to benefit from sorafenib. The preclinical study b...

journal_title：BMC medicine

authors： Zhu AX

更新日期：2009-08-24 00:00:00

abstract：BACKGROUND:Brazil's Estratégia Saúde da Família (ESF) is one of the largest and most robustly evaluated primary healthcare programmes of the world, but it could be affected by fiscal austerity measures and by the possible end of the Mais Médicos programme (MMP)-a major intervention to increase primary care doctors in u...

journal_title：BMC medicine

authors： Rasella D,Hone T,de Souza LE,Tasca R,Basu S,Millett C

更新日期：2019-04-26 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD). The current evidence on platelet activation levels in patients with HIV remains inconclusive. We therefore aimed to systematically synthesise ev...

journal_title：BMC medicine

authors： Nkambule BB,Mxinwa V,Mkandla Z,Mutize T,Mokgalaboni K,Nyambuya TM,Dludla PV

更新日期：2020-11-18 00:00:00

abstract：BACKGROUND:Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved. METHODS:An open-label, non-inferiority, 1:1 randomized trial was conducted at three academic hospitals in So...

journal_title：BMC medicine

authors： Syn NL,Wong AL,Lee SC,Teoh HL,Yip JWL,Seet RC,Yeo WT,Kristanto W,Bee PC,Poon LM,Marban P,Wu TS,Winther MD,Brunham LR,Soong R,Tai BC,Goh BC

更新日期：2018-07-10 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) elimination is being seriously considered globally. Current elimination models require a combination of highly effective HCV treatment and harm reduction, but high treatment costs make such strategies prohibitively expensive. Vaccines should play a key role in elimination but their be...

journal_title：BMC medicine

authors： Scott N,McBryde E,Vickerman P,Martin NK,Stone J,Drummer H,Hellard M

更新日期：2015-08-20 00:00:00

abstract：BACKGROUND:Migraine aura may be difficult to differentiate from transient ischemic attacks and other transient neurological disorders in pregnant women. The aims of the present study were to investigate and diagnose all pregnant women with transient neurological disorders of suspected central nervous system origin, and...

journal_title：BMC medicine

authors： Ertresvg JM,Stovner LJ,Kvavik LE,Johnsen HJ,Zwart JA,Helde G,Bovim G

更新日期：2007-07-17 00:00:00

abstract：BACKGROUND:Contrast-induced nephropathy is an important cause of acute renal failure. We assess the efficacy of acetylcysteine for prevention of contrast-induced nephropathy among patients undergoing intravascular angiography. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials c...

journal_title：BMC medicine

authors： Bagshaw SM,Ghali WA

更新日期：2004-10-22 00:00:00

abstract：BACKGROUND:Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unknown. To investigate the role of the normal breast microenvironment on breast cancer cell tumorigenic...

journal_title：BMC medicine

authors： Fleming JM,Miller TC,Quinones M,Xiao Z,Xu X,Meyer MJ,Ginsburg E,Veenstra TD,Vonderhaar BK

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:Participation in randomized controlled trials (RCTs) may be quite demanding and could represent an important burden for patients. We aimed to explore this research burden (i.e., the psychological, physical, and financial burdens) experienced by patients through their participation in a RCT. METHODS:We condu...

journal_title：BMC medicine

authors： Naidoo N,Nguyen VT,Ravaud P,Young B,Amiel P,Schanté D,Clarke M,Boutron I

更新日期：2020-01-20 00:00:00

abstract：:Due to the easier access to information, the availability of low cost technologies and the involvement of well educated, passionate patients, a group of citizen 'Health Hackers', who are building their own medical systems to help them overcome the unmet needs of their conditions, is emerging. This has recently been th...

journal_title：BMC medicine

authors： Omer T

更新日期：2016-08-17 00:00:00

abstract：:A series of primarily laboratory-based studies found attention bias modification in socially anxious participants to lead to reduced anxiety. It is argued that the failure to replicate the positive results of attention bias modification in the study of Carlbring et al. may be due to reasons other than the application ...

journal_title：BMC medicine

authors： Emmelkamp PM

更新日期：2012-06-25 00:00:00

abstract：BACKGROUND:The objectives of this study were to understand the differences in mortality rate, risk factors for mortality, and cause of death distribution in three neonatal age sub-groups (0-2, 3-7, and 8-27 days) and assess the change in mortality rate with previous assessments to inform programmatic decision-making in...

journal_title：BMC medicine

authors： Dandona R,Kumar GA,Bhattacharya D,Akbar M,Atmavilas Y,Nanda P,Dandona L

更新日期：2019-07-19 00:00:00

abstract：BACKGROUND:Off-label and unlicensed (OLUL) prescribing has been prevalent in pediatric practice. Using data from a prospective cohort study of adverse drug reactions (ADRs) among pediatric inpatients, we aimed to test the hypothesis that OLUL status is a risk factor for ADRs. METHODS:A nested case?control study was co...

journal_title：BMC medicine

authors： Bellis JR,Kirkham JJ,Thiesen S,Conroy EJ,Bracken LE,Mannix HL,Bird KA,Duncan JC,Peak M,Turner MA,Smyth RL,Nunn AJ,Pirmohamed M

更新日期：2013-11-07 00:00:00

abstract：BACKGROUND:Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sensitive behavioral assays in low-income settings, which has hindered researchers' ability to explain h...

journal_title：BMC medicine

authors： Xie W,Jensen SKG,Wade M,Kumar S,Westerlund A,Kakon SH,Haque R,Petri WA,Nelson CA

更新日期：2019-11-25 00:00:00

abstract：:The complexity of tissue and the alterations that distinguish normal from cancer remain a challenge for translating results from tumor biological studies into clinical medicine. This has generated an unmet need to exploit the findings from studies based on cell lines and model organisms to develop, validate and clinic...

journal_title：BMC medicine

authors： Kampf C,Bergman J,Oksvold P,Asplund A,Navani S,Wiking M,Lundberg E,Uhlén M,Ponten F

更新日期：2012-09-12 00:00:00

abstract：BACKGROUND:Medical apps are widely available, increasingly used by patients and clinicians, and are being actively promoted for use in routine care. However, there is little systematic evidence exploring possible risks associated with apps intended for patient use. Because self-medication errors are a recognized source...

journal_title：BMC medicine

authors： Huckvale K,Adomaviciute S,Prieto JT,Leow MK,Car J

更新日期：2015-05-06 00:00:00

abstract：:The Fluid Expansion as Supportive Therapy (FEAST study) was an extremely well conducted study that gave unexpected results. The investigators had reported that febrile children with impaired perfusion treated in low-income countries without access to intensive care are more likely to die if they receive bolus resuscit...

journal_title：BMC medicine

authors： Myburgh J,Finfer S

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:Publication bias and other reporting bias have been well documented for journal articles, but no study has evaluated the nature of results posted at ClinicalTrials.gov. We aimed to assess how many randomized controlled trials (RCTs) with results posted at ClinicalTrials.gov report statistically significant r...

journal_title：BMC medicine

authors： Dechartres A,Bond EG,Scheer J,Riveros C,Atal I,Ravaud P

更新日期：2016-11-30 00:00:00

abstract：BACKGROUND:Accurate and timely cause of death (COD) data are essential for informed public health policymaking. Medical certification of COD generally provides the majority of COD data in a population and is an essential component of civil registration and vital statistics (CRVS) systems. Accurate completion of the med...

journal_title：BMC medicine

authors： Hart JD,Sorchik R,Bo KS,Chowdhury HR,Gamage S,Joshi R,Kwa V,Li H,Mahesh BPK,Mclaughlin D,Mikkelsen L,Miki J,Napulan R,Rampatige R,Reeve M,Sarmiento C,War NS,Richards N,Riley ID,Lopez AD

更新日期：2020-03-09 00:00:00

abstract：:Although prostate-specific antigen (PSA) screening has improved the detection of prostate cancer, allowing for stage migration to less advanced disease, the precise mortality benefit of early detection is unclear. This is in part due to a discrepancy between the two large randomized controlled trials comparing PSA scr...

journal_title：BMC medicine

authors： Kim EH,Andriole GL

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:Persistent disabilities are key manifestations of Chikungunya virus (CHIKV) infection, especially incapacitating polyarthralgia and fatigue. So far, little is known about their impact on health status. The present study aimed at describing the burden of CHIKV prolonged or late-onset symptoms on the self-perc...

journal_title：BMC medicine

authors： Gérardin P,Fianu A,Malvy D,Mussard C,Boussaïd K,Rollot O,Michault A,Gaüzere BA,Bréart G,Favier F

更新日期：2011-01-14 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) can be caused by life threatening illness, such as cancer and coronary events. The study by Forbes et al. made the unexpected finding that military personnel evacuation with medical illness have similar rates of PTSD to those evacuated with combat injuries. It may be that the illn...

journal_title：BMC medicine

authors： McFarlane AC

更新日期：2012-10-24 00:00:00

abstract：BACKGROUND:It is critically important to conduct research on stigmatized conditions, to include marginalized groups that experience stigma, and to develop interventions to reduce stigma. However, such research is ethically challenging. Though superficial reference is frequently made to these widely acknowledged challen...

journal_title：BMC medicine

authors： Millum J,Campbell M,Luna F,Malekzadeh A,Karim QA

更新日期：2019-04-29 00:00:00

abstract：:Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an obvious and attractive therapeutic strategy. After concerted effort...

journal_title：BMC medicine

authors： Quashie PK,Sloan RD,Wainberg MA

更新日期：2012-04-12 00:00:00

abstract：BACKGROUND:Armed conflicts are associated with a wide range of impacts on the mental health of children and adolescents. We evaluated the effectiveness of a school-based intervention aimed at reducing symptoms of posttraumatic stress disorder, depression, and anxiety (treatment aim); and improving a sense of hope and f...

journal_title：BMC medicine

authors： Tol WA,Komproe IH,Jordans MJ,Ndayisaba A,Ntamutumba P,Sipsma H,Smallegange ES,Macy RD,de Jong JT

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Interventions to promote positive parenting are often reported to offer good outcomes for children but they can consume substantial resources and they require rigorous appraisal. METHODS:Evaluations of the Triple P parenting program were subjected to systematic review and meta-analysis with analysis of bias...

journal_title：BMC medicine

authors： Wilson P,Rush R,Hussey S,Puckering C,Sim F,Allely CS,Doku P,McConnachie A,Gillberg C

更新日期：2012-11-02 00:00:00

abstract：:Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, wi...

journal_title：BMC medicine

authors： Mijajlović MD,Pavlović A,Brainin M,Heiss WD,Quinn TJ,Ihle-Hansen HB,Hermann DM,Assayag EB,Richard E,Thiel A,Kliper E,Shin YI,Kim YH,Choi S,Jung S,Lee YB,Sinanović O,Levine DA,Schlesinger I,Mead G,Milošević V,Ley

更新日期：2017-01-18 00:00:00

abstract：:Although strong evidence exists that the benefits of vaccination by far outweigh potential adverse events, controversy still exists. This has led opponents of vaccination to question its safety, efficacy and necessity. In an interview with Professor Elizabeth Miller, we discuss the continuum of beliefs held by vaccine...

journal_title：BMC medicine

authors： Miller E

更新日期：2015-10-16 00:00:00

abstract：:The microbes colonizing the infant gastrointestinal tract have been implicated in later-life disease states such as allergies and obesity. Recently, the medical research community has begun to realize that very early colonization events may be most impactful on future health, with the presence of key taxa required for...

journal_title：BMC medicine

authors： Ward TL,Knights D,Gale CA

更新日期：2017-02-13 00:00:00