Causes of death after fluid bolus resuscitation: new insights from FEAST.

abstract：BACKGROUND:Skin toxicity is a common side effect of radiotherapy for solid tumors. Its management can cause treatment gaps and thus can impair cancer treatment. At present, in many countries no standard recommendation for treatment of skin during radiotherapy exists. In this study, we explored the effect of topically-a...

journal_title：BMC medicine

authors： Pajonk F,Riedisser A,Henke M,McBride WH,Fiebich B

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Exercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within...

journal_title：BMC medicine

authors： Travier N,Velthuis MJ,Steins Bisschop CN,van den Buijs B,Monninkhof EM,Backx F,Los M,Erdkamp F,Bloemendal HJ,Rodenhuis C,de Roos MA,Verhaar M,ten Bokkel Huinink D,van der Wall E,Peeters PH,May AM

更新日期：2015-06-08 00:00:00

abstract：BACKGROUND:Strategies in many countries have sought to improve palliative care and reduce hospital deaths for non-cancer patients, but their effects are not evaluated. We aimed to determine the trends and factors associated with dying in hospital in two common progressive respiratory diseases, and the impact of a natio...

journal_title：BMC medicine

authors： Higginson IJ,Reilly CC,Bajwah S,Maddocks M,Costantini M,Gao W,GUIDE_Care project.

更新日期：2017-02-01 00:00:00

abstract：:The microbes colonizing the infant gastrointestinal tract have been implicated in later-life disease states such as allergies and obesity. Recently, the medical research community has begun to realize that very early colonization events may be most impactful on future health, with the presence of key taxa required for...

journal_title：BMC medicine

authors： Ward TL,Knights D,Gale CA

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:Extended use of combined pharmacotherapies to treat tobacco dependence may increase smoking abstinence; few studies have examined their effectiveness. The objective of this study was to evaluate smoking abstinence with standard nicotine patch (NRT), extended use of combined formulations of nicotine replaceme...

journal_title：BMC medicine

authors： Tulloch HE,Pipe AL,Els C,Clyde MJ,Reid RD

更新日期：2016-06-07 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer deaths globally. However, there is overwhelming evidence that a large proportion of CRC cases and deaths could be prevented by screening. Nevertheless, CRC screening programmes are offered in a minority of coun...

journal_title：BMC medicine

authors： Brenner H,Stock C,Hoffmeister M

更新日期：2015-10-13 00:00:00

abstract：BACKGROUND:The declining efficacy of dihydroartemisinin-piperaquine against Plasmodium falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests resistance to both artemisinin and piperaquine. Available in vitro piperaquine susceptibility assays do not correlate with treatment outcome. A nov...

journal_title：BMC medicine

authors： Duru V,Khim N,Leang R,Kim S,Domergue A,Kloeung N,Ke S,Chy S,Eam R,Khean C,Loch K,Ken M,Lek D,Beghain J,Ariey F,Guerin PJ,Huy R,Mercereau-Puijalon O,Witkowski B,Menard D

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy characterized by motor dysfunction of the lower extremities and urinary disturbance. Immunomodulatory treatments are the main strategy for HAM/TSP, but several issues are associated...

journal_title：BMC medicine

authors： Nakamura T,Matsuo T,Fukuda T,Yamato S,Yamaguchi K,Kinoshita I,Matsuzaki T,Nishiura Y,Nagasato K,Narita-Masuda T,Nakamura H,Satoh K,Sasaki H,Sakai H,Kawakami A

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world. Unintentional overspray of ATR poses an immune function health hazard. The biomolecular mechanisms responsible for ATR-induced immunotoxicity, however, are little unders...

journal_title：BMC medicine

authors： Zhang X,Wang M,Gao S,Ren R,Zheng J,Zhang Y

更新日期：2011-10-27 00:00:00

abstract：BACKGROUND:The burden of malaria in sub-Saharan Africa remains challenging to measure relying on epidemiological modelling to evaluate the impact of investments and providing an in-depth analysis of progress and trends in malaria response globally. In malaria-endemic countries of Africa, there is increasing use of rout...

journal_title：BMC medicine

authors： Alegana VA,Okiro EA,Snow RW

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Clinicians are less likely to prescribe guideline-recommended treatments to people with multimorbidity than to people with a single condition. Doubts as to the applicability of clinical trials of drug treatments (the gold standard for evidence-based medicine) when people have co-existing diseases (comorbidit...

journal_title：BMC medicine

authors： Hanlon P,Hannigan L,Rodriguez-Perez J,Fischbacher C,Welton NJ,Dias S,Mair FS,Guthrie B,Wild S,McAllister DA

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:We investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation. METHODS:eAPS was induced in heterozygous and homozygous FVL transgenic mice (C57BL/6 background) by immunizat...

journal_title：BMC medicine

authors： Katzav A,Grigoriadis NC,Ebert T,Touloumi O,Blank M,Pick CG,Shoenfeld Y,Chapman J

更新日期：2013-04-04 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is of clinical and public health importance as it is very common, affecting up to one in five women of reproductive age. It has significant and diverse clinical implications including reproductive (infertility, hyperandrogenism, hirsutism), metabolic (insulin resistance, impaired gluco...

journal_title：BMC medicine

authors： Teede H,Deeks A,Moran L

更新日期：2010-06-30 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD). The current evidence on platelet activation levels in patients with HIV remains inconclusive. We therefore aimed to systematically synthesise ev...

journal_title：BMC medicine

authors： Nkambule BB,Mxinwa V,Mkandla Z,Mutize T,Mokgalaboni K,Nyambuya TM,Dludla PV

更新日期：2020-11-18 00:00:00

abstract：BACKGROUND:The vascular contributions to neurodegeneration and neuroinflammation may be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review summarises the methodology for these widely available, safe and relatively low cost tools and analyses recent work highlighting their potential utili...

journal_title：BMC medicine

authors： Malojcic B,Giannakopoulos P,Sorond FA,Azevedo E,Diomedi M,Oblak JP,Carraro N,Boban M,Olah L,Schreiber SJ,Pavlovic A,Garami Z,Bornstein NM,Rosengarten B

更新日期：2017-02-09 00:00:00

abstract：BACKGROUND:Mucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown. METHODS:To correlate MUC4 polymorphism with the risk of endometriosis and endometriosis-related infertility, we performed ...

journal_title：BMC medicine

authors： Chang CY,Chang HW,Chen CM,Lin CY,Chen CP,Lai CH,Lin WY,Liu HP,Sheu JJ,Tsai FJ

更新日期：2011-02-24 00:00:00

abstract：BACKGROUND:Clinical pathways (CPs) are used to improve the outcomes of acute stroke, but their use in stroke care is questionable, because the evidence on their effectiveness is still inconclusive. The objective of this study was to evaluate whether CPs improve the outcomes and the quality of care provided to patients ...

journal_title：BMC medicine

authors： Panella M,Marchisio S,Brambilla R,Vanhaecht K,Di Stanislao F

更新日期：2012-07-10 00:00:00

abstract：BACKGROUND:A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence of impaired glucose metabolism on the relation between dietary intake of n-3 LCPUFAs and risk of a...

journal_title：BMC medicine

authors： Strand E,Pedersen ER,Svingen GF,Schartum-Hansen H,Rebnord EW,Bjørndal B,Seifert R,Bohov P,Meyer K,Hiltunen JK,Nordrehaug JE,Nilsen DW,Berge RK,Nygård O

更新日期：2013-10-08 00:00:00

abstract：BACKGROUND:Prescription of non-steroidal anti-inflammatory drugs (NSAIDs) should be based on the assessment of both gastrointestinal (GI) and cardiovascular (CV) risk for the individual patient. We aimed to assess the GI/CV risk profile and the pharmacological management of patients with osteoarthritis (OA) in clinical...

journal_title：BMC medicine

authors： Lanas A,Garcia-Tell G,Armada B,Oteo-Alvaro A

更新日期：2011-04-14 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pathogenesis and progression of NAFLD is complex with many unanswered questions. We conducted genome-w...

journal_title：BMC medicine

authors： Namjou B,Lingren T,Huang Y,Parameswaran S,Cobb BL,Stanaway IB,Connolly JJ,Mentch FD,Benoit B,Niu X,Wei WQ,Carroll RJ,Pacheco JA,Harley ITW,Divanovic S,Carrell DS,Larson EB,Carey DJ,Verma S,Ritchie MD,Gharavi AG,

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:Predicting treatment benefit and/or outcome before any therapeutic intervention has taken place would be clinically very useful. Herein, we evaluate the ability of the intrinsic subtypes and the risk of relapse score at diagnosis to predict survival and response following neoadjuvant chemotherapy. In additio...

journal_title：BMC medicine

authors： Prat A,Fan C,Fernández A,Hoadley KA,Martinello R,Vidal M,Viladot M,Pineda E,Arance A,Muñoz M,Paré L,Cheang MC,Adamo B,Perou CM

更新日期：2015-12-18 00:00:00

abstract：:Singapore is endemic for Dengue virus, with approximately 10,000 to 20,000 annual cases reported in recent years. In 2012, Chikungunya was introduced, although the numbers of cases reported is much fewer. The current Zika virus pandemic originating in Brazil represents a threat to all regions with Aedes mosquitoes, pa...

journal_title：BMC medicine

authors： Fisher D,Cutter J

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:The term 'lower value services' concerns healthcare that is of little or no value to the patient and consequently should not be provided routinely, or not be provided at all. De-adoption of lower value care may occur through explicit recommendations in clinical guidelines. The present study aimed to generate...

journal_title：BMC medicine

authors： Wammes JJ,van den Akker-van Marle ME,Verkerk EW,van Dulmen SA,Westert GP,van Asselt AD,Kool RB

更新日期：2016-11-25 00:00:00

abstract：BACKGROUND:The objectives of this study were to understand the differences in mortality rate, risk factors for mortality, and cause of death distribution in three neonatal age sub-groups (0-2, 3-7, and 8-27 days) and assess the change in mortality rate with previous assessments to inform programmatic decision-making in...

journal_title：BMC medicine

authors： Dandona R,Kumar GA,Bhattacharya D,Akbar M,Atmavilas Y,Nanda P,Dandona L

更新日期：2019-07-19 00:00:00

abstract：BACKGROUND:The World Health Organisation (WHO) recommends parasitological diagnosis of malaria before treatment, but use of malaria rapid diagnostic tests (mRDTs) by community health workers (CHWs) has not been fully tested within health services in south and central Asia. mRDTs could allow CHWs to diagnose malaria acc...

journal_title：BMC medicine

authors： Leslie T,Rowland M,Mikhail A,Cundill B,Willey B,Alokozai A,Mayan I,Hasanzai A,Baktash SH,Mohammed N,Wood M,Rahimi HU,Laurent B,Buhler C,Whitty CJM

更新日期：2017-07-07 00:00:00

abstract：BACKGROUND:Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score is the only currently available midlife risk score for dementia. We compared CAIDE to Framingham cardiovascular Risk Score (FRS) and FINDRISC diabetes score as predictors of dementia and assessed the role of age in their associa...

journal_title：BMC medicine

authors： Fayosse A,Nguyen DP,Dugravot A,Dumurgier J,Tabak AG,Kivimäki M,Sabia S,Singh-Manoux A

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Monogenic diabetes (MgD) accounts for 1-2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-generation sequencing in patients with late adolescence/adult-onset diabetes referred for a clinical ...

journal_title：BMC medicine

authors： Donath X,Saint-Martin C,Dubois-Laforgue D,Rajasingham R,Mifsud F,Ciangura C,Timsit J,Bellanné-Chantelot C,Monogenic Diabetes Study Group of the Société Francophone du Diabète.

更新日期：2019-07-11 00:00:00

abstract：BACKGROUND:Previous studies have suggested that there may be an association between some immune-mediated diseases and risk of tuberculosis (TB). METHODS:We analyzed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999 to 2011), and a similar database (th...

journal_title：BMC medicine

authors： Ramagopalan SV,Goldacre R,Skingsley A,Conlon C,Goldacre MJ

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease...

journal_title：BMC medicine

authors： Ferreira JP,Girerd N,Pellicori P,Duarte K,Girerd S,Pfeffer MA,McMurray JJ,Pitt B,Dickstein K,Jacobs L,Staessen JA,Butler J,Latini R,Masson S,Mebazaa A,Rocca HP,Delles C,Heymans S,Sattar N,Jukema JW,Cleland JG,Za

更新日期：2016-11-10 00:00:00

abstract：:Verotoxigenic Escherichia coli (VTEC) are a specialized group of E. coli that can cause severe colonic disease and renal failure. Their pathogenicity derives from virulence factors that enable the bacteria to colonize the colon and deliver extremely powerful toxins known as verotoxins (VT) or Shiga toxins (Stx) to the...

journal_title：BMC medicine

authors： Goldwater PN,Bettelheim KA

更新日期：2012-02-02 00:00:00