Abstract:
BACKGROUND:The objectives of this study were to understand the differences in mortality rate, risk factors for mortality, and cause of death distribution in three neonatal age sub-groups (0-2, 3-7, and 8-27 days) and assess the change in mortality rate with previous assessments to inform programmatic decision-making in the Indian state of Bihar, a large state with a high burden of newborn deaths. METHODS:Detailed interviews were conducted in a representative sample of 23,602 live births between January and December 2016 (96.2% participation) in Bihar state. We estimated the neonatal mortality rate (NMR) for the three age sub-groups and explored the association of these deaths with a variety of risk factors using a hierarchical logistic regression model approach. Verbal autopsies were conducted using the PHMRC questionnaire and the cause of death assigned using the SmartVA automated algorithm. Change in NMR from 2011 to 2016 was estimated by comparing it with a previous assessment. RESULTS:The NMR 0-2-day, 3-7-day, and 8-27-day mortality estimates in 2016 were 24.7 (95% CI 21.8-28.0), 13.2 (11.1 to 15.7), 5.8 (4.4 to 7.5), and 5.8 (4.5 to 7.5) per 1000 live births, respectively. A statistically significant reduction of 23.3% (95% CI 9.2% to 37.3) was seen in NMR from 2011 to 2016, driven by a reduction of 35.3% (95% CI 18.4% to 52.2) in 0-2-day mortality. In the final regression model, the highest odds for mortality in 0-2 days were related to the gestation period of ≤ 8 months (OR 16.5, 95% CI 11.9-22.9) followed by obstetric complications, no antiseptic cord care, and delivery at a private health facility or home. The 3-7- and 8-27-day mortality was driven by illness in the neonatal period (OR 10.33, 95% CI 6.31-16.90, and OR 4.88, 95% CI 3.13-7.61, respectively) and pregnancy with multiple foetuses (OR 5.15, 95% CI 2.39-11.10, and OR 11.77, 95% CI 6.43-21.53, respectively). Birth asphyxia (61.1%) and preterm delivery (22.1%) accounted for most of 0-2-day deaths; pneumonia (34.5%), preterm delivery (33.7%), and meningitis/sepsis (20.1%) accounted for the majority of 3-7-day deaths; meningitis/sepsis (30.6%), pneumonia (29.1%), and preterm delivery (26.2%) were the leading causes of death at 8-27 days. CONCLUSIONS:To our knowledge, this is the first study to report a detailed neonatal epidemiology by age sub-groups for a major Indian state, which has highlighted the distinctly different mortality rate, risk factors, and causes of death at 0-2 days versus the rest of the neonatal period. Monitoring mortality at 0-2 and 3-7 days separately in the traditional early neonatal period of 0-7 days would enable more effective programming to reduce neonatal mortality.
journal_name
BMC Medjournal_title
BMC medicineauthors
Dandona R,Kumar GA,Bhattacharya D,Akbar M,Atmavilas Y,Nanda P,Dandona Ldoi
10.1186/s12916-019-1372-zsubject
Has Abstractpub_date
2019-07-19 00:00:00pages
140issue
1issn
1741-7015pii
10.1186/s12916-019-1372-zjournal_volume
17pub_type
杂志文章相关文献
BMC Medicine文献大全abstract:BACKGROUND:Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-016-0731-2
更新日期:2016-11-10 00:00:00
abstract:BACKGROUND:Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessitates effective targeting and monitoring of interventions. This requires a valid, reliable measure of ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-018-1078-7
更新日期:2018-06-13 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy is an important cause of acute renal failure. We assess the efficacy of acetylcysteine for prevention of contrast-induced nephropathy among patients undergoing intravascular angiography. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials c...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1741-7015-2-38
更新日期:2004-10-22 00:00:00
abstract:BACKGROUND:The 2012 World Health Assembly set a target for Member States to reduce premature non-communicable disease (NCD) mortality by 25% over the period 2010 to 2025. This reflected concerns about increasing NCD mortality burdens among productive adults globally. This article first considers whether the WHO target ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0313-8
更新日期:2015-03-30 00:00:00
abstract:BACKGROUND:Alcohol consumption is a leading contributor to death and disability worldwide, but previous research has not examined the effects of different patterns of alcohol consumption. The study objective was to understand the relationship between different alcohol consumption patterns and adverse health outcomes ri...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01878-2
更新日期:2021-01-12 00:00:00
abstract:BACKGROUND:The consumption of free sugars in the UK is more than double the guideline intake for adults and close to triple for children, with soft drinks representing a significant proportion. The aim of this study was to assess how individual soft drink companies and consumers have responded to calls to reduce sugar ...
journal_title:BMC medicine
pub_type: 历史文章,杂志文章
doi:10.1186/s12916-019-1477-4
更新日期:2020-01-13 00:00:00
abstract::Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic A...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-11
更新日期:2011-02-02 00:00:00
abstract:BACKGROUND:The vascular contributions to neurodegeneration and neuroinflammation may be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review summarises the methodology for these widely available, safe and relatively low cost tools and analyses recent work highlighting their potential utili...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-017-0799-3
更新日期:2017-02-09 00:00:00
abstract:BACKGROUND:Exercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12916-015-0362-z
更新日期:2015-06-08 00:00:00
abstract:BACKGROUND:Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score is the only currently available midlife risk score for dementia. We compared CAIDE to Framingham cardiovascular Risk Score (FRS) and FINDRISC diabetes score as predictors of dementia and assessed the role of age in their associa...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01578-x
更新日期:2020-05-19 00:00:00
abstract::Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and control to discuss the ways in which malaria mig...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0384-6
更新日期:2015-07-25 00:00:00
abstract::Psychiatric nosology is widely criticized, but solutions are proving elusive. Planned revisions of diagnostic criteria will not resolve heterogeneity, comorbidity, fuzzy boundaries between normal and pathological, and lack of specific biomarkers. Concern about these difficulties reflects a narrow model that assumes mo...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-5
更新日期:2012-01-13 00:00:00
abstract:BACKGROUND:We update a previous systematic review to inform new World Health Organization HIV self-testing (HIVST) recommendations. We compared the effects of HIVST to standard HIV testing services to understand which service delivery models are effective for key populations. METHODS:We did a systematic review of rand...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01835-z
更新日期:2020-12-03 00:00:00
abstract::The damage to health caused by intimate partner violence demands effective responses from healthcare providers and healthcare systems worldwide. To date, most evidence for the few existing, effective interventions in use comes from high-income countries. Gupta et al. provide rare evidence of a nurse-delivered intimate...
journal_title:BMC medicine
pub_type: 评论,信件
doi:10.1186/s12916-017-0886-5
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:Fetal and neonatal mortality rates in low-income countries are at least 10-fold greater than in high-income countries. These differences have been related to poor access to and poor quality of obstetric and neonatal care. METHODS:This trial tested the hypothesis that teams of health care providers, administ...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1741-7015-11-215
更新日期:2013-10-03 00:00:00
abstract:BACKGROUND:The major psychoactive cannabinoid compound of marijuana, delta-9 tetrahydrocannabinol (THC), has been shown to modulate immune responses and lymphocyte function. After primary infection the viral DNA genome of gamma herpesviruses persists in lymphoid cell nuclei in a latent episomal circular form. In respon...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-2-34
更新日期:2004-09-15 00:00:00
abstract::How should we approach trial design when we can get some, but not all, of the way to the numbers required for a randomised phase III trial?We present an ordered framework for designing randomised trials to address the problem when the ideal sample size is considered larger than the number of participants that can be r...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-016-0722-3
更新日期:2016-11-25 00:00:00
abstract::The lack of formal training programs for peer reviewers places the scientific quality of biomedical publications at risk, as the introduction of 'hidden' bias may not be easily recognized by the reader. The exponential increase in the number of manuscripts submitted for publication worldwide, estimated in the millions...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0179-1
更新日期:2014-09-26 00:00:00
abstract:BACKGROUND:Niemann-Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this disorder by harnessing the body's endogenous cholesterol scavenging particle, high-de...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1423-5
更新日期:2019-11-11 00:00:00
abstract:BACKGROUND:Previous studies have suggested that there may be an association between some immune-mediated diseases and risk of tuberculosis (TB). METHODS:We analyzed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999 to 2011), and a similar database (th...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-97
更新日期:2013-04-04 00:00:00
abstract::Clinical pathologies draw us to envisage disease as either an independent entity or a diverse set of traits governed by common physiopathological mechanisms, prompted by environmental assaults throughout life. Autoimmune diseases are not an exception, given they represent a diverse collection of diseases in terms of t...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-11-197
更新日期:2013-09-04 00:00:00
abstract::In this video Q&A, we talk to Professor Carlos Caldas about the identification of breast cancer subtypes through molecular profiling, and the clinical implications for diagnosis and treatment. ...
journal_title:BMC medicine
pub_type: 面试,杂志文章
doi:10.1186/1741-7015-11-150
更新日期:2013-06-18 00:00:00
abstract::Malaria at international borders presents particular challenges with regards to elimination. International borders share common malaria ecologies, yet neighboring countries are often at different stages of the control-to-elimination pathway. Herein, we present a case study on malaria, and its control, at the border be...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1081-z
更新日期:2018-06-26 00:00:00
abstract::Migraine is a highly prevalent neurological disorder imparting a major burden on health care around the world. The primary pathology may be a state of hyperresponsiveness of the nervous system, but the molecular mechanisms are yet to be fully elucidated. We could now be at a watershed moment in this respect, as the ge...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-9-116
更新日期:2011-10-25 00:00:00
abstract:BACKGROUND:Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world. Unintentional overspray of ATR poses an immune function health hazard. The biomolecular mechanisms responsible for ATR-induced immunotoxicity, however, are little unders...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-117
更新日期:2011-10-27 00:00:00
abstract:BACKGROUND:Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between comorbidities and to investigate the association between comorbidity groups and outcomes. METHODS:Lat...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01881-7
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:The spatial spread of many mosquito-borne diseases occurs by focal spread at the scale of a few hundred meters and over longer distances due to human mobility. The relative contributions of different spatial scales for transmission of chikungunya virus require definition to improve outbreak vector control re...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01674-y
更新日期:2020-08-07 00:00:00
abstract::The original article [1] contained an error in the presentation of Figure 1; this error has now been rectified and Figure 1 is now presented correctly. ...
journal_title:BMC medicine
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12916-018-1232-2
更新日期:2018-12-28 00:00:00
abstract:BACKGROUND:Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy characterized by motor dysfunction of the lower extremities and urinary disturbance. Immunomodulatory treatments are the main strategy for HAM/TSP, but several issues are associated...
journal_title:BMC medicine
pub_type: 临床试验,杂志文章
doi:10.1186/1741-7015-11-182
更新日期:2013-08-15 00:00:00
abstract:BACKGROUND:Little is known about the impact of growing migration on the pattern of tuberculosis (TB) transmission in middle-income countries. We estimated TB recent transmission and its associated factors and investigated the presence of cross-transmission between South American migrants and Brazilians. METHODS:We stu...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1055-1
更新日期:2018-04-30 00:00:00