Controversies and challenges of vaccination: an interview with Elizabeth Miller.

abstract：BACKGROUND:When an outbreak of a novel pathogen occurs, some of the most pressing questions from a public-health point of view relate to its transmissibility, and the probabilities of different clinical outcomes following infection, to allow an informed response. Estimates of these quantities are often based on househo...

journal_title：BMC medicine

authors： House T,Inglis N,Ross JV,Wilson F,Suleman S,Edeghere O,Smith G,Olowokure B,Keeling MJ

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:Clinicians are less likely to prescribe guideline-recommended treatments to people with multimorbidity than to people with a single condition. Doubts as to the applicability of clinical trials of drug treatments (the gold standard for evidence-based medicine) when people have co-existing diseases (comorbidit...

journal_title：BMC medicine

authors： Hanlon P,Hannigan L,Rodriguez-Perez J,Fischbacher C,Welton NJ,Dias S,Mair FS,Guthrie B,Wild S,McAllister DA

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss. Clinical management and outcomes are challenged by current limited immunosuppressive and immunomodulating regimens. METHODS...

journal_title：BMC medicine

authors： Li Y,Yan B,Wang H,Li H,Li Q,Zhao D,Chen Y,Zhang Y,Li W,Zhang J,Wang S,Shen J,Li Y,Guindi E,Zhao Y

更新日期：2015-04-20 00:00:00

abstract：BACKGROUND:Clinical pathways are tools used to guide evidence-based healthcare that have been implemented internationally since the 1980s. However, there is widespread lack of agreement on the impact of clinical pathways on hospital resources and patient outcomes. This can be partially attributed to the confusion for b...

journal_title：BMC medicine

authors： Kinsman L,Rotter T,James E,Snow P,Willis J

更新日期：2010-05-27 00:00:00

abstract：BACKGROUND:Wild type 2 poliovirus was last observed in 1999. The Sabin-strain oral polio vaccine type 2 (OPV2) was critical to eradication, but it is known to revert to a neurovirulent phenotype, causing vaccine-associated paralytic poliomyelitis. OPV2 is also transmissible and can establish circulating lineages, calle...

journal_title：BMC medicine

authors： McCarthy KA,Chabot-Couture G,Famulare M,Lyons HM,Mercer LD

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis. METHODS:We conducted a population-based cohort study using data from Stockholm Mammography Screening Program, Stockholm-Gotla...

journal_title：BMC medicine

authors： He W,Eriksson L,Törnberg S,Strand F,Hall P,Czene K

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:The RTS,S/AS01 malaria vaccine candidate recently completed Phase III trials in 11 African sites. Recommendations for its deployment will partly depend on predictions of public health impact in endemic countries. Previous predictions of these used only limited information on underlying vaccine properties and...

journal_title：BMC medicine

authors： Penny MA,Galactionova K,Tarantino M,Tanner M,Smith TA

更新日期：2015-07-29 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of the three leading causes of cancer-related deaths worldwide. Growing evidence suggests that a subset of cells exists among cancer stem cells. This distinct subpopulation is thought to contribute to liver metastasis; however, it ha...

journal_title：BMC medicine

authors： Zhang SS,Han ZP,Jing YY,Tao SF,Li TJ,Wang H,Wang Y,Li R,Yang Y,Zhao X,Xu XD,Yu ED,Rui YC,Liu HJ,Zhang L,Wei LX

更新日期：2012-08-07 00:00:00

abstract：BACKGROUND:Health-related research funders, regulators and journals expect that de-identified individual-level health data be shared widely, with as few restrictions as possible; yet, in reality, the volume of shared data remains low. MAIN BODY:Health researchers and other data producers are reluctant to share their d...

journal_title：BMC medicine

authors： Waithira N,Mutinda B,Cheah PY

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:The study investigated the extent to which approaches to work, workplace climate, stress, burnout and satisfaction with medicine as a career in doctors aged about thirty are predicted by measures of learning style and personality measured five to twelve years earlier when the doctors were applicants to medic...

journal_title：BMC medicine

authors： McManus IC,Keeling A,Paice E

更新日期：2004-08-18 00:00:00

abstract：:Intra-tumour heterogeneity is a common molecular phenomenon in metastatic clear cell renal carcinoma (mRCC), representing the genetic complexity of a tumour with multiple metastatic sites. The present commentary discusses the observed phenomena of phenotypic intra-tumour heterogeneity in mRCC patients treated with the...

journal_title：BMC medicine

authors： Stühler V,Bedke J

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:Current policies encourage healthcare institutions to acquire clinical information systems (CIS) so that captured data can be used for secondary purposes, including clinical process improvement. Such policies do not account for the extra work required to repurpose data for uses other than direct clinical car...

journal_title：BMC medicine

authors： Morrison C,Jones M,Jones R,Vuylsteke A

更新日期：2013-04-10 00:00:00

abstract：BACKGROUND:Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world. Unintentional overspray of ATR poses an immune function health hazard. The biomolecular mechanisms responsible for ATR-induced immunotoxicity, however, are little unders...

journal_title：BMC medicine

authors： Zhang X,Wang M,Gao S,Ren R,Zheng J,Zhang Y

更新日期：2011-10-27 00:00:00

abstract：BACKGROUND:While step counter use has become popular among type 2 diabetes (T2D) patients, its effectiveness in increasing physical activity (PA) and improving glycemic control has been poorly defined. The aim of this meta-analysis of randomized controlled trials (RCTs) was to evaluate the association of step counter u...

journal_title：BMC medicine

authors： Qiu S,Cai X,Chen X,Yang B,Sun Z

更新日期：2014-02-27 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring involves therapeutic modifications based on the measurement of drug levels and antidrug antibodies. The viability of therapeutic drug monitoring in vedolizumab-treated patients with inflammatory bowel disease remains questioned. MAIN BODY:Accumulating evidence from clinical trial...

journal_title：BMC medicine

authors： Pouillon L,Vermeire S,Bossuyt P

更新日期：2019-05-08 00:00:00

abstract：BACKGROUND:The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need for more thorough and comprehensive characterization of the spectrum of resulting clinical complica...

journal_title：BMC medicine

authors： Siqueira AM,Lacerda MV,Magalhães BM,Mourão MP,Melo GC,Alexandre MA,Alecrim MG,Kochar D,Kochar S,Kochar A,Nayak K,del Portillo H,Guinovart C,Alonso P,Bassat Q

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:Associations between type 2 diabetes (T2D) and amyotrophic lateral sclerosis (ALS) were discovered in observational studies in both European and East Asian populations. However, whether such associations are causal remains largely unknown. METHODS:We employed a two-sample Mendelian randomization approach to...

journal_title：BMC medicine

authors： Zeng P,Wang T,Zheng J,Zhou X

更新日期：2019-12-04 00:00:00

abstract：:Severe anemia contributes significantly to child mortality in sub-Saharan Africa. Blood transfusion is used in emergencies but carries risks. In BMC Medicine, Olupot-Olupot and colleagues report the findings of a phase II trial in children with severe anemia in Eastern Uganda. They provide important early safety and e...

journal_title：BMC medicine

authors： Brick T,Peters MJ

更新日期：2014-04-25 00:00:00

abstract：BACKGROUND:Smokers have been shown to have lower mortality after acute coronary syndrome than non-smokers. This has been attributed to the younger age, lower co-morbidity, more aggressive treatment and lower risk profile of the smoker. Some studies, however, have used multivariate analyses to show a residual survival b...

journal_title：BMC medicine

authors： Aune E,Røislien J,Mathisen M,Thelle DS,Otterstad JE

更新日期：2011-08-23 00:00:00

abstract：BACKGROUND:The cost-effectiveness of universal rotavirus (RV) vaccination is controversial in developed countries. As a result, RV vaccination programs do not currently exist in most European countries. Hospitalization is the main driver of RV disease costs, and prematurity, low birth weight (LBW) and underlying medica...

journal_title：BMC medicine

authors： Bruijning-Verhagen P,Mangen MJ,Felderhof M,Hartwig NG,van Houten M,Winkel L,de Waal WJ,Bonten MJ

更新日期：2013-04-26 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) can be caused by life threatening illness, such as cancer and coronary events. The study by Forbes et al. made the unexpected finding that military personnel evacuation with medical illness have similar rates of PTSD to those evacuated with combat injuries. It may be that the illn...

journal_title：BMC medicine

authors： McFarlane AC

更新日期：2012-10-24 00:00:00

abstract：BACKGROUND:The objectives of this study were to understand the differences in mortality rate, risk factors for mortality, and cause of death distribution in three neonatal age sub-groups (0-2, 3-7, and 8-27 days) and assess the change in mortality rate with previous assessments to inform programmatic decision-making in...

journal_title：BMC medicine

authors： Dandona R,Kumar GA,Bhattacharya D,Akbar M,Atmavilas Y,Nanda P,Dandona L

更新日期：2019-07-19 00:00:00

abstract：:Verotoxigenic Escherichia coli (VTEC) are a specialized group of E. coli that can cause severe colonic disease and renal failure. Their pathogenicity derives from virulence factors that enable the bacteria to colonize the colon and deliver extremely powerful toxins known as verotoxins (VT) or Shiga toxins (Stx) to the...

journal_title：BMC medicine

authors： Goldwater PN,Bettelheim KA

更新日期：2012-02-02 00:00:00

abstract：BACKGROUND:Guidelines recommend that clinicians should make brief opportunistic behavioural interventions to patients who are obese to increase the uptake of effective weight loss programmes. The objective was to assess the effect of this policy on socioeconomic equity. METHODS:One thousand eight hundred eighty-two co...

journal_title：BMC medicine

authors： Graham J,Tudor K,Jebb SA,Lewis A,Tearne S,Adab P,Begh R,Jolly K,Daley A,Farley A,Lycett D,Nickless A,Aveyard P

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease...

journal_title：BMC medicine

authors： Ferreira JP,Girerd N,Pellicori P,Duarte K,Girerd S,Pfeffer MA,McMurray JJ,Pitt B,Dickstein K,Jacobs L,Staessen JA,Butler J,Latini R,Masson S,Mebazaa A,Rocca HP,Delles C,Heymans S,Sattar N,Jukema JW,Cleland JG,Za

更新日期：2016-11-10 00:00:00

abstract：:The approval of sorafenib and active development of many other molecularly targeted agents in hepatocellular carcinoma (HCC) have presented a challenge to understand the mechanism of action of sorafenib and identify predictive biomarkers to select patients more likely to benefit from sorafenib. The preclinical study b...

journal_title：BMC medicine

authors： Zhu AX

更新日期：2009-08-24 00:00:00

abstract：:The Fluid Expansion as Supportive Therapy (FEAST study) was an extremely well conducted study that gave unexpected results. The investigators had reported that febrile children with impaired perfusion treated in low-income countries without access to intensive care are more likely to die if they receive bolus resuscit...

journal_title：BMC medicine

authors： Myburgh J,Finfer S

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:Clinical decision support systems assist physicians in interpreting complex patient data. However, they typically operate on a per-patient basis and do not exploit the extensive latent medical knowledge in electronic health records (EHRs). The emergence of large EHR systems offers the opportunity to integrat...

journal_title：BMC medicine

authors： Gottlieb A,Stein GY,Ruppin E,Altman RB,Sharan R

更新日期：2013-09-02 00:00:00

abstract：BACKGROUND:Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomized controlled trial (RCT) investigating the impact of fatty fish on cognition in preschool children....

journal_title：BMC medicine

authors： Øyen J,Kvestad I,Midtbø LK,Graff IE,Hysing M,Stormark KM,Markhus MW,Baste V,Frøyland L,Koletzko B,Demmelmair H,Dahl L,Lie Ø,Kjellevold M

更新日期：2018-03-12 00:00:00

abstract：BACKGROUND:The prognostic significance of tumor-associated macrophages (TAM) in adult classical Hodgkin lymphoma (cHL) remains controversial. Here, we report a meta-analysis of the association of CD68 and CD163 infiltration on the clinical outcome of adult cHL. METHODS:A comprehensive search to identify relevant artic...

journal_title：BMC medicine

authors： Guo B,Cen H,Tan X,Ke Q

更新日期：2016-10-17 00:00:00