The "smoker's paradox" in patients with acute coronary syndrome: a systematic review.

abstract：BACKGROUND:Recent global progress in scaling up malaria control interventions has revived the goal of complete elimination in many countries. Decreasing transmission intensity generally leads to increasingly patchy spatial patterns of malaria transmission in elimination settings, with control programs having to accurat...

journal_title：BMC medicine

authors： Wesolowski A,Taylor AR,Chang HH,Verity R,Tessema S,Bailey JA,Alex Perkins T,Neafsey DE,Greenhouse B,Buckee CO

更新日期：2018-10-18 00:00:00

abstract：BACKGROUND:The burden of malaria in sub-Saharan Africa remains challenging to measure relying on epidemiological modelling to evaluate the impact of investments and providing an in-depth analysis of progress and trends in malaria response globally. In malaria-endemic countries of Africa, there is increasing use of rout...

journal_title：BMC medicine

authors： Alegana VA,Okiro EA,Snow RW

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Tobacco smoking is a leading cause of cardiovascular disease (CVD) morbidity and mortality. Evidence on the relation of smoking to different subtypes of CVD, across fatal and non-fatal outcomes, is limited. METHODS:A prospective study of 188,167 CVD- and cancer-free individuals aged ≥ 45 years from the Aust...

journal_title：BMC medicine

authors： Banks E,Joshy G,Korda RJ,Stavreski B,Soga K,Egger S,Day C,Clarke NE,Lewington S,Lopez AD

更新日期：2019-07-03 00:00:00

abstract：BACKGROUND:We update a previous systematic review to inform new World Health Organization HIV self-testing (HIVST) recommendations. We compared the effects of HIVST to standard HIV testing services to understand which service delivery models are effective for key populations. METHODS:We did a systematic review of rand...

journal_title：BMC medicine

authors： Witzel TC,Eshun-Wilson I,Jamil MS,Tilouche N,Figueroa C,Johnson CC,Reid D,Baggaley R,Siegfried N,Burns FM,Rodger AJ,Weatherburn P

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pathogenesis and progression of NAFLD is complex with many unanswered questions. We conducted genome-w...

journal_title：BMC medicine

authors： Namjou B,Lingren T,Huang Y,Parameswaran S,Cobb BL,Stanaway IB,Connolly JJ,Mentch FD,Benoit B,Niu X,Wei WQ,Carroll RJ,Pacheco JA,Harley ITW,Divanovic S,Carrell DS,Larson EB,Carey DJ,Verma S,Ritchie MD,Gharavi AG,

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease (COPD). Our aim was to externally validate and concurrently compare prognostic scores for 3-year...

journal_title：BMC medicine

authors： Guerra B,Haile SR,Lamprecht B,Ramírez AS,Martinez-Camblor P,Kaiser B,Alfageme I,Almagro P,Casanova C,Esteban-González C,Soler-Cataluña JJ,de-Torres JP,Miravitlles M,Celli BR,Marin JM,Ter Riet G,Sobradillo P,Lange P,Ga

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collected from neighborhoods surrounding a prison in Lima, Peru, where inmates experience a high risk of M...

journal_title：BMC medicine

authors： Warren JL,Grandjean L,Moore DAJ,Lithgow A,Coronel J,Sheen P,Zelner JL,Andrews JR,Cohen T

更新日期：2018-08-03 00:00:00

abstract：:Migraine is a highly prevalent neurological disorder imparting a major burden on health care around the world. The primary pathology may be a state of hyperresponsiveness of the nervous system, but the molecular mechanisms are yet to be fully elucidated. We could now be at a watershed moment in this respect, as the ge...

journal_title：BMC medicine

authors： Weir GA,Cader MZ

更新日期：2011-10-25 00:00:00

abstract：BACKGROUND:Chronic fatigue syndrome (CFS) is a complex multifactorial disorder. This paper reports the prevalence of chronic fatigue (CF) and CFS in an ethnically diverse population sample and tests whether prevalence varies by social adversity, social support, physical inactivity, anxiety and depression. METHODS:Anal...

journal_title：BMC medicine

authors： Bhui KS,Dinos S,Ashby D,Nazroo J,Wessely S,White PD

更新日期：2011-03-21 00:00:00

abstract：BACKGROUND:The 2012 World Health Assembly set a target for Member States to reduce premature non-communicable disease (NCD) mortality by 25% over the period 2010 to 2025. This reflected concerns about increasing NCD mortality burdens among productive adults globally. This article first considers whether the WHO target ...

journal_title：BMC medicine

authors： Santosa A,Rocklöv J,Högberg U,Byass P

更新日期：2015-03-30 00:00:00

abstract：BACKGROUND:The 'Older People's Exercise intervention in Residential and nursing Accommodation' (OPERA) cluster randomised trial evaluated the impact of training for care home staff together with twice-weekly, physiotherapist-led exercise classes on depressive symptoms in care home residents, but found no effect. We rep...

journal_title：BMC medicine

authors： Ellard DR,Thorogood M,Underwood M,Seale C,Taylor SJ

更新日期：2014-01-03 00:00:00

abstract：BACKGROUND:The ability to do online searches for health information has led to concerns that patients find the results confusing and that they often lead to expectations for treatments that have little supportive evidence. At the same time, the science of summarizing research evidence has advanced to the point where it...

journal_title：BMC medicine

authors： Elwyn G,Quinlan C,Mulley A,Agoritsas T,Vandvik PO,Guyatt G

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The RTS,S/AS01 malaria vaccine candidate recently completed Phase III trials in 11 African sites. Recommendations for its deployment will partly depend on predictions of public health impact in endemic countries. Previous predictions of these used only limited information on underlying vaccine properties and...

journal_title：BMC medicine

authors： Penny MA,Galactionova K,Tarantino M,Tanner M,Smith TA

更新日期：2015-07-29 00:00:00

abstract：:There is evidence that the life expectancy (LE) of individuals infected with the human immunodeficiency virus (HIV) has increased since the introduction of combination antiretroviral therapy (cART). However, mortality rates in recent years in HIV-positive individuals appear to have remained higher than would be expect...

journal_title：BMC medicine

authors： Sabin CA

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:We investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation. METHODS:eAPS was induced in heterozygous and homozygous FVL transgenic mice (C57BL/6 background) by immunizat...

journal_title：BMC medicine

authors： Katzav A,Grigoriadis NC,Ebert T,Touloumi O,Blank M,Pick CG,Shoenfeld Y,Chapman J

更新日期：2013-04-04 00:00:00

abstract：:Due to the easier access to information, the availability of low cost technologies and the involvement of well educated, passionate patients, a group of citizen 'Health Hackers', who are building their own medical systems to help them overcome the unmet needs of their conditions, is emerging. This has recently been th...

journal_title：BMC medicine

authors： Omer T

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on pregnancy or birth outcomes. A limited number of studies have examined iodine status and birth outco...

journal_title：BMC medicine

authors： Snart CJP,Threapleton DE,Keeble C,Taylor E,Waiblinger D,Reid S,Alwan NA,Mason D,Azad R,Cade JE,Simpson NAB,Meadows S,McKillion A,Santorelli G,Waterman AH,Zimmermann M,Stewart PM,Wright J,Mon-Williams M,Greenwood DC

更新日期：2020-06-11 00:00:00

abstract：BACKGROUND:The inverse equity hypothesis asserts that new health policies initially widen inequality, then attenuate inequalities over time. Since 2004, the UK's pay-for-performance scheme for chronic disease management (CDM) in primary care general practices (the Quality and Outcomes Framework) has permitted practices...

journal_title：BMC medicine

authors： Lowrie R,McConnachie A,Williamson AE,Kontopantelis E,Forrest M,Lannigan N,Mercer SW,Mair FS

更新日期：2017-04-11 00:00:00

abstract：:In this video Q&A, we talk to Professor Carlos Caldas about the identification of breast cancer subtypes through molecular profiling, and the clinical implications for diagnosis and treatment. ...

journal_title：BMC medicine

authors： Caldas C

更新日期：2013-06-18 00:00:00

abstract：BACKGROUND:Strategies in many countries have sought to improve palliative care and reduce hospital deaths for non-cancer patients, but their effects are not evaluated. We aimed to determine the trends and factors associated with dying in hospital in two common progressive respiratory diseases, and the impact of a natio...

journal_title：BMC medicine

authors： Higginson IJ,Reilly CC,Bajwah S,Maddocks M,Costantini M,Gao W,GUIDE_Care project.

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy characterized by motor dysfunction of the lower extremities and urinary disturbance. Immunomodulatory treatments are the main strategy for HAM/TSP, but several issues are associated...

journal_title：BMC medicine

authors： Nakamura T,Matsuo T,Fukuda T,Yamato S,Yamaguchi K,Kinoshita I,Matsuzaki T,Nishiura Y,Nagasato K,Narita-Masuda T,Nakamura H,Satoh K,Sasaki H,Sakai H,Kawakami A

更新日期：2013-08-15 00:00:00

abstract：:Although prostate-specific antigen (PSA) screening has improved the detection of prostate cancer, allowing for stage migration to less advanced disease, the precise mortality benefit of early detection is unclear. This is in part due to a discrepancy between the two large randomized controlled trials comparing PSA scr...

journal_title：BMC medicine

authors： Kim EH,Andriole GL

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:Populations exposed to humanitarian emergencies are particularly vulnerable to mental health problems, including new onset, relapse and deterioration of psychotic disorders. Inadequate care for this group may lead to human rights abuses and even premature death. The WHO Mental Health Gap Action Programme Int...

journal_title：BMC medicine

authors： Ostuzzi G,Barbui C,Hanlon C,Chatterjee S,Eaton J,Jones L,Silove D,Ventevogel P

更新日期：2017-12-11 00:00:00

abstract：BACKGROUND:Network meta-analyses using individual participant data (IPD-NMAs) have been increasingly used to compare the effects of multiple interventions. Although there have been many studies on statistical methods for IPD-NMAs, it is unclear whether there are statistical defects in published IPD-NMAs and whether the...

journal_title：BMC medicine

authors： Gao Y,Shi S,Li M,Luo X,Liu M,Yang K,Zhang J,Song F,Tian J

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Accurate and timely cause of death (COD) data are essential for informed public health policymaking. Medical certification of COD generally provides the majority of COD data in a population and is an essential component of civil registration and vital statistics (CRVS) systems. Accurate completion of the med...

journal_title：BMC medicine

authors： Hart JD,Sorchik R,Bo KS,Chowdhury HR,Gamage S,Joshi R,Kwa V,Li H,Mahesh BPK,Mclaughlin D,Mikkelsen L,Miki J,Napulan R,Rampatige R,Reeve M,Sarmiento C,War NS,Richards N,Riley ID,Lopez AD

更新日期：2020-03-09 00:00:00

abstract：BACKGROUND:Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based study aimed at exploring factors associated with survival in patients with resected TNM stage I-II PaC r...

journal_title：BMC medicine

authors： Huang L,Balavarca Y,van der Geest L,Lemmens V,Van Eycken L,De Schutter H,Johannesen TB,Zadnik V,Primic-Žakelj M,Mägi M,Grützmann R,Besselink MG,Schrotz-King P,Brenner H,Jansen L

更新日期：2019-03-25 00:00:00

abstract：:There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquitoes. The Worldwide ...

journal_title：BMC medicine

authors： Karunajeewa HA,Mueller I

更新日期：2016-06-18 00:00:00

abstract：BACKGROUND:Although nut consumption has been associated with a reduced risk of cardiovascular disease and all-cause mortality, data on less common causes of death has not been systematically assessed. Previous reviews missed several studies and additional studies have since been published. We therefore conducted a syst...

journal_title：BMC medicine

authors： Aune D,Keum N,Giovannucci E,Fadnes LT,Boffetta P,Greenwood DC,Tonstad S,Vatten LJ,Riboli E,Norat T

更新日期：2016-12-05 00:00:00

abstract：BACKGROUND:Three large new trials of unprecedented scale and cost, which included novel factorial designs, have found no effect of basic water, sanitation and hygiene (WASH) interventions on childhood stunting, and only mixed effects on childhood diarrhea. Arriving at the inception of the United Nations' Sustainable De...

journal_title：BMC medicine

authors： Cumming O,Arnold BF,Ban R,Clasen T,Esteves Mills J,Freeman MC,Gordon B,Guiteras R,Howard G,Hunter PR,Johnston RB,Pickering AJ,Prendergast AJ,Prüss-Ustün A,Rosenboom JW,Spears D,Sundberg S,Wolf J,Null C,Luby SP,Hum

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessitates effective targeting and monitoring of interventions. This requires a valid, reliable measure of ...

journal_title：BMC medicine

authors： Burt J,Elmore N,Campbell SM,Rodgers S,Avery AJ,Payne RA

更新日期：2018-06-13 00:00:00