当前位置： SCI文献检索 > BMC Medicine期刊下所有文献 > Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort.

Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort.

Abstract：

BACKGROUND:Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on pregnancy or birth outcomes. A limited number of studies have examined iodine status and birth outcomes, finding inconsistent evidence for specific outcomes. METHODS:Maternal iodine status was estimated from spot urine samples collected at 26-28 weeks' gestation from 6971 mothers in the Born in Bradford birth cohort. Associations with outcomes were examined for both urinary iodine concentration (UIC) and iodine-to-creatinine ratio (I:Cr). Outcomes assessed included customised birthweight (primary outcome), birthweight, small for gestational age (SGA), low birthweight, head circumference and APGAR score. RESULTS:There was a small positive association between I:Cr and birthweight in adjusted analyses. For a typical participant, the predicted birthweight centile at the 25th percentile of I:Cr (59 μg/g) was 2.7 percentage points lower than that at the 75th percentile of I:Cr (121 μg/g) (99% confidence interval (CI) 0.8 to 4.6), birthweight was predicted to be 41 g lower (99% CI 13 to 69) and the predicted probability of SGA was 1.9 percentage points higher (99% CI 0.0 to 3.7). There was no evidence of associations using UIC or other birth outcomes, including stillbirth, preterm birth, ultrasound growth measures or congenital anomalies. CONCLUSION:Lower maternal iodine status was associated with lower birthweight and greater probability of SGA. Whilst small, the effect size for lower iodine on birthweight is comparable to environmental tobacco smoke exposure. Iodine insufficiency is avoidable, and strategies to avoid deficiency in women of reproductive age should be considered. TRIAL REGISTRATION:ClinicalTrials.gov NCT03552341. Registered on June 11, 2018.

journal_name

BMC Med

journal_title

BMC medicine

authors

Snart CJP,Threapleton DE,Keeble C,Taylor E,Waiblinger D,Reid S,Alwan NA,Mason D,Azad R,Cade JE,Simpson NAB,Meadows S,McKillion A,Santorelli G,Waterman AH,Zimmermann M,Stewart PM,Wright J,Mon-Williams M,Greenwood DC

doi

10.1186/s12916-020-01602-0

subject

Has Abstract

pub_date

2020-06-11 00:00:00

pages

132

issue

issn

1741-7015

pii

10.1186/s12916-020-01602-0

journal_volume

pub_type

杂志文章

在线工具

Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort.