Investigating spillover of multidrug-resistant tuberculosis from a prison: a spatial and molecular epidemiological analysis.

abstract：BACKGROUND:The treatment of patients with haematological malignancies by means of haematopoietic stem cell transplantation (HSCT) is often accompanied by life threatening infections. With emerging antimicrobial resistance there is an increased need for new agents, with a beneficial safety profile. Therefore we evaluate...

journal_title：BMC medicine

authors： Velden WJ,van Iersel TM,Blijlevens NM,Donnelly JP

更新日期：2009-09-08 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring involves therapeutic modifications based on the measurement of drug levels and antidrug antibodies. The viability of therapeutic drug monitoring in vedolizumab-treated patients with inflammatory bowel disease remains questioned. MAIN BODY:Accumulating evidence from clinical trial...

journal_title：BMC medicine

authors： Pouillon L,Vermeire S,Bossuyt P

更新日期：2019-05-08 00:00:00

abstract：BACKGROUND:Persistent disabilities are key manifestations of Chikungunya virus (CHIKV) infection, especially incapacitating polyarthralgia and fatigue. So far, little is known about their impact on health status. The present study aimed at describing the burden of CHIKV prolonged or late-onset symptoms on the self-perc...

journal_title：BMC medicine

authors： Gérardin P,Fianu A,Malvy D,Mussard C,Boussaïd K,Rollot O,Michault A,Gaüzere BA,Bréart G,Favier F

更新日期：2011-01-14 00:00:00

abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they present mild diseases on admission. METHODS:A multicenter nested case-control study was conducted in four...

journal_title：BMC medicine

authors： Shi J,Li Y,Zhou X,Zhang Q,Ye X,Wu Z,Jiang X,Yu H,Shao L,Ai JW,Zhang H,Xu B,Sun F,Zhang W

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Studies addressing the effects of aerobic exercise and a prudent diet on lipid and lipoprotein concentrations in adults have reached conflicting conclusions. The purpose of this study was to determine the effects of aerobic exercise combined with a prudent diet on lipid and lipoprotein concentrations in adul...

journal_title：BMC medicine

authors： Kelley GA,Kelley KS,Roberts S,Haskell W

更新日期：2011-06-15 00:00:00

abstract：BACKGROUND:The spatial spread of many mosquito-borne diseases occurs by focal spread at the scale of a few hundred meters and over longer distances due to human mobility. The relative contributions of different spatial scales for transmission of chikungunya virus require definition to improve outbreak vector control re...

journal_title：BMC medicine

authors： Guzzetta G,Vairo F,Mammone A,Lanini S,Poletti P,Manica M,Rosa R,Caputo B,Solimini A,Torre AD,Scognamiglio P,Zumla A,Ippolito G,Merler S

更新日期：2020-08-07 00:00:00

abstract：BACKGROUND:Clinicians are less likely to prescribe guideline-recommended treatments to people with multimorbidity than to people with a single condition. Doubts as to the applicability of clinical trials of drug treatments (the gold standard for evidence-based medicine) when people have co-existing diseases (comorbidit...

journal_title：BMC medicine

authors： Hanlon P,Hannigan L,Rodriguez-Perez J,Fischbacher C,Welton NJ,Dias S,Mair FS,Guthrie B,Wild S,McAllister DA

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:The spread of infectious diseases crucially depends on the pattern of contacts between individuals. Knowledge of these patterns is thus essential to inform models and computational efforts. However, there are few empirical studies available that provide estimates of the number and duration of contacts betwee...

journal_title：BMC medicine

authors： Stehlé J,Voirin N,Barrat A,Cattuto C,Colizza V,Isella L,Régis C,Pinton JF,Khanafer N,Van den Broeck W,Vanhems P

更新日期：2011-07-19 00:00:00

abstract：BACKGROUND:The TransEurope FootRace 2009 (TEFR09) was one of the longest transcontinental ultramarathons with an extreme endurance physical load of running nearly 4,500 km in 64 days. The aim of this study was to assess the wide spectrum of adaptive responses in humans regarding the different tissues, organs and functi...

journal_title：BMC medicine

authors： Schütz UH,Schmidt-Trucksäss A,Knechtle B,Machann J,Wiedelbach H,Ehrhardt M,Freund W,Gröninger S,Brunner H,Schulze I,Brambs HJ,Billich C

更新日期：2012-07-19 00:00:00

abstract：:The original article [1] contained an error in the presentation of Figure 1; this error has now been rectified and Figure 1 is now presented correctly. ...

journal_title：BMC medicine

authors： Wesolowski A,Taylor AR,Chang HH,Verity R,Tessema S,Bailey JA,Alex Perkins T,Neafsey DE,Greenhouse B,Buckee CO

更新日期：2018-12-28 00:00:00

abstract：:Intra-tumour heterogeneity is a common molecular phenomenon in metastatic clear cell renal carcinoma (mRCC), representing the genetic complexity of a tumour with multiple metastatic sites. The present commentary discusses the observed phenomena of phenotypic intra-tumour heterogeneity in mRCC patients treated with the...

journal_title：BMC medicine

authors： Stühler V,Bedke J

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:The placebo response in patients with diabetes mellitus is very common. A systematic evaluation needs to be updated with the current evidence about the placebo response in diabetes mellitus and the associated factors in clinical trials of anti-diabetic medicine. METHODS:Literature research was conducted in ...

journal_title：BMC medicine

authors： Lin C,Cai X,Yang W,Lv F,Nie L,Ji L

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:Complex neurodevelopmental disorders may be characterized by subtle brain function signatures early in life before behavioral symptoms are apparent. Such endophenotypes may be measurable biomarkers for later cognitive impairments. The nonlinear complexity of electroencephalography (EEG) signals is believed t...

journal_title：BMC medicine

authors： Bosl W,Tierney A,Tager-Flusberg H,Nelson C

更新日期：2011-02-22 00:00:00

abstract：BACKGROUND:The possible relationship between chronic inflammatory diseases and their co-morbidities has become an increasing focus of research. Both chronic periodontitis and chronic obstructive pulmonary disease are neutrophilic, inflammatory conditions characterized by the loss of local connective tissue. Evidence su...

journal_title：BMC medicine

authors： Usher AK,Stockley RA

更新日期：2013-11-13 00:00:00

abstract：BACKGROUND:Israeli citizens have been exposed to intense and ongoing terrorism since September 2000. We previously studied the mental health impact of terrorism on the Israeli population (Bleich et al., 2002), however the long-term impact of ongoing terrorism has not yet been examined. The present study evaluated the p...

journal_title：BMC medicine

authors： Bleich A,Gelkopf M,Melamed Y,Solomon Z

更新日期：2006-08-27 00:00:00

abstract：BACKGROUND:It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. METHODS:To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal ...

journal_title：BMC medicine

authors： Xu X,Chow EPF,Ong JJ,Hoebe CJPA,Zou Z,Hocking JS,Fairley CK,Zhang L

更新日期：2020-11-17 00:00:00

abstract：:In recent years, the introduction and Federal Drug Administration approval of immune checkpoint inhibitor antibodies has dramatically improved the clinical outcomes for patients with advanced melanoma. These antagonist monoclonal antibodies are capable of unleashing dormant or exhausted antitumor immunity, which has l...

journal_title：BMC medicine

authors： Redman JM,Gibney GT,Atkins MB

更新日期：2016-02-06 00:00:00

abstract：BACKGROUND:Clinical pathways are tools used to guide evidence-based healthcare that have been implemented internationally since the 1980s. However, there is widespread lack of agreement on the impact of clinical pathways on hospital resources and patient outcomes. This can be partially attributed to the confusion for b...

journal_title：BMC medicine

authors： Kinsman L,Rotter T,James E,Snow P,Willis J

更新日期：2010-05-27 00:00:00

abstract：BACKGROUND:In many developing countries, the majority of births are attended by traditional birth attendants, who lack formal training in neonatal resuscitation and other essential care required by the newly born infant. In these countries, the major causes of neonatal mortality are birth asphyxia, infection, and low-b...

journal_title：BMC medicine

authors： Matendo R,Engmann C,Ditekemena J,Gado J,Tshefu A,Kinoshita R,McClure EM,Moore J,Wallace D,Carlo WA,Wright LL,Bose C

更新日期：2011-08-04 00:00:00

abstract：BACKGROUND:Clinical pathways (CPs) are used to improve the outcomes of acute stroke, but their use in stroke care is questionable, because the evidence on their effectiveness is still inconclusive. The objective of this study was to evaluate whether CPs improve the outcomes and the quality of care provided to patients ...

journal_title：BMC medicine

authors： Panella M,Marchisio S,Brambilla R,Vanhaecht K,Di Stanislao F

更新日期：2012-07-10 00:00:00

abstract：BACKGROUND:Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of survival in critically ill adults, but little data exist for African children living in malaria-endemic...

journal_title：BMC medicine

authors： Aramburo A,Todd J,George EC,Kiguli S,Olupot-Olupot P,Opoka RO,Engoru C,Akech SO,Nyeko R,Mtove G,Gibb DM,Babiker AG,Maitland K

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many cases of diagnosed dystroglycanopathies, only a small fraction can be linked directly to mutations ...

journal_title：BMC medicine

authors： Yatsenko AS,Kucherenko MM,Xie Y,Aweida D,Urlaub H,Scheibe RJ,Cohen S,Shcherbata HR

更新日期：2020-01-21 00:00:00

abstract：:Several factors contribute to the high mortality attributed to severe infections in resource-limited settings. While improvements in survival and processes of care have been made in high-income settings among patients with severe conditions, such as sepsis, guidelines necessary for achieving these improvements may lac...

journal_title：BMC medicine

authors： Jacob ST,Lim M,Banura P,Bhagwanjee S,Bion J,Cheng AC,Cohen H,Farrar J,Gove S,Hopewell P,Moore CC,Roth C,West TE

更新日期：2013-04-18 00:00:00

abstract：BACKGROUND:Most UK medical schools use aptitude tests during student selection, but large-scale studies of predictive validity are rare. This study assesses the United Kingdom Clinical Aptitude Test (UKCAT), and its four sub-scales, along with measures of educational attainment, individual and contextual socio-economic...

journal_title：BMC medicine

authors： McManus IC,Dewberry C,Nicholson S,Dowell JS

更新日期：2013-11-14 00:00:00

abstract：BACKGROUND:Abnormal BMI is associated with discouraging IVF outcomes in fresh autologous or oocyte donor cycles, whether or not such a relation also holds true for women undergoing frozen-thawed embryo transfer (FET) remains unknown. In addition, it remains unclear the detrimental effect of abnormal BMI on IVF outcomes...

journal_title：BMC medicine

authors： Zhang J,Liu H,Mao X,Chen Q,Fan Y,Xiao Y,Wang Y,Kuang Y

更新日期：2019-06-26 00:00:00

abstract：:The Ebola virus disease (EVD) outbreak in the three West Africa countries of Guinea, Liberia, and Sierra Leone, was declared by the World Health Organization (WHO) as a public health event of international concern in August 2014. The disease, which has caused more than 10,000 deaths from over 25,000 cases, has thrived...

journal_title：BMC medicine

authors： Tomori O

更新日期：2015-05-14 00:00:00

abstract：BACKGROUND:Ancestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The present work examined the potential transgenerational actions of the insecticide dichlorodiphenyltrichloroethane (DDT) on o...

journal_title：BMC medicine

authors： Skinner MK,Manikkam M,Tracey R,Guerrero-Bosagna C,Haque M,Nilsson EE

更新日期：2013-10-23 00:00:00

abstract：BACKGROUND:Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on pregnancy or birth outcomes. A limited number of studies have examined iodine status and birth outco...

journal_title：BMC medicine

authors： Snart CJP,Threapleton DE,Keeble C,Taylor E,Waiblinger D,Reid S,Alwan NA,Mason D,Azad R,Cade JE,Simpson NAB,Meadows S,McKillion A,Santorelli G,Waterman AH,Zimmermann M,Stewart PM,Wright J,Mon-Williams M,Greenwood DC

更新日期：2020-06-11 00:00:00

abstract：BACKGROUND:Since the late 1980s, genetic discrimination has remained one of the major concerns associated with genetic research and clinical genetics. Europe has adopted a plethora of laws and policies, both at the regional and national levels, to prevent insurers from having access to genetic information for underwrit...

journal_title：BMC medicine

authors： Joly Y,Ngueng Feze I,Simard J

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Use of fenfluramines for weight loss has been associated with the development of characteristic plaques on cardiac valves causing regurgitation. However, previously published studies of exposure to fenfluramines have been limited by relatively small sample size, short duration of follow-up, and the lack of a...

journal_title：BMC medicine

authors： Dahl CF,Allen MR,Urie PM,Hopkins PN

更新日期：2008-11-06 00:00:00