Abstract：
BACKGROUND:Use of fenfluramines for weight loss has been associated with the development of characteristic plaques on cardiac valves causing regurgitation. However, previously published studies of exposure to fenfluramines have been limited by relatively small sample size, short duration of follow-up, and the lack of any estimate of the frequency of subsequent valvular surgery. We performed an observational study of 5743 users of fenfluramines examined by echocardiography between July 1997 and February 2004 in a single large cardiology clinic. RESULTS:The prevalence of at least mild aortic regurgitation (AR) or moderate mitral regurgitation (MR) was 19.6% in women and 11.8% in men (p < 0.0001 for gender difference). Duration of use was strongly predictive of mild or greater AR (p < 0.0001 for trend), MR (p = 0.002), and tricuspid regurgitation (TR) (p < 0.0001), as was earlier scan date (p < 0.0001 for those scanned prior to 1 January 2000 versus later). Increasing age was also independently associated with increased risk of AR and MR (both p < 0.0001). With mean follow-up of 30.3 months, AR worsened in 15.2%, remained the same in 63.1%, and improved in 21.7%. Corresponding values for MR were 24.8%, 47.4% and 27.9%. Pulmonary hypertension was strongly associated with MR but not AR. Valve surgery was performed on 38 patients (0.66% of 5743), 25 (0.44%) with clear evidence of fenfluramine-related etiology. CONCLUSION:Regurgitant valvulopathy was common in individuals exposed to fenfluramines, more frequent in females, and associated with duration of use in all valves assessed. Valve surgery was performed as frequently for aortic as mitral valves and some tricuspid valve surgeries were also performed. The incidence of surgery appeared to be substantially increased compared with limited general population data.
journal_name
BMC Medjournal_title
BMC medicineauthors
Dahl CF,Allen MR,Urie PM,Hopkins PNdoi
10.1186/1741-7015-6-34subject
Has Abstractpub_date
2008-11-06 00:00:00pages
34issn
1741-7015pii
1741-7015-6-34journal_volume
6pub_type
杂志文章相关文献
BMC Medicine文献大全abstract：BACKGROUND:Intimate partner violence is common among women having abortions, with between 6% and 22% reporting recent violence from an intimate partner. Concern about violence is a reason some pregnant women decide to terminate their pregnancies. Whether risk of violence decreases after having an abortion, remains unkn...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-014-0144-z
更新日期：2014-09-29 00:00:00
abstract：BACKGROUND:The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need for more thorough and comprehensive characterization of the spectrum of resulting clinical complica...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-015-0302-y
更新日期：2015-03-20 00:00:00
abstract：BACKGROUND:Therapeutic drug monitoring involves therapeutic modifications based on the measurement of drug levels and antidrug antibodies. The viability of therapeutic drug monitoring in vedolizumab-treated patients with inflammatory bowel disease remains questioned. MAIN BODY:Accumulating evidence from clinical trial...
journal_title：BMC medicine
pub_type： 杂志文章,评审
doi：10.1186/s12916-019-1323-8
更新日期：2019-05-08 00:00:00
abstract：BACKGROUND:Armed conflicts are associated with a wide range of impacts on the mental health of children and adolescents. We evaluated the effectiveness of a school-based intervention aimed at reducing symptoms of posttraumatic stress disorder, depression, and anxiety (treatment aim); and improving a sense of hope and f...
journal_title：BMC medicine
pub_type： 杂志文章,随机对照试验
doi：10.1186/1741-7015-12-56
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-020-1505-4
更新日期：2020-03-03 00:00:00
abstract：BACKGROUND:Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collected from neighborhoods surrounding a prison in Lima, Peru, where inmates experience a high risk of M...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-018-1111-x
更新日期：2018-08-03 00:00:00
abstract：BACKGROUND:The 'Older People's Exercise intervention in Residential and nursing Accommodation' (OPERA) cluster randomised trial evaluated the impact of training for care home staff together with twice-weekly, physiotherapist-led exercise classes on depressive symptoms in care home residents, but found no effect. We rep...
journal_title：BMC medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/1741-7015-12-1
更新日期：2014-01-03 00:00:00
abstract：BACKGROUND:In an era when obesity prevalence is high throughout much of the world, there is a correspondingly pervasive and strong culture of weight stigma. For example, representative studies show that some forms of weight discrimination are more prevalent even than discrimination based on race or ethnicity. DISCUSSI...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-018-1116-5
更新日期：2018-08-15 00:00:00
abstract：:This is an Erratum to BMC Medicine 2015, 13:59, highlighting previously undeclared competing interests and including more information in the acknowledgements section.Please see related article: http://www.biomedcentral.com/1741-7015/13/59. The statement in the competing interests should read as follows: This study is ...
journal_title：BMC medicine
pub_type： 已发布勘误
doi：10.1186/s12916-015-0338-z
更新日期：2015-04-16 00:00:00
abstract：BACKGROUND:Risk stratification and management of acute myocardial infarction patients continue to be challenging despite considerable efforts made in the last decades by many clinicians and researchers. The aim of this study was to investigate the metabolomic fingerprint of acute myocardial infarction using nuclear mag...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-018-1240-2
更新日期：2019-01-07 00:00:00
abstract：:Verotoxigenic Escherichia coli (VTEC) are a specialized group of E. coli that can cause severe colonic disease and renal failure. Their pathogenicity derives from virulence factors that enable the bacteria to colonize the colon and deliver extremely powerful toxins known as verotoxins (VT) or Shiga toxins (Stx) to the...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/1741-7015-10-12
更新日期：2012-02-02 00:00:00
abstract：BACKGROUND:Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relationships of cancer with other adiposity markers, and if these associations are linear or not. The aim ...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-020-01848-8
更新日期：2021-01-11 00:00:00
abstract：BACKGROUND:The UK, like a number of other countries, has a refugee resettlement programme. External factors, such as higher prevalence of infectious diseases in the country of origin and circumstances of travel, are likely to increase the infectious disease risk of refugees, but published data is scarce. The Internatio...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-018-1125-4
更新日期：2018-08-28 00:00:00
abstract：BACKGROUND:Current policies encourage healthcare institutions to acquire clinical information systems (CIS) so that captured data can be used for secondary purposes, including clinical process improvement. Such policies do not account for the extra work required to repurpose data for uses other than direct clinical car...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/1741-7015-11-103
更新日期：2013-04-10 00:00:00
abstract：BACKGROUND:There are widespread concerns about communication and support for patients and families, especially when they face clinical uncertainty, a situation most marked in intensive care units (ICUs). Therefore, we aimed to develop and evaluate an interventional tool to improve communication and palliative care, usi...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/1741-7015-11-213
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Previous studies have suggested that there may be an association between some immune-mediated diseases and risk of tuberculosis (TB). METHODS:We analyzed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999 to 2011), and a similar database (th...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/1741-7015-11-97
更新日期：2013-04-04 00:00:00
abstract：BACKGROUND:Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomized controlled trial (RCT) investigating the impact of fatty fish on cognition in preschool children....
journal_title：BMC medicine
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12916-018-1020-z
更新日期：2018-03-12 00:00:00
abstract：BACKGROUND:Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis. METHODS:We conducted a population-based cohort study using data from Stockholm Mammography Screening Program, Stockholm-Gotla...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-019-1252-6
更新日期：2019-01-31 00:00:00
abstract：:There is evidence that the life expectancy (LE) of individuals infected with the human immunodeficiency virus (HIV) has increased since the introduction of combination antiretroviral therapy (cART). However, mortality rates in recent years in HIV-positive individuals appear to have remained higher than would be expect...
journal_title：BMC medicine
pub_type： 杂志文章,评审
doi：10.1186/1741-7015-11-251
更新日期：2013-11-27 00:00:00
abstract：BACKGROUND:We update a previous systematic review to inform new World Health Organization HIV self-testing (HIVST) recommendations. We compared the effects of HIVST to standard HIV testing services to understand which service delivery models are effective for key populations. METHODS:We did a systematic review of rand...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-020-01835-z
更新日期：2020-12-03 00:00:00
abstract：BACKGROUND:Recent global progress in scaling up malaria control interventions has revived the goal of complete elimination in many countries. Decreasing transmission intensity generally leads to increasingly patchy spatial patterns of malaria transmission in elimination settings, with control programs having to accurat...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-018-1181-9
更新日期：2018-10-18 00:00:00
abstract：BACKGROUND:The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines Agency (EMA) concerning human papillomavirus (HPV) vaccines during a European Union (EU) referral pro...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-017-0850-4
更新日期：2017-05-02 00:00:00
abstract：:Wheat, once thought to be a critical ingredient in a healthy diet, has become a major threat, according to public opinion. The term non-celiac gluten sensitivity has been widely adopted to describe a clinical entity characterized by symptoms induced by gluten without the diagnostic criteria found in other gluten-relat...
journal_title：BMC medicine
pub_type： 评论,杂志文章
doi：10.1186/1741-7015-12-86
更新日期：2014-05-23 00:00:00
abstract：BACKGROUND:Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake. METHODS:We followed-up 5,505 h...
journal_title：BMC medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/1741-7015-11-192
更新日期：2013-08-30 00:00:00
abstract：:The internet has opened up vast possibilities for research. An increasing number of studies are being conducted using the internet as both a source of data and a venue for research. Use of the internet in research has created many challenges, not just for those conducting and reviewing the studies, but also for editor...
journal_title：BMC medicine
pub_type： 社论
doi：10.1186/s12916-014-0124-3
更新日期：2014-07-15 00:00:00
abstract：BACKGROUND:Monogenic diabetes (MgD) accounts for 1-2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-generation sequencing in patients with late adolescence/adult-onset diabetes referred for a clinical ...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-019-1363-0
更新日期：2019-07-11 00:00:00
abstract：BACKGROUND:Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many cases of diagnosed dystroglycanopathies, only a small fraction can be linked directly to mutations ...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/s12916-019-1478-3
更新日期：2020-01-21 00:00:00
abstract：:Migraine is a highly prevalent neurological disorder imparting a major burden on health care around the world. The primary pathology may be a state of hyperresponsiveness of the nervous system, but the molecular mechanisms are yet to be fully elucidated. We could now be at a watershed moment in this respect, as the ge...
journal_title：BMC medicine
pub_type： 杂志文章,评审
doi：10.1186/1741-7015-9-116
更新日期：2011-10-25 00:00:00
abstract：BACKGROUND:Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early d...
journal_title：BMC medicine
pub_type： 杂志文章
doi：10.1186/1741-7015-11-63
更新日期：2013-03-07 00:00:00
abstract：BACKGROUND:We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased oxidative and nitrosative stress (O&NS), which contribute to ...
journal_title：BMC medicine
pub_type： 杂志文章,评审
doi：10.1186/1741-7015-11-200
更新日期：2013-09-12 00:00:00
