Vedolizumab trough level monitoring in inflammatory bowel disease: a state-of-the-art overview.

abstract：BACKGROUND:Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. The utility of the new quantitative PCR test (Xpert MTB/RIF) for the diagnosis...

journal_title：BMC medicine

authors： Pandie S,Peter JG,Kerbelker ZS,Meldau R,Theron G,Govender U,Ntsekhe M,Dheda K,Mayosi BM

更新日期：2014-06-18 00:00:00

abstract：BACKGROUND:External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease (COPD). Our aim was to externally validate and concurrently compare prognostic scores for 3-year...

journal_title：BMC medicine

authors： Guerra B,Haile SR,Lamprecht B,Ramírez AS,Martinez-Camblor P,Kaiser B,Alfageme I,Almagro P,Casanova C,Esteban-González C,Soler-Cataluña JJ,de-Torres JP,Miravitlles M,Celli BR,Marin JM,Ter Riet G,Sobradillo P,Lange P,Ga

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:This study was conducted to assess whether patient-reported outcomes (PROs) differ by the underlying diagnosis (rheumatoid arthritis (RA)/inflammatory arthritis, osteoarthritis (OA), avascular necrosis of bone (AVN), other) in patients undergoing primary total hip arthroplasty (THA). METHODS:We used prospec...

journal_title：BMC medicine

authors： Singh JA,Lewallen DG

更新日期：2013-09-24 00:00:00

abstract：BACKGROUND:The inverse equity hypothesis asserts that new health policies initially widen inequality, then attenuate inequalities over time. Since 2004, the UK's pay-for-performance scheme for chronic disease management (CDM) in primary care general practices (the Quality and Outcomes Framework) has permitted practices...

journal_title：BMC medicine

authors： Lowrie R,McConnachie A,Williamson AE,Kontopantelis E,Forrest M,Lannigan N,Mercer SW,Mair FS

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased oxidative and nitrosative stress (O&NS), which contribute to ...

journal_title：BMC medicine

authors： Berk M,Williams LJ,Jacka FN,O'Neil A,Pasco JA,Moylan S,Allen NB,Stuart AL,Hayley AC,Byrne ML,Maes M

更新日期：2013-09-12 00:00:00

abstract：BACKGROUND:Health-related research funders, regulators and journals expect that de-identified individual-level health data be shared widely, with as few restrictions as possible; yet, in reality, the volume of shared data remains low. MAIN BODY:Health researchers and other data producers are reluctant to share their d...

journal_title：BMC medicine

authors： Waithira N,Mutinda B,Cheah PY

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of survival in critically ill adults, but little data exist for African children living in malaria-endemic...

journal_title：BMC medicine

authors： Aramburo A,Todd J,George EC,Kiguli S,Olupot-Olupot P,Opoka RO,Engoru C,Akech SO,Nyeko R,Mtove G,Gibb DM,Babiker AG,Maitland K

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pathogenesis and progression of NAFLD is complex with many unanswered questions. We conducted genome-w...

journal_title：BMC medicine

authors： Namjou B,Lingren T,Huang Y,Parameswaran S,Cobb BL,Stanaway IB,Connolly JJ,Mentch FD,Benoit B,Niu X,Wei WQ,Carroll RJ,Pacheco JA,Harley ITW,Divanovic S,Carrell DS,Larson EB,Carey DJ,Verma S,Ritchie MD,Gharavi AG,

更新日期：2019-07-17 00:00:00

abstract：:Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed better than 50% improvement in 50% of patients in a clinical trial....

journal_title：BMC medicine

authors： Mitsikostas DD,Rapoport AM

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:In an era when obesity prevalence is high throughout much of the world, there is a correspondingly pervasive and strong culture of weight stigma. For example, representative studies show that some forms of weight discrimination are more prevalent even than discrimination based on race or ethnicity. DISCUSSI...

journal_title：BMC medicine

authors： Tomiyama AJ,Carr D,Granberg EM,Major B,Robinson E,Sutin AR,Brewis A

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:Resistance and tolerance to Plasmodium falciparum can determine the progression of malaria disease. However, quantitative evidence of tolerance is still limited. We investigated variations in the adverse impact of P. falciparum infections among African pregnant women under different intensities of malaria tr...

journal_title：BMC medicine

authors： Ndam NT,Mbuba E,González R,Cisteró P,Kariuki S,Sevene E,Rupérez M,Fonseca AM,Vala A,Maculuve S,Jiménez A,Quintó L,Ouma P,Ramharter M,Aponte JJ,Nhacolo A,Massougbodji A,Briand V,Kremsner PG,Mombo-Ngoma G,Desai M,

更新日期：2017-07-17 00:00:00

abstract：BACKGROUND:The major psychoactive cannabinoid compound of marijuana, delta-9 tetrahydrocannabinol (THC), has been shown to modulate immune responses and lymphocyte function. After primary infection the viral DNA genome of gamma herpesviruses persists in lymphoid cell nuclei in a latent episomal circular form. In respon...

journal_title：BMC medicine

authors： Medveczky MM,Sherwood TA,Klein TW,Friedman H,Medveczky PG

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessitates effective targeting and monitoring of interventions. This requires a valid, reliable measure of ...

journal_title：BMC medicine

authors： Burt J,Elmore N,Campbell SM,Rodgers S,Avery AJ,Payne RA

更新日期：2018-06-13 00:00:00

abstract：BACKGROUND:Ineffective risk stratification can delay diagnosis of serious disease in patients with hematuria. We applied a systems biology approach to analyze clinical, demographic and biomarker measurements (n = 29) collected from 157 hematuric patients: 80 urothelial cancer (UC) and 77 controls with confounding patho...

journal_title：BMC medicine

authors： Emmert-Streib F,Abogunrin F,de Matos Simoes R,Duggan B,Ruddock MW,Reid CN,Roddy O,White L,O'Kane HF,O'Rourke D,Anderson NH,Nambirajan T,Williamson KE

更新日期：2013-01-17 00:00:00

abstract：BACKGROUND:Multiple-arm randomized trials can be more complex in their design, data analysis, and result reporting than two-arm trials. We conducted a systematic review to assess the reporting of analyses in reports of randomized controlled trials (RCTs) with multiple arms. METHODS:The literature in the MEDLINE databa...

journal_title：BMC medicine

authors： Baron G,Perrodeau E,Boutron I,Ravaud P

更新日期：2013-03-27 00:00:00

abstract：BACKGROUND:The consumption of free sugars in the UK is more than double the guideline intake for adults and close to triple for children, with soft drinks representing a significant proportion. The aim of this study was to assess how individual soft drink companies and consumers have responded to calls to reduce sugar ...

journal_title：BMC medicine

authors： Bandy LK,Scarborough P,Harrington RA,Rayner M,Jebb SA

更新日期：2020-01-13 00:00:00

abstract：BACKGROUND:Most UK medical schools use aptitude tests during student selection, but large-scale studies of predictive validity are rare. This study assesses the United Kingdom Clinical Aptitude Test (UKCAT), and its four sub-scales, along with measures of educational attainment, individual and contextual socio-economic...

journal_title：BMC medicine

authors： McManus IC,Dewberry C,Nicholson S,Dowell JS

更新日期：2013-11-14 00:00:00

abstract：:This comment relates to articles published in archived content of the journal Head and Neck Oncology and is not related to the content of BMC Medicine in any way. ...

journal_title：BMC medicine

authors： BioMed Central.

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:The spread of infectious diseases crucially depends on the pattern of contacts between individuals. Knowledge of these patterns is thus essential to inform models and computational efforts. However, there are few empirical studies available that provide estimates of the number and duration of contacts betwee...

journal_title：BMC medicine

authors： Stehlé J,Voirin N,Barrat A,Cattuto C,Colizza V,Isella L,Régis C,Pinton JF,Khanafer N,Van den Broeck W,Vanhems P

更新日期：2011-07-19 00:00:00

abstract：BACKGROUND:Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomized controlled trial (RCT) investigating the impact of fatty fish on cognition in preschool children....

journal_title：BMC medicine

authors： Øyen J,Kvestad I,Midtbø LK,Graff IE,Hysing M,Stormark KM,Markhus MW,Baste V,Frøyland L,Koletzko B,Demmelmair H,Dahl L,Lie Ø,Kjellevold M

更新日期：2018-03-12 00:00:00

abstract：:Malaria at international borders presents particular challenges with regards to elimination. International borders share common malaria ecologies, yet neighboring countries are often at different stages of the control-to-elimination pathway. Herein, we present a case study on malaria, and its control, at the border be...

journal_title：BMC medicine

authors： Al Zahrani MH,Omar AI,Abdoon AMO,Ibrahim AA,Alhogail A,Elmubarak M,Elamin YE,AlHelal MA,Alshahrani AM,Abdelgader TM,Saeed I,El Gamri TB,Alattas MS,Dahlan AA,Assiri AM,Maina J,Li XH,Snow RW

更新日期：2018-06-26 00:00:00

abstract：BACKGROUND:Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score is the only currently available midlife risk score for dementia. We compared CAIDE to Framingham cardiovascular Risk Score (FRS) and FINDRISC diabetes score as predictors of dementia and assessed the role of age in their associa...

journal_title：BMC medicine

authors： Fayosse A,Nguyen DP,Dugravot A,Dumurgier J,Tabak AG,Kivimäki M,Sabia S,Singh-Manoux A

更新日期：2020-05-19 00:00:00

abstract：:The launch of the 5th version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) has sparked a debate about the current approach to psychiatric classification. The most basic and enduring problem of the DSM is that its classifications are heterogeneous clinical descriptions rather than valid diagnose...

journal_title：BMC medicine

authors： Wardenaar KJ,de Jonge P

更新日期：2013-09-12 00:00:00

abstract：BACKGROUND:The spatial spread of many mosquito-borne diseases occurs by focal spread at the scale of a few hundred meters and over longer distances due to human mobility. The relative contributions of different spatial scales for transmission of chikungunya virus require definition to improve outbreak vector control re...

journal_title：BMC medicine

authors： Guzzetta G,Vairo F,Mammone A,Lanini S,Poletti P,Manica M,Rosa R,Caputo B,Solimini A,Torre AD,Scognamiglio P,Zumla A,Ippolito G,Merler S

更新日期：2020-08-07 00:00:00

abstract：BACKGROUND:The RTS,S/AS01 malaria vaccine candidate recently completed Phase III trials in 11 African sites. Recommendations for its deployment will partly depend on predictions of public health impact in endemic countries. Previous predictions of these used only limited information on underlying vaccine properties and...

journal_title：BMC medicine

authors： Penny MA,Galactionova K,Tarantino M,Tanner M,Smith TA

更新日期：2015-07-29 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD). The current evidence on platelet activation levels in patients with HIV remains inconclusive. We therefore aimed to systematically synthesise ev...

journal_title：BMC medicine

authors： Nkambule BB,Mxinwa V,Mkandla Z,Mutize T,Mokgalaboni K,Nyambuya TM,Dludla PV

更新日期：2020-11-18 00:00:00

abstract：BACKGROUND:Although vaccination has been proved to be a safe, efficacious, and cost-effective intervention, immunisation rates remain suboptimal in many European countries, resulting in poor control of many vaccine-preventable diseases. DISCUSSION:The Summit of Independent European Vaccination Experts focused on the p...

journal_title：BMC medicine

authors： Schmitt HJ,Booy R,Aston R,Van Damme P,Schumacher RF,Campins M,Rodrigo C,Heikkinen T,Weil-Olivier C,Finn A,Olcén P,Fedson D,Peltola H

更新日期：2007-05-29 00:00:00

abstract：BACKGROUND:Armed conflict can indirectly affect population health through detrimental impacts on political and social institutions and destruction of infrastructure. This study aimed to quantify indirect mortality impacts of armed conflict in civilian populations globally and explore differential effects by armed confl...

journal_title：BMC medicine

authors： Jawad M,Hone T,Vamos EP,Roderick P,Sullivan R,Millett C

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:Adiposity is associated with many adverse health outcomes but little direct evidence exists about its impact on the use of health care services. We aim to describe the relationship between body mass index (BMI) and rates of hospital admission in middle-aged UK women. METHODS:Among 1,251,619 Million Women St...

journal_title：BMC medicine

authors： Reeves GK,Balkwill A,Cairns BJ,Green J,Beral V,Million Women Study Collaborators.

更新日期：2014-03-15 00:00:00

abstract：:Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an obvious and attractive therapeutic strategy. After concerted effort...

journal_title：BMC medicine

authors： Quashie PK,Sloan RD,Wainberg MA

更新日期：2012-04-12 00:00:00