New players in the preventive treatment of migraine.

abstract：BACKGROUND:Individuals with co-occurring hyperactivity disorder/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) can have complex presentations that may complicate diagnosis and treatment. There are established guidelines with regard to the identification and treatment of ADHD and ASD as independent con...

journal_title：BMC medicine

authors： Young S,Hollingdale J,Absoud M,Bolton P,Branney P,Colley W,Craze E,Dave M,Deeley Q,Farrag E,Gudjonsson G,Hill P,Liang HL,Murphy C,Mackintosh P,Murin M,O'Regan F,Ougrin D,Rios P,Stover N,Taylor E,Woodhouse E

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:Brazil's Estratégia Saúde da Família (ESF) is one of the largest and most robustly evaluated primary healthcare programmes of the world, but it could be affected by fiscal austerity measures and by the possible end of the Mais Médicos programme (MMP)-a major intervention to increase primary care doctors in u...

journal_title：BMC medicine

authors： Rasella D,Hone T,de Souza LE,Tasca R,Basu S,Millett C

更新日期：2019-04-26 00:00:00

abstract：BACKGROUND:Three large new trials of unprecedented scale and cost, which included novel factorial designs, have found no effect of basic water, sanitation and hygiene (WASH) interventions on childhood stunting, and only mixed effects on childhood diarrhea. Arriving at the inception of the United Nations' Sustainable De...

journal_title：BMC medicine

authors： Cumming O,Arnold BF,Ban R,Clasen T,Esteves Mills J,Freeman MC,Gordon B,Guiteras R,Howard G,Hunter PR,Johnston RB,Pickering AJ,Prendergast AJ,Prüss-Ustün A,Rosenboom JW,Spears D,Sundberg S,Wolf J,Null C,Luby SP,Hum

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a 10-year period. METHODS:The community-based cohort included 7381 p...

journal_title：BMC medicine

authors： Carrière I,Norton J,Farré A,Wyart M,Tzourio C,Noize P,Pérès K,Fourrier-Réglat A,Ritchie K,Ancelin ML

更新日期：2017-04-19 00:00:00

abstract：BACKGROUND:Interventions to promote positive parenting are often reported to offer good outcomes for children but they can consume substantial resources and they require rigorous appraisal. METHODS:Evaluations of the Triple P parenting program were subjected to systematic review and meta-analysis with analysis of bias...

journal_title：BMC medicine

authors： Wilson P,Rush R,Hussey S,Puckering C,Sim F,Allely CS,Doku P,McConnachie A,Gillberg C

更新日期：2012-11-02 00:00:00

abstract：:Although clinical nutrition is a frequently used intervention in inpatient care, high quality trials proving its effectiveness and safety when used in the acutely-ill polymorbid medical inpatient population are largely lacking. From an evolutionary perspective, illness-related low appetite is protective and part of th...

journal_title：BMC medicine

authors： Schuetz P

更新日期：2017-02-24 00:00:00

abstract：BACKGROUND:It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. METHODS:To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal ...

journal_title：BMC medicine

authors： Xu X,Chow EPF,Ong JJ,Hoebe CJPA,Zou Z,Hocking JS,Fairley CK,Zhang L

更新日期：2020-11-17 00:00:00

abstract：:Migraine is a highly prevalent neurological disorder imparting a major burden on health care around the world. The primary pathology may be a state of hyperresponsiveness of the nervous system, but the molecular mechanisms are yet to be fully elucidated. We could now be at a watershed moment in this respect, as the ge...

journal_title：BMC medicine

authors： Weir GA,Cader MZ

更新日期：2011-10-25 00:00:00

abstract：:There is evidence that the life expectancy (LE) of individuals infected with the human immunodeficiency virus (HIV) has increased since the introduction of combination antiretroviral therapy (cART). However, mortality rates in recent years in HIV-positive individuals appear to have remained higher than would be expect...

journal_title：BMC medicine

authors： Sabin CA

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:The nature of symptoms in the prodromal period of first episode psychosis (FEP) remains unclear. The objective was to determine the patterns of symptoms recorded in primary care in the 5 years before FEP diagnosis. METHODS:The study was set within 568 practices contributing to a UK primary care health recor...

journal_title：BMC medicine

authors： Chen Y,Farooq S,Edwards J,Chew-Graham CA,Shiers D,Frisher M,Hayward R,Sumathipala A,Jordan KP

更新日期：2019-12-04 00:00:00

abstract：:Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic A...

journal_title：BMC medicine

authors： Munshi R,Hsu C,Himmelfarb J

更新日期：2011-02-02 00:00:00

abstract：BACKGROUND:The spread of infectious diseases crucially depends on the pattern of contacts between individuals. Knowledge of these patterns is thus essential to inform models and computational efforts. However, there are few empirical studies available that provide estimates of the number and duration of contacts betwee...

journal_title：BMC medicine

authors： Stehlé J,Voirin N,Barrat A,Cattuto C,Colizza V,Isella L,Régis C,Pinton JF,Khanafer N,Van den Broeck W,Vanhems P

更新日期：2011-07-19 00:00:00

abstract：BACKGROUND:It is critically important to conduct research on stigmatized conditions, to include marginalized groups that experience stigma, and to develop interventions to reduce stigma. However, such research is ethically challenging. Though superficial reference is frequently made to these widely acknowledged challen...

journal_title：BMC medicine

authors： Millum J,Campbell M,Luna F,Malekzadeh A,Karim QA

更新日期：2019-04-29 00:00:00

abstract：:Psychiatric nosology is widely criticized, but solutions are proving elusive. Planned revisions of diagnostic criteria will not resolve heterogeneity, comorbidity, fuzzy boundaries between normal and pathological, and lack of specific biomarkers. Concern about these difficulties reflects a narrow model that assumes mo...

journal_title：BMC medicine

authors： Nesse RM,Stein DJ

更新日期：2012-01-13 00:00:00

abstract：BACKGROUND:The UK Clinical Aptitude Test (UKCAT) has been shown to have a modest but statistically significant ability to predict aspects of academic performance throughout medical school. Previously, this ability has been shown to be incremental to conventional measures of educational performance for the first year of...

journal_title：BMC medicine

authors： Tiffin PA,Mwandigha LM,Paton LW,Hesselgreaves H,McLachlan JC,Finn GM,Kasim AS

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND:Extended use of combined pharmacotherapies to treat tobacco dependence may increase smoking abstinence; few studies have examined their effectiveness. The objective of this study was to evaluate smoking abstinence with standard nicotine patch (NRT), extended use of combined formulations of nicotine replaceme...

journal_title：BMC medicine

authors： Tulloch HE,Pipe AL,Els C,Clyde MJ,Reid RD

更新日期：2016-06-07 00:00:00

abstract：BACKGROUND:Observational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomisation study to investigate whether serum magnesium levels may be causally associated with coronary art...

journal_title：BMC medicine

authors： Larsson SC,Burgess S,Michaëlsson K

更新日期：2018-05-17 00:00:00

abstract：:Verotoxigenic Escherichia coli (VTEC) are a specialized group of E. coli that can cause severe colonic disease and renal failure. Their pathogenicity derives from virulence factors that enable the bacteria to colonize the colon and deliver extremely powerful toxins known as verotoxins (VT) or Shiga toxins (Stx) to the...

journal_title：BMC medicine

authors： Goldwater PN,Bettelheim KA

更新日期：2012-02-02 00:00:00

abstract：BACKGROUND:There are widespread concerns about communication and support for patients and families, especially when they face clinical uncertainty, a situation most marked in intensive care units (ICUs). Therefore, we aimed to develop and evaluate an interventional tool to improve communication and palliative care, usi...

journal_title：BMC medicine

authors： Higginson IJ,Koffman J,Hopkins P,Prentice W,Burman R,Leonard S,Rumble C,Noble J,Dampier O,Bernal W,Hall S,Morgan M,Shipman C

更新日期：2013-10-01 00:00:00

abstract：:Alzheimer's disease is a devastating neurological disorder that affects more than 37 million people worldwide. The economic burden of Alzheimer's disease is massive; in the United States alone, the estimated direct and indirect annual cost of patient care is at least $100 billion. Current FDA-approved drugs for Alzhei...

journal_title：BMC medicine

authors： Rafii MS,Aisen PS

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Obesity is common in young women, increasing insulin resistance (IR) and worsening pregnancy complications, including gestational diabetes (GDM). Women with polycystic ovary syndrome (PCOS) are commonly obese, which aggravates the severity of PCOS clinical expression. Relationships between these common insul...

journal_title：BMC medicine

authors： Kakoly NS,Earnest A,Moran LJ,Teede HJ,Joham AE

更新日期：2017-11-06 00:00:00

abstract：:In this video Q&A, we talk to Professor Carlos Caldas about the identification of breast cancer subtypes through molecular profiling, and the clinical implications for diagnosis and treatment. ...

journal_title：BMC medicine

authors： Caldas C

更新日期：2013-06-18 00:00:00

abstract：BACKGROUND:In many developing countries, the majority of births are attended by traditional birth attendants, who lack formal training in neonatal resuscitation and other essential care required by the newly born infant. In these countries, the major causes of neonatal mortality are birth asphyxia, infection, and low-b...

journal_title：BMC medicine

authors： Matendo R,Engmann C,Ditekemena J,Gado J,Tshefu A,Kinoshita R,McClure EM,Moore J,Wallace D,Carlo WA,Wright LL,Bose C

更新日期：2011-08-04 00:00:00

abstract：:Proteinuria is a defining criterion for the diagnosis of pre-eclampsia. The amount of protein lost per day has been thought by some to predict both maternal and fetal outcome. The systematic review of 16 primary papers including over 6700 patients by Thangaratinam and colleagues published this month in BMC Medicine su...

journal_title：BMC medicine

authors： Hofmeyr GJ,Belfort M

更新日期：2009-03-24 00:00:00

abstract：BACKGROUND:Associations between type 2 diabetes (T2D) and amyotrophic lateral sclerosis (ALS) were discovered in observational studies in both European and East Asian populations. However, whether such associations are causal remains largely unknown. METHODS:We employed a two-sample Mendelian randomization approach to...

journal_title：BMC medicine

authors： Zeng P,Wang T,Zheng J,Zhou X

更新日期：2019-12-04 00:00:00

abstract：:The stratification of patients for treatment of prostate cancer is based on very general parameters like prostate-specific antigen, Gleason score, and TNM classification. We use these rough parameters for selection of active surveillance, active treatment, and even for the treatment selection in metastasized or castra...

journal_title：BMC medicine

authors： Sedelaar JP,Schalken JA

更新日期：2015-05-09 00:00:00

abstract：BACKGROUND:There has been concern that the incidence of autism and other pervasive developmental disorders (PDDs) is increasing. Previous studies have been smaller, restricted to autism (excluding other pervasive developmental disorders such as Asperger's syndrome), included boys only, or have not been based on a natio...

journal_title：BMC medicine

authors： Smeeth L,Cook C,Fombonne PE,Heavey L,Rodrigues LC,Smith PG,Hall AJ

更新日期：2004-11-09 00:00:00

abstract：BACKGROUND:Network meta-analyses using individual participant data (IPD-NMAs) have been increasingly used to compare the effects of multiple interventions. Although there have been many studies on statistical methods for IPD-NMAs, it is unclear whether there are statistical defects in published IPD-NMAs and whether the...

journal_title：BMC medicine

authors： Gao Y,Shi S,Li M,Luo X,Liu M,Yang K,Zhang J,Song F,Tian J

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Strategies in many countries have sought to improve palliative care and reduce hospital deaths for non-cancer patients, but their effects are not evaluated. We aimed to determine the trends and factors associated with dying in hospital in two common progressive respiratory diseases, and the impact of a natio...

journal_title：BMC medicine

authors： Higginson IJ,Reilly CC,Bajwah S,Maddocks M,Costantini M,Gao W,GUIDE_Care project.

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:In 2015, the Zika virus spread from Brazil throughout the Americas, posing an unprecedented challenge to the public health community. During the epidemic, international public health officials lacked reliable predictions of the outbreak's expected geographic scale and prevalence of cases, and were therefore ...

journal_title：BMC medicine

authors： Akhtar M,Kraemer MUG,Gardner LM

更新日期：2019-09-02 00:00:00