A tool to facilitate clinical biomarker studies--a tissue dictionary based on the Human Protein Atlas.

abstract：BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...

journal_title：BMC medicine

authors： Burton C,Fink P,Henningsen P,Löwe B,Rief W,EURONET-SOMA Group.

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:The NPC1 gene encodes a protein involved in intracellular lipid trafficking; its second endosomal loop (loop 2) is a receptor for filoviruses. A polymorphism (His215Arg) in NPC1 was associated with obesity in Europeans. Adaptations to diet and pathogens represented powerful selective forces; thus, we analyze...

journal_title：BMC medicine

authors： Al-Daghri NM,Cagliani R,Forni D,Alokail MS,Pozzoli U,Alkharfy KM,Sabico S,Clerici M,Sironi M

更新日期：2012-11-15 00:00:00

abstract：:Breast cancer is the most common cause of cancer and cancer death worldwide. Although most patients present with localized breast cancer and may be rendered disease-free with local therapy, distant recurrence is common and is the primary cause of death from the disease. Adjuvant systemic therapies are effective in red...

journal_title：BMC medicine

authors： Anampa J,Makower D,Sparano JA

更新日期：2015-08-17 00:00:00

abstract：BACKGROUND:In July 2014, an outbreak of Ebola virus disease (EVD) started in Pujehun district, Sierra Leone. On January 10th, 2015, the district was the first to be declared Ebola-free by local authorities after 49 cases and a case fatality rate of 85.7%. The Pujehun outbreak represents a precious opportunity for impro...

journal_title：BMC medicine

authors： Ajelli M,Parlamento S,Bome D,Kebbi A,Atzori A,Frasson C,Putoto G,Carraro D,Merler S

更新日期：2015-11-26 00:00:00

abstract：:The internet has opened up vast possibilities for research. An increasing number of studies are being conducted using the internet as both a source of data and a venue for research. Use of the internet in research has created many challenges, not just for those conducting and reviewing the studies, but also for editor...

journal_title：BMC medicine

authors： Harriman S,Patel J

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:Adiposity is associated with many adverse health outcomes but little direct evidence exists about its impact on the use of health care services. We aim to describe the relationship between body mass index (BMI) and rates of hospital admission in middle-aged UK women. METHODS:Among 1,251,619 Million Women St...

journal_title：BMC medicine

authors： Reeves GK,Balkwill A,Cairns BJ,Green J,Beral V,Million Women Study Collaborators.

更新日期：2014-03-15 00:00:00

abstract：:This is an Erratum to BMC Medicine 2015, 13:59, highlighting previously undeclared competing interests and including more information in the acknowledgements section.Please see related article: http://www.biomedcentral.com/1741-7015/13/59. The statement in the competing interests should read as follows: This study is ...

journal_title：BMC medicine

authors： Huang T,Xu M,Lee A,Cho S,Qi L

更新日期：2015-04-16 00:00:00

abstract：BACKGROUND:Recent reviews on placebo effects in clinical trials suggest that objective changes following placebo treatments may not exist or, at least, have been considerably overestimated. However, the possibility that yet unidentified subsets of parameters are responsive to placebo treatments has not been taken into ...

journal_title：BMC medicine

authors： Meissner K,Distel H,Mitzdorf U

更新日期：2007-03-19 00:00:00

abstract：BACKGROUND:Armed conflicts are associated with a wide range of impacts on the mental health of children and adolescents. We evaluated the effectiveness of a school-based intervention aimed at reducing symptoms of posttraumatic stress disorder, depression, and anxiety (treatment aim); and improving a sense of hope and f...

journal_title：BMC medicine

authors： Tol WA,Komproe IH,Jordans MJ,Ndayisaba A,Ntamutumba P,Sipsma H,Smallegange ES,Macy RD,de Jong JT

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Most UK medical schools use aptitude tests during student selection, but large-scale studies of predictive validity are rare. This study assesses the United Kingdom Clinical Aptitude Test (UKCAT), and its four sub-scales, along with measures of educational attainment, individual and contextual socio-economic...

journal_title：BMC medicine

authors： McManus IC,Dewberry C,Nicholson S,Dowell JS

更新日期：2013-11-14 00:00:00

abstract：BACKGROUND:Obesity is common in young women, increasing insulin resistance (IR) and worsening pregnancy complications, including gestational diabetes (GDM). Women with polycystic ovary syndrome (PCOS) are commonly obese, which aggravates the severity of PCOS clinical expression. Relationships between these common insul...

journal_title：BMC medicine

authors： Kakoly NS,Earnest A,Moran LJ,Teede HJ,Joham AE

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:Australia was one of the first countries to introduce a publicly funded national human papillomavirus (HPV) vaccination program that commenced in April 2007, using the quadrivalent HPV vaccine targeting 12- to 13-year-old girls on an ongoing basis. Two-year catch-up programs were offered to 14- to 17- year-o...

journal_title：BMC medicine

authors： Gertig DM,Brotherton JM,Budd AC,Drennan K,Chappell G,Saville AM

更新日期：2013-10-22 00:00:00

abstract：BACKGROUND:The UK, like a number of other countries, has a refugee resettlement programme. External factors, such as higher prevalence of infectious diseases in the country of origin and circumstances of travel, are likely to increase the infectious disease risk of refugees, but published data is scarce. The Internatio...

journal_title：BMC medicine

authors： Crawshaw AF,Pareek M,Were J,Schillinger S,Gorbacheva O,Wickramage KP,Mandal S,Delpech V,Gill N,Kirkbride H,Zenner D

更新日期：2018-08-28 00:00:00

abstract：BACKGROUND:We conducted this analysis to determine i) which journals publish high-quality, clinically relevant studies in internal medicine, general/family practice, general practice nursing, and mental health; and ii) the proportion of clinically relevant articles in each journal. METHODS:We performed an analytic sur...

journal_title：BMC medicine

authors： McKibbon KA,Wilczynski NL,Haynes RB

更新日期：2004-09-06 00:00:00

abstract：:The original article [1] contained an error in the presentation of Figure 1; this error has now been rectified and Figure 1 is now presented correctly. ...

journal_title：BMC medicine

authors： Wesolowski A,Taylor AR,Chang HH,Verity R,Tessema S,Bailey JA,Alex Perkins T,Neafsey DE,Greenhouse B,Buckee CO

更新日期：2018-12-28 00:00:00

abstract：BACKGROUND:Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collected from neighborhoods surrounding a prison in Lima, Peru, where inmates experience a high risk of M...

journal_title：BMC medicine

authors： Warren JL,Grandjean L,Moore DAJ,Lithgow A,Coronel J,Sheen P,Zelner JL,Andrews JR,Cohen T

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sensitive behavioral assays in low-income settings, which has hindered researchers' ability to explain h...

journal_title：BMC medicine

authors： Xie W,Jensen SKG,Wade M,Kumar S,Westerlund A,Kakon SH,Haque R,Petri WA,Nelson CA

更新日期：2019-11-25 00:00:00

abstract：BACKGROUND:Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications. However, the underlying mechanisms in anthrax lethal toxin-induced cardiac anomalies remain unknown. This study was designed to evaluate the impact of antioxidant enzyme ...

journal_title：BMC medicine

authors： Kandadi MR,Yu X,Frankel AE,Ren J

更新日期：2012-11-07 00:00:00

abstract：BACKGROUND:Abnormal BMI is associated with discouraging IVF outcomes in fresh autologous or oocyte donor cycles, whether or not such a relation also holds true for women undergoing frozen-thawed embryo transfer (FET) remains unknown. In addition, it remains unclear the detrimental effect of abnormal BMI on IVF outcomes...

journal_title：BMC medicine

authors： Zhang J,Liu H,Mao X,Chen Q,Fan Y,Xiao Y,Wang Y,Kuang Y

更新日期：2019-06-26 00:00:00

abstract：BACKGROUND:Cognitive impairment is common in patients with cerebral small vessel disease, but is not well detected using common cognitive screening tests which have been primarily devised for cortical dementias. We developed the Brief Memory and Executive Test (BMET); a rapid screening measure sensitive to the impaired...

journal_title：BMC medicine

authors： Brookes RL,Hollocks MJ,Khan U,Morris RG,Markus HS

更新日期：2015-03-11 00:00:00

abstract：BACKGROUND:Health-related research funders, regulators and journals expect that de-identified individual-level health data be shared widely, with as few restrictions as possible; yet, in reality, the volume of shared data remains low. MAIN BODY:Health researchers and other data producers are reluctant to share their d...

journal_title：BMC medicine

authors： Waithira N,Mutinda B,Cheah PY

更新日期：2019-04-17 00:00:00

abstract：:Severe anemia contributes significantly to child mortality in sub-Saharan Africa. Blood transfusion is used in emergencies but carries risks. In BMC Medicine, Olupot-Olupot and colleagues report the findings of a phase II trial in children with severe anemia in Eastern Uganda. They provide important early safety and e...

journal_title：BMC medicine

authors： Brick T,Peters MJ

更新日期：2014-04-25 00:00:00

abstract：BACKGROUND:Clinical pathways (CPs) are used to improve the outcomes of acute stroke, but their use in stroke care is questionable, because the evidence on their effectiveness is still inconclusive. The objective of this study was to evaluate whether CPs improve the outcomes and the quality of care provided to patients ...

journal_title：BMC medicine

authors： Panella M,Marchisio S,Brambilla R,Vanhaecht K,Di Stanislao F

更新日期：2012-07-10 00:00:00

abstract：BACKGROUND:The 'Older People's Exercise intervention in Residential and nursing Accommodation' (OPERA) cluster randomised trial evaluated the impact of training for care home staff together with twice-weekly, physiotherapist-led exercise classes on depressive symptoms in care home residents, but found no effect. We rep...

journal_title：BMC medicine

authors： Ellard DR,Thorogood M,Underwood M,Seale C,Taylor SJ

更新日期：2014-01-03 00:00:00

abstract：:Alzheimer's disease is a devastating neurological disorder that affects more than 37 million people worldwide. The economic burden of Alzheimer's disease is massive; in the United States alone, the estimated direct and indirect annual cost of patient care is at least $100 billion. Current FDA-approved drugs for Alzhei...

journal_title：BMC medicine

authors： Rafii MS,Aisen PS

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Vaccination has reduced the global incidence of measles to the lowest rates in history. However, local interruption of measles virus transmission requires sustained high levels of population immunity that can be challenging to achieve and maintain. The herd immunity threshold for measles is typically stipula...

journal_title：BMC medicine

authors： Funk S,Knapp JK,Lebo E,Reef SE,Dabbagh AJ,Kretsinger K,Jit M,Edmunds WJ,Strebel PM

更新日期：2019-09-25 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is of clinical and public health importance as it is very common, affecting up to one in five women of reproductive age. It has significant and diverse clinical implications including reproductive (infertility, hyperandrogenism, hirsutism), metabolic (insulin resistance, impaired gluco...

journal_title：BMC medicine

authors： Teede H,Deeks A,Moran L

更新日期：2010-06-30 00:00:00

abstract：:Primary care clinicians and researchers are growing increasingly aware of the prevalence of multimorbidity among long-term conditions, and the impact on patient experience, health, and utilisation of care. The correspondence paper by Muth et al. entitled 'The Ariadne principles: how to handle multimorbidity in primary...

journal_title：BMC medicine

authors： Bower P

更新日期：2014-12-08 00:00:00

abstract：BACKGROUND:Three large new trials of unprecedented scale and cost, which included novel factorial designs, have found no effect of basic water, sanitation and hygiene (WASH) interventions on childhood stunting, and only mixed effects on childhood diarrhea. Arriving at the inception of the United Nations' Sustainable De...

journal_title：BMC medicine

authors： Cumming O,Arnold BF,Ban R,Clasen T,Esteves Mills J,Freeman MC,Gordon B,Guiteras R,Howard G,Hunter PR,Johnston RB,Pickering AJ,Prendergast AJ,Prüss-Ustün A,Rosenboom JW,Spears D,Sundberg S,Wolf J,Null C,Luby SP,Hum

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:There has been concern that the incidence of autism and other pervasive developmental disorders (PDDs) is increasing. Previous studies have been smaller, restricted to autism (excluding other pervasive developmental disorders such as Asperger's syndrome), included boys only, or have not been based on a natio...

journal_title：BMC medicine

authors： Smeeth L,Cook C,Fombonne PE,Heavey L,Rodrigues LC,Smith PG,Hall AJ

更新日期：2004-11-09 00:00:00