Towards a genuinely medical model for psychiatric nosology.

abstract：BACKGROUND:Mucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown. METHODS:To correlate MUC4 polymorphism with the risk of endometriosis and endometriosis-related infertility, we performed ...

journal_title：BMC medicine

authors： Chang CY,Chang HW,Chen CM,Lin CY,Chen CP,Lai CH,Lin WY,Liu HP,Sheu JJ,Tsai FJ

更新日期：2011-02-24 00:00:00

abstract：:The hypothalamic-pituitary-adrenal axis is activated in response to stress. One of the activated hypothalamic hormones is arginine vasopressin, a hormone involved in hemodynamics and osmoregulation. Copeptin, the C-terminal part of the arginine vasopressin precursor peptide, is a sensitive and stable surrogate marker ...

journal_title：BMC medicine

authors： Nickel CH,Bingisser R,Morgenthaler NG

更新日期：2012-01-20 00:00:00

abstract：:Primary care clinicians and researchers are growing increasingly aware of the prevalence of multimorbidity among long-term conditions, and the impact on patient experience, health, and utilisation of care. The correspondence paper by Muth et al. entitled 'The Ariadne principles: how to handle multimorbidity in primary...

journal_title：BMC medicine

authors： Bower P

更新日期：2014-12-08 00:00:00

abstract：BACKGROUND:Scale-up of malaria interventions over the last decade have yielded a significant reduction in malaria transmission and disease burden in sub-Saharan Africa. We estimated economic gradients in the distribution of these efforts and of their impacts within and across endemic countries. METHODS:Using Demograph...

journal_title：BMC medicine

authors： Galactionova K,Smith TA,de Savigny D,Penny MA

更新日期：2017-10-18 00:00:00

abstract：BACKGROUND:Heterogeneity of prostate cancer (PCa) contributes to inaccurate cancer screening and diagnosis, unnecessary biopsies, and overtreatment. We intended to develop non-invasive urine tests for accurate PCa diagnosis to avoid unnecessary biopsies. METHODS:Using a machine learning program, we identified a 25-Gen...

journal_title：BMC medicine

authors： Johnson H,Guo J,Zhang X,Zhang H,Simoulis A,Wu AHB,Xia T,Li F,Tan W,Johnson A,Dizeyi N,Abrahamsson PA,Kenner L,Feng X,Zou C,Xiao K,Persson JL,Chen L

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...

journal_title：BMC medicine

authors： Burton C,Fink P,Henningsen P,Löwe B,Rief W,EURONET-SOMA Group.

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:Inappropriate treatment of non-malaria fevers with artemisinin-based combination therapies (ACTs) is a growing concern, particularly in light of emerging artemisinin resistance, but it is a behavior that has proven difficult to change. Pay for performance (P4P) programs have generated interest as a mechanism...

journal_title：BMC medicine

authors： Menya D,Platt A,Manji I,Sang E,Wafula R,Ren J,Cheruiyot O,Armstrong J,Neelon B,O'Meara WP

更新日期：2015-10-16 00:00:00

abstract：BACKGROUND:Guidelines recommend that clinicians should make brief opportunistic behavioural interventions to patients who are obese to increase the uptake of effective weight loss programmes. The objective was to assess the effect of this policy on socioeconomic equity. METHODS:One thousand eight hundred eighty-two co...

journal_title：BMC medicine

authors： Graham J,Tudor K,Jebb SA,Lewis A,Tearne S,Adab P,Begh R,Jolly K,Daley A,Farley A,Lycett D,Nickless A,Aveyard P

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Obesity is common in young women, increasing insulin resistance (IR) and worsening pregnancy complications, including gestational diabetes (GDM). Women with polycystic ovary syndrome (PCOS) are commonly obese, which aggravates the severity of PCOS clinical expression. Relationships between these common insul...

journal_title：BMC medicine

authors： Kakoly NS,Earnest A,Moran LJ,Teede HJ,Joham AE

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:Comorbidity between depressive and anxiety disorders is common. A hypothesis of the network perspective on psychopathology is that comorbidity arises due to the interplay of symptoms shared by both disorders, with overlapping symptoms acting as so-called bridges, funneling symptom activation between symptom ...

journal_title：BMC medicine

authors： Groen RN,Ryan O,Wigman JTW,Riese H,Penninx BWJH,Giltay EJ,Wichers M,Hartman CA

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:In adults with febrile urinary tract infection (fUTI), data on optimal treatment duration in patients other than non-pregnant women without comorbidities are lacking. METHODS:A randomized placebo-controlled, double-blind, non-inferiority trial among 35 primary care centers and 7 emergency departments of reg...

journal_title：BMC medicine

authors： van Nieuwkoop C,van der Starre WE,Stalenhoef JE,van Aartrijk AM,van der Reijden TJ,Vollaard AM,Delfos NM,van 't Wout JW,Blom JW,Spelt IC,Leyten EM,Koster T,Ablij HC,van der Beek MT,Knol MJ,van Dissel JT

更新日期：2017-04-03 00:00:00

abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they present mild diseases on admission. METHODS:A multicenter nested case-control study was conducted in four...

journal_title：BMC medicine

authors： Shi J,Li Y,Zhou X,Zhang Q,Ye X,Wu Z,Jiang X,Yu H,Shao L,Ai JW,Zhang H,Xu B,Sun F,Zhang W

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring involves therapeutic modifications based on the measurement of drug levels and antidrug antibodies. The viability of therapeutic drug monitoring in vedolizumab-treated patients with inflammatory bowel disease remains questioned. MAIN BODY:Accumulating evidence from clinical trial...

journal_title：BMC medicine

authors： Pouillon L,Vermeire S,Bossuyt P

更新日期：2019-05-08 00:00:00

abstract：BACKGROUND:Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth the adrenals are essential for neonate salt retention through secretion of aldosterone, while adequate glucocorticoids are required to prevent adrenal in...

journal_title：BMC medicine

authors： Johnston ZC,Bellingham M,Filis P,Soffientini U,Hough D,Bhattacharya S,Simard M,Hammond GL,King P,O'Shaughnessy PJ,Fowler PA

更新日期：2018-02-12 00:00:00

abstract：BACKGROUND:The consumption of free sugars in the UK is more than double the guideline intake for adults and close to triple for children, with soft drinks representing a significant proportion. The aim of this study was to assess how individual soft drink companies and consumers have responded to calls to reduce sugar ...

journal_title：BMC medicine

authors： Bandy LK,Scarborough P,Harrington RA,Rayner M,Jebb SA

更新日期：2020-01-13 00:00:00

abstract：:Due to the easier access to information, the availability of low cost technologies and the involvement of well educated, passionate patients, a group of citizen 'Health Hackers', who are building their own medical systems to help them overcome the unmet needs of their conditions, is emerging. This has recently been th...

journal_title：BMC medicine

authors： Omer T

更新日期：2016-08-17 00:00:00

abstract：:In this video Q&A, we talk to Professor Carlos Caldas about the identification of breast cancer subtypes through molecular profiling, and the clinical implications for diagnosis and treatment. ...

journal_title：BMC medicine

authors： Caldas C

更新日期：2013-06-18 00:00:00

abstract：BACKGROUND:Individuals with co-occurring hyperactivity disorder/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) can have complex presentations that may complicate diagnosis and treatment. There are established guidelines with regard to the identification and treatment of ADHD and ASD as independent con...

journal_title：BMC medicine

authors： Young S,Hollingdale J,Absoud M,Bolton P,Branney P,Colley W,Craze E,Dave M,Deeley Q,Farrag E,Gudjonsson G,Hill P,Liang HL,Murphy C,Mackintosh P,Murin M,O'Regan F,Ougrin D,Rios P,Stover N,Taylor E,Woodhouse E

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol trafficking characterized by increased plasma plant sterol levels. Based upo...

journal_title：BMC medicine

authors： Klett EL,Lu K,Kosters A,Vink E,Lee MH,Altenburg M,Shefer S,Batta AK,Yu H,Chen J,Klein R,Looije N,Oude-Elferink R,Groen AK,Maeda N,Salen G,Patel SB

更新日期：2004-03-24 00:00:00

abstract：BACKGROUND:The mind-body nexus has been a topic of growing interest. Further data are however required to understand the specific relationship between mood and anxiety disorders and individual physical health conditions, and to verify whether these psychiatric disorders are linked to overall medical burden. METHODS:Th...

journal_title：BMC medicine

authors： Sanna L,Stuart AL,Pasco JA,Kotowicz MA,Berk M,Girardi P,Brennan SL,Williams LJ

更新日期：2013-04-24 00:00:00

abstract：:Although imatinib is firmly established as an effective therapy for newly diagnosed patients with chronic myeloid leukemia (CML), the field continues to advance on several fronts. In this minireview we cover recent results of second generation tyrosine kinase inhibitors in newly diagnosed patients, investigate the sta...

journal_title：BMC medicine

authors： Eiring AM,Khorashad JS,Morley K,Deininger MW

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:Wide implementation of mammography screening has resulted in increased numbers of women diagnosed with breast carcinoma in situ. We aimed to determine the risk of invasive breast cancer in relatives of patients with breast carcinoma in situ in comparison to the risk in relatives of patients with invasive bre...

journal_title：BMC medicine

authors： Mukama T,Fallah M,Brenner H,Xu X,Sundquist K,Sundquist J,Kharazmi E

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Little is known about the impact of growing migration on the pattern of tuberculosis (TB) transmission in middle-income countries. We estimated TB recent transmission and its associated factors and investigated the presence of cross-transmission between South American migrants and Brazilians. METHODS:We stu...

journal_title：BMC medicine

authors： Pescarini JM,Simonsen V,Ferrazoli L,Rodrigues LC,Oliveira RS,Waldman EA,Houben R

更新日期：2018-04-30 00:00:00

abstract：BACKGROUND:The 'Older People's Exercise intervention in Residential and nursing Accommodation' (OPERA) cluster randomised trial evaluated the impact of training for care home staff together with twice-weekly, physiotherapist-led exercise classes on depressive symptoms in care home residents, but found no effect. We rep...

journal_title：BMC medicine

authors： Ellard DR,Thorogood M,Underwood M,Seale C,Taylor SJ

更新日期：2014-01-03 00:00:00

abstract：BACKGROUND:The term 'lower value services' concerns healthcare that is of little or no value to the patient and consequently should not be provided routinely, or not be provided at all. De-adoption of lower value care may occur through explicit recommendations in clinical guidelines. The present study aimed to generate...

journal_title：BMC medicine

authors： Wammes JJ,van den Akker-van Marle ME,Verkerk EW,van Dulmen SA,Westert GP,van Asselt AD,Kool RB

更新日期：2016-11-25 00:00:00

abstract：BACKGROUND:Major depression, although frequent in primary care, is commonly hidden behind multiple physical complaints that are often the first and only reason for patient consultation. Major depression can be screened by two validated questions that are easier to use in primary care than the full Diagnostic and Statis...

journal_title：BMC medicine

authors： Lombardo P,Vaucher P,Haftgoli N,Burnand B,Favrat B,Verdon F,Bischoff T,Herzig L

更新日期：2011-10-18 00:00:00

abstract：BACKGROUND:The rapidly increasing number of activity-induced musculoskeletal injuries among adolescents and young adults is currently a true public health burden. The objective of this study was to investigate whether a neuromuscular training programme with injury prevention counselling is effective in preventing acute...

journal_title：BMC medicine

authors： Parkkari J,Taanila H,Suni J,Mattila VM,Ohrankämmen O,Vuorinen P,Kannus P,Pihlajamäki H

更新日期：2011-04-11 00:00:00

abstract：BACKGROUND:Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis. METHODS:We conducted a population-based cohort study using data from Stockholm Mammography Screening Program, Stockholm-Gotla...

journal_title：BMC medicine

authors： He W,Eriksson L,Törnberg S,Strand F,Hall P,Czene K

更新日期：2019-01-31 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is of clinical and public health importance as it is very common, affecting up to one in five women of reproductive age. It has significant and diverse clinical implications including reproductive (infertility, hyperandrogenism, hirsutism), metabolic (insulin resistance, impaired gluco...

journal_title：BMC medicine

authors： Teede H,Deeks A,Moran L

更新日期：2010-06-30 00:00:00

abstract：BACKGROUND:Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of key antigens, the im...

journal_title：BMC medicine

authors： Terheggen U,Drew DR,Hodder AN,Cross NJ,Mugyenyi CK,Barry AE,Anders RF,Dutta S,Osier FH,Elliott SR,Senn N,Stanisic DI,Marsh K,Siba PM,Mueller I,Richards JS,Beeson JG

更新日期：2014-10-16 00:00:00