Food for thought: why does the medical community struggle with research about nutritional therapy in the acute care setting?

abstract：BACKGROUND:The United States Preventive Services Task Force (USPSTF) recommends screening adults for depression in primary care settings when staff-assisted depression management programs are available. This recommendation, however, is based on evidence from depression management programs conducted with patients alread...

journal_title：BMC medicine

authors： Thombs BD,Ziegelstein RC,Roseman M,Kloda LA,Ioannidis JP

更新日期：2014-01-28 00:00:00

abstract：BACKGROUND:Risk stratification and management of acute myocardial infarction patients continue to be challenging despite considerable efforts made in the last decades by many clinicians and researchers. The aim of this study was to investigate the metabolomic fingerprint of acute myocardial infarction using nuclear mag...

journal_title：BMC medicine

authors： Vignoli A,Tenori L,Giusti B,Takis PG,Valente S,Carrabba N,Balzi D,Barchielli A,Marchionni N,Gensini GF,Marcucci R,Luchinat C,Gori AM

更新日期：2019-01-07 00:00:00

abstract：BACKGROUND:Scale-up of malaria interventions over the last decade have yielded a significant reduction in malaria transmission and disease burden in sub-Saharan Africa. We estimated economic gradients in the distribution of these efforts and of their impacts within and across endemic countries. METHODS:Using Demograph...

journal_title：BMC medicine

authors： Galactionova K,Smith TA,de Savigny D,Penny MA

更新日期：2017-10-18 00:00:00

abstract：BACKGROUND:The focus of this study is to identify particular microRNA (miRNA) signatures in exosomes derived from plasma of 435 human epidermal growth factor receptor 2 (HER2)-positive and triple-negative (TN) subtypes of breast cancer (BC). METHODS:First, miRNA expression profiles were determined in exosomes derived ...

journal_title：BMC medicine

authors： Stevic I,Müller V,Weber K,Fasching PA,Karn T,Marmé F,Schem C,Stickeler E,Denkert C,van Mackelenbergh M,Salat C,Schneeweiss A,Pantel K,Loibl S,Untch M,Schwarzenbach H

更新日期：2018-10-10 00:00:00

abstract：BACKGROUND:Adiposity is associated with many adverse health outcomes but little direct evidence exists about its impact on the use of health care services. We aim to describe the relationship between body mass index (BMI) and rates of hospital admission in middle-aged UK women. METHODS:Among 1,251,619 Million Women St...

journal_title：BMC medicine

authors： Reeves GK,Balkwill A,Cairns BJ,Green J,Beral V,Million Women Study Collaborators.

更新日期：2014-03-15 00:00:00

abstract：:Although imatinib is firmly established as an effective therapy for newly diagnosed patients with chronic myeloid leukemia (CML), the field continues to advance on several fronts. In this minireview we cover recent results of second generation tyrosine kinase inhibitors in newly diagnosed patients, investigate the sta...

journal_title：BMC medicine

authors： Eiring AM,Khorashad JS,Morley K,Deininger MW

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased oxidative and nitrosative stress (O&NS), which contribute to ...

journal_title：BMC medicine

authors： Berk M,Williams LJ,Jacka FN,O'Neil A,Pasco JA,Moylan S,Allen NB,Stuart AL,Hayley AC,Byrne ML,Maes M

更新日期：2013-09-12 00:00:00

abstract：BACKGROUND:Mucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown. METHODS:To correlate MUC4 polymorphism with the risk of endometriosis and endometriosis-related infertility, we performed ...

journal_title：BMC medicine

authors： Chang CY,Chang HW,Chen CM,Lin CY,Chen CP,Lai CH,Lin WY,Liu HP,Sheu JJ,Tsai FJ

更新日期：2011-02-24 00:00:00

abstract：BACKGROUND:Reliable data on the distribution of causes of death (COD) in a population are fundamental to good public health practice. In the absence of comprehensive medical certification of deaths, the only feasible way to collect essential mortality data is verbal autopsy (VA). The Tariff Method was developed by the ...

journal_title：BMC medicine

authors： Serina P,Riley I,Stewart A,James SL,Flaxman AD,Lozano R,Hernandez B,Mooney MD,Luning R,Black R,Ahuja R,Alam N,Alam SS,Ali SM,Atkinson C,Baqui AH,Chowdhury HR,Dandona L,Dandona R,Dantzer E,Darmstadt GL,Das V,Dh

更新日期：2015-12-08 00:00:00

abstract：:The diagnosis of multidrug resistant tuberculosis (MDR-TB) in any individual is the beginning of a prolonged and difficult therapeutic journey. It also marks the moment from which to begin consideration of how to manage close contacts. Preventive therapy for drug-susceptible latent tuberculosis infection has been demo...

journal_title：BMC medicine

authors： Moore DA

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...

journal_title：BMC medicine

authors： Burton C,Fink P,Henningsen P,Löwe B,Rief W,EURONET-SOMA Group.

更新日期：2020-03-03 00:00:00

abstract：:Singapore is endemic for Dengue virus, with approximately 10,000 to 20,000 annual cases reported in recent years. In 2012, Chikungunya was introduced, although the numbers of cases reported is much fewer. The current Zika virus pandemic originating in Brazil represents a threat to all regions with Aedes mosquitoes, pa...

journal_title：BMC medicine

authors： Fisher D,Cutter J

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:The cost-effectiveness of universal rotavirus (RV) vaccination is controversial in developed countries. As a result, RV vaccination programs do not currently exist in most European countries. Hospitalization is the main driver of RV disease costs, and prematurity, low birth weight (LBW) and underlying medica...

journal_title：BMC medicine

authors： Bruijning-Verhagen P,Mangen MJ,Felderhof M,Hartwig NG,van Houten M,Winkel L,de Waal WJ,Bonten MJ

更新日期：2013-04-26 00:00:00

abstract：BACKGROUND:Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sensitive behavioral assays in low-income settings, which has hindered researchers' ability to explain h...

journal_title：BMC medicine

authors： Xie W,Jensen SKG,Wade M,Kumar S,Westerlund A,Kakon SH,Haque R,Petri WA,Nelson CA

更新日期：2019-11-25 00:00:00

abstract：BACKGROUND:The peer review process is a cornerstone of biomedical research. We aimed to evaluate the impact of interventions to improve the quality of peer review for biomedical publications. METHODS:We performed a systematic review and meta-analysis. We searched CENTRAL, MEDLINE (PubMed), Embase, Cochrane Database of...

journal_title：BMC medicine

authors： Bruce R,Chauvin A,Trinquart L,Ravaud P,Boutron I

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:We update a previous systematic review to inform new World Health Organization HIV self-testing (HIVST) recommendations. We compared the effects of HIVST to standard HIV testing services to understand which service delivery models are effective for key populations. METHODS:We did a systematic review of rand...

journal_title：BMC medicine

authors： Witzel TC,Eshun-Wilson I,Jamil MS,Tilouche N,Figueroa C,Johnson CC,Reid D,Baggaley R,Siegfried N,Burns FM,Rodger AJ,Weatherburn P

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Iron deficiency without anemia is related to adverse symptoms that can be relieved by supplementation. Since a blood donation can induce such an iron deficiency, we investigated the clinical impact of iron treatment after a blood donation. METHODS:One week after donation, we randomly assigned 154 female don...

journal_title：BMC medicine

authors： Waldvogel S,Pedrazzini B,Vaucher P,Bize R,Cornuz J,Tissot JD,Favrat B

更新日期：2012-01-24 00:00:00

abstract：BACKGROUND:Involving adults lacking capacity (ALC) in research on end of life care (EoLC) or serious illness is important, but often omitted. We aimed to develop evidence-based guidance on how best to include individuals with impaired capacity nearing the end of life in research, by identifying the challenges and solut...

journal_title：BMC medicine

authors： Evans CJ,Yorganci E,Lewis P,Koffman J,Stone K,Tunnard I,Wee B,Bernal W,Hotopf M,Higginson IJ,MORECare_Capacity.

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world. Unintentional overspray of ATR poses an immune function health hazard. The biomolecular mechanisms responsible for ATR-induced immunotoxicity, however, are little unders...

journal_title：BMC medicine

authors： Zhang X,Wang M,Gao S,Ren R,Zheng J,Zhang Y

更新日期：2011-10-27 00:00:00

abstract：BACKGROUND:Multiple treatments are frequently available for a given condition, and clinicians and patients need a comprehensive, up-to-date synthesis of evidence for all competing treatments. We aimed to quantify the waste of research related to the failure of systematic reviews to provide a complete and up-to-date evi...

journal_title：BMC medicine

authors： Créquit P,Trinquart L,Yavchitz A,Ravaud P

更新日期：2016-01-20 00:00:00

abstract：BACKGROUND:Dietary assessment is complex, and strategies to select the most appropriate dietary assessment tool (DAT) in epidemiological research are needed. The DIETary Assessment Tool NETwork (DIET@NET) aimed to establish expert consensus on Best Practice Guidelines (BPGs) for dietary assessment using self-report. M...

journal_title：BMC medicine

authors： Cade JE,Warthon-Medina M,Albar S,Alwan NA,Ness A,Roe M,Wark PA,Greathead K,Burley VJ,Finglas P,Johnson L,Page P,Roberts K,Steer T,Hooson J,Greenwood DC,Robinson S,DIET@NET consortium.

更新日期：2017-11-15 00:00:00

abstract：BACKGROUND:Virtual histology intravascular ultrasound (VH-IVUS) imaging is an innovative tool for the morphological evaluation of coronary atherosclerosis. Evidence for the effects of statin therapy on VH-IVUS parameters have been inconclusive. Consequently, we performed a systematic review and meta-analysis to investi...

journal_title：BMC medicine

authors： Banach M,Serban C,Sahebkar A,Mikhailidis DP,Ursoniu S,Ray KK,Rysz J,Toth PP,Muntner P,Mosteoru S,García-García HM,Hovingh GK,Kastelein JJ,Serruys PW,Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group.

更新日期：2015-09-18 00:00:00

abstract：:The lack of formal training programs for peer reviewers places the scientific quality of biomedical publications at risk, as the introduction of 'hidden' bias may not be easily recognized by the reader. The exponential increase in the number of manuscripts submitted for publication worldwide, estimated in the millions...

journal_title：BMC medicine

authors： Stahel PF,Moore EE

更新日期：2014-09-26 00:00:00

abstract：:Wheat, once thought to be a critical ingredient in a healthy diet, has become a major threat, according to public opinion. The term non-celiac gluten sensitivity has been widely adopted to describe a clinical entity characterized by symptoms induced by gluten without the diagnostic criteria found in other gluten-relat...

journal_title：BMC medicine

authors： Lundin KE

更新日期：2014-05-23 00:00:00

abstract：BACKGROUND:Recent global progress in scaling up malaria control interventions has revived the goal of complete elimination in many countries. Decreasing transmission intensity generally leads to increasingly patchy spatial patterns of malaria transmission in elimination settings, with control programs having to accurat...

journal_title：BMC medicine

authors： Wesolowski A,Taylor AR,Chang HH,Verity R,Tessema S,Bailey JA,Alex Perkins T,Neafsey DE,Greenhouse B,Buckee CO

更新日期：2018-10-18 00:00:00

abstract：BACKGROUND:The use of early morning sputum samples (EMS) to diagnose tuberculosis (TB) can result in treatment delay given the need for the patient to return to the clinic with the EMS, increasing the chance of patients being lost during their diagnostic workup. However, there is little evidence to support the superior...

journal_title：BMC medicine

authors： Murphy ME,Phillips PPJ,Mendel CM,Bongard E,Bateson ALC,Hunt R,Murthy S,Singh KP,Brown M,Crook AM,Nunn AJ,Meredith SK,Lipman M,McHugh TD,Gillespie SH,REMoxTB Consortium.

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. METHODS:To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal ...

journal_title：BMC medicine

authors： Xu X,Chow EPF,Ong JJ,Hoebe CJPA,Zou Z,Hocking JS,Fairley CK,Zhang L

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based study aimed at exploring factors associated with survival in patients with resected TNM stage I-II PaC r...

journal_title：BMC medicine

authors： Huang L,Balavarca Y,van der Geest L,Lemmens V,Van Eycken L,De Schutter H,Johannesen TB,Zadnik V,Primic-Žakelj M,Mägi M,Grützmann R,Besselink MG,Schrotz-King P,Brenner H,Jansen L

更新日期：2019-03-25 00:00:00

abstract：:In the past decade, numerous studies have made connections between sequence variants in human genomes and predisposition to complex diseases. However, most of these variants lie outside of the charted regions of the human genome whose function we understand; that is, the sequences that encode proteins. Consequently, t...

journal_title：BMC medicine

authors： St Laurent G,Vyatkin Y,Kapranov P

更新日期：2014-06-12 00:00:00

abstract：BACKGROUND:Accurate and timely cause of death (COD) data are essential for informed public health policymaking. Medical certification of COD generally provides the majority of COD data in a population and is an essential component of civil registration and vital statistics (CRVS) systems. Accurate completion of the med...

journal_title：BMC medicine

authors： Hart JD,Sorchik R,Bo KS,Chowdhury HR,Gamage S,Joshi R,Kwa V,Li H,Mahesh BPK,Mclaughlin D,Mikkelsen L,Miki J,Napulan R,Rampatige R,Reeve M,Sarmiento C,War NS,Richards N,Riley ID,Lopez AD

更新日期：2020-03-09 00:00:00