Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis.

abstract：BACKGROUND:Health-related research funders, regulators and journals expect that de-identified individual-level health data be shared widely, with as few restrictions as possible; yet, in reality, the volume of shared data remains low. MAIN BODY:Health researchers and other data producers are reluctant to share their d...

journal_title：BMC medicine

authors： Waithira N,Mutinda B,Cheah PY

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:It is critically important to conduct research on stigmatized conditions, to include marginalized groups that experience stigma, and to develop interventions to reduce stigma. However, such research is ethically challenging. Though superficial reference is frequently made to these widely acknowledged challen...

journal_title：BMC medicine

authors： Millum J,Campbell M,Luna F,Malekzadeh A,Karim QA

更新日期：2019-04-29 00:00:00

abstract：BACKGROUND:The UK Clinical Aptitude Test (UKCAT) has been shown to have a modest but statistically significant ability to predict aspects of academic performance throughout medical school. Previously, this ability has been shown to be incremental to conventional measures of educational performance for the first year of...

journal_title：BMC medicine

authors： Tiffin PA,Mwandigha LM,Paton LW,Hesselgreaves H,McLachlan JC,Finn GM,Kasim AS

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND:We update a previous systematic review to inform new World Health Organization HIV self-testing (HIVST) recommendations. We compared the effects of HIVST to standard HIV testing services to understand which service delivery models are effective for key populations. METHODS:We did a systematic review of rand...

journal_title：BMC medicine

authors： Witzel TC,Eshun-Wilson I,Jamil MS,Tilouche N,Figueroa C,Johnson CC,Reid D,Baggaley R,Siegfried N,Burns FM,Rodger AJ,Weatherburn P

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Clinicians are less likely to prescribe guideline-recommended treatments to people with multimorbidity than to people with a single condition. Doubts as to the applicability of clinical trials of drug treatments (the gold standard for evidence-based medicine) when people have co-existing diseases (comorbidit...

journal_title：BMC medicine

authors： Hanlon P,Hannigan L,Rodriguez-Perez J,Fischbacher C,Welton NJ,Dias S,Mair FS,Guthrie B,Wild S,McAllister DA

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines Agency (EMA) concerning human papillomavirus (HPV) vaccines during a European Union (EU) referral pro...

journal_title：BMC medicine

authors： Bahri P,Fogd J,Morales D,Kurz X,ADVANCE consortium.

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol trafficking characterized by increased plasma plant sterol levels. Based upo...

journal_title：BMC medicine

authors： Klett EL,Lu K,Kosters A,Vink E,Lee MH,Altenburg M,Shefer S,Batta AK,Yu H,Chen J,Klein R,Looije N,Oude-Elferink R,Groen AK,Maeda N,Salen G,Patel SB

更新日期：2004-03-24 00:00:00

abstract：BACKGROUND:While step counter use has become popular among type 2 diabetes (T2D) patients, its effectiveness in increasing physical activity (PA) and improving glycemic control has been poorly defined. The aim of this meta-analysis of randomized controlled trials (RCTs) was to evaluate the association of step counter u...

journal_title：BMC medicine

authors： Qiu S,Cai X,Chen X,Yang B,Sun Z

更新日期：2014-02-27 00:00:00

abstract：:Singapore is endemic for Dengue virus, with approximately 10,000 to 20,000 annual cases reported in recent years. In 2012, Chikungunya was introduced, although the numbers of cases reported is much fewer. The current Zika virus pandemic originating in Brazil represents a threat to all regions with Aedes mosquitoes, pa...

journal_title：BMC medicine

authors： Fisher D,Cutter J

更新日期：2016-11-21 00:00:00

abstract：:Wheat, once thought to be a critical ingredient in a healthy diet, has become a major threat, according to public opinion. The term non-celiac gluten sensitivity has been widely adopted to describe a clinical entity characterized by symptoms induced by gluten without the diagnostic criteria found in other gluten-relat...

journal_title：BMC medicine

authors： Lundin KE

更新日期：2014-05-23 00:00:00

abstract：BACKGROUND:Although neutrophils have been linked to the progression of cancer, uncertainty exists around their association with cancer outcomes, depending on the site, outcome and treatments considered. We aimed to evaluate the strength and validity of evidence on the association between either the neutrophil to lympho...

journal_title：BMC medicine

authors： Cupp MA,Cariolou M,Tzoulaki I,Aune D,Evangelou E,Berlanga-Taylor AJ

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:Publication bias and other reporting bias have been well documented for journal articles, but no study has evaluated the nature of results posted at ClinicalTrials.gov. We aimed to assess how many randomized controlled trials (RCTs) with results posted at ClinicalTrials.gov report statistically significant r...

journal_title：BMC medicine

authors： Dechartres A,Bond EG,Scheer J,Riveros C,Atal I,Ravaud P

更新日期：2016-11-30 00:00:00

abstract：BACKGROUND:The possible relationship between chronic inflammatory diseases and their co-morbidities has become an increasing focus of research. Both chronic periodontitis and chronic obstructive pulmonary disease are neutrophilic, inflammatory conditions characterized by the loss of local connective tissue. Evidence su...

journal_title：BMC medicine

authors： Usher AK,Stockley RA

更新日期：2013-11-13 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) elimination is being seriously considered globally. Current elimination models require a combination of highly effective HCV treatment and harm reduction, but high treatment costs make such strategies prohibitively expensive. Vaccines should play a key role in elimination but their be...

journal_title：BMC medicine

authors： Scott N,McBryde E,Vickerman P,Martin NK,Stone J,Drummer H,Hellard M

更新日期：2015-08-20 00:00:00

abstract：:This comment relates to articles published in archived content of the journal Head and Neck Oncology and is not related to the content of BMC Medicine in any way. ...

journal_title：BMC medicine

authors： BioMed Central.

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:Several accomplishments have been achieved in triple-negative breast cancer (TNBC) research over the last year. The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer into the immunotherapy era. Nevertheless, despite encouraging result...

journal_title：BMC medicine

authors： Marra A,Viale G,Curigliano G

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Vertical and horizontal trust, as dimensions of social capital, may be important determinants of health. As mass media campaigns have been used extensively to promote healthy lifestyles and convey health-related information, high levels of individual trust in the media may facilitate the success of such camp...

journal_title：BMC medicine

authors： Tokuda Y,Fujii S,Jimba M,Inoguchi T

更新日期：2009-01-22 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial Parkinson's disease (PD). Variation around the LRRK2 locus also contributes to the risk of sporadic PD. The LRRK2 protein contains a central catalytic region, and pathogenic mutations cluster in the Ras of complex protein C termi...

journal_title：BMC medicine

authors： Rudenko IN,Chia R,Cookson MR

更新日期：2012-02-23 00:00:00

abstract：BACKGROUND:Recent reviews on placebo effects in clinical trials suggest that objective changes following placebo treatments may not exist or, at least, have been considerably overestimated. However, the possibility that yet unidentified subsets of parameters are responsive to placebo treatments has not been taken into ...

journal_title：BMC medicine

authors： Meissner K,Distel H,Mitzdorf U

更新日期：2007-03-19 00:00:00

abstract：BACKGROUND:Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sensitive behavioral assays in low-income settings, which has hindered researchers' ability to explain h...

journal_title：BMC medicine

authors： Xie W,Jensen SKG,Wade M,Kumar S,Westerlund A,Kakon SH,Haque R,Petri WA,Nelson CA

更新日期：2019-11-25 00:00:00

abstract：:In recent years, the introduction and Federal Drug Administration approval of immune checkpoint inhibitor antibodies has dramatically improved the clinical outcomes for patients with advanced melanoma. These antagonist monoclonal antibodies are capable of unleashing dormant or exhausted antitumor immunity, which has l...

journal_title：BMC medicine

authors： Redman JM,Gibney GT,Atkins MB

更新日期：2016-02-06 00:00:00

abstract：BACKGROUND:The United States Preventive Services Task Force (USPSTF) recommends screening adults for depression in primary care settings when staff-assisted depression management programs are available. This recommendation, however, is based on evidence from depression management programs conducted with patients alread...

journal_title：BMC medicine

authors： Thombs BD,Ziegelstein RC,Roseman M,Kloda LA,Ioannidis JP

更新日期：2014-01-28 00:00:00

abstract：BACKGROUND:The prognostic significance of tumor-associated macrophages (TAM) in adult classical Hodgkin lymphoma (cHL) remains controversial. Here, we report a meta-analysis of the association of CD68 and CD163 infiltration on the clinical outcome of adult cHL. METHODS:A comprehensive search to identify relevant artic...

journal_title：BMC medicine

authors： Guo B,Cen H,Tan X,Ke Q

更新日期：2016-10-17 00:00:00

abstract：BACKGROUND:Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications. However, the underlying mechanisms in anthrax lethal toxin-induced cardiac anomalies remain unknown. This study was designed to evaluate the impact of antioxidant enzyme ...

journal_title：BMC medicine

authors： Kandadi MR,Yu X,Frankel AE,Ren J

更新日期：2012-11-07 00:00:00

abstract：:The damage to health caused by intimate partner violence demands effective responses from healthcare providers and healthcare systems worldwide. To date, most evidence for the few existing, effective interventions in use comes from high-income countries. Gupta et al. provide rare evidence of a nurse-delivered intimate...

journal_title：BMC medicine

authors： Taft A,Colombini M

更新日期：2017-07-12 00:00:00

abstract：:The complexity of tissue and the alterations that distinguish normal from cancer remain a challenge for translating results from tumor biological studies into clinical medicine. This has generated an unmet need to exploit the findings from studies based on cell lines and model organisms to develop, validate and clinic...

journal_title：BMC medicine

authors： Kampf C,Bergman J,Oksvold P,Asplund A,Navani S,Wiking M,Lundberg E,Uhlén M,Ponten F

更新日期：2012-09-12 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer deaths globally. However, there is overwhelming evidence that a large proportion of CRC cases and deaths could be prevented by screening. Nevertheless, CRC screening programmes are offered in a minority of coun...

journal_title：BMC medicine

authors： Brenner H,Stock C,Hoffmeister M

更新日期：2015-10-13 00:00:00

abstract：BACKGROUND:Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score is the only currently available midlife risk score for dementia. We compared CAIDE to Framingham cardiovascular Risk Score (FRS) and FINDRISC diabetes score as predictors of dementia and assessed the role of age in their associa...

journal_title：BMC medicine

authors： Fayosse A,Nguyen DP,Dugravot A,Dumurgier J,Tabak AG,Kivimäki M,Sabia S,Singh-Manoux A

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:In many developing countries, the majority of births are attended by traditional birth attendants, who lack formal training in neonatal resuscitation and other essential care required by the newly born infant. In these countries, the major causes of neonatal mortality are birth asphyxia, infection, and low-b...

journal_title：BMC medicine

authors： Matendo R,Engmann C,Ditekemena J,Gado J,Tshefu A,Kinoshita R,McClure EM,Moore J,Wallace D,Carlo WA,Wright LL,Bose C

更新日期：2011-08-04 00:00:00

abstract：BACKGROUND:Network meta-analyses using individual participant data (IPD-NMAs) have been increasingly used to compare the effects of multiple interventions. Although there have been many studies on statistical methods for IPD-NMAs, it is unclear whether there are statistical defects in published IPD-NMAs and whether the...

journal_title：BMC medicine

authors： Gao Y,Shi S,Li M,Luo X,Liu M,Yang K,Zhang J,Song F,Tian J

更新日期：2020-06-01 00:00:00