Healthcare system responses to intimate partner violence in low and middle-income countries: evidence is growing and the challenges become clearer.

abstract：BACKGROUND:Clinicians have known for centuries that there is substantial variability between patients in their response to medications-some individuals exhibit a miraculous recovery while others fail to respond at all. Still others experience dangerous side effects. The hunt for the factors responsible for this variati...

journal_title：BMC medicine

authors： Nayak RR,Turnbaugh PJ

更新日期：2016-05-04 00:00:00

abstract：BACKGROUND:Clinical decision support systems assist physicians in interpreting complex patient data. However, they typically operate on a per-patient basis and do not exploit the extensive latent medical knowledge in electronic health records (EHRs). The emergence of large EHR systems offers the opportunity to integrat...

journal_title：BMC medicine

authors： Gottlieb A,Stein GY,Ruppin E,Altman RB,Sharan R

更新日期：2013-09-02 00:00:00

abstract：BACKGROUND:Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between comorbidities and to investigate the association between comorbidity groups and outcomes. METHODS:Lat...

journal_title：BMC medicine

authors： Gulea C,Zakeri R,Quint JK

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease (COPD). Our aim was to externally validate and concurrently compare prognostic scores for 3-year...

journal_title：BMC medicine

authors： Guerra B,Haile SR,Lamprecht B,Ramírez AS,Martinez-Camblor P,Kaiser B,Alfageme I,Almagro P,Casanova C,Esteban-González C,Soler-Cataluña JJ,de-Torres JP,Miravitlles M,Celli BR,Marin JM,Ter Riet G,Sobradillo P,Lange P,Ga

更新日期：2018-03-02 00:00:00

abstract：:Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, wi...

journal_title：BMC medicine

authors： Mijajlović MD,Pavlović A,Brainin M,Heiss WD,Quinn TJ,Ihle-Hansen HB,Hermann DM,Assayag EB,Richard E,Thiel A,Kliper E,Shin YI,Kim YH,Choi S,Jung S,Lee YB,Sinanović O,Levine DA,Schlesinger I,Mead G,Milošević V,Ley

更新日期：2017-01-18 00:00:00

abstract：BACKGROUND:Depression in tuberculosis increases the risk for adverse health outcomes. However, little is known about comorbid depression and tuberculosis in the general population. Thus, we assessed the association between depression and tuberculosis, and the decrements in health status associated with this comorbidity...

journal_title：BMC medicine

authors： Koyanagi A,Vancampfort D,Carvalho AF,DeVylder JE,Haro JM,Pizzol D,Veronese N,Stubbs B

更新日期：2017-11-28 00:00:00

abstract：BACKGROUND:The possible relationship between chronic inflammatory diseases and their co-morbidities has become an increasing focus of research. Both chronic periodontitis and chronic obstructive pulmonary disease are neutrophilic, inflammatory conditions characterized by the loss of local connective tissue. Evidence su...

journal_title：BMC medicine

authors： Usher AK,Stockley RA

更新日期：2013-11-13 00:00:00

abstract：BACKGROUND:Cognitive impairment is common in patients with cerebral small vessel disease, but is not well detected using common cognitive screening tests which have been primarily devised for cortical dementias. We developed the Brief Memory and Executive Test (BMET); a rapid screening measure sensitive to the impaired...

journal_title：BMC medicine

authors： Brookes RL,Hollocks MJ,Khan U,Morris RG,Markus HS

更新日期：2015-03-11 00:00:00

abstract：:Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial Parkinson's disease (PD). Variation around the LRRK2 locus also contributes to the risk of sporadic PD. The LRRK2 protein contains a central catalytic region, and pathogenic mutations cluster in the Ras of complex protein C termi...

journal_title：BMC medicine

authors： Rudenko IN,Chia R,Cookson MR

更新日期：2012-02-23 00:00:00

abstract：BACKGROUND:The study investigated the extent to which approaches to work, workplace climate, stress, burnout and satisfaction with medicine as a career in doctors aged about thirty are predicted by measures of learning style and personality measured five to twelve years earlier when the doctors were applicants to medic...

journal_title：BMC medicine

authors： McManus IC,Keeling A,Paice E

更新日期：2004-08-18 00:00:00

abstract：BACKGROUND:Although neutrophils have been linked to the progression of cancer, uncertainty exists around their association with cancer outcomes, depending on the site, outcome and treatments considered. We aimed to evaluate the strength and validity of evidence on the association between either the neutrophil to lympho...

journal_title：BMC medicine

authors： Cupp MA,Cariolou M,Tzoulaki I,Aune D,Evangelou E,Berlanga-Taylor AJ

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:To reduce inequalities between individuals with and without mental health problems, a better understanding is required of triggers and success of quit attempts among the third of smokers with mental health problems. The aim was to assess whether there are differences by mental health status in (i) triggers f...

journal_title：BMC medicine

authors： Brose LS,Brown J,McNeill A

更新日期：2020-06-25 00:00:00

abstract：BACKGROUND:Thymic size in early infancy predicts subsequent survival in low-income settings. The human thymus develops from early gestation, is most active in early life and is highly sensitive to malnutrition. Our objective was to test whether thymic size in infancy could be increased by maternal and/or infant nutriti...

journal_title：BMC medicine

authors： Moore SE,Fulford AJC,Sosseh F,Nshe P,Darboe MK,Prentice AM

更新日期：2019-02-18 00:00:00

abstract：BACKGROUND:Wild type 2 poliovirus was last observed in 1999. The Sabin-strain oral polio vaccine type 2 (OPV2) was critical to eradication, but it is known to revert to a neurovirulent phenotype, causing vaccine-associated paralytic poliomyelitis. OPV2 is also transmissible and can establish circulating lineages, calle...

journal_title：BMC medicine

authors： McCarthy KA,Chabot-Couture G,Famulare M,Lyons HM,Mercer LD

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:Bangladesh, India and Nepal are working towards the elimination of visceral leishmaniasis (VL) by 2015. In 2005 the World Health Organization/Training in Tropical Diseases launched an implementation research programme to support integrated vector management for the elimination of VL from Bangladesh, India an...

journal_title：BMC medicine

authors： Joshi AB,Das ML,Akhter S,Chowdhury R,Mondal D,Kumar V,Das P,Kroeger A,Boelaert M,Petzold M

更新日期：2009-10-05 00:00:00

abstract：BACKGROUND:Ancestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The present work examined the potential transgenerational actions of the insecticide dichlorodiphenyltrichloroethane (DDT) on o...

journal_title：BMC medicine

authors： Skinner MK,Manikkam M,Tracey R,Guerrero-Bosagna C,Haque M,Nilsson EE

更新日期：2013-10-23 00:00:00

abstract：:Environmental enteropathy (EE) is a poorly defined state of intestinal inflammation without overt diarrhea that occurs in individuals exposed over time to poor sanitation and hygiene. It is implicated as a cause of stunting and malnutrition, oral vaccine failure and impaired development in children from low-income cou...

journal_title：BMC medicine

authors： Petri WA Jr,Naylor C,Haque R

更新日期：2014-10-14 00:00:00

abstract：BACKGROUND:Due to the overlapping clinical features of coronavirus disease 2019 (COVID-19) and influenza, parallels are often drawn between the two diseases. Patients with pre-existing cardiovascular diseases (CVD) are at a higher risk for severe manifestations of both illnesses. Considering the high transmission rate ...

journal_title：BMC medicine

authors： Khan MS,Shahid I,Anker SD,Solomon SD,Vardeny O,Michos ED,Fonarow GC,Butler J

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:Major depression, although frequent in primary care, is commonly hidden behind multiple physical complaints that are often the first and only reason for patient consultation. Major depression can be screened by two validated questions that are easier to use in primary care than the full Diagnostic and Statis...

journal_title：BMC medicine

authors： Lombardo P,Vaucher P,Haftgoli N,Burnand B,Favrat B,Verdon F,Bischoff T,Herzig L

更新日期：2011-10-18 00:00:00

abstract：:The stratification of patients for treatment of prostate cancer is based on very general parameters like prostate-specific antigen, Gleason score, and TNM classification. We use these rough parameters for selection of active surveillance, active treatment, and even for the treatment selection in metastasized or castra...

journal_title：BMC medicine

authors： Sedelaar JP,Schalken JA

更新日期：2015-05-09 00:00:00

abstract：BACKGROUND:Pneumonia in people with dementia has been associated with severe discomfort. We sought to assess the effectiveness of a practice guideline for optimal symptom relief for nursing home residents with dementia and pneumonia. METHODS:A single-blind, multicenter, cluster randomized controlled trial was conducte...

journal_title：BMC medicine

authors： van der Maaden T,de Vet HC,Achterberg WP,Boersma F,Schols JM,Mehr DR,Galindo-Garre F,Hertogh CM,Koopmans RT,van der Steen JT

更新日期：2016-08-11 00:00:00

abstract：BACKGROUND:Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many cases of diagnosed dystroglycanopathies, only a small fraction can be linked directly to mutations ...

journal_title：BMC medicine

authors： Yatsenko AS,Kucherenko MM,Xie Y,Aweida D,Urlaub H,Scheibe RJ,Cohen S,Shcherbata HR

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unknown. To investigate the role of the normal breast microenvironment on breast cancer cell tumorigenic...

journal_title：BMC medicine

authors： Fleming JM,Miller TC,Quinones M,Xiao Z,Xu X,Meyer MJ,Ginsburg E,Veenstra TD,Vonderhaar BK

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:Health-related research funders, regulators and journals expect that de-identified individual-level health data be shared widely, with as few restrictions as possible; yet, in reality, the volume of shared data remains low. MAIN BODY:Health researchers and other data producers are reluctant to share their d...

journal_title：BMC medicine

authors： Waithira N,Mutinda B,Cheah PY

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:Despite our substantial understanding of molecular mechanisms and gene mutations involved in cancer, the technical approaches for diagnosis and prognosis of cancer are limited. In routine clinical diagnosis of cancer, the procedure is very basic: nuclear morphology is used as a common assessment of the degre...

journal_title：BMC medicine

authors： Capo-chichi CD,Cai KQ,Simpkins F,Ganjei-Azar P,Godwin AK,Xu XX

更新日期：2011-03-26 00:00:00

abstract：:Although strong evidence exists that the benefits of vaccination by far outweigh potential adverse events, controversy still exists. This has led opponents of vaccination to question its safety, efficacy and necessity. In an interview with Professor Elizabeth Miller, we discuss the continuum of beliefs held by vaccine...

journal_title：BMC medicine

authors： Miller E

更新日期：2015-10-16 00:00:00

abstract：BACKGROUND:Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessitates effective targeting and monitoring of interventions. This requires a valid, reliable measure of ...

journal_title：BMC medicine

authors： Burt J,Elmore N,Campbell SM,Rodgers S,Avery AJ,Payne RA

更新日期：2018-06-13 00:00:00

abstract：BACKGROUND:Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. The utility of the new quantitative PCR test (Xpert MTB/RIF) for the diagnosis...

journal_title：BMC medicine

authors： Pandie S,Peter JG,Kerbelker ZS,Meldau R,Theron G,Govender U,Ntsekhe M,Dheda K,Mayosi BM

更新日期：2014-06-18 00:00:00

abstract：BACKGROUND:The mind-body nexus has been a topic of growing interest. Further data are however required to understand the specific relationship between mood and anxiety disorders and individual physical health conditions, and to verify whether these psychiatric disorders are linked to overall medical burden. METHODS:Th...

journal_title：BMC medicine

authors： Sanna L,Stuart AL,Pasco JA,Kotowicz MA,Berk M,Girardi P,Brennan SL,Williams LJ

更新日期：2013-04-24 00:00:00

abstract：:Wheat, once thought to be a critical ingredient in a healthy diet, has become a major threat, according to public opinion. The term non-celiac gluten sensitivity has been widely adopted to describe a clinical entity characterized by symptoms induced by gluten without the diagnostic criteria found in other gluten-relat...

journal_title：BMC medicine

authors： Lundin KE

更新日期：2014-05-23 00:00:00