Mirror, mirror on the wall: which microbiomes will help heal them all?

abstract：BACKGROUND:Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based study aimed at exploring factors associated with survival in patients with resected TNM stage I-II PaC r...

journal_title：BMC medicine

authors： Huang L,Balavarca Y,van der Geest L,Lemmens V,Van Eycken L,De Schutter H,Johannesen TB,Zadnik V,Primic-Žakelj M,Mägi M,Grützmann R,Besselink MG,Schrotz-King P,Brenner H,Jansen L

更新日期：2019-03-25 00:00:00

abstract：BACKGROUND:Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved. METHODS:An open-label, non-inferiority, 1:1 randomized trial was conducted at three academic hospitals in So...

journal_title：BMC medicine

authors： Syn NL,Wong AL,Lee SC,Teoh HL,Yip JWL,Seet RC,Yeo WT,Kristanto W,Bee PC,Poon LM,Marban P,Wu TS,Winther MD,Brunham LR,Soong R,Tai BC,Goh BC

更新日期：2018-07-10 00:00:00

abstract：:This comment relates to articles published in archived content of the journal Head and Neck Oncology and is not related to the content of BMC Medicine in any way. ...

journal_title：BMC medicine

authors： BioMed Central.

更新日期：2014-02-05 00:00:00

abstract：BACKGROUND:Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications. However, the underlying mechanisms in anthrax lethal toxin-induced cardiac anomalies remain unknown. This study was designed to evaluate the impact of antioxidant enzyme ...

journal_title：BMC medicine

authors： Kandadi MR,Yu X,Frankel AE,Ren J

更新日期：2012-11-07 00:00:00

abstract：BACKGROUND:Although nut consumption has been associated with a reduced risk of cardiovascular disease and all-cause mortality, data on less common causes of death has not been systematically assessed. Previous reviews missed several studies and additional studies have since been published. We therefore conducted a syst...

journal_title：BMC medicine

authors： Aune D,Keum N,Giovannucci E,Fadnes LT,Boffetta P,Greenwood DC,Tonstad S,Vatten LJ,Riboli E,Norat T

更新日期：2016-12-05 00:00:00

abstract：BACKGROUND:The 2012 World Health Assembly set a target for Member States to reduce premature non-communicable disease (NCD) mortality by 25% over the period 2010 to 2025. This reflected concerns about increasing NCD mortality burdens among productive adults globally. This article first considers whether the WHO target ...

journal_title：BMC medicine

authors： Santosa A,Rocklöv J,Högberg U,Byass P

更新日期：2015-03-30 00:00:00

abstract：BACKGROUND:Atrazine (2-chloro-4-ethytlamino-6-isopropylamine-1,3,5-triazine; ATR), is the most commonly applied broad-spectrum herbicide in the world. Unintentional overspray of ATR poses an immune function health hazard. The biomolecular mechanisms responsible for ATR-induced immunotoxicity, however, are little unders...

journal_title：BMC medicine

authors： Zhang X,Wang M,Gao S,Ren R,Zheng J,Zhang Y

更新日期：2011-10-27 00:00:00

abstract：BACKGROUND:The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines Agency (EMA) concerning human papillomavirus (HPV) vaccines during a European Union (EU) referral pro...

journal_title：BMC medicine

authors： Bahri P,Fogd J,Morales D,Kurz X,ADVANCE consortium.

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:The rapidly increasing number of activity-induced musculoskeletal injuries among adolescents and young adults is currently a true public health burden. The objective of this study was to investigate whether a neuromuscular training programme with injury prevention counselling is effective in preventing acute...

journal_title：BMC medicine

authors： Parkkari J,Taanila H,Suni J,Mattila VM,Ohrankämmen O,Vuorinen P,Kannus P,Pihlajamäki H

更新日期：2011-04-11 00:00:00

abstract：BACKGROUND:Breast cancer studies frequently focus on the role of the tumor microenvironment in the promotion of cancer; however, the influence of the normal breast microenvironment on cancer cells remains relatively unknown. To investigate the role of the normal breast microenvironment on breast cancer cell tumorigenic...

journal_title：BMC medicine

authors： Fleming JM,Miller TC,Quinones M,Xiao Z,Xu X,Meyer MJ,Ginsburg E,Veenstra TD,Vonderhaar BK

更新日期：2010-05-21 00:00:00

abstract：:Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed better than 50% improvement in 50% of patients in a clinical trial....

journal_title：BMC medicine

authors： Mitsikostas DD,Rapoport AM

更新日期：2015-11-10 00:00:00

abstract：:Clinical pathologies draw us to envisage disease as either an independent entity or a diverse set of traits governed by common physiopathological mechanisms, prompted by environmental assaults throughout life. Autoimmune diseases are not an exception, given they represent a diverse collection of diseases in terms of t...

journal_title：BMC medicine

authors： Castiblanco J,Arcos-Burgos M,Anaya JM

更新日期：2013-09-04 00:00:00

abstract：:Several factors contribute to the high mortality attributed to severe infections in resource-limited settings. While improvements in survival and processes of care have been made in high-income settings among patients with severe conditions, such as sepsis, guidelines necessary for achieving these improvements may lac...

journal_title：BMC medicine

authors： Jacob ST,Lim M,Banura P,Bhagwanjee S,Bion J,Cheng AC,Cohen H,Farrar J,Gove S,Hopewell P,Moore CC,Roth C,West TE

更新日期：2013-04-18 00:00:00

abstract：BACKGROUND:Castration-resistant prostate cancer (CRPC) is associated with wide variations in survival. Recent studies of whole blood mRNA expression-based biomarkers strongly predicted survival but the genes used in these biomarker models were non-overlapping and their relationship was unknown. We developed a biomarker...

journal_title：BMC medicine

authors： Wang L,Gong Y,Chippada-Venkata U,Heck MM,Retz M,Nawroth R,Galsky M,Tsao CK,Schadt E,de Bono J,Olmos D,Zhu J,Oh WK

更新日期：2015-08-21 00:00:00

abstract：BACKGROUND:Multiple-arm randomized trials can be more complex in their design, data analysis, and result reporting than two-arm trials. We conducted a systematic review to assess the reporting of analyses in reports of randomized controlled trials (RCTs) with multiple arms. METHODS:The literature in the MEDLINE databa...

journal_title：BMC medicine

authors： Baron G,Perrodeau E,Boutron I,Ravaud P

更新日期：2013-03-27 00:00:00

abstract：BACKGROUND:Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relationships of cancer with other adiposity markers, and if these associations are linear or not. The aim ...

journal_title：BMC medicine

authors： Parra-Soto S,Cowley ES,Rezende LFM,Ferreccio C,Mathers JC,Pell JP,Ho FK,Celis-Morales C

更新日期：2021-01-11 00:00:00

abstract：BACKGROUND:The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need for more thorough and comprehensive characterization of the spectrum of resulting clinical complica...

journal_title：BMC medicine

authors： Siqueira AM,Lacerda MV,Magalhães BM,Mourão MP,Melo GC,Alexandre MA,Alecrim MG,Kochar D,Kochar S,Kochar A,Nayak K,del Portillo H,Guinovart C,Alonso P,Bassat Q

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between comorbidities and to investigate the association between comorbidity groups and outcomes. METHODS:Lat...

journal_title：BMC medicine

authors： Gulea C,Zakeri R,Quint JK

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:Managing hearing communication for residents living with hearing loss and dementia in long-term care settings is challenging. This paper explores how care can be effective in optimising hearing communication for residents living with dementia. We argue that the underlying notion of permission or authorisatio...

journal_title：BMC medicine

authors： Crosbie B,Ferguson M,Wong G,Walker DM,Vanhegan S,Dening T

更新日期：2019-03-04 00:00:00

abstract：BACKGROUND:Inflammatory cytokines play a crucial role in coronary artery disease (CAD). We investigated the association between 48 coding and three non-coding single nucleotide polymorphisms (SNPs) from 35 inflammatory genes and the development of CAD, using a large discordant sibship collection (2699 individuals in 89...

journal_title：BMC medicine

authors： Brown BD,Nsengimana J,Barrett JH,Lawrence RA,Steiner L,Cheng S,Bishop DT,Samani NJ,Ball SG,Balmforth AJ,Hall AS

更新日期：2010-01-13 00:00:00

abstract：BACKGROUND:The spread of infectious diseases crucially depends on the pattern of contacts between individuals. Knowledge of these patterns is thus essential to inform models and computational efforts. However, there are few empirical studies available that provide estimates of the number and duration of contacts betwee...

journal_title：BMC medicine

authors： Stehlé J,Voirin N,Barrat A,Cattuto C,Colizza V,Isella L,Régis C,Pinton JF,Khanafer N,Van den Broeck W,Vanhems P

更新日期：2011-07-19 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased risk of cardiovascular disease (CVD). The current evidence on platelet activation levels in patients with HIV remains inconclusive. We therefore aimed to systematically synthesise ev...

journal_title：BMC medicine

authors： Nkambule BB,Mxinwa V,Mkandla Z,Mutize T,Mokgalaboni K,Nyambuya TM,Dludla PV

更新日期：2020-11-18 00:00:00

abstract：BACKGROUND:Multiple treatments are frequently available for a given condition, and clinicians and patients need a comprehensive, up-to-date synthesis of evidence for all competing treatments. We aimed to quantify the waste of research related to the failure of systematic reviews to provide a complete and up-to-date evi...

journal_title：BMC medicine

authors： Créquit P,Trinquart L,Yavchitz A,Ravaud P

更新日期：2016-01-20 00:00:00

abstract：BACKGROUND:External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease (COPD). Our aim was to externally validate and concurrently compare prognostic scores for 3-year...

journal_title：BMC medicine

authors： Guerra B,Haile SR,Lamprecht B,Ramírez AS,Martinez-Camblor P,Kaiser B,Alfageme I,Almagro P,Casanova C,Esteban-González C,Soler-Cataluña JJ,de-Torres JP,Miravitlles M,Celli BR,Marin JM,Ter Riet G,Sobradillo P,Lange P,Ga

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:We aimed to show the non-inferiority of home fortification with a daily dose of 3 mg iron in the form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) compared with 12.5 mg iron as encapsulated ferrous fumarate in Kenyan children aged 12-36 months. In addition, we updated a recent meta-analysi...

journal_title：BMC medicine

authors： Teshome EM,Andang'o PEA,Osoti V,Terwel SR,Otieno W,Demir AY,Prentice AM,Verhoef H

更新日期：2017-04-28 00:00:00

abstract：BACKGROUND:Tobacco smoking is a leading cause of cardiovascular disease (CVD) morbidity and mortality. Evidence on the relation of smoking to different subtypes of CVD, across fatal and non-fatal outcomes, is limited. METHODS:A prospective study of 188,167 CVD- and cancer-free individuals aged ≥ 45 years from the Aust...

journal_title：BMC medicine

authors： Banks E,Joshy G,Korda RJ,Stavreski B,Soga K,Egger S,Day C,Clarke NE,Lewington S,Lopez AD

更新日期：2019-07-03 00:00:00

abstract：BACKGROUND:Predicting treatment benefit and/or outcome before any therapeutic intervention has taken place would be clinically very useful. Herein, we evaluate the ability of the intrinsic subtypes and the risk of relapse score at diagnosis to predict survival and response following neoadjuvant chemotherapy. In additio...

journal_title：BMC medicine

authors： Prat A,Fan C,Fernández A,Hoadley KA,Martinello R,Vidal M,Viladot M,Pineda E,Arance A,Muñoz M,Paré L,Cheang MC,Adamo B,Perou CM

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Several accomplishments have been achieved in triple-negative breast cancer (TNBC) research over the last year. The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer into the immunotherapy era. Nevertheless, despite encouraging result...

journal_title：BMC medicine

authors： Marra A,Viale G,Curigliano G

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:The Diagnostic and Statistical Manual fifth edition (DSM-5) provides new criteria for delirium diagnosis. We examined delirium diagnosis using these new criteria compared with the Diagnostic and Statistical Manual fourth edition (DSM-IV) in a large dataset of patients assessed for delirium and related presen...

journal_title：BMC medicine

authors： Meagher DJ,Morandi A,Inouye SK,Ely W,Adamis D,Maclullich AJ,Rudolph JL,Neufeld K,Leonard M,Bellelli G,Davis D,Teodorczuk A,Kreisel S,Thomas C,Hasemann W,Timmons S,O'Regan N,Grover S,Jabbar F,Cullen W,Dunne C,Kam

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Exercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within...

journal_title：BMC medicine

authors： Travier N,Velthuis MJ,Steins Bisschop CN,van den Buijs B,Monninkhof EM,Backx F,Los M,Erdkamp F,Bloemendal HJ,Rodenhuis C,de Roos MA,Verhaar M,ten Bokkel Huinink D,van der Wall E,Peeters PH,May AM

更新日期：2015-06-08 00:00:00