Abstract:
:Environmental enteropathy (EE) is a poorly defined state of intestinal inflammation without overt diarrhea that occurs in individuals exposed over time to poor sanitation and hygiene. It is implicated as a cause of stunting and malnutrition, oral vaccine failure and impaired development in children from low-income countries. The burden on child health of malnutrition alone, which affects 25% of all children and is estimated to result in more than a million deaths annually due to heightened susceptibility to infection, makes urgent a solution to EE. Efforts are thus underway to treat EE even while work continues to identify it through the use of non-invasive biomarkers, and delineate its pathogenesis. A recent study published in BMC Medicine reports the first randomized controlled phase I trial of an anti-inflammatory drug for EE. The aminosalicylate mesalazine was found to be safe in short-term treatment of a small number of severely malnourished children, although efficacy was not established. Whether such treatment trials are premature, or instead a way both to understand and intervene in EE, is the focus of this article. Please see related article: http://www.biomedcentral.com/1741-7015/12/133.
journal_name
BMC Medjournal_title
BMC medicineauthors
Petri WA Jr,Naylor C,Haque Rdoi
10.1186/s12916-014-0187-1subject
Has Abstractpub_date
2014-10-14 00:00:00pages
187issn
1741-7015pii
s12916-014-0187-1journal_volume
12pub_type
评论,杂志文章相关文献
BMC Medicine文献大全abstract:BACKGROUND:Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a 10-year period. METHODS:The community-based cohort included 7381 p...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0847-z
更新日期:2017-04-19 00:00:00
abstract::Psychiatric nosology is widely criticized, but solutions are proving elusive. Planned revisions of diagnostic criteria will not resolve heterogeneity, comorbidity, fuzzy boundaries between normal and pathological, and lack of specific biomarkers. Concern about these difficulties reflects a narrow model that assumes mo...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-10-5
更新日期:2012-01-13 00:00:00
abstract:BACKGROUND:Persistent disabilities are key manifestations of Chikungunya virus (CHIKV) infection, especially incapacitating polyarthralgia and fatigue. So far, little is known about their impact on health status. The present study aimed at describing the burden of CHIKV prolonged or late-onset symptoms on the self-perc...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-5
更新日期:2011-01-14 00:00:00
abstract:BACKGROUND:Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of survival in critically ill adults, but little data exist for African children living in malaria-endemic...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1014-x
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:Depression in tuberculosis increases the risk for adverse health outcomes. However, little is known about comorbid depression and tuberculosis in the general population. Thus, we assessed the association between depression and tuberculosis, and the decrements in health status associated with this comorbidity...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0975-5
更新日期:2017-11-28 00:00:00
abstract:BACKGROUND:There are widespread concerns about communication and support for patients and families, especially when they face clinical uncertainty, a situation most marked in intensive care units (ICUs). Therefore, we aimed to develop and evaluate an interventional tool to improve communication and palliative care, usi...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-213
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:During the past decades, life expectancy has continued to increase in most high-income countries. Previous research suggests that improvements in life expectancy have primarily been driven by advances at the upper end of the health distribution, while parts of the population have lagged behind. Using data fr...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01514-z
更新日期:2020-03-20 00:00:00
abstract::The microbes colonizing the infant gastrointestinal tract have been implicated in later-life disease states such as allergies and obesity. Recently, the medical research community has begun to realize that very early colonization events may be most impactful on future health, with the presence of key taxa required for...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-017-0802-z
更新日期:2017-02-13 00:00:00
abstract:BACKGROUND:We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased oxidative and nitrosative stress (O&NS), which contribute to ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-11-200
更新日期:2013-09-12 00:00:00
abstract:BACKGROUND:Armed conflict can indirectly affect population health through detrimental impacts on political and social institutions and destruction of infrastructure. This study aimed to quantify indirect mortality impacts of armed conflict in civilian populations globally and explore differential effects by armed confl...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01708-5
更新日期:2020-09-10 00:00:00
abstract:BACKGROUND:Although neutrophils have been linked to the progression of cancer, uncertainty exists around their association with cancer outcomes, depending on the site, outcome and treatments considered. We aimed to evaluate the strength and validity of evidence on the association between either the neutrophil to lympho...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01817-1
更新日期:2020-11-20 00:00:00
abstract::In this video Q&A, we talk to Professor Carlos Caldas about the identification of breast cancer subtypes through molecular profiling, and the clinical implications for diagnosis and treatment. ...
journal_title:BMC medicine
pub_type: 面试,杂志文章
doi:10.1186/1741-7015-11-150
更新日期:2013-06-18 00:00:00
abstract:BACKGROUND:Off-label and unlicensed (OLUL) prescribing has been prevalent in pediatric practice. Using data from a prospective cohort study of adverse drug reactions (ADRs) among pediatric inpatients, we aimed to test the hypothesis that OLUL status is a risk factor for ADRs. METHODS:A nested case?control study was co...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-238
更新日期:2013-11-07 00:00:00
abstract::The internet has opened up vast possibilities for research. An increasing number of studies are being conducted using the internet as both a source of data and a venue for research. Use of the internet in research has created many challenges, not just for those conducting and reviewing the studies, but also for editor...
journal_title:BMC medicine
pub_type: 社论
doi:10.1186/s12916-014-0124-3
更新日期:2014-07-15 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy is an important cause of acute renal failure. We assess the efficacy of acetylcysteine for prevention of contrast-induced nephropathy among patients undergoing intravascular angiography. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials c...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1741-7015-2-38
更新日期:2004-10-22 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a risk factor for non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Since N...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0137-y
更新日期:2014-08-26 00:00:00
abstract:BACKGROUND:Monogenic diabetes (MgD) accounts for 1-2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-generation sequencing in patients with late adolescence/adult-onset diabetes referred for a clinical ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1363-0
更新日期:2019-07-11 00:00:00
abstract:BACKGROUND:Managing hearing communication for residents living with hearing loss and dementia in long-term care settings is challenging. This paper explores how care can be effective in optimising hearing communication for residents living with dementia. We argue that the underlying notion of permission or authorisatio...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1286-9
更新日期:2019-03-04 00:00:00
abstract::The lack of formal training programs for peer reviewers places the scientific quality of biomedical publications at risk, as the introduction of 'hidden' bias may not be easily recognized by the reader. The exponential increase in the number of manuscripts submitted for publication worldwide, estimated in the millions...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-014-0179-1
更新日期:2014-09-26 00:00:00
abstract:BACKGROUND:Recent reviews on placebo effects in clinical trials suggest that objective changes following placebo treatments may not exist or, at least, have been considerably overestimated. However, the possibility that yet unidentified subsets of parameters are responsive to placebo treatments has not been taken into ...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1741-7015-5-3
更新日期:2007-03-19 00:00:00
abstract:BACKGROUND:Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effects of IGF-I on cancer cells and stromal cells separately. METHODS:We used an ex vivo culture model ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-8-1
更新日期:2010-01-05 00:00:00
abstract:BACKGROUND:Current policies encourage healthcare institutions to acquire clinical information systems (CIS) so that captured data can be used for secondary purposes, including clinical process improvement. Such policies do not account for the extra work required to repurpose data for uses other than direct clinical car...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-103
更新日期:2013-04-10 00:00:00
abstract:BACKGROUND:Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol trafficking characterized by increased plasma plant sterol levels. Based upo...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-2-5
更新日期:2004-03-24 00:00:00
abstract:BACKGROUND:Accurate and timely cause of death (COD) data are essential for informed public health policymaking. Medical certification of COD generally provides the majority of COD data in a population and is an essential component of civil registration and vital statistics (CRVS) systems. Accurate completion of the med...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01519-8
更新日期:2020-03-09 00:00:00
abstract:BACKGROUND:Comorbidities affect outcomes in heart failure (HF), but are not reflected in current HF classification. The aim of this study is to characterize HF groups that account for higher-order interactions between comorbidities and to investigate the association between comorbidity groups and outcomes. METHODS:Lat...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01881-7
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:Thymic size in early infancy predicts subsequent survival in low-income settings. The human thymus develops from early gestation, is most active in early life and is highly sensitive to malnutrition. Our objective was to test whether thymic size in infancy could be increased by maternal and/or infant nutriti...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-019-1264-2
更新日期:2019-02-18 00:00:00
abstract:BACKGROUND:Since the late 1980s, genetic discrimination has remained one of the major concerns associated with genetic research and clinical genetics. Europe has adopted a plethora of laws and policies, both at the regional and national levels, to prevent insurers from having access to genetic information for underwrit...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-11-25
更新日期:2013-01-31 00:00:00
abstract::Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and control to discuss the ways in which malaria mig...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0384-6
更新日期:2015-07-25 00:00:00
abstract:BACKGROUND:Observational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomisation study to investigate whether serum magnesium levels may be causally associated with coronary art...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1065-z
更新日期:2018-05-17 00:00:00
abstract:BACKGROUND:The 2012 World Health Assembly set a target for Member States to reduce premature non-communicable disease (NCD) mortality by 25% over the period 2010 to 2025. This reflected concerns about increasing NCD mortality burdens among productive adults globally. This article first considers whether the WHO target ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0313-8
更新日期:2015-03-30 00:00:00