Abstract:
BACKGROUND:Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a 10-year period. METHODS:The community-based cohort included 7381 participants aged 65 years and above. Five cognitive domains (verbal fluency, psychomotor speed, executive function, visuospatial skills and global cognition) were assessed up to five times over 10 years of follow-up. Treatment groups included participants under a specific antidepressant class at both baseline and the first follow-up and their follow-up cognitive data were considered until the last consecutive follow-up with a report of antidepressant use of the same class. Linear mixed models were used to compare baseline cognitive performance and cognitive decline over time according to antidepressant treatment. The models were adjusted for multiple confounders including residual depressive symptoms assessed by the Center for Epidemiologic Studies-Depression scale. RESULTS:At baseline, 4.0% of participants were taking antidepressants. Compared to non-users, tricyclic antidepressant users had lower baseline performances in verbal fluency, visual memory and psychomotor speed, and selective serotonin reuptake inhibitor users in verbal fluency and psychomotor speed. For the two other cognitive abilities, executive function and global cognition, no significant differences were found at baseline irrespective of the antidepressant class. Regarding changes over time, no significant differences were observed in comparison with non-users whatever the cognitive domain, except for a slight additional improvement over the follow-up in verbal fluency skills for tricyclic antidepressant users. CONCLUSIONS:In this large elderly general population cohort, we found no evidence for an association between antidepressant use and post-treatment cognitive decline over 10 years of follow-up in various cognitive domains.
journal_name
BMC Medjournal_title
BMC medicineauthors
Carrière I,Norton J,Farré A,Wyart M,Tzourio C,Noize P,Pérès K,Fourrier-Réglat A,Ritchie K,Ancelin MLdoi
10.1186/s12916-017-0847-zsubject
Has Abstractpub_date
2017-04-19 00:00:00pages
81issue
1issn
1741-7015pii
10.1186/s12916-017-0847-zjournal_volume
15pub_type
杂志文章相关文献
BMC Medicine文献大全abstract:BACKGROUND:In adults with febrile urinary tract infection (fUTI), data on optimal treatment duration in patients other than non-pregnant women without comorbidities are lacking. METHODS:A randomized placebo-controlled, double-blind, non-inferiority trial among 35 primary care centers and 7 emergency departments of reg...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12916-017-0835-3
更新日期:2017-04-03 00:00:00
abstract:BACKGROUND:Many agree that the biopsychosocial contributions to psychopathology are complex, yet it is unclear how we can make sense of this complexity. One approach is to reduce this complexity to a few necessary and sufficient biopsychosocial factors; although this approach is easy to understand, it has little explan...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-019-1435-1
更新日期:2019-10-18 00:00:00
abstract:BACKGROUND:The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines Agency (EMA) concerning human papillomavirus (HPV) vaccines during a European Union (EU) referral pro...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0850-4
更新日期:2017-05-02 00:00:00
abstract:BACKGROUND:Major depression, although frequent in primary care, is commonly hidden behind multiple physical complaints that are often the first and only reason for patient consultation. Major depression can be screened by two validated questions that are easier to use in primary care than the full Diagnostic and Statis...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-114
更新日期:2011-10-18 00:00:00
abstract:BACKGROUND:The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need for more thorough and comprehensive characterization of the spectrum of resulting clinical complica...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0302-y
更新日期:2015-03-20 00:00:00
abstract::There is evidence that the life expectancy (LE) of individuals infected with the human immunodeficiency virus (HIV) has increased since the introduction of combination antiretroviral therapy (cART). However, mortality rates in recent years in HIV-positive individuals appear to have remained higher than would be expect...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-11-251
更新日期:2013-11-27 00:00:00
abstract:BACKGROUND:Use of fenfluramines for weight loss has been associated with the development of characteristic plaques on cardiac valves causing regurgitation. However, previously published studies of exposure to fenfluramines have been limited by relatively small sample size, short duration of follow-up, and the lack of a...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-6-34
更新日期:2008-11-06 00:00:00
abstract::The diagnosis of multidrug resistant tuberculosis (MDR-TB) in any individual is the beginning of a prolonged and difficult therapeutic journey. It also marks the moment from which to begin consideration of how to manage close contacts. Preventive therapy for drug-susceptible latent tuberculosis infection has been demo...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-016-0610-x
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Clinical decision support systems assist physicians in interpreting complex patient data. However, they typically operate on a per-patient basis and do not exploit the extensive latent medical knowledge in electronic health records (EHRs). The emergence of large EHR systems offers the opportunity to integrat...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-194
更新日期:2013-09-02 00:00:00
abstract:BACKGROUND:Several accomplishments have been achieved in triple-negative breast cancer (TNBC) research over the last year. The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer into the immunotherapy era. Nevertheless, despite encouraging result...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-019-1326-5
更新日期:2019-05-09 00:00:00
abstract:BACKGROUND:Gluten-free diet (GFD) decreases the quality of life of celiac disease (CD) patients, who frequently ask to occasionally ingest gluten-containing food. We evaluated CD patients reporting voluntary and occasional transgressions to their GFD. METHODS:From October 2017 to September 2018, the patients reporting...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-1511-6
更新日期:2020-03-16 00:00:00
abstract:BACKGROUND:Virtual histology intravascular ultrasound (VH-IVUS) imaging is an innovative tool for the morphological evaluation of coronary atherosclerosis. Evidence for the effects of statin therapy on VH-IVUS parameters have been inconclusive. Consequently, we performed a systematic review and meta-analysis to investi...
journal_title:BMC medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12916-015-0459-4
更新日期:2015-09-18 00:00:00
abstract:BACKGROUND:Predicting treatment benefit and/or outcome before any therapeutic intervention has taken place would be clinically very useful. Herein, we evaluate the ability of the intrinsic subtypes and the risk of relapse score at diagnosis to predict survival and response following neoadjuvant chemotherapy. In additio...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0540-z
更新日期:2015-12-18 00:00:00
abstract::Primary care clinicians and researchers are growing increasingly aware of the prevalence of multimorbidity among long-term conditions, and the impact on patient experience, health, and utilisation of care. The correspondence paper by Muth et al. entitled 'The Ariadne principles: how to handle multimorbidity in primary...
journal_title:BMC medicine
pub_type: 社论
doi:10.1186/s12916-014-0222-2
更新日期:2014-12-08 00:00:00
abstract:BACKGROUND:The inverse equity hypothesis asserts that new health policies initially widen inequality, then attenuate inequalities over time. Since 2004, the UK's pay-for-performance scheme for chronic disease management (CDM) in primary care general practices (the Quality and Outcomes Framework) has permitted practices...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0833-5
更新日期:2017-04-11 00:00:00
abstract::Malaria at international borders presents particular challenges with regards to elimination. International borders share common malaria ecologies, yet neighboring countries are often at different stages of the control-to-elimination pathway. Herein, we present a case study on malaria, and its control, at the border be...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1081-z
更新日期:2018-06-26 00:00:00
abstract:BACKGROUND:In recent years, medical practice has followed two different paradigms: evidence-based medicine (EBM) and values-based medicine (VBM). There is an urgent need to promote medical education that strengthens the relationship between these two paradigms. This work is designed to establish the foundations for a c...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-39
更新日期:2013-02-15 00:00:00
abstract:BACKGROUND:In animal models, lack of thyroid hormone is associated with cone photoreceptor preservation, while administration of high doses of active thyroid hormone leads to deterioration. The association between thyroid function and age-related macular degeneration (AMD) has not been investigated in the general popul...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-015-0329-0
更新日期:2015-04-23 00:00:00
abstract:BACKGROUND:The burden of malaria in sub-Saharan Africa remains challenging to measure relying on epidemiological modelling to evaluate the impact of investments and providing an in-depth analysis of progress and trends in malaria response globally. In malaria-endemic countries of Africa, there is increasing use of rout...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01593-y
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Over the last 100 years, several persistent misconceptions or 'false beliefs' have built up around allergen immunotherapy and its use in allergic rhinitis. This is perhaps because enthusiastic physicians administered complex allergen extracts to a diverse population of patients suffering from heterogeneous a...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-11-255
更新日期:2013-12-05 00:00:00
abstract::Intra-tumour heterogeneity is a common molecular phenomenon in metastatic clear cell renal carcinoma (mRCC), representing the genetic complexity of a tumour with multiple metastatic sites. The present commentary discusses the observed phenomena of phenotypic intra-tumour heterogeneity in mRCC patients treated with the...
journal_title:BMC medicine
pub_type: 社论
doi:10.1186/s12916-016-0754-8
更新日期:2016-12-07 00:00:00
abstract:BACKGROUND:Scale-up of malaria interventions over the last decade have yielded a significant reduction in malaria transmission and disease burden in sub-Saharan Africa. We estimated economic gradients in the distribution of these efforts and of their impacts within and across endemic countries. METHODS:Using Demograph...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0948-8
更新日期:2017-10-18 00:00:00
abstract::The hypothalamic-pituitary-adrenal axis is activated in response to stress. One of the activated hypothalamic hormones is arginine vasopressin, a hormone involved in hemodynamics and osmoregulation. Copeptin, the C-terminal part of the arginine vasopressin precursor peptide, is a sensitive and stable surrogate marker ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/1741-7015-10-7
更新日期:2012-01-20 00:00:00
abstract:BACKGROUND:Accurate and timely cause of death (COD) data are essential for informed public health policymaking. Medical certification of COD generally provides the majority of COD data in a population and is an essential component of civil registration and vital statistics (CRVS) systems. Accurate completion of the med...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01519-8
更新日期:2020-03-09 00:00:00
abstract:BACKGROUND:It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. METHODS:To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01796-3
更新日期:2020-11-17 00:00:00
abstract:BACKGROUND:There are widespread concerns about communication and support for patients and families, especially when they face clinical uncertainty, a situation most marked in intensive care units (ICUs). Therefore, we aimed to develop and evaluate an interventional tool to improve communication and palliative care, usi...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-11-213
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:In 2015, the Zika virus spread from Brazil throughout the Americas, posing an unprecedented challenge to the public health community. During the epidemic, international public health officials lacked reliable predictions of the outbreak's expected geographic scale and prevalence of cases, and were therefore ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1389-3
更新日期:2019-09-02 00:00:00
abstract:BACKGROUND:Involving adults lacking capacity (ALC) in research on end of life care (EoLC) or serious illness is important, but often omitted. We aimed to develop evidence-based guidance on how best to include individuals with impaired capacity nearing the end of life in research, by identifying the challenges and solut...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-020-01654-2
更新日期:2020-07-22 00:00:00
abstract:BACKGROUND:The spread of infectious diseases crucially depends on the pattern of contacts between individuals. Knowledge of these patterns is thus essential to inform models and computational efforts. However, there are few empirical studies available that provide estimates of the number and duration of contacts betwee...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/1741-7015-9-87
更新日期:2011-07-19 00:00:00
abstract:BACKGROUND:Fetal and neonatal mortality rates in low-income countries are at least 10-fold greater than in high-income countries. These differences have been related to poor access to and poor quality of obstetric and neonatal care. METHODS:This trial tested the hypothesis that teams of health care providers, administ...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1741-7015-11-215
更新日期:2013-10-03 00:00:00