Spectrum of gluten-related disorders: consensus on new nomenclature and classification.

abstract：BACKGROUND:Inflammatory cytokines play a crucial role in coronary artery disease (CAD). We investigated the association between 48 coding and three non-coding single nucleotide polymorphisms (SNPs) from 35 inflammatory genes and the development of CAD, using a large discordant sibship collection (2699 individuals in 89...

journal_title：BMC medicine

authors： Brown BD,Nsengimana J,Barrett JH,Lawrence RA,Steiner L,Cheng S,Bishop DT,Samani NJ,Ball SG,Balmforth AJ,Hall AS

更新日期：2010-01-13 00:00:00

abstract：BACKGROUND:The ability to do online searches for health information has led to concerns that patients find the results confusing and that they often lead to expectations for treatments that have little supportive evidence. At the same time, the science of summarizing research evidence has advanced to the point where it...

journal_title：BMC medicine

authors： Elwyn G,Quinlan C,Mulley A,Agoritsas T,Vandvik PO,Guyatt G

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Pregnancy and pregnancy loss may be linked to cardiovascular disease (CVD). However, the evidence is still inconsistent, especially in East Asians, whose reproductive patterns differ importantly from those in the West. We examined the associations of pregnancy, miscarriage, induced abortion, and stillbirth w...

journal_title：BMC medicine

authors： Peters SAE,Yang L,Guo Y,Chen Y,Bian Z,Tian X,Chang L,Zhang S,Liu J,Wang T,Chen J,Li L,Woodward M,Chen Z,China Kadoorie Biobank collaboration group.

更新日期：2017-08-08 00:00:00

abstract：BACKGROUND:The focus of this study is to identify particular microRNA (miRNA) signatures in exosomes derived from plasma of 435 human epidermal growth factor receptor 2 (HER2)-positive and triple-negative (TN) subtypes of breast cancer (BC). METHODS:First, miRNA expression profiles were determined in exosomes derived ...

journal_title：BMC medicine

authors： Stevic I,Müller V,Weber K,Fasching PA,Karn T,Marmé F,Schem C,Stickeler E,Denkert C,van Mackelenbergh M,Salat C,Schneeweiss A,Pantel K,Loibl S,Untch M,Schwarzenbach H

更新日期：2018-10-10 00:00:00

abstract：BACKGROUND:Pneumonia in people with dementia has been associated with severe discomfort. We sought to assess the effectiveness of a practice guideline for optimal symptom relief for nursing home residents with dementia and pneumonia. METHODS:A single-blind, multicenter, cluster randomized controlled trial was conducte...

journal_title：BMC medicine

authors： van der Maaden T,de Vet HC,Achterberg WP,Boersma F,Schols JM,Mehr DR,Galindo-Garre F,Hertogh CM,Koopmans RT,van der Steen JT

更新日期：2016-08-11 00:00:00

abstract：BACKGROUND:A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence of impaired glucose metabolism on the relation between dietary intake of n-3 LCPUFAs and risk of a...

journal_title：BMC medicine

authors： Strand E,Pedersen ER,Svingen GF,Schartum-Hansen H,Rebnord EW,Bjørndal B,Seifert R,Bohov P,Meyer K,Hiltunen JK,Nordrehaug JE,Nilsen DW,Berge RK,Nygård O

更新日期：2013-10-08 00:00:00

abstract：BACKGROUND:Involving adults lacking capacity (ALC) in research on end of life care (EoLC) or serious illness is important, but often omitted. We aimed to develop evidence-based guidance on how best to include individuals with impaired capacity nearing the end of life in research, by identifying the challenges and solut...

journal_title：BMC medicine

authors： Evans CJ,Yorganci E,Lewis P,Koffman J,Stone K,Tunnard I,Wee B,Bernal W,Hotopf M,Higginson IJ,MORECare_Capacity.

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effects of IGF-I on cancer cells and stromal cells separately. METHODS:We used an ex vivo culture model ...

journal_title：BMC medicine

authors： Rajski M,Zanetti-Dällenbach R,Vogel B,Herrmann R,Rochlitz C,Buess M

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:Use of fenfluramines for weight loss has been associated with the development of characteristic plaques on cardiac valves causing regurgitation. However, previously published studies of exposure to fenfluramines have been limited by relatively small sample size, short duration of follow-up, and the lack of a...

journal_title：BMC medicine

authors： Dahl CF,Allen MR,Urie PM,Hopkins PN

更新日期：2008-11-06 00:00:00

abstract：BACKGROUND:Mucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown. METHODS:To correlate MUC4 polymorphism with the risk of endometriosis and endometriosis-related infertility, we performed ...

journal_title：BMC medicine

authors： Chang CY,Chang HW,Chen CM,Lin CY,Chen CP,Lai CH,Lin WY,Liu HP,Sheu JJ,Tsai FJ

更新日期：2011-02-24 00:00:00

abstract：BACKGROUND:Heterogeneity of prostate cancer (PCa) contributes to inaccurate cancer screening and diagnosis, unnecessary biopsies, and overtreatment. We intended to develop non-invasive urine tests for accurate PCa diagnosis to avoid unnecessary biopsies. METHODS:Using a machine learning program, we identified a 25-Gen...

journal_title：BMC medicine

authors： Johnson H,Guo J,Zhang X,Zhang H,Simoulis A,Wu AHB,Xia T,Li F,Tan W,Johnson A,Dizeyi N,Abrahamsson PA,Kenner L,Feng X,Zou C,Xiao K,Persson JL,Chen L

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:It has been presumed that Chlamydia trachomatis is transmitted between men only through anal or oral sex, but no mathematical models have tested this presumption. METHODS:To test this presumption, we created 20 compartmental mathematical models of different sexual practices that included both oral and anal ...

journal_title：BMC medicine

authors： Xu X,Chow EPF,Ong JJ,Hoebe CJPA,Zou Z,Hocking JS,Fairley CK,Zhang L

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:Bangladesh, India and Nepal are working towards the elimination of visceral leishmaniasis (VL) by 2015. In 2005 the World Health Organization/Training in Tropical Diseases launched an implementation research programme to support integrated vector management for the elimination of VL from Bangladesh, India an...

journal_title：BMC medicine

authors： Joshi AB,Das ML,Akhter S,Chowdhury R,Mondal D,Kumar V,Das P,Kroeger A,Boelaert M,Petzold M

更新日期：2009-10-05 00:00:00

abstract：:In this video Q&A, we talk to Associate Professor Felice Jacka about population health approaches to the primary prevention of mental disorders across the lifespan. These include addressing lifestyle factors, such as diet, smoking and physical activity. Latest strategies are being developed through epidemiological stu...

journal_title：BMC medicine

authors： Jacka FN

更新日期：2015-10-14 00:00:00

abstract：:Although prostate-specific antigen (PSA) screening has improved the detection of prostate cancer, allowing for stage migration to less advanced disease, the precise mortality benefit of early detection is unclear. This is in part due to a discrepancy between the two large randomized controlled trials comparing PSA scr...

journal_title：BMC medicine

authors： Kim EH,Andriole GL

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY:We outline five pr...

journal_title：BMC medicine

authors： Burton C,Fink P,Henningsen P,Löwe B,Rief W,EURONET-SOMA Group.

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:The TransEurope FootRace 2009 (TEFR09) was one of the longest transcontinental ultramarathons with an extreme endurance physical load of running nearly 4,500 km in 64 days. The aim of this study was to assess the wide spectrum of adaptive responses in humans regarding the different tissues, organs and functi...

journal_title：BMC medicine

authors： Schütz UH,Schmidt-Trucksäss A,Knechtle B,Machann J,Wiedelbach H,Ehrhardt M,Freund W,Gröninger S,Brunner H,Schulze I,Brambs HJ,Billich C

更新日期：2012-07-19 00:00:00

abstract：BACKGROUND:Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy characterized by motor dysfunction of the lower extremities and urinary disturbance. Immunomodulatory treatments are the main strategy for HAM/TSP, but several issues are associated...

journal_title：BMC medicine

authors： Nakamura T,Matsuo T,Fukuda T,Yamato S,Yamaguchi K,Kinoshita I,Matsuzaki T,Nishiura Y,Nagasato K,Narita-Masuda T,Nakamura H,Satoh K,Sasaki H,Sakai H,Kawakami A

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Studies addressing the effects of aerobic exercise and a prudent diet on lipid and lipoprotein concentrations in adults have reached conflicting conclusions. The purpose of this study was to determine the effects of aerobic exercise combined with a prudent diet on lipid and lipoprotein concentrations in adul...

journal_title：BMC medicine

authors： Kelley GA,Kelley KS,Roberts S,Haskell W

更新日期：2011-06-15 00:00:00

abstract：BACKGROUND:Ancestral environmental exposures to a variety of environmental factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The present work examined the potential transgenerational actions of the insecticide dichlorodiphenyltrichloroethane (DDT) on o...

journal_title：BMC medicine

authors： Skinner MK,Manikkam M,Tracey R,Guerrero-Bosagna C,Haque M,Nilsson EE

更新日期：2013-10-23 00:00:00

abstract：BACKGROUND:The inverse equity hypothesis asserts that new health policies initially widen inequality, then attenuate inequalities over time. Since 2004, the UK's pay-for-performance scheme for chronic disease management (CDM) in primary care general practices (the Quality and Outcomes Framework) has permitted practices...

journal_title：BMC medicine

authors： Lowrie R,McConnachie A,Williamson AE,Kontopantelis E,Forrest M,Lannigan N,Mercer SW,Mair FS

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Schools are the most frequent target for intervention programs aimed at preventing child obesity; however, the overall effectiveness of these programs has been limited. It has therefore been recommended that interventions target multiple ecological levels (community, family, school and individual) to have gr...

journal_title：BMC medicine

authors： Gentile DA,Welk G,Eisenmann JC,Reimer RA,Walsh DA,Russell DW,Callahan R,Walsh M,Strickland S,Fritz K

更新日期：2009-09-18 00:00:00

abstract：:In this video Q&A, we talk to Professor Carlos Caldas about the identification of breast cancer subtypes through molecular profiling, and the clinical implications for diagnosis and treatment. ...

journal_title：BMC medicine

authors： Caldas C

更新日期：2013-06-18 00:00:00

abstract：:Malaria at international borders presents particular challenges with regards to elimination. International borders share common malaria ecologies, yet neighboring countries are often at different stages of the control-to-elimination pathway. Herein, we present a case study on malaria, and its control, at the border be...

journal_title：BMC medicine

authors： Al Zahrani MH,Omar AI,Abdoon AMO,Ibrahim AA,Alhogail A,Elmubarak M,Elamin YE,AlHelal MA,Alshahrani AM,Abdelgader TM,Saeed I,El Gamri TB,Alattas MS,Dahlan AA,Assiri AM,Maina J,Li XH,Snow RW

更新日期：2018-06-26 00:00:00

abstract：BACKGROUND:Pendred syndrome, a common autosomal-recessive disorder characterized by congenital deafness and goiter, is caused by mutations of SLC26A4, which codes for pendrin. We investigated the relationship between pendrin and deafness using mice that have (Slc26a4+/+) or lack a complete Slc26a4 gene (Slc26a4-/-). M...

journal_title：BMC medicine

authors： Wangemann P,Itza EM,Albrecht B,Wu T,Jabba SV,Maganti RJ,Lee JH,Everett LA,Wall SM,Royaux IE,Green ED,Marcus DC

更新日期：2004-08-20 00:00:00

abstract：BACKGROUND:A sizeable fraction of tuberculosis (TB) cases go undiagnosed. By analysing data from enhanced demographic, microbiological and geospatial surveillance of TB registrations, we aimed to identify modifiable predictors of inequitable access to diagnosis and care. METHODS:Governmental community health workers (...

journal_title：BMC medicine

authors： MacPherson P,Khundi M,Nliwasa M,Choko AT,Phiri VK,Webb EL,Dodd PJ,Cohen T,Harris R,Corbett EL

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Extended use of combined pharmacotherapies to treat tobacco dependence may increase smoking abstinence; few studies have examined their effectiveness. The objective of this study was to evaluate smoking abstinence with standard nicotine patch (NRT), extended use of combined formulations of nicotine replaceme...

journal_title：BMC medicine

authors： Tulloch HE,Pipe AL,Els C,Clyde MJ,Reid RD

更新日期：2016-06-07 00:00:00

abstract：:Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, wi...

journal_title：BMC medicine

authors： Mijajlović MD,Pavlović A,Brainin M,Heiss WD,Quinn TJ,Ihle-Hansen HB,Hermann DM,Assayag EB,Richard E,Thiel A,Kliper E,Shin YI,Kim YH,Choi S,Jung S,Lee YB,Sinanović O,Levine DA,Schlesinger I,Mead G,Milošević V,Ley

更新日期：2017-01-18 00:00:00

abstract：BACKGROUND:Castration-resistant prostate cancer (CRPC) is associated with wide variations in survival. Recent studies of whole blood mRNA expression-based biomarkers strongly predicted survival but the genes used in these biomarker models were non-overlapping and their relationship was unknown. We developed a biomarker...

journal_title：BMC medicine

authors： Wang L,Gong Y,Chippada-Venkata U,Heck MM,Retz M,Nawroth R,Galsky M,Tsao CK,Schadt E,de Bono J,Olmos D,Zhu J,Oh WK

更新日期：2015-08-21 00:00:00

abstract：BACKGROUND:In animal models, lack of thyroid hormone is associated with cone photoreceptor preservation, while administration of high doses of active thyroid hormone leads to deterioration. The association between thyroid function and age-related macular degeneration (AMD) has not been investigated in the general popul...

journal_title：BMC medicine

authors： Chaker L,Buitendijk GH,Dehghan A,Medici M,Hofman A,Vingerling JR,Franco OH,Klaver CC,Peeters RP

更新日期：2015-04-23 00:00:00