abstract：:Secretory leukocyte protease inhibitor (SLPI) and progranulin (PGRN) are secretory proteins with an anti-inflammatory property. Their involvement in cervical remodeling in pregnant uterus is not yet elucidated. Thus, this study aimed to explore the significance of SLPI and PGRN in the maintenance of pregnancy by inves...

journal_title：Journal of reproductive immunology

authors： Samejima T,Nagamatsu T,Akiba N,Fujii T,Sayama S,Kawana K,Taguchi A,Kumasawa K,Iriyama T,Osuga Y,Fujii T

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Repeated implantation failure (RIF) has been shown related to maternal immune imbalance. Many studies suggested that prednisone promoted the Th17/Treg balance shift to the direction of immune tolerance. Our study aimed to evaluate the role of prednisone in Th17/Treg balance and pregnancy outcome in RIF patien...

journal_title：Journal of reproductive immunology

authors： Huang Q,Wu H,Li M,Yang Y,Fu X

更新日期：2021-02-01 00:00:00

abstract：:Recurrent implantation failure (RIF) refers to cases in which women have had the failure of the embryo implantation after several in vitro fertilization (IVF). The success rate for IVF depends on many different factors. Implantation is a complex step in a successful pregnancy. Antiphospholipid antibodies (aPLs) and pl...

journal_title：Journal of reproductive immunology

authors： Mahdian S,Pirjani R,Favaedi R,Movahedi M,Moini A,Shahhoseini M

更新日期：2021-02-01 00:00:00

abstract：:We aimed to investigate the effect of intrauterine administration of autologous hCG-activated PBMCs in RIF women with low Th-17/Treg cell ratio. 248 women with a history of implantation failure volunteered to receive PBMC-therapy. After immunologic consultation and doing flow cytometry analysis, 100 women with at leas...

journal_title：Journal of reproductive immunology

authors： Pourmoghadam Z,Soltani-Zangbar MS,Sheikhansari G,Azizi R,Eghbal-Fard S,Mohammadi H,Siahmansouri H,Aghebati-Maleki L,Danaii S,Mehdizadeh A,Hojjat-Farsangi M,Motavalli R,Yousefi M

更新日期：2020-11-01 00:00:00

abstract：:The functional competence of leukemia inhibitory factor (LIF), as immunocontraceptive vaccine in mice, was investigated. Balb/c mice were divided into two groups of vaccinated and controls. The recombinant human LIF (rhLIF) protein and phosphate buffer saline was emulsified with Freund's adjuvant and injected into vac...

journal_title：Journal of reproductive immunology

authors： Zare F,Amiri MM,Hadinedoushan H,Dehghan-Manshadi M,Mansouri F,Fesahat F,Saboor-Yaraghi AA

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:To analyze the risk factors associated with pregnancy failure in patients with positive antiphospholipid antibodies (aPL) and prior pregnancy losses, with or without a diagnosis of antiphospholipid syndrome. METHODS:We retrospectively reviewed the medical records of all the pregnant patients with positive a...

journal_title：Journal of reproductive immunology

authors： Duan H,Li X,Liu C,Ge Y,Deng X

更新日期：2020-09-01 00:00:00

abstract：:Recurrent spontaneous abortion (RSA) can be attributed to multiple factors, and abnormal invasion and apoptosis of trophoblast cells have attracted extensive attention. Our study aimed to investigate the expression of PTEN and miRNAs with potential regulatory relationships in the placental villi of RSA patients. Ninet...

journal_title：Journal of reproductive immunology

authors： Tian S,Yu J,Zhang Y,Bian Y,Ma J,Yan J

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Elongation factor Tu GTP binding domain containing 2 (EFTUD2) is an alternative splicing factor that modulates cell differentiation and activation processes. EFTUD2 is known to modulate immune responses and mutation of the EFTUD2-gene lead to fetal malformation. Little is known about its expression and role ...

journal_title：Journal of reproductive immunology

authors： Löb S,Vattai A,Kuhn C,Schmoeckel E,Mahner S,Wöckel A,Kolben T,Szekeres-Bartho J,Jeschke U,Vilsmaier T

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas. PATIENTS AND METHODS:We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas...

journal_title：Journal of reproductive immunology

authors： Meister S,Kolben T,Beyer S,Hutter S,Hofmann S,Kuhn C,Messner J,Mayr D,Solano ME,Jegen M,Obermeier V,Mahner S,Arck P,Jeschke U

更新日期：2020-06-01 00:00:00

abstract：:The present review article compares NK cell subsets and cytokine patterns determined in the peripheral blood as well as results of functional in-vitro assays using peripheral NK cells of idiopathic recurrent miscarriage (iRM) patients with corresponding results obtained in female healthy controls and female renal tran...

journal_title：Journal of reproductive immunology

authors： Toth B,Zhu L,Karakizlis H,Weimer R,Morath C,Opelz G,Kuon RJ,Daniel V

更新日期：2020-04-01 00:00:00

abstract：PROBLEM:Markers of maternal inflammation may determine infant birth outcomes. METHOD OF STUDY:Maternal serum samples were collected at 28 weeks gestation (n = 1418) in the Seychelles Child Development Study Nutrition Cohort 2 and analyzed for immune markers by MSD multiplex assay, including cytokines from the Th1 (IFN...

journal_title：Journal of reproductive immunology

authors： Yeates AJ,McSorley EM,Mulhern MS,Spence T,Crowe W,Grzesik K,Thurston SW,Watson GE,Myers GJ,Davidson PW,Shamlaye CF,van Wijngaarden E,Strain JJ

更新日期：2020-02-01 00:00:00

abstract：:Natural killer (NK) cells comprise of ∼70% of the immune cell population in the maternal decidua and ∼15% of the mononuclear cells in the peripheral blood. The decidual NK cells capable of producing high levels of cytokines are functionally distinct from the peripheral NK cells that exhibit high cytotoxicity. The numb...

journal_title：Journal of reproductive immunology

authors： Dixit A,Karande AA

更新日期：2020-02-01 00:00:00

abstract：:Pregnancy is a kind of natural immune tolerance. Immune factors play an important role in recurrent spontaneous abortion and repeated implantation failure. Salvianolic acid B (SalB) has anti-tumor, anti-inflammatory, anti-oxidation and immunomodulatory functions. However, there are few reports on the relationship betw...

journal_title：Journal of reproductive immunology

authors： Wang J,Liu C,Que W,Fujino M,Tong G,Yan H,Li XK

更新日期：2020-02-01 00:00:00

abstract：:During a pregnancy, the mother accepts her semi-allogeneic fetus with no signs of immunological rejection. Therefore, some modulation of the maternal immune system must occur. Similarly, changes in the host's immune system occurs during infections with parasites. In a study conducted in an endemic area in Bolivia, it ...

journal_title：Journal of reproductive immunology

authors： Persson G,Ekmann JR,Hviid TVF

更新日期：2019-11-01 00:00:00

abstract：PROBLEM:Exposure to systemic maternal inflammation (i.e., maternal sepsis, influenza, human immunodeficiency virus, or pyelonephritis) and intrauterine (IU) inflammation (i.e., chorioamnionitis or preterm labor) have been associated with adverse perinatal sequelae. Whether systemic and localized inflammation leading to...

journal_title：Journal of reproductive immunology

authors： Lee JY,Shin NE,Na Q,Dong J,Chudnovets A,Li S,Novak CM,McLane MW,Lei J,Burd I

更新日期：2019-06-01 00:00:00

abstract：:Endometriosis is a prevalent gynaecological disorder with a still unclear pathogenesis. So far inflammatory mechanisms are associated with disease progression and critical reviews have discussed the so-called 'danger theory' related to endometriosis. Hence, we performed immunoassays to evaluate whether local inflammat...

journal_title：Journal of reproductive immunology

authors： Jaeger-Lansky A,Schmidthaler K,Kuessel L,Gstöttner M,Waidhofer-Söllner P,Zlabinger GJ,Wenzl R,Eiwegger T

更新日期：2018-11-01 00:00:00

abstract：:The detrimental consequences of obesity on female fertility are well known, but the functional changes that occur in the ovary in response to elevated BMI are not clear. Obesity induces multiple components of a systemic inflammatory state that is a key pathway by which it initiates tissue dysfunction in adipose, liver...

journal_title：Journal of reproductive immunology

authors： Gonzalez MB,Lane M,Knight EJ,Robker RL

更新日期：2018-11-01 00:00:00

abstract：:An elevated level of insulin growth factor (IGF-1) in rat uterine fluid has been shown to exert detrimental effects of embryo development possibly leading to an increase in pregnancy loss. Interestingly, the administration of somatostatin to rats undergoing superovulation reduced IGF-1 levels in uterine luminal fluid ...

journal_title：Journal of reproductive immunology

authors： Irani M,Nasioudis D,Witkin SS,Gunnala V,Spandorfer SD

更新日期：2018-06-01 00:00:00

abstract：:The testis has been described in animal models as a site of immune privilege, which protects spermatids against tissue damage during inflammation. Myeloid cells, including macrophages and dendritic cells (DC), are defined as key players in the testicular immune privilege in animal models. However, their distribution a...

journal_title：Journal of reproductive immunology

authors： Ponte R,Dupuy FP,Brimo F,Mehraj V,Brassard P,Belanger M,Yurchenko E,Jenabian MA,Bernard NF,Routy JP,ORCHID study group.

更新日期：2018-02-01 00:00:00

abstract：:The central role of inflammatory processes in labour and delivery is now well-recognised. However, the biomolecular, immunological and endocrine mechanisms involved in the labour process, and the clinical manifestations of inflammation in pregnancy, are complex, variable and modulated by factors such as aetiology, eth...

journal_title：Journal of reproductive immunology

authors： Keelan JA

更新日期：2018-02-01 00:00:00

abstract：:Thyroid autoimmunity (TAI) appears to play a crucial role in female infertility, recurrent pregnancy loss and IVF failure. Thyroid autoantibodies against thyroid peroxidase and thyroglobulin have been shown to represent an independent risk factor for infertility and miscarriage. Moreover, thyroxin hormone administrati...

journal_title：Journal of reproductive immunology

authors： Miko E,Meggyes M,Doba K,Farkas N,Bogar B,Barakonyi A,Szereday L,Szekeres-Bartho J,Mezosi E

更新日期：2017-11-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved process in eukaryotes to maintain cellular homeostasis against stress. This process has two main functions: producing energy and quality control of intracellular proteins. During early pregnancy, extravillous trophoblasts (EVTs) invade the uterine myometrium and migrate along t...

journal_title：Journal of reproductive immunology

authors： Nakashima A,Aoki A,Kusabiraki T,Cheng SB,Sharma S,Saito S

更新日期：2017-09-01 00:00:00

abstract：:In addition to natural killer cells, other innate lymphoid cells have recently been identified in the mouse and human uterus, but their roles in successful pregnancy remain poorly defined. In this study, we examined the dynamic changes of uterine innate lymphoid cells throughout pregnancy in mice. We found that the to...

journal_title：Journal of reproductive immunology

authors： Li M,Gao Y,Yong L,Huang D,Shen J,Liu M,Ren C,Hou X

更新日期：2017-09-01 00:00:00

abstract：:For some time, reproductive immunologists have worked to understand the balance between maternal tolerance of the fetus, maternal health, and fetal protection which leads to successful pregnancy in mammalian species. We have always understood the potential importance of multiple factors, including nutrition, genetics,...

journal_title：Journal of reproductive immunology

authors： Bonney EA

更新日期：2017-09-01 00:00:00

abstract：:Endometriosis is a benign, chronic inflammatory disease that presents alterations in immune response that can be detected in eutopic endometrium, peritoneal fluid and peripheral blood of affected women. Regulatory T (TReg) cells are a subpopulation of T lymphocytes specialized in immune regulation that seem to partici...

journal_title：Journal of reproductive immunology

authors： de Barros IBL,Malvezzi H,Gueuvoghlanian-Silva BY,Piccinato CA,Rizzo LV,Podgaec S

更新日期：2017-04-01 00:00:00

abstract：:Monocytes are short-lived cells, arising from the bone marrow and maturing in the circulation. They play an important role in immune responses and are thought to be important for healthy pregnancy. In humans, 3 subpopulations of monocytes have been identified: classical, intermediate and non-classical monocytes. These...

journal_title：Journal of reproductive immunology

authors： Faas MM,de Vos P

更新日期：2017-02-01 00:00:00

abstract：:A maternal low-protein (LP) diet in Sprague-Dawley rats results in low birth weight, rapid adipose tissue catch-up growth, adult obesity, and insulin resistance. The placenta functions to fulfill the fetus' nutrient demands. Adequate angiogenic factor concentrations help to ensure normal growth and vasculature develop...

journal_title：Journal of reproductive immunology

authors： Vomhof-DeKrey E,Darland D,Ghribi O,Bundy A,Roemmich J,Claycombe K

更新日期：2016-11-01 00:00:00

abstract：:Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placental trophoblast in ovine host defence remains poorly understood. This study characterises expression of genes for cathelicidin and defensin pepti...

journal_title：Journal of reproductive immunology

authors： Coyle C,Wheelhouse N,Jacques M,Longbottom D,Svoboda P,Pohl J,Duncan WC,Rae MT,Barlow PG

更新日期：2016-09-01 00:00:00

abstract：AIM:Th17 cells are a newly discovered T helper lymphocyte subpopulation, producing interleukin IL-17. Th17 cells are present in blood and peritoneal fluid (PF) at different stages of endometriosis. We aim to establish their potential importance in the pathogenesis and clinical features of the disease. METHODS:The perc...

journal_title：Journal of reproductive immunology

authors： Gogacz M,Winkler I,Bojarska-Junak A,Tabarkiewicz J,Semczuk A,Rechberger T,Adamiak A

更新日期：2016-09-01 00:00:00

abstract：:Considerable work is being carried out on endometrial NK cells to determine whether they play a role in successful pregnancy outcome. In addition there is debate about whether measurements of uNK should be included in the clinical assessment for women with recurrent implantation failure or recurrent miscarriage. A hin...

journal_title：Journal of reproductive immunology

authors： Lash GE,Bulmer JN,Li TC,Innes BA,Mariee N,Patel G,Sanderson J,Quenby S,Laird SM

更新日期：2016-08-01 00:00:00

abstract：:The main message of this work is the fact that female sex hormones, progesterone and estradiol, whose levels significantly rise during pregnancy, inhibit the production of anti-inflammatory cytokine IL-10 with no apparent effect on pro-inflammatory cytokine TNF-α by activated MZ B cells. This is an important piece of ...

journal_title：Journal of reproductive immunology

authors： Bommer I,Muzzio DO,Zygmunt M,Jensen F

更新日期：2016-08-01 00:00:00

abstract：:Although inflammation is associated with risk of gestational diabetes mellitus (GDM), little is known if there is an association between inflammation and GDM in African-American women, a group at higher risk for GDM complications. In the present study, we aimed to determine if selected inflammatory cytokines (i.e. TNF...

journal_title：Journal of reproductive immunology

authors： Bossick AS,Peters RM,Burmeister C,Kakumanu N,Shill JE,Cassidy-Bushrow AE

更新日期：2016-06-01 00:00:00

abstract：:In oocyte donation (OD) pregnancies, a fetus is a complete allograft to the maternal host and OD pregnancies are an independent risk factor for preeclampsia. Immunocompetent cells contribute to spiral artery remodeling and the failure of this process could contribute to the pathophysiology of preeclampsia. Recent data...

journal_title：Journal of reproductive immunology

authors： Nakabayashi Y,Nakashima A,Yoshino O,Shima T,Shiozaki A,Adachi T,Nakabayashi M,Okai T,Kushima M,Saito S

更新日期：2016-04-01 00:00:00

abstract：:Galectin-1 (gal-1), a member of a family of conserved β-galactoside-binding proteins, has been shown to exert a key role during gestation. Though gal-1 is expressed at higher levels in the placenta from HELLP patients, it is still poorly understood whether systemic gal-1 levels also differ in HELLP patients. In the pr...

journal_title：Journal of reproductive immunology

authors： Schnabel A,Blois SM,Meint P,Freitag N,Ernst W,Barrientos G,Conrad ML,Rose M,Seelbach-Göbel B

更新日期：2016-04-01 00:00:00

abstract：:We aimed to investigate if women with recurrent miscarriage disclosed abnormalities in the maturation and activation status of peripheral blood lymphocyte subsets. In a case control study, 24 women with recurrent miscarriage, 37 women with children but no history of miscarriage and 39 women without previous pregnancie...

journal_title：Journal of reproductive immunology

authors： Carbone J,Sarmiento E,Gallego A,Lanio N,Navarro J,García S,Fernandez-Cruz E

更新日期：2016-02-01 00:00:00

abstract：:In vitro fertilization (IVF) pregnancies potentially have a higher rate of preterm delivery (PTD) than do spontaneously conceived gestations, and differences persist following adjustment for multiple gestation, maternal age, and parity. The reasons for this increased susceptibility to PTD remain incompletely elucidate...

journal_title：Journal of reproductive immunology

authors： Kanninen TT,Sisti G,Ramer I,Goldschlag D,Witkin SS,Spandorfer SD

更新日期：2015-11-01 00:00:00

abstract：:Visfatin (PBEF/Nampt) is an adipocytokine that exerts pleiotropic effects within the human body, particularly affecting its metabolism and immunity. Visfatin was originally identified as being secreted by peripheral blood lymphocytes acting as a pre-B-cell colony-enhancing factor (PBEF). However, it was subsequently r...

journal_title：Journal of reproductive immunology

authors： Pavlová T,Novák J,Bienertová-Vašků J

更新日期：2015-11-01 00:00:00

abstract：:The aim of the study was to evaluate the effect of pregnancy on the production of donor- and nondonor-specific anti-human leukocyte antigen antibodies (anti-HLA Abs) in organ allograft recipients. The study group included four pregnant kidney (RT) and four liver (LT) transplant recipients. The genotype of HLA class I ...

journal_title：Journal of reproductive immunology

authors： Cyganek A,Nowaczyk M,Sańko-Resmer J,Pietrzak B,Grzechocińska B,Pączek L,Międzybrodzki R,Wielgoś M

更新日期：2015-11-01 00:00:00

abstract：:Decidual stromal cells (DSCs) are an important component of decidual tissues where they are in strict proximity with immune cells. Although previous research has indicated that DSCs participate in the regulation of immune cells during pregnancy, the crosstalk between DSCs and decidual NK cells (dNKs) has not been full...

journal_title：Journal of reproductive immunology

authors： Hu WT,Huang LL,Li MQ,Jin LP,Li DJ,Zhu XY

更新日期：2015-06-01 00:00:00

abstract：:Reproductive immunology applies general immunology principles to specialised targets, reproduction and development. The involvement of colony-stimulating factors (CSFs) in reproduction illustrates this. The CSF family includes CSF-1 or macrophage CSF (M-CSF), CSF-2 or granulocyte macrophage CSF (GM-CSF), and CSF-3 or ...

journal_title：Journal of reproductive immunology

authors： Rahmati M,Petitbarat M,Dubanchet S,Bensussan A,Chaouat G,Ledee N

更新日期：2015-06-01 00:00:00