abstract：OBJECTIVE:Previous studies have shown that air pollution exposure primes the body to heightened responses to everyday stressors of the cardiovascular system. The purpose of this study was to examine the utility of postprandial responses to a high carbohydrate oral load, a cardiometabolic stressor long used to predict c...

journal_title：Inhalation toxicology

authors： Martin BL,Thompson LC,Kim YH,Snow SJ,Schladweiler MC,Phillips P,Harmon M,King C,Richards J,George I,W Kyle Martin,Haykal-Coates N,Gilmour MI,Kodavanti UP,Hazari MS,Farraj AK

更新日期：2020-07-01 00:00:00

abstract：:Background: Allergies and smoking are common reasons for nasal mucosa inflammations, which in turn, cause nasal obstructions. Nevertheless, the impact of coexisting allergies and smoking on nasal mucosa inflammation has not been studied.Objectives: To study the impact of smoking with relation to allergies on nasal muc...

journal_title：Inhalation toxicology

authors： Warman M,Tiomkin E,Huszar M,Halperin D,Asher I,Cohen O

更新日期：2020-05-01 00:00:00

abstract：:Background: High-mobility group box 1 (HMGB1) protein plays an important pathogenic role in various diseases such as pulmonary fibrosis. However, the relationship between variation of HMGB1 gene and susceptibility to coal worker's pneumoconiosis (CWP) remains unclear. The objective of the study was to determine the as...

journal_title：Inhalation toxicology

authors： Tang Y,Duan J,Wang Y,Yuan L

更新日期：2020-03-01 00:00:00

abstract：:Background: While the role of lysosomal membrane permeabilization (LMP) in NP-induced inflammatory responses has been recognized, the underlying mechanism of LMP is still unclear. The assumption has been that zinc oxide (ZnO)-induced LMP is due to Zn2+; however, little is known about the role of ZnO nanoparticles (NP)...

journal_title：Inhalation toxicology

authors： Ziglari T,Anderson DS,Holian A

更新日期：2020-02-01 00:00:00

abstract：:Objective: Cigarette tobacco smoking has been shown to cause cancer through different mechanisms that include epigenetic modulation of tumor-suppressor genes. In the present study, the association between global and MLH1 gene promoter methylation and waterpipe tobacco smoking was investigated. Materials and Methods: B...

journal_title：Inhalation toxicology

authors： Sabi SH,Khabour OF,Alzoubi KH,Cobb CO,Eissenberg T

更新日期：2020-02-01 00:00:00

abstract：:Objective: Ethanol is used as a solvent for flavoring chemicals in some electronic cigarette (e-cigarette) liquids (e-liquids). However, there are limited data available regarding the effects of inhalation of ethanol on blood alcohol concentration (BAC) during e-cigarette use. In this study, a modified physiologically...

journal_title：Inhalation toxicology

authors： More SL,Thornton SA,Maskrey JR,Sharma A,de Gandiaga E,Cheng TJ,Fung ES,Bernal AJ,Madl AK

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Rodents used in scientific research are typically housed in cages containing natural bedding materials. Despite extensive evidence of biological harm from inhaled particulate matter (PM), relatively little work has been performed to measure bedding-generated PM exposure in caged animals used in basic science...

journal_title：Inhalation toxicology

authors： Hudda N,Durant JL,Nemeth A,Mann P,Petitto J,Brugge D,Nephew BC

更新日期：2019-08-01 00:00:00

abstract：:Background: The correlation of physico-chemical properties with mechanisms of toxicity has been proposed as an approach to predict the toxic potential of the vast number of emerging nanomaterials. Although relationships have been established between properties and the acute pulmonary inflammation induced by nanomateri...

journal_title：Inhalation toxicology

authors： Roach KA,Anderson SE,Stefaniak AB,Shane HL,Kodali V,Kashon M,Roberts JR

更新日期：2019-07-01 00:00:00

abstract：:Introduction: Tobacco use is a major risk factor of cardiovascular diseases (CVD) and atherosclerosis in particular. The use of waterpipe smoking (WPS) is increasing due to the misperception that it is less harmful than cigarette smoking due to its flavor and the use of water as a filter. Thus, research that investiga...

journal_title：Inhalation toxicology

authors： Rababa'h AM,Bsoul RW,Alkhatatbeh MJ,Alzoubi KH,Khabour OF

更新日期：2019-02-01 00:00:00

abstract：:Objectives: This follow-up study set out to evaluate the natural course and radiographic progression of silicosis among ceramic workers and describe the risk factors related with disease progression. Materials and methods: We retrospectively analyzed the data of ceramic workers with silicosis who were referred to our ...

journal_title：Inhalation toxicology

authors： Karataş M,Gündüzöz M,Büyükşekerci M,Özakıncı OG,Nadir Öziş T

更新日期：2019-02-01 00:00:00

abstract：:Objectives: To (1) design and build a low-cost exposure chamber system for whole-body exposure of rodents to electronic cigarette aerosol, (2) provide detailed instructions with particular focus on automated e-cigarette activation, and (3) develop a simple mathematical model for aerosol levels in the exposure chamber....

journal_title：Inhalation toxicology

authors： Hilpert M,Ilievski V,Coady M,Andrade-Gutierrez M,Yan B,Chillrud SN,Navas-Acien A,Kleiman NJ

更新日期：2019-01-01 00:00:00

abstract：:Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial ...

journal_title：Inhalation toxicology

authors： Song MK,Kim DI,Lee K

更新日期：2019-01-01 00:00:00

abstract：:Objective: To develop a physiologically based pharmacokinetic (PBPK) model for chloroprene in the mouse, rat and human, relying only on in vitro data to estimate tissue metabolism rates and partitioning, and to apply the model to calculate an inhalation unit risk (IUR) for chloroprene.Materials and methods: Female B6C...

journal_title：Inhalation toxicology

authors： Clewell HJ 3rd,Campbell JL,Van Landingham C,Franzen A,Yoon M,Dodd DE,Andersen ME,Gentry PR

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Dimethyl sulfide (DMS, CAS 75-18-3) is an industrial chemical. It is both an irritant and neurotoxicant that may be life-threatening because of accidental release. The effects of DMS on public health and associated public health response depend on the exposure concentration and duration. However, currently, p...

journal_title：Inhalation toxicology

authors： Demchuk E,Ball SL,Le SL,Prussia AJ

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Worldwide popularity of waterpipe tobacco smoking has increased, including in pregnant women. This study investigates the effect of prenatal waterpipe tobacco smoke (WTS) exposure on airway inflammation in a murine model of asthma of adult offspring mice. MATERIALS AND METHODS:Pregnant BALB/c mice were expos...

journal_title：Inhalation toxicology

authors： Al-Sawalha NA,Al-Bo'ul HF,Alzoubi KH,Khabour OF,Thanawala VJ

更新日期：2017-07-01 00:00:00

abstract：:The primary objective of this study was to correlate the emission of macro and nanoparticles released during the process of metal inert gas/metal active gas (MIG/MAG) of stainless steel with different gas mixtures. Using different gas mixtures with different heat inputs, it was possible to determine fume formation rat...

journal_title：Inhalation toxicology

authors： Pacheco RP,Gomes JF,Miranda RM,Quintino ML

更新日期：2017-05-01 00:00:00

abstract：:Epidemiological and experimental data suggest that obesity exacerbates the health effects of air pollutants such as ozone (O3). Maternal inactivity and calorically rich diets lead to offspring that show signs of obesity. Exacerbated O3 susceptibility of offspring could thus be manifested by maternal obesity. Thirty-da...

journal_title：Inhalation toxicology

authors： Gordon CJ,Phillips PM,Johnstone AFM,Schmid J,Schladweiler MC,Ledbetter A,Snow SJ,Kodavanti UP

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Due to some historical (and inaccurate) reports that asbestos might be present in some cosmetic talc products, questions are occasionally raised regarding the potential pleural mesothelioma risks associated with cosmetic talc products. Our objective was to determine the incidence of pleural mesothelioma of in...

journal_title：Inhalation toxicology

authors： Finley BL,Benson SM,Marsh GM

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:There has been an increase in the popularity of waterpipe tobacco smoking (WTS) worldwide, especially in the younger population, including asthma patients. In this study, we investigated the effects of waterpipe smoking on airway inflammation, cytokine levels and oxidative stress markers in an antigen-driven ...

journal_title：Inhalation toxicology

authors： Al-Sawalha NA,Migdadi AM,Alzoubi KH,Khabour OF,Qinna NA

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Epidemiologic studies have linked inhalation of air pollutants such as ozone to cardiovascular mortality. Human exposure studies have shown that inhalation of ambient levels of ozone causes airway and systemic inflammation and an imbalance in sympathetic/parasympathetic tone. METHODS:To explore molecular me...

journal_title：Inhalation toxicology

authors： Tham A,Lullo D,Dalton S,Zeng S,van Koeverden I,Arjomandi M

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:Mucociliary clearance sustains a baseline functionality and an "on demand" capability to upregulate clearance upon irritant exposure involving mucus hypersecretion and accelerated ciliary beat frequency (CBF) modulated by nitric oxide (NO). This study characterized these elements as well as cellular and exoge...

journal_title：Inhalation toxicology

authors： Carson JL,Zhou L,Brighton L,Mills KH,Zhou H,Jaspers I,Hazucha M

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS:In order to identify a gr...

journal_title：Inhalation toxicology

authors： Świątkowska B,Szeszenia-Dąbrowska N

更新日期：2017-01-01 00:00:00

abstract：:The C9 alkylbenzenes, composed mostly of ethyltoluenes and trimethylbenzenes, comprise 75-90% of the naphtha fraction of crude oil. Occupational and environmental exposure to C9 alkylbenzenes occur via inhalation. We conducted short-term inhalation studies on the ethyltoluene isomers (2-, 3- or 4-) to select one isome...

journal_title：Inhalation toxicology

authors： Roberts GK,Willson CJ,Olivera DS,Malarkey DE,Morgan DL

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:This study aimed to investigate whether increased carboxyhemoglobin (COHB) levels and ECG changes, which associated with fatal ventricular dysrhythmias, including increased QT, P-wave and T peak (Tp)-Tend (Te) dispersion, can be detected after smoking narghile, which is a traditional method of smoking tobacco t...

journal_title：Inhalation toxicology

authors： Yıldırım F,Çevik Y,Emektar E,Çorbacıoğlu ŞK,Katırcı Y

更新日期：2016-10-01 00:00:00

abstract：:The purpose of this work is to define a sample preparation protocol that allows inorganic fibers and particulate matter extracted from different biological samples to be characterized morphologically, crystallographically and chemically by transmission electron microscopy-energy dispersive spectroscopy (TEM-EDS). The ...

journal_title：Inhalation toxicology

authors： Vigliaturo R,Capella S,Rinaudo C,Belluso E

更新日期：2016-07-01 00:00:00

abstract：:Epidemiological studies suggest that diabetics may be more susceptible to the adverse health effects from exposure to high ambient concentrations of ozone, the primary oxidant gas in photochemical smog. While increased morbidity and mortality from ozone inhalation has been linked to disruption of normal cardiovascular...

journal_title：Inhalation toxicology

authors： Ying Z,Allen K,Zhong J,Chen M,Williams KM,Wagner JG,Lewandowski R,Sun Q,Rajagopalan S,Harkema JR

更新日期：2016-01-01 00:00:00

abstract：:Diesel engine exhaust (DEE), a ubiquitous environmental pollutant, has been associated with adverse health effects. Revelation of cellular and molecular changes is critical for understanding environmental exposure-related diseases. Although the molecular-level effects of DEE exposure have been investigated, whether it...

journal_title：Inhalation toxicology

authors： Zhang X,Xiao X,Duan H,Gao F,Li Y,Niu Y,Gao W,Wang H,Yu S,Zheng Y

更新日期：2016-01-01 00:00:00

abstract：:Acute exposure to ambient fine particulate matter (PM2.5) is tied to cardiovascular morbidity and mortality, especially among those with prior cardiac injury. The mechanisms and pathophysiological events precipitating these outcomes remain poorly understood but may involve inflammation, oxidative stress, arrhythmia an...

journal_title：Inhalation toxicology

authors： Carll AP,Haykal-Coates N,Winsett DW,Hazari MS,Ledbetter AD,Richards JH,Cascio WE,Costa DL,Farraj AK

更新日期：2015-02-01 00:00:00

abstract：CONTEXT:Air pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, the major organ that senses changes in arterial oxygen...

journal_title：Inhalation toxicology

authors： Perez CM,Hazari MS,Ledbetter AD,Haykal-Coates N,Carll AP,Cascio WE,Winsett DW,Costa DL,Farraj AK

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in diffe...

journal_title：Inhalation toxicology

authors： Fagundes LS,Fleck Ada S,Zanchi AC,Saldiva PH,Rhoden CR

更新日期：2015-01-01 00:00:00

abstract：:This study aims to investigate the negative effects of chronic exposure to isoflurane on spermatogenesis and explore the underlying mechanisms. Sixty male rats were randomly allocated to two groups: control group, receiving no treatment, and anesthesia group, administrated exposure to isoflurane (2 ppm) for 25 consecu...

journal_title：Inhalation toxicology

authors： Ding Y,Yu J,Qu P,Ma P,Yu Z

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:This research describes a novel "minitower" dry powder delivery system for nose-only delivery of dry powder aerosols to spontaneously breathing rats. METHODS:The minitower system forces pressurized air through pre-filled capsules to deliver aerosolized drug to four nose ports; three of which house spontaneousl...

journal_title：Inhalation toxicology

authors： Sellers S,Horodnik W,House A,Wylie J,Mauser P,Donovan B

更新日期：2015-01-01 00:00:00

abstract：:Biodiesel made from the transesterification of plant- and animal-derived oils is an important alternative fuel source for diesel engines. Although numerous studies have reported health effects associated with petroleum diesel emissions, information on biodiesel emissions are more limited. To this end, a program at the...

journal_title：Inhalation toxicology

authors： Mutlu E,Nash DG,King C,Krantz TQ,Preston WT,Kooter IM,Higuchi M,DeMarini D,Linak WP,Gilmour MI

更新日期：2015-01-01 00:00:00

abstract：:The molecular bases for variability in air pollutant-induced pulmonary injury due to underlying cardiovascular (CVD) and/or metabolic diseases are unknown. We hypothesized that healthy and genetic CVD-prone rat models will exhibit exacerbated response to acute ozone exposure dependent on the type and severity of disea...

journal_title：Inhalation toxicology

authors： Kodavanti UP,Ledbetter AD,Thomas RF,Richards JE,Ward WO,Schladweiler MC,Costa DL

更新日期：2015-01-01 00:00:00

abstract：:A number of Norwegian soldiers have reported health problems after live-fire training using the HK416 rifle. The objective of this study was to characterize gaseous and particulate emissions from three different types of ammunition, and record the health effects after exposure to emissions from live-firing. Fifty-five...

journal_title：Inhalation toxicology

authors： Voie Ø,Borander AK,Sikkeland LI,Grahnstedt S,Johnsen A,Danielsen TE,Longva K,Kongerud J

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:The toxicity of multi-walled carbon nanotubes (MWCNT) may be related to the immune system. The objective of this study was to obtain information for immunotoxic mechanisms of MWCNT in situ. METHODS:Using whole-body inhalation, male and female rats were exposed to 0, 0.2, 1 or 5 mg MWCNT/m³ for 13 weeks. The...

journal_title：Inhalation toxicology

authors： Kido T,Tsunoda M,Kasai T,Sasaki T,Umeda Y,Senoh H,Yanagisawa H,Asakura M,Aizawa Y,Fukushima S

更新日期：2014-10-01 00:00:00

abstract：:An approach to identify causal components of complex air pollution mixtures was explored. Rats and mice were exposed by inhalation 6 h daily for 1 week or 6 months to dilutions of simulated downwind coal emissions, diesel and gasoline exhausts and wood smoke. Organ weights, hematology, serum chemistry, bronchoalveolar...

journal_title：Inhalation toxicology

authors： Mauderly JL,Seilkop SK

更新日期：2014-09-01 00:00:00

abstract：CONTEXT:Sulfur mustard exposure, as the most widely used chemical weapon, can lead to acute and long-term pulmonary complications via various pathways, such as triggering an imbalance between the oxidant and antioxidant system. Currently, there is no validated antidote, chemoprophylaxis and curative modality for pulmon...

journal_title：Inhalation toxicology

authors： Shohrati M,Karimzadeh I,Saburi A,Khalili H,Ghanei M

更新日期：2014-08-01 00:00:00

abstract：:Antisense oligonucleotides (ASOs) bind and facilitate degradation of RNA and inhibit protein expression in pathways not easily targeted with small molecules or antibodies. Interleukin (IL)-4 and IL-13 potentiate signaling through the shared IL-4 receptor-α (IL-4Rα) subunit of their receptors. ASO targeting of IL-4Rα m...

journal_title：Inhalation toxicology

authors： Fey RA,Templin MV,McDonald JD,Yu RZ,Hutt JA,Gigliotti AP,Henry SP,Reed MD

更新日期：2014-07-01 00:00:00

abstract：:The World Health Organization identified urban outdoor air pollution as the eighth highest mortality risk factor in high-income countries. Exposure to ambient pollutants such as ozone (O3) increases the number of hospital admissions. O3 is a highly reactive gas that reacts with cells lining the airways, producing the ...

journal_title：Inhalation toxicology

authors： González-Guevara E,Martínez-Lazcano JC,Custodio V,Hernández-Cerón M,Rubio C,Paz C

更新日期：2014-07-01 00:00:00