The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: III. Components of diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions driving non-cancer biological resp

Abstract:

:An approach to identify causal components of complex air pollution mixtures was explored. Rats and mice were exposed by inhalation 6 h daily for 1 week or 6 months to dilutions of simulated downwind coal emissions, diesel and gasoline exhausts and wood smoke. Organ weights, hematology, serum chemistry, bronchoalveolar lavage, central vascular and respiratory allergic responses were measured. Multiple additive regression tree (MART) analysis of the combined database ranked 45 exposure (predictor) variables for importance to models best fitting 47 significant responses. Single-predictor concentration-response data were examined for evidence of single response functions across all exposure groups. Replication of the responses by the combined influences of the two most important predictors was tested. Statistical power was limited by inclusion of only four mixtures, albeit in multiple concentrations each and with particles removed for some groups. Results gave suggestive or strong evidence of causation of 19 of the 47 responses. The top two predictors of the 19 responses included only 12 organic and 6 inorganic species or classes. An increase in red blood cell count of rats by ammonia and pro-atherosclerotic vascular responses of mice by inorganic gases yielded the strongest evidence for causation and the best opportunity for confirmation. The former was a novel finding; the latter was consistent with other results. The results demonstrated the plausibility of identifying putative causal components of highly complex mixtures, given a database in which the ratios of the components are varied sufficiently and exposures and response measurements are conducted using a consistent protocol.

journal_name

Inhal Toxicol

journal_title

Inhalation toxicology

authors

Mauderly JL,Seilkop SK

doi

10.3109/08958378.2014.920440

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

668-90

issue

11

eissn

0895-8378

issn

1091-7691

journal_volume

26

pub_type

杂志文章
  • The in vitro and in vivo investigation of a novel small chamber dry powder inhalation delivery system for preclinical dosing to rats.

    abstract:PURPOSE:This research describes a novel "minitower" dry powder delivery system for nose-only delivery of dry powder aerosols to spontaneously breathing rats. METHODS:The minitower system forces pressurized air through pre-filled capsules to deliver aerosolized drug to four nose ports; three of which house spontaneousl...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2015.1089959

    authors: Sellers S,Horodnik W,House A,Wylie J,Mauser P,Donovan B

    更新日期:2015-01-01 00:00:00

  • Bedding-generated particulate matter: implications for rodent studies.

    abstract:OBJECTIVES:Rodents used in scientific research are typically housed in cages containing natural bedding materials. Despite extensive evidence of biological harm from inhaled particulate matter (PM), relatively little work has been performed to measure bedding-generated PM exposure in caged animals used in basic science...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958378.2019.1694109

    authors: Hudda N,Durant JL,Nemeth A,Mann P,Petitto J,Brugge D,Nephew BC

    更新日期:2019-08-01 00:00:00

  • Chronic Inflammation and Tumor Formation in Rats After Intratracheal Instillation of High Doses of Coal Dusts, Titanium Dioxides, and Quartz.

    abstract::Coal mine dust's possible carcinogenicity has recently drawn attention because of the IARC review of quartz, some new epidemiological data in German coal miners, and findings on other poorly soluble, nontoxic dusts in the rat. The aim of this study was to investigate persistent inflammation and tumor response in the r...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958378.2000.11463217

    authors: Borm PJ,Höhr D,Steinfartz Y,Zeitträger I,Albrecht C

    更新日期:2000-01-01 00:00:00

  • Local and systemic tolerability of a 2'O-methoxyethyl antisense oligonucleotide targeting interleukin-4 receptor-α delivery by inhalation in mouse and monkey.

    abstract::Antisense oligonucleotides (ASOs) bind and facilitate degradation of RNA and inhibit protein expression in pathways not easily targeted with small molecules or antibodies. Interleukin (IL)-4 and IL-13 potentiate signaling through the shared IL-4 receptor-α (IL-4Rα) subunit of their receptors. ASO targeting of IL-4Rα m...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2014.907587

    authors: Fey RA,Templin MV,McDonald JD,Yu RZ,Hutt JA,Gigliotti AP,Henry SP,Reed MD

    更新日期:2014-07-01 00:00:00

  • Particles from wood smoke and road traffic differently affect the innate immune system of the lung.

    abstract::The effect of particles from road traffic and wood smoke on the innate immune response in the lung was studied in a lung challenge model with the intracellular bacterium Listeria monocytogenes. Female Balb/cA mice were instilled intratracheally with wood smoke particles, particles from road traffic collected during wi...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370802590499

    authors: Samuelsen M,Cecilie Nygaard U,Løvik M

    更新日期:2009-09-01 00:00:00

  • Modeling vascular inflammation and atherogenicity after inhalation of ambient levels of ozone: exploratory lessons from transcriptomics.

    abstract:BACKGROUND:Epidemiologic studies have linked inhalation of air pollutants such as ozone to cardiovascular mortality. Human exposure studies have shown that inhalation of ambient levels of ozone causes airway and systemic inflammation and an imbalance in sympathetic/parasympathetic tone. METHODS:To explore molecular me...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章,meta分析

    doi:10.1080/08958378.2017.1310333

    authors: Tham A,Lullo D,Dalton S,Zeng S,van Koeverden I,Arjomandi M

    更新日期:2017-02-01 00:00:00

  • Physiologically based clearance/extraction models for compounds metabolized in the nose: an example with methyl methacrylate.

    abstract::Airstream clearance (with units of volume/time) is the volumetric flow from which chemical would have to be completely removed to account for the net loss in the nose. Extraction is the proportion of airflow from which the chemical is completely removed. Over the past several years we have developed physiologically ba...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370151126284

    authors: Andersen ME,Sarangapani R

    更新日期:2001-05-01 00:00:00

  • Subacute inhalation exposure to ozone induces systemic inflammation but not insulin resistance in a diabetic mouse model.

    abstract::Epidemiological studies suggest that diabetics may be more susceptible to the adverse health effects from exposure to high ambient concentrations of ozone, the primary oxidant gas in photochemical smog. While increased morbidity and mortality from ozone inhalation has been linked to disruption of normal cardiovascular...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2016.1146808

    authors: Ying Z,Allen K,Zhong J,Chen M,Williams KM,Wagner JG,Lewandowski R,Sun Q,Rajagopalan S,Harkema JR

    更新日期:2016-01-01 00:00:00

  • Cross-fostering inhalation toxicity study with HCFC-123 in lactating Sprague-Dawley rats.

    abstract::A study was performed in Sprague-Dawley rats (Crl:CD BR) to differentiate between effects of hydrofluorocarbon 123 (HCFC-123) on the lactating dam or on the fetus using fostering and cross-fostering of the offspring. Pregnant and/or lactating dams without the pups present were exposed to the test substance (1000 ppm) ...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370126866

    authors: Buschmann J,Bartsch W,Dasenbrock C,Fuhst R,Pohlmann G,Preiss A,Berger-Preiss E

    更新日期:2001-08-01 00:00:00

  • Calculated deposition in growing tracheobronchial airways: effect of growth-rate assumptions.

    abstract::Most current deterministic computer dosimetry models use idealized dichotomous symmetrical infant, child, and adolescent tracheobronchial geometries for dosimetry predictions. These tracheobronchial geometries were derived from either the morphometric measurements of J. D. Mortensen and colleagues or those of R. F. Ph...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370600748349

    authors: Oldham MJ,Robinson RJ

    更新日期:2006-09-01 00:00:00

  • Tumorigenicity of cellulose fibers injected into the rat peritoneal cavity.

    abstract::Cellulose fibers, along with many other organic fibers, are durable. Therefore, if inhaled, they have the potential to persist within the lung, and may then cause disease. Here we report the effects of injecting high-purity cellulose fibers into the abdominal cavity of rats. A respirable fraction of cellulose fiber wa...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370290084584

    authors: Cullen RT,Miller BG,Clark S,Davis JM

    更新日期:2002-07-01 00:00:00

  • Air pollution and postneonatal mortality in a tropical city: Kaohsiung, Taiwan.

    abstract::With growing evidence of the association between daily mortality and air pollution in adults, it is important to investigate whether infants are also susceptible to the adverse health effects of ambient air pollutants. The purpose of this study is to examine the relationship between air pollution and postneonatal mort...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370500434214

    authors: Tsai SS,Chen CC,Hsieh HJ,Chang CC,Yang CY

    更新日期:2006-03-01 00:00:00

  • Cardiomyopathy confers susceptibility to particulate matter-induced oxidative stress, vagal dominance, arrhythmia and pulmonary inflammation in heart failure-prone rats.

    abstract::Acute exposure to ambient fine particulate matter (PM2.5) is tied to cardiovascular morbidity and mortality, especially among those with prior cardiac injury. The mechanisms and pathophysiological events precipitating these outcomes remain poorly understood but may involve inflammation, oxidative stress, arrhythmia an...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2014.995387

    authors: Carll AP,Haykal-Coates N,Winsett DW,Hazari MS,Ledbetter AD,Richards JH,Cascio WE,Costa DL,Farraj AK

    更新日期:2015-02-01 00:00:00

  • Health effects of subchronic inhalation exposure to simulated downwind coal combustion emissions.

    abstract:CONTEXT:There have been no animal studies of the health effects of repeated inhalation of mixtures representing downwind pollution from coal combustion. Environmental exposures typically follow atmospheric processing and mixing with pollutants from other sources. OBJECTIVE:This was the fourth study by the National Env...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2011.572932

    authors: Mauderly JL,Barrett EG,Gigliotti AP,McDonald JD,Reed MD,Seagrave J,Mitchell LA,Seilkop SK

    更新日期:2011-05-01 00:00:00

  • Time course for expression of VEGF and its receptor and regulator levels of contraction and relaxation in increased vascular permeability of lung induced by phosgene.

    abstract::Acute lung injury (ALI) induced by phosgene increases risk of serious edema and mortality. Increased permeability of the microvascular endothelium is implicated in the progression of ALI, but the processing interaction and time course activity of the vascular regulators in exudation are still not understood. The main ...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370802015091

    authors: Zhang XD,Hai CX,Cai FL,Liang X,Liu R,Chen HL,Qin XJ,Feng AJ

    更新日期:2008-07-01 00:00:00

  • A review of the toxicology and epidemiology of wollastonite.

    abstract::Wollastonite is a naturally occurring calcium silicate (CaSiO(3)) that is produced in both powder and fibrous forms. It is a valuable industrial mineral used in plastics, ceramics, metallurgical applications, paint, and friction products. For some applications wollastonite serves as an asbestos replacement. To varying...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章,评审

    doi:10.1080/08958370591002030

    authors: Maxim LD,McConnell EE

    更新日期:2005-08-01 00:00:00

  • Increased transforming growth factor beta 1 expression mediates ozone-induced airway fibrosis in mice.

    abstract::Ozone (O₃), a commonly encountered environmental pollutant, has been shown to induce pulmonary fibrosis in different animal models; the underlying mechanism, however, remains elusive. To investigate the molecular mechanism underlying O₃-induced pulmonary fibrosis, 6- to 8-week-old C57BL/6 male mice were exposed to a c...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2011.584919

    authors: Katre A,Ballinger C,Akhter H,Fanucchi M,Kim DK,Postlethwait E,Liu RM

    更新日期:2011-07-01 00:00:00

  • Spores of Aspergillus versicolor isolated from indoor air of a moisture-damaged building provoke acute inflammation in mouse lungs.

    abstract::Microbial growth in moisture-damaged buildings has been associated with respiratory health effects, and the spores of the mycotoxin producing fungus Aspergillus versicolor are frequently present in the indoor air. To characterize the potential of these spores to cause harmful respiratory effects, mice were exposed via...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370290084908

    authors: Jussila J,Komulainen H,Kosma VM,Nevalainen A,Pelkonen J,Hirvonen MR

    更新日期:2002-12-01 00:00:00

  • Calibration study on subchronic inhalation toxicity of man-made vitreous fibers in rats.

    abstract::This 3-mo inhalation study investigated the biological effects of a special-purpose glass microfiber (E-glass microfiber), the stone wool fiber MMVF21, and a new high-temperature application fiber (calcium-magnesium-silicate fiber, CMS) in Wistar rats. Rats were exposed 6 h/day, 5 days/wk for 3 mo to fiber aerosol con...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370390229843

    authors: Bellmann B,Muhle H,Creutzenberg O,Ernst H,Müller M,Bernstein DM,Riego Sintes JM

    更新日期:2003-10-01 00:00:00

  • Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. VI. Gene expression in heart and lung tissue.

    abstract::The purpose of this exploratory study within the integrated subchronic inhalation exposure study (Lippmann et al., 2005) was to identify genes in heart and lung tissue that changed in expression level as a result of subchronic exposure to concentrated ambient particles (CAPs). Identification of CAPs exposure-related c...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370590912851

    authors: Gunnison A,Chen LC

    更新日期:2005-04-01 00:00:00

  • Are airborne refractory ceramic fibers similar to asbestos in their carcinogenicity?

    abstract:BACKGROUND:Animal studies on refractory ceramic fiber (RCF) have led to the suggestion that RCF might resemble asbestos in carcinogenicity. Human data are available to test this hypothesis. METHODS:We compared the occurrence of lung cancer and mesothelioma in 605 men engaged in the manufacture of RCF and followed sinc...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2012.683892

    authors: Walker AM,Maxim LD,Utell MJ

    更新日期:2012-06-01 00:00:00

  • Sulfur mustard vapor effects on differentiated human lung cells.

    abstract:CONTEXT:Sulfur mustard (SM) causes skin blistering and long-term pulmonary dysfunction. Its adverse effects have been studied in battlefield-exposed humans, but lack of knowledge regarding confounding factors makes interpretation challenging. Animal studies are critical to understanding mechanisms, but differences betw...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2010.493901

    authors: Seagrave J,Weber WM,Grotendorst GR

    更新日期:2010-09-01 00:00:00

  • Sensory nerve-mediated nasal vasodilatory response to inspired ethyl acrylate.

    abstract::The irritants acrolein, acetaldehyde, and acetic acid induce a rapid sensory nerve-mediated nasal vasodilatory response in the rat. The aim of the current study was to examine acute nasal sensory nerve-mediated acute responses to an irritant ester vapor, ethyl acrylate. For this purpose, the upper respiratory tract of...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370290084511

    authors: Morris JB

    更新日期:2002-06-01 00:00:00

  • Comparison of high MRI T1 signals with manganese concentration in brains of cynomolgus monkeys after 8 months of stainless steel welding-fume exposure.

    abstract::Several pharmacokinetic studies on inhalation exposure to manganese (Mn) have already demonstrated that Mn readily accumulates in the olfactory and brain regions. However, a shortening of the magnetic resonance imaging (MRI) T1 relaxation time or high T1 signal intensity in specific sites of the brain, including the g...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370701516108

    authors: Park JD,Chung YH,Kim CY,Ha CS,Yang SO,Khang HS,Yu IK,Cheong HK,Lee JS,Song CW,Kwon IH,Han JH,Sung JH,Heo JD,Choi BS,Im R,Jeong J,Yu IJ

    更新日期:2007-09-01 00:00:00

  • Immunotoxicity and hematotoxicity induced by tetrachloroethylene in egyptian dry cleaning workers.

    abstract::The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carried out on 80 adult...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958370902934894

    authors: Emara AM,Abo El-Noor MM,Hassan NA,Wagih AA

    更新日期:2010-02-01 00:00:00

  • Cosmetic talc as a risk factor for pleural mesothelioma: a weight of evidence evaluation of the epidemiology.

    abstract:OBJECTIVE:Due to some historical (and inaccurate) reports that asbestos might be present in some cosmetic talc products, questions are occasionally raised regarding the potential pleural mesothelioma risks associated with cosmetic talc products. Our objective was to determine the incidence of pleural mesothelioma of in...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章,评审

    doi:10.1080/08958378.2017.1336187

    authors: Finley BL,Benson SM,Marsh GM

    更新日期:2017-03-01 00:00:00

  • Effect of growth medium on potential of Streptomyces Anulatus spores to induce inflammatory responses and cytotoxicity in RAW264.7 macrophages.

    abstract::Epidemiological studies have shown an association between microbial growth in buildings and increased risk of respiratory symptoms and disease related to inflammatory reactions in the inhabitants96. The current study examined the affects of growth conditions of Streptomyces anulatus, isolated from indoor air of a mold...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/089583701459065

    authors: Hirvonen MR,Suutari M,Ruotsalainen M,Lignell U,Nevalainen A

    更新日期:2001-01-01 00:00:00

  • Genotoxic potential of respirable bentonite particles with different quartz contents and chemical modifications in human lung fibroblasts.

    abstract::Crystalline silica has been classified as a human carcinogen, but there is still considerable controversy regarding its fibrogenic and carcinogenic potential. In the present study, we investigated the genotoxic potential of bentonite particles (diameter < 10 microm) with an a-quartz content of up to 6% and different c...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370600563524

    authors: Geh S,Shi T,Shokouhi B,Schins RP,Armbruster L,Rettenmeier AW,Dopp E

    更新日期:2006-05-01 00:00:00

  • Influence of exhaled air on inhalation exposure delivered through a directed-flow nose-only exposure system.

    abstract::In order to conserve material that is available in limited quantities, "directed-flow" nose-only exposure systems have at times been run at flow rates close to the minute ventilation of the animal. Such low-flow-rate conditions can contribute to a decrease of test substance concentration in inhaled air; near the anima...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370500282555

    authors: Moss OR,James RA,Asgharian B

    更新日期:2006-01-01 00:00:00

  • Characterization of airborne particles generated from metal active gas welding process.

    abstract::This study is focused on the characterization of particles emitted in the metal active gas welding of carbon steel using mixture of Ar + CO2, and intends to analyze which are the main process parameters that influence the emission itself. It was found that the amount of emitted particles (measured by particle number a...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2014.897400

    authors: Guerreiro C,Gomes JF,Carvalho P,Santos TJ,Miranda RM,Albuquerque P

    更新日期:2014-05-01 00:00:00