Determination of the relative contribution of the non-dissolved fraction of ZnO NP on membrane permeability and cytotoxicity.

abstract：:Epidemiological studies suggest that diabetics may be more susceptible to the adverse health effects from exposure to high ambient concentrations of ozone, the primary oxidant gas in photochemical smog. While increased morbidity and mortality from ozone inhalation has been linked to disruption of normal cardiovascular...

journal_title：Inhalation toxicology

authors： Ying Z,Allen K,Zhong J,Chen M,Williams KM,Wagner JG,Lewandowski R,Sun Q,Rajagopalan S,Harkema JR

更新日期：2016-01-01 00:00:00

abstract：:Species differences in the handling of particles are topics of interest for setting ambient particulate matter standards as well as for studies involving the phenomenon of lung overload and the implications, if any, of such studies for workplace dust exposure standards. The dosimetry of inhaled particles differs among...

journal_title：Inhalation toxicology

authors： Miller FJ

更新日期：2000-01-01 00:00:00

abstract：:Laboratory animals exposed to methyl iodide (MeI) have previously demonstrated lesions of the olfactory epithelium that were associated with local metabolism in the nasal tissues. Interactions of MeI in the nasal passage may, therefore, alter systemic toxicokinetics. The current study used unrestrained plethysmographs...

journal_title：Inhalation toxicology

authors： DeLorme MP,Himmelstein MW,Kemper RA,Kegelman TA,Gargas ML,Kinzell JH

更新日期：2009-05-01 00:00:00

abstract：:The aim of this study was to investigate the potential cytotoxicity of solid lipid nanoparticles (SLN) loaded with sildenafil. The SLNs were tested as a new drug delivery system (DDS) for the inhalable treatment of pulmonary hypertension in human lungs. Solubility of sildenafil in SLN lipid matrix (30:70 phospholipid:...

journal_title：Inhalation toxicology

authors： Paranjpe M,Neuhaus V,Finke JH,Richter C,Gothsch T,Kwade A,Büttgenbach S,Braun A,Müller-Goymann CC

更新日期：2013-08-01 00:00:00

abstract：:The World Health Organization identified urban outdoor air pollution as the eighth highest mortality risk factor in high-income countries. Exposure to ambient pollutants such as ozone (O3) increases the number of hospital admissions. O3 is a highly reactive gas that reacts with cells lining the airways, producing the ...

journal_title：Inhalation toxicology

authors： González-Guevara E,Martínez-Lazcano JC,Custodio V,Hernández-Cerón M,Rubio C,Paz C

更新日期：2014-07-01 00:00:00

abstract：:Several pharmacokinetic studies on inhalation exposure to manganese (Mn) have already demonstrated that Mn readily accumulates in the olfactory and brain regions. However, a shortening of the magnetic resonance imaging (MRI) T1 relaxation time or high T1 signal intensity in specific sites of the brain, including the g...

journal_title：Inhalation toxicology

authors： Park JD,Chung YH,Kim CY,Ha CS,Yang SO,Khang HS,Yu IK,Cheong HK,Lee JS,Song CW,Kwon IH,Han JH,Sung JH,Heo JD,Choi BS,Im R,Jeong J,Yu IJ

更新日期：2007-09-01 00:00:00

abstract：CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...

journal_title：Inhalation toxicology

authors： Ramos-Bonilla JP,Breysse PN,Dominici F,Geyh A,Tankersley CG

更新日期：2010-03-01 00:00:00

abstract：:During the "Commonwealth Games" 2010 (CWG-2010) in Delhi, the Indian government has implemented an ambitious project "System of Air quality Forecasting And Research (SAFAR)" for monitoring and forecasting air-quality scenario. Using high-precision spatio-temporal measurements of criteria pollutants from the SAFAR netw...

journal_title：Inhalation toxicology

authors： Chate D,Beig G,Satpute T,Sahu SK,Ali K,Parkhi N,Ghude S

更新日期：2013-05-01 00:00:00

abstract：:Nano-sized particles (NSPs) have a diameter of less than 100 nm. When inhaled, they preferentially deposit in the deeper lung, where pulmonary surfactant covers the thin aqueous lining layer. Thus, pulmonary surfactant is the initial contact where NSPs impinge. This can lead to various consequences. For example, bindi...

journal_title：Inhalation toxicology

authors： Schleh C,Hohlfeld JM

更新日期：2009-07-01 00:00:00

abstract：:Cell signaling by pathogenic minerals may initiate the transactivation of genes that are critical to carcinogenesis and fibroproliferative diseases of the lung and pleura. We have shown previously that stimulation of the mitogen-activated protein kinase (MAPK) cascade by asbestos fibers leads to phosphorylation events...

journal_title：Inhalation toxicology

authors： Mossman B,Hubbard A,Shukla A,Timblin CR

更新日期：2000-01-01 00:00:00

abstract：:This article addresses results from a single 4-h and repeated 1- and 4-wk inhalation exposure studies in Wistar rats with vapor and/or aerosol atmospheres of 4-ethoxyaniline (p-phenetidine). Groups of 10 rats/sex were exposed nose-only to mean analytical concentrations of 11.1, 86.2, and 882.6 mg p-phenetidine/m(3) us...

journal_title：Inhalation toxicology

authors： Pauluhn J,Mohr U

更新日期：2001-11-01 00:00:00

abstract：:This study assessed the association between ambient air pollution and daily elementary school absenteeism in Washoe County, NV, between 1996 and 1998. All 57 elementary schools in Washoe County in northern Nevada were included in the data set. There was a total of 27,793 student enrollments during this study period. T...

journal_title：Inhalation toxicology

authors： Chen L,Jennison BL,Yang W,Omaye ST

更新日期：2000-11-01 00:00:00

abstract：:Computational fluid dynamic modeling software has enabled microdosimetry patterns of inhaled toxins and toxicants to be predicted and visualized, and is being used in inhalation toxicology and risk assessment. These predicted microdosimetry patterns in airway structures are derived from predicted airflow patterns with...

journal_title：Inhalation toxicology

authors： Robinson RJ,Snyder P,Oldham MJ

更新日期：2007-05-01 00:00:00

abstract：:Coal mine dust's possible carcinogenicity has recently drawn attention because of the IARC review of quartz, some new epidemiological data in German coal miners, and findings on other poorly soluble, nontoxic dusts in the rat. The aim of this study was to investigate persistent inflammation and tumor response in the r...

journal_title：Inhalation toxicology

authors： Borm PJ,Höhr D,Steinfartz Y,Zeitträger I,Albrecht C

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Numerous studies have found an association between transiently increased particulate matter air pollution and acute adverse cardiovascular health effects; however, the mechanisms underlying these effects are not clear. Translocation of ultra-fine ambient particulate matter has been proposed to play a key role...

journal_title：Inhalation toxicology

authors： Bai N,van Eeden SF

更新日期：2013-11-01 00:00:00

abstract：:Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, the effect of airway irritation by synthetic amorphous silica (SAS) on respiratory allergy to trimellitic anhydride (TMA) was studied. Brown Norway (BN) rats were topically sensitized on...

journal_title：Inhalation toxicology

authors： Arts JH,Schijf MA,Kuper CF

更新日期：2008-08-01 00:00:00

abstract：:Crystalline silica has been classified as a human carcinogen, but there is still considerable controversy regarding its fibrogenic and carcinogenic potential. In the present study, we investigated the genotoxic potential of bentonite particles (diameter < 10 microm) with an a-quartz content of up to 6% and different c...

journal_title：Inhalation toxicology

authors： Geh S,Shi T,Shokouhi B,Schins RP,Armbruster L,Rettenmeier AW,Dopp E

更新日期：2006-05-01 00:00:00

abstract：:Pulmonary tissue injury and repair processes involve complex and coordinated cellular events such as necrosis, inflammation, cell growth/differentiation, apoptosis, and remodeling of extracellular matrix. These processes are regulated by expression of multiple mediator genes. Commercially available microarray blots an...

journal_title：Inhalation toxicology

authors： Nadadur SS,Schladweiler MC,Kodavanti UP

更新日期：2000-12-01 00:00:00

abstract：:Background: Allergies and smoking are common reasons for nasal mucosa inflammations, which in turn, cause nasal obstructions. Nevertheless, the impact of coexisting allergies and smoking on nasal mucosa inflammation has not been studied.Objectives: To study the impact of smoking with relation to allergies on nasal muc...

journal_title：Inhalation toxicology

authors： Warman M,Tiomkin E,Huszar M,Halperin D,Asher I,Cohen O

更新日期：2020-05-01 00:00:00

abstract：CONTEXT:Ambient particulate matter (PM) is associated with acute exacerbations of airflow obstruction. Additionally, elderly individuals are more susceptible to increased functional morbidity following acute PM exposure. OBJECTIVE:The purpose of this study is to determine the aging effects of PM exposure on the respon...

journal_title：Inhalation toxicology

authors： Bennett BA,Mitzner W,Tankersley CG

更新日期：2012-12-01 00:00:00

abstract：:This 3-mo inhalation study investigated the biological effects of a special-purpose glass microfiber (E-glass microfiber), the stone wool fiber MMVF21, and a new high-temperature application fiber (calcium-magnesium-silicate fiber, CMS) in Wistar rats. Rats were exposed 6 h/day, 5 days/wk for 3 mo to fiber aerosol con...

journal_title：Inhalation toxicology

authors： Bellmann B,Muhle H,Creutzenberg O,Ernst H,Müller M,Bernstein DM,Riego Sintes JM

更新日期：2003-10-01 00:00:00

abstract：:Endotoxin causes an inflammation at the bronchial and alveolar level. The inflammation-induced increase in permeability of the bronchoalveolar epithelial barrier is supposed to cause a leakage of pneumoproteins. Therefore, their concentrations are expected to increase in the bloodstream. This study aimed at examining ...

journal_title：Inhalation toxicology

authors： Widmeier S,Bernard A,Tschopp A,Jeggli S,Dumont X,Hilfiker S,Oppliger A,Hotz P

更新日期：2007-04-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of low-level concentrations, under the occupational acceptable limits, of toluene exposure and peptidoglycan (PGN) stimulation on Th1/Th2 immunity in infant mice. Pregnant BALB/c mice and their offspring were exposed to low-level toluene inhalation (0, 5, and ...

journal_title：Inhalation toxicology

authors： Yamamoto S,Win-Shwe TT,Yoshida Y,Kunugita N,Arashidani K,Fujimaki H

更新日期：2009-08-01 00:00:00

abstract：:The application of a proportional-integral-derivative (PID) control algorithm to an inhalation exposure system using a building automation system is described. Previous studies had utilized a control system in which concentration was monitored continuously and adjustments to the generator were made on a continuous bas...

journal_title：Inhalation toxicology

authors： Wong BA

更新日期：2003-07-01 00:00:00

abstract：:Microbial growth in moisture-damaged buildings has been associated with respiratory health effects, and the spores of the mycotoxin producing fungus Aspergillus versicolor are frequently present in the indoor air. To characterize the potential of these spores to cause harmful respiratory effects, mice were exposed via...

journal_title：Inhalation toxicology

authors： Jussila J,Komulainen H,Kosma VM,Nevalainen A,Pelkonen J,Hirvonen MR

更新日期：2002-12-01 00:00:00

abstract：CONTEXT:High malaria burden has led to the increased use of insecticides in the tropics and subtropics. This study thus aimed at assessing the hematological effects alteration of pyrethroid insecticide exposure using the experimental animal model. OBJECTIVE:A commonly available Electric Mosquito-Repellent Liquid pyret...

journal_title：Inhalation toxicology

authors： Al-Damegh MA

更新日期：2013-04-01 00:00:00

abstract：:Objective: Ethanol is used as a solvent for flavoring chemicals in some electronic cigarette (e-cigarette) liquids (e-liquids). However, there are limited data available regarding the effects of inhalation of ethanol on blood alcohol concentration (BAC) during e-cigarette use. In this study, a modified physiologically...

journal_title：Inhalation toxicology

authors： More SL,Thornton SA,Maskrey JR,Sharma A,de Gandiaga E,Cheng TJ,Fung ES,Bernal AJ,Madl AK

更新日期：2020-01-01 00:00:00

abstract：:Increasing evidence suggests a role for a systemic pro-coagulant state in the pathogenesis of cardiac dysfunction subsequent to inhalation of airborne particulate matter (PM). We evaluated platelet activation, systemic cytokines and pulmonary gene expression in mice exposed to concentrated ambient particulate matter (...

journal_title：Inhalation toxicology

authors： Tablin F,den Hartigh LJ,Aung HH,Lame MW,Kleeman MJ,Ham W,Norris JW,Pombo M,Wilson DW

更新日期：2012-07-01 00:00:00

abstract：:Objective: Cigarette tobacco smoking has been shown to cause cancer through different mechanisms that include epigenetic modulation of tumor-suppressor genes. In the present study, the association between global and MLH1 gene promoter methylation and waterpipe tobacco smoking was investigated. Materials and Methods: B...

journal_title：Inhalation toxicology

authors： Sabi SH,Khabour OF,Alzoubi KH,Cobb CO,Eissenberg T

更新日期：2020-02-01 00:00:00

abstract：:Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial ...

journal_title：Inhalation toxicology

authors： Song MK,Kim DI,Lee K

更新日期：2019-01-01 00:00:00