Abstract:
:The aim of the present study was to investigate the effect of low-level concentrations, under the occupational acceptable limits, of toluene exposure and peptidoglycan (PGN) stimulation on Th1/Th2 immunity in infant mice. Pregnant BALB/c mice and their offspring were exposed to low-level toluene inhalation (0, 5, and 50 ppm) for 4 wk (from the late prenatal stage to early postnatal stage) in a whole-body exposure chamber. Some of the pregnant mice and their offspring were stimulated with PGN during toluene exposure. We measured total immunoglobulins of different subclasses in plasma, and production and expression level of cytokines in the lung and spleen, and transcription factors related to Th1/Th2 immunity in the spleen of infant (3 wk old) mice. Exposure of mice to 5 or 50 ppm toluene resulted in increased immunoglobulin (Ig) G1 and decreased IgG2a and IgE antibodies in the plasma; significantly decreased T-bet, GATA-3, and Foxp3 mRNA in the spleen; and a tendency toward decreased interferon (IFN)-gamma mRNA in spleen. Exposure of mice to low-level toluene together with PGN stimulation resulted in decreased IgG1 as well as IgG2a antibodies in the plasma and Foxp3 mRNA in spleen as compared with control or PGN-treated mice. These findings suggest that low-level toluene exposure and PGN stimulation from the late prenatal to early postnatal stage suppressed the splenic parameter related to Th1/Th2 immunity in infant mice.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Yamamoto S,Win-Shwe TT,Yoshida Y,Kunugita N,Arashidani K,Fujimaki Hdoi
10.1080/08958370902798448subject
Has Abstractpub_date
2009-08-01 00:00:00pages
793-802issue
9eissn
0895-8378issn
1091-7691journal_volume
21pub_type
杂志文章abstract::Nasal efficiency for removing fine particles from inhaled air may be affected by variations in nasal structure associated with race. In 11 African American and 11 Caucasian adults (age 18-31 yr) we measured the fractional deposition (DF) of fine particles (1 and 2 mum mass median aerodynamic diameter) (MMAD) for oral ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370500188984
更新日期:2005-11-01 00:00:00
abstract::Epidemiologic studies have provided strong evidence that episodic exposure to ambient particulate matter is associated with increases in morbidity and mortality. These adverse effects have been demonstrated at concentrations far below the National Ambient Air Quality Standard (NAAQS), and thus, the biological plausibi...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583799197276
更新日期:1999-01-01 00:00:00
abstract::Sexually mature male and female Gottingen minipigs were exposed to various concentrations of GB and GF vapor via whole-body inhalation exposures or to liquid GB or GF via intravenous or subcutaneous injections. Vapor inhalation exposures were for 10, 60 or 180 min. Maximum likelihood estimation was used to calculate t...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.872212
更新日期:2014-02-01 00:00:00
abstract::Diagnosis of an exposure to airborne toxicants can be problematic. Phosgene is used widely in industry for the production of many synthetic products, such as polyfoam rubber, plastics, and dyes. Although nearly 100% of the gas is consumed during processing, there is the potential problem of accidental or even intentio...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390197254
更新日期:2003-06-01 00:00:00
abstract::A method for inhalative exposure of minipigs to aerosols and gases has been developed. Minipigs are exposed via mask inhalation to the test substance using a computer-controlled exposure system that permits simultaneous exposure of groups of four animals in parallel to different controlled dose levels. We studied inha...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370150502476
更新日期:2001-03-01 00:00:00
abstract::Results from epidemiology studies have shown statistical associations between ambient air particulate matter (PM) concentrations and mortality/morbidity, particularly among susceptible subpopulations. Although the epidemiology of ambient air PM is compelling, there remains considerable uncertainty in PM risk assessmen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463230
更新日期:2000-01-01 00:00:00
abstract::The Provisional Advisory Level (PAL) protocol was applied to estimate inhalation exposure limits for phosgene (CG). Three levels (PAL 1, PAL 2, and PAL 3), distinguished by severity of toxic effects, are developed for 24-hour, 30-day, 90-day, and 2-year durations of potential drinking water and inhalation exposures fo...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.3109/08958370903202820
更新日期:2009-12-01 00:00:00
abstract::This 3-mo inhalation study investigated the biological effects of a special-purpose glass microfiber (E-glass microfiber), the stone wool fiber MMVF21, and a new high-temperature application fiber (calcium-magnesium-silicate fiber, CMS) in Wistar rats. Rats were exposed 6 h/day, 5 days/wk for 3 mo to fiber aerosol con...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390229843
更新日期:2003-10-01 00:00:00
abstract::This study aims to investigate the negative effects of chronic exposure to isoflurane on spermatogenesis and explore the underlying mechanisms. Sixty male rats were randomly allocated to two groups: control group, receiving no treatment, and anesthesia group, administrated exposure to isoflurane (2 ppm) for 25 consecu...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1080772
更新日期:2015-01-01 00:00:00
abstract::Concurrent exposure to SO(2) and benzo(a)pyrene (B(a)P) resulted in an increased incidence of lung tumors in rodents compared to exposure to B(a)P alone. A synergistic effect on the expression of c-fos and c-jun between SO(2) and B(a)P was observed in lungs after SO(2) and B(a)P exposure. However, tumorigenesis occurs...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370903341891
更新日期:2010-03-01 00:00:00
abstract::We examined the effect of breathing pattern on ozone reaction product content within the respiratory tract. Thirty-four anesthetized, male Wistar rats were exposed to oxygen-18 ((18)O)-labeled ozone at 1.0 ppm for 2 h using a dual-chamber, negative-pressure ventilation system. Frequency was set at 80 (n = 9), 120 (n =...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490264852
更新日期:2004-02-01 00:00:00
abstract::Wollastonite is a naturally occurring calcium silicate (CaSiO(3)) that is produced in both powder and fibrous forms. It is a valuable industrial mineral used in plastics, ceramics, metallurgical applications, paint, and friction products. For some applications wollastonite serves as an asbestos replacement. To varying...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370591002030
更新日期:2005-08-01 00:00:00
abstract::Acute carbon monoxide (CO) poisoning may cause cardiotoxicity. The natriuretic peptides, including atrial natriuretic peptide, brain natriuretic peptide (BNP), N-BNP, and NT-proBNP (N-terminal pro brain natriuretic peptide), are endogenous cardiac hormones that may be secreted upon myocardial stress. The aim of this s...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370500305885
更新日期:2006-02-01 00:00:00
abstract:CONTEXT:Sulfur mustard exposure, as the most widely used chemical weapon, can lead to acute and long-term pulmonary complications via various pathways, such as triggering an imbalance between the oxidant and antioxidant system. Currently, there is no validated antidote, chemoprophylaxis and curative modality for pulmon...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.3109/08958378.2014.920439
更新日期:2014-08-01 00:00:00
abstract::Regulatory guidelines are intended to provide recommendations on ways to achieve greater harmonization in the interpretation and application of technical procedures and requirements for product registration in order to reduce or obviate replication of the testing carried out during the research and development of new ...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.3109/08958378.2012.757400
更新日期:2013-02-01 00:00:00
abstract::The purpose of this exploratory study within the integrated subchronic inhalation exposure study (Lippmann et al., 2005) was to identify genes in heart and lung tissue that changed in expression level as a result of subchronic exposure to concentrated ambient particles (CAPs). Identification of CAPs exposure-related c...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370590912851
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:Numerous studies have found an association between transiently increased particulate matter air pollution and acute adverse cardiovascular health effects; however, the mechanisms underlying these effects are not clear. Translocation of ultra-fine ambient particulate matter has been proposed to play a key role...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.844749
更新日期:2013-11-01 00:00:00
abstract::The effect of particles from road traffic and wood smoke on the innate immune response in the lung was studied in a lung challenge model with the intracellular bacterium Listeria monocytogenes. Female Balb/cA mice were instilled intratracheally with wood smoke particles, particles from road traffic collected during wi...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802590499
更新日期:2009-09-01 00:00:00
abstract::Objective: Cigarette tobacco smoking has been shown to cause cancer through different mechanisms that include epigenetic modulation of tumor-suppressor genes. In the present study, the association between global and MLH1 gene promoter methylation and waterpipe tobacco smoking was investigated. Materials and Methods: B...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1754972
更新日期:2020-02-01 00:00:00
abstract::Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, the effect of airway irritation by synthetic amorphous silica (SAS) on respiratory allergy to trimellitic anhydride (TMA) was studied. Brown Norway (BN) rats were topically sensitized on...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802105371
更新日期:2008-08-01 00:00:00
abstract::Coal mine dust's possible carcinogenicity has recently drawn attention because of the IARC review of quartz, some new epidemiological data in German coal miners, and findings on other poorly soluble, nontoxic dusts in the rat. The aim of this study was to investigate persistent inflammation and tumor response in the r...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463217
更新日期:2000-01-01 00:00:00
abstract:CONTEXT:Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body. OBJECTIVES:To describe the normal lung deposition and 1 week particle retention of indium-111 labeled UF carbo...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.708065
更新日期:2012-08-01 00:00:00
abstract::Manganese (Mn) is ubiquitous in ambient air due to both industrial and crustal sources. It is also a component of the octane-enhancing fuel additive methylcyclopentadienyl manganese tricarbonyl (MMT). The combustion of MMT by the automobile engine results in the formation of Mn particulates including phosphate, sulfat...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370050138003
更新日期:2000-10-01 00:00:00
abstract::Nano-sized particles (NSPs) have a diameter of less than 100 nm. When inhaled, they preferentially deposit in the deeper lung, where pulmonary surfactant covers the thin aqueous lining layer. Thus, pulmonary surfactant is the initial contact where NSPs impinge. This can lead to various consequences. For example, bindi...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370903005744
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS:In order to identify a gr...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2016.1272652
更新日期:2017-01-01 00:00:00
abstract::The understanding of historical ambient asbestos concentrations is critical to exposure mapping and retrospective health impact studies involving asbestos related diseases. Two presentations at the University of Montana Center for Environmental Health Sciences Asbestos Conference (July 28, 2005) introduced novel metho...
journal_title:Inhalation toxicology
pub_type: 历史文章,杂志文章
doi:10.1080/08958370600835138
更新日期:2006-11-01 00:00:00
abstract::Hypersensitivity pneumonitis (HP) represents the immunologically mediated lung disease induced by repeated inhalations of a wide variety of certain finely dispersed organic antigens. In susceptible subjects, these inhalations provoke a hypersensitivity reaction characterized by intense inflammation of the terminal bro...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.827284
更新日期:2013-09-01 00:00:00
abstract::The purpose of this work is to define a sample preparation protocol that allows inorganic fibers and particulate matter extracted from different biological samples to be characterized morphologically, crystallographically and chemically by transmission electron microscopy-energy dispersive spectroscopy (TEM-EDS). The ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2016.1175527
更新日期:2016-07-01 00:00:00
abstract::Ozone (O₃), a commonly encountered environmental pollutant, has been shown to induce pulmonary fibrosis in different animal models; the underlying mechanism, however, remains elusive. To investigate the molecular mechanism underlying O₃-induced pulmonary fibrosis, 6- to 8-week-old C57BL/6 male mice were exposed to a c...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.584919
更新日期:2011-07-01 00:00:00
abstract::Studies have shown associations between acute ambient particulate matter (PM) levels and increases in morbidity and mortality from cardiovascular diseases. We have previously reported in 24 healthy adults that exposure to concentrated ambient particles plus ozone (CAP + O(3)) caused a mean decrease of 0.09 mm in brach...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490439489
更新日期:2004-06-01 00:00:00