Inhalation studies with the Göttingen minipig.

abstract：:Ultrafine particles (diameter < 100 nm) may be important in the health effects of air pollution, in part because of their predicted high respiratory deposition. However, there are few measurements of ultrafine particle deposition during spontaneous breathing. The fractional deposition for the total respiratory tract o...

journal_title：Inhalation toxicology

authors： Daigle CC,Chalupa DC,Gibb FR,Morrow PE,Oberdörster G,Utell MJ,Frampton MW

更新日期：2003-05-01 00:00:00

abstract：:Respiratory disturbances play a central role in chemical warfare nerve agent (CWNA) induced toxicity; they are the starting point of mass casualty and the major cause of death. We developed a microinstillation technique of inhalation exposure to nerve agent VX and assessed lung injury by biochemical analysis of the br...

journal_title：Inhalation toxicology

authors： Graham JR,Wright BS,Rezk PE,Gordon RK,Sciuto AM,Nambiar MP

更新日期：2006-06-01 00:00:00

abstract：:The purpose of this work is to define a sample preparation protocol that allows inorganic fibers and particulate matter extracted from different biological samples to be characterized morphologically, crystallographically and chemically by transmission electron microscopy-energy dispersive spectroscopy (TEM-EDS). The ...

journal_title：Inhalation toxicology

authors： Vigliaturo R,Capella S,Rinaudo C,Belluso E

更新日期：2016-07-01 00:00:00

abstract：:Wollastonite is a naturally occurring calcium silicate (CaSiO(3)) that is produced in both powder and fibrous forms. It is a valuable industrial mineral used in plastics, ceramics, metallurgical applications, paint, and friction products. For some applications wollastonite serves as an asbestos replacement. To varying...

journal_title：Inhalation toxicology

authors： Maxim LD,McConnell EE

更新日期：2005-08-01 00:00:00

abstract：:Although the association between exposure to asbestos fibers and the development of lung cancer and mesothelioma has been well established in humans, the carcinogenic potential of other natural and man-made fibers/particles is not clear. Various in vitro genotoxicity studies have been employed to assess their in vivo ...

journal_title：Inhalation toxicology

authors： Hei TK,Xu A,Louie D,Zhao YL

更新日期：2000-01-01 00:00:00

abstract：:The purpose of this exploratory study within the integrated subchronic inhalation exposure study (Lippmann et al., 2005) was to identify genes in heart and lung tissue that changed in expression level as a result of subchronic exposure to concentrated ambient particles (CAPs). Identification of CAPs exposure-related c...

journal_title：Inhalation toxicology

authors： Gunnison A,Chen LC

更新日期：2005-04-01 00:00:00

abstract：:Biodiesel made from the transesterification of plant- and animal-derived oils is an important alternative fuel source for diesel engines. Although numerous studies have reported health effects associated with petroleum diesel emissions, information on biodiesel emissions are more limited. To this end, a program at the...

journal_title：Inhalation toxicology

authors： Mutlu E,Nash DG,King C,Krantz TQ,Preston WT,Kooter IM,Higuchi M,DeMarini D,Linak WP,Gilmour MI

更新日期：2015-01-01 00:00:00

abstract：:A subchronic, nose-only inhalation study compared the effects of mainstream smoke from a 1R4F research cigarette to that of a 2R4F research cigarette. Male and female rats were exposed for 1 h/day, 5 days/wk, for 13 wk to mainstream smoke at 0, 0.06, 0.20, or 0.80 mg wet total particulate matter per liter of air. Clin...

journal_title：Inhalation toxicology

authors： Higuchi MA,Sagartz J,Shreve WK,Ayres PH

更新日期：2004-01-01 00:00:00

abstract：:In February 2006, an IARC Monographs Working Group reevaluated the carcinogenic hazards to humans of carbon black, titanium dioxide, and talc, which belong to the group of poorly soluble, low-toxicity particles. The review of the relevant literature and the evaluations by the Working Group will be published in Volume ...

journal_title：Inhalation toxicology

authors： Baan RA

更新日期：2007-01-01 00:00:00

abstract：:Vanillin is a flavoring agent used in cigarettes. Previous toxicological examinations of the effects on the addition of vanillin to tobacco used mixtures with several other flavoring agents. In the present work, toxicological comparisons were made of experimental cigarettes containing no added vanillin against otherwi...

journal_title：Inhalation toxicology

authors： Lemus R,Carmines EL,Van Miert E,Coggins CR,Anskeit E,Gerstenberg B,Meisgen TJ,Schramke H,Stabbert R,Völkel H,Terpstra PM

更新日期：2007-06-01 00:00:00

abstract：:With regard to genotoxicity testing and cancer risk assessment, particles and fibers form a rather specific group among all toxicants. First, the physicochemical behavior of fibrous and nonfibrous particles is usually very different from that of nonparticulate, chemical carcinogens. Reactive oxygen species (ROS) are b...

journal_title：Inhalation toxicology

authors： Schins RP

更新日期：2002-01-01 00:00:00

abstract：:Nonhuman primates are often the animal models of choice to study the infectivity and therapy of inhaled infectious agents. Most animal models for inhaled infectious diseases use aerosol/droplets generated by an atomization technique such as a Collison nebulizer that produces particles in the size range of 1 to 3 micro...

journal_title：Inhalation toxicology

authors： Cheng YS,Irshad H,Kuehl P,Holmes TD,Sherwood R,Hobbs CH

更新日期：2008-09-01 00:00:00

abstract：:The Provisional Advisory Level (PAL) protocol was applied to estimate inhalation exposure limits for phosgene (CG). Three levels (PAL 1, PAL 2, and PAL 3), distinguished by severity of toxic effects, are developed for 24-hour, 30-day, 90-day, and 2-year durations of potential drinking water and inhalation exposures fo...

journal_title：Inhalation toxicology

authors： Glass D,McClanahan M,Koller L,Adeshina F

更新日期：2009-12-01 00:00:00

abstract：:Increased lung cancer incidence with workers at the production site of crude silicon carbide (SiC) using the Acheson process has been reported. Several agents derived from the process were discussed as causative factors. Recently concern had been expressed about the presence of cleavage fragments (CFs) in commercial p...

journal_title：Inhalation toxicology

authors： Bruch J,Rehn B,Duval-Arnould G,Efskind J,Röderer G,Sébastian P

更新日期：2014-04-01 00:00:00

abstract：:Concurrent exposure to SO(2) and benzo(a)pyrene (B(a)P) resulted in an increased incidence of lung tumors in rodents compared to exposure to B(a)P alone. A synergistic effect on the expression of c-fos and c-jun between SO(2) and B(a)P was observed in lungs after SO(2) and B(a)P exposure. However, tumorigenesis occurs...

journal_title：Inhalation toxicology

authors： Qin G,Meng Z

更新日期：2010-03-01 00:00:00

abstract：:This study is focused on the characterization of particles emitted in the metal active gas welding of carbon steel using mixture of Ar + CO2, and intends to analyze which are the main process parameters that influence the emission itself. It was found that the amount of emitted particles (measured by particle number a...

journal_title：Inhalation toxicology

authors： Guerreiro C,Gomes JF,Carvalho P,Santos TJ,Miranda RM,Albuquerque P

更新日期：2014-05-01 00:00:00

abstract：:To investigate effects of neurobehavioral disturbances in mice caused by sub-chronic exposure to low-dose volatile organic compounds (VOCs) and the possible mechanism for these effects, 60 male Kunming mice were exposed in 5 similar static chambers, 0 (control) and 4 different doses of VOCs mixture (G1-4) for consecut...

journal_title：Inhalation toxicology

authors： Wang F,Li C,Liu W,Jin Y

更新日期：2014-03-01 00:00:00

abstract：:This study was designed to investigate effects of sulfur dioxide (SO(2)) and its derivatives (bisulfite and sulfite) on the rat blood pressure. The blood pressures of male Wistar rats exposed to SO(2) and its derivatives at various doses were measured. Findings were that: (1) with acute-one time exposure to SO(2) for ...

journal_title：Inhalation toxicology

authors： Meng Z,Geng H,Bai J,Yan G

更新日期：2003-08-01 00:00:00

abstract：:Objectives: This follow-up study set out to evaluate the natural course and radiographic progression of silicosis among ceramic workers and describe the risk factors related with disease progression. Materials and methods: We retrospectively analyzed the data of ceramic workers with silicosis who were referred to our ...

journal_title：Inhalation toxicology

authors： Karataş M,Gündüzöz M,Büyükşekerci M,Özakıncı OG,Nadir Öziş T

更新日期：2019-02-01 00:00:00

abstract：:This article addresses results from a single 4-h and repeated 1- and 4-wk inhalation exposure studies in Wistar rats with vapor and/or aerosol atmospheres of 4-ethoxyaniline (p-phenetidine). Groups of 10 rats/sex were exposed nose-only to mean analytical concentrations of 11.1, 86.2, and 882.6 mg p-phenetidine/m(3) us...

journal_title：Inhalation toxicology

authors： Pauluhn J,Mohr U

更新日期：2001-11-01 00:00:00

abstract：:In order to evaluate the chronic effect of polymerized toner particles on the lung, inflammation- and fibrosis-related genes were analyzed and 8-hydroxydeoxyguanosine (8-OHdG) was examined by using the lung tissue of rats subjected to 24 months of toner inhalation exposure. Wistar female rats were divided into four gr...

journal_title：Inhalation toxicology

authors： Morimoto Y,Hirohashi M,Kasai T,Oyabu T,Ogami A,Myojo T,Murakami M,Nishi K,Kadoya C,Todoroki M,Yamamoto M,Kawai K,Kasai H,Tanaka I

更新日期：2009-09-01 00:00:00

abstract：:Microbial growth in moisture-damaged buildings has been associated with respiratory health effects, and the spores of the mycotoxin producing fungus Aspergillus versicolor are frequently present in the indoor air. To characterize the potential of these spores to cause harmful respiratory effects, mice were exposed via...

journal_title：Inhalation toxicology

authors： Jussila J,Komulainen H,Kosma VM,Nevalainen A,Pelkonen J,Hirvonen MR

更新日期：2002-12-01 00:00:00

abstract：:Sexually mature male and female Gottingen minipigs were exposed to various concentrations of GB and GF vapor via whole-body inhalation exposures or to liquid GB or GF via intravenous or subcutaneous injections. Vapor inhalation exposures were for 10, 60 or 180 min. Maximum likelihood estimation was used to calculate t...

journal_title：Inhalation toxicology

authors： Hulet SW,Sommerville DR,Miller DB,Scotto JA,Muse WT,Burnett DC

更新日期：2014-02-01 00:00:00

abstract：:Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial ...

journal_title：Inhalation toxicology

authors： Song MK,Kim DI,Lee K

更新日期：2019-01-01 00:00:00

abstract：:Diagnosis of an exposure to airborne toxicants can be problematic. Phosgene is used widely in industry for the production of many synthetic products, such as polyfoam rubber, plastics, and dyes. Although nearly 100% of the gas is consumed during processing, there is the potential problem of accidental or even intentio...

journal_title：Inhalation toxicology

authors： Sciuto AM,Clapp DL,Hess ZA,Moran TS

更新日期：2003-06-01 00:00:00

abstract：CONTEXT:High malaria burden has led to the increased use of insecticides in the tropics and subtropics. This study thus aimed at assessing the hematological effects alteration of pyrethroid insecticide exposure using the experimental animal model. OBJECTIVE:A commonly available Electric Mosquito-Repellent Liquid pyret...

journal_title：Inhalation toxicology

authors： Al-Damegh MA

更新日期：2013-04-01 00:00:00

abstract：:Crystalline silica has been classified as a human carcinogen, but there is still considerable controversy regarding its fibrogenic and carcinogenic potential. In the present study, we investigated the genotoxic potential of bentonite particles (diameter < 10 microm) with an a-quartz content of up to 6% and different c...

journal_title：Inhalation toxicology

authors： Geh S,Shi T,Shokouhi B,Schins RP,Armbruster L,Rettenmeier AW,Dopp E

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Worldwide popularity of waterpipe tobacco smoking has increased, including in pregnant women. This study investigates the effect of prenatal waterpipe tobacco smoke (WTS) exposure on airway inflammation in a murine model of asthma of adult offspring mice. MATERIALS AND METHODS:Pregnant BALB/c mice were expos...

journal_title：Inhalation toxicology

authors： Al-Sawalha NA,Al-Bo'ul HF,Alzoubi KH,Khabour OF,Thanawala VJ

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Dimethyl sulfide (DMS, CAS 75-18-3) is an industrial chemical. It is both an irritant and neurotoxicant that may be life-threatening because of accidental release. The effects of DMS on public health and associated public health response depend on the exposure concentration and duration. However, currently, p...

journal_title：Inhalation toxicology

authors： Demchuk E,Ball SL,Le SL,Prussia AJ

更新日期：2018-01-01 00:00:00

abstract：:Nasal efficiency for removing fine particles from inhaled air may be affected by variations in nasal structure associated with race. In 11 African American and 11 Caucasian adults (age 18-31 yr) we measured the fractional deposition (DF) of fine particles (1 and 2 mum mass median aerodynamic diameter) (MMAD) for oral ...

journal_title：Inhalation toxicology

authors： Bennett WD,Zeman KL

更新日期：2005-11-01 00:00:00