Abstract：
:This study was designed to investigate effects of sulfur dioxide (SO(2)) and its derivatives (bisulfite and sulfite) on the rat blood pressure. The blood pressures of male Wistar rats exposed to SO(2) and its derivatives at various doses were measured. Findings were that: (1) with acute-one time exposure to SO(2) for 6 h, the rat blood pressures were lowered in contrast to their controls and their background levels in a dose-dependent manner. (2) There were both a dose-response relationship and a time-response relationship between subchronic SO(2) exposure and the rat blood pressure. For SO(2) exposure at 10 ppm, first the blood pressures decreased significantly with exposure days in contrast to their controls and their background levels, and then these decreases became not significant, suggesting an adaption mechanism might be induced. However, SO(2) exposures at 40 ppm caused significant decreases of the blood pressures during the whole experiment, and no adaptation process was found. (3) SO(2) derivatives (bisulfite and sulfite) also caused the decreases of rat blood pressures in a dose-dependent manner. There are two conclusions: (1) Short-time, even acute one-time, exposure to SO(2) or its derivatives may cause a decrease of blood pressure of the animals in both dose-dependent and time-dependent manners. (2) SO(2) is a systemic toxic agent, not only to the respiratory system. SO(2) can cause at least functional damage to the cardiovascular system.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Meng Z,Geng H,Bai J,Yan Gdoi
10.1080/08958370390215785subject
Has Abstractpub_date
2003-08-01 00:00:00pages
951-9issue
9eissn
0895-8378issn
1091-7691pii
X9UKX4P8YMRMC2MWjournal_volume
15pub_type
杂志文章abstract：:To investigate effects of neurobehavioral disturbances in mice caused by sub-chronic exposure to low-dose volatile organic compounds (VOCs) and the possible mechanism for these effects, 60 male Kunming mice were exposed in 5 similar static chambers, 0 (control) and 4 different doses of VOCs mixture (G1-4) for consecut...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2014.882447
更新日期：2014-03-01 00:00:00
abstract：:This article addresses results from a single 4-h and repeated 1- and 4-wk inhalation exposure studies in Wistar rats with vapor and/or aerosol atmospheres of 4-ethoxyaniline (p-phenetidine). Groups of 10 rats/sex were exposed nose-only to mean analytical concentrations of 11.1, 86.2, and 882.6 mg p-phenetidine/m(3) us...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/089583701753210371
更新日期：2001-11-01 00:00:00
abstract：:Respiratory disturbances play a central role in chemical warfare nerve agent (CWNA) induced toxicity; they are the starting point of mass casualty and the major cause of death. We developed a microinstillation technique of inhalation exposure to nerve agent VX and assessed lung injury by biochemical analysis of the br...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370600602116
更新日期：2006-06-01 00:00:00
abstract：CONTEXT:There have been no animal studies of the health effects of repeated inhalation of mixtures representing downwind pollution from coal combustion. Environmental exposures typically follow atmospheric processing and mixing with pollutants from other sources. OBJECTIVE:This was the fourth study by the National Env...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2011.572932
更新日期：2011-05-01 00:00:00
abstract：:The use of methylcyclopentadienyl manganese tricarbonyl (MMT) in unleaded gasoline has given rise to numerous debates on the potential public health risk associated with manganese emissions. In fact, combustion products are mainly Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. Our research group did sever...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370490277245
更新日期：2004-04-01 00:00:00
abstract：:A number of Norwegian soldiers have reported health problems after live-fire training using the HK416 rifle. The objective of this study was to characterize gaseous and particulate emissions from three different types of ammunition, and record the health effects after exposure to emissions from live-firing. Fifty-five...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2014.970783
更新日期：2014-12-01 00:00:00
abstract：:The lung toxicity of inhalable polymer materials is normally carried out by evaluation of the histopathology responses of rat lungs to repeat, nose-only, exposures of an inhalable aerosol of material in a 13-wk subchronic repeat dose toxicity study. The introduction of transcriptomics into toxicology has allowed the c...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370500444304
更新日期：2006-04-01 00:00:00
abstract：:Tire and road wear particles (TRWP) are a component of ambient particulate matter (PM) produced from the interaction of tires with the roadway. Inhalation of PM has been associated with cardiopulmonary morbidities and mortalities thought to stem from pulmonary inflammation. To determine whether TRWP may contribute to ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2012.730071
更新日期：2012-11-01 00:00:00
abstract：:The Toxicological Evaluation of Realistic Emissions Source Aerosols (TERESA) study was carried out at three US coal-fired power plants to investigate the potential toxicological effects of primary and photochemically aged (secondary) particles using in situ stack emissions. The exposure system designed successfully si...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958371003728040
更新日期：2011-08-01 00:00:00
abstract：:Laboratory animals exposed to methyl iodide (MeI) have previously demonstrated lesions of the olfactory epithelium that were associated with local metabolism in the nasal tissues. Interactions of MeI in the nasal passage may, therefore, alter systemic toxicokinetics. The current study used unrestrained plethysmographs...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802596926
更新日期：2009-05-01 00:00:00
abstract：:The purpose of this work is to define a sample preparation protocol that allows inorganic fibers and particulate matter extracted from different biological samples to be characterized morphologically, crystallographically and chemically by transmission electron microscopy-energy dispersive spectroscopy (TEM-EDS). The ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2016.1175527
更新日期：2016-07-01 00:00:00
abstract：:An approach to identify causal components of complex air pollution mixtures was explored. Rats and mice were exposed by inhalation 6 h daily for 1 week or 6 months to dilutions of simulated downwind coal emissions, diesel and gasoline exhausts and wood smoke. Organ weights, hematology, serum chemistry, bronchoalveolar...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2014.920440
更新日期：2014-09-01 00:00:00
abstract：:Nasal efficiency for removing fine particles from inhaled air may be affected by variations in nasal structure associated with race. In 11 African American and 11 Caucasian adults (age 18-31 yr) we measured the fractional deposition (DF) of fine particles (1 and 2 mum mass median aerodynamic diameter) (MMAD) for oral ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370500188984
更新日期：2005-11-01 00:00:00
abstract：:Cellulose fibers, along with many other organic fibers, are durable. Therefore, if inhaled, they have the potential to persist within the lung, and may then cause disease. Here we report the effects of injecting high-purity cellulose fibers into the abdominal cavity of rats. A respirable fraction of cellulose fiber wa...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370290084584
更新日期：2002-07-01 00:00:00
abstract：:Acute lung injury (ALI) induced by phosgene increases risk of serious edema and mortality. Increased permeability of the microvascular endothelium is implicated in the progression of ALI, but the processing interaction and time course activity of the vascular regulators in exudation are still not understood. The main ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802015091
更新日期：2008-07-01 00:00:00
abstract：:This article addresses results of two 13-wk inhalation toxicity studies in Wistar rats with aerosolized 1,6-hexamethylene diisocyanate (HDI) homopolymers using either the isocyanurate (HDI-IC) type or biuret (HDI-BT) type. Groups of 10 rats/sex/level were exposed nose-only to breathing zone concentrations of 0.5, 3.3,...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370118600
更新日期：2001-06-01 00:00:00
abstract：:Most current deterministic computer dosimetry models use idealized dichotomous symmetrical infant, child, and adolescent tracheobronchial geometries for dosimetry predictions. These tracheobronchial geometries were derived from either the morphometric measurements of J. D. Mortensen and colleagues or those of R. F. Ph...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370600748349
更新日期：2006-09-01 00:00:00
abstract：:Multi-walled carbon nanotubes (MWCNT) have been reported to cause lung pathologies in multiple studies. However, the mechanism responsible for the bioactivity has not been determined. This study used nine different well-characterized MWCNT and examined the outcomes in vitro and in vivo. MWCNT, from a variety of source...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2012.745633
更新日期：2012-12-01 00:00:00
abstract：:The World Health Organization identified urban outdoor air pollution as the eighth highest mortality risk factor in high-income countries. Exposure to ambient pollutants such as ozone (O3) increases the number of hospital admissions. O3 is a highly reactive gas that reacts with cells lining the airways, producing the ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2014.922648
更新日期：2014-07-01 00:00:00
abstract：:A combination of high fuel prices, bus maintenance costs, and the health and safety of school children, along with a consideration of federal and state regulations, prompted Medford Township school district in southern New Jersey to explore the use of alternative fuels, specifically biodiesel. The school district owns...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370701533467
更新日期：2007-09-01 00:00:00
abstract：:Background: The correlation of physico-chemical properties with mechanisms of toxicity has been proposed as an approach to predict the toxic potential of the vast number of emerging nanomaterials. Although relationships have been established between properties and the acute pulmonary inflammation induced by nanomateri...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2019.1680775
更新日期：2019-07-01 00:00:00
abstract：:The effects of low-level ozone exposure (0.08 ppm) on pulmonary function in healthy young adults are well known; however, much less is known about the inflammatory and immunomodulatory effects of low-level ozone in the airways. Techniques such as induced sputum and flow cytometry make it possible to examine airways in...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958371003596587
更新日期：2010-06-01 00:00:00
abstract：CONTEXT:Cocoa-derived ingredients are used in cigarette tobacco. OBJECTIVE:A battery of tests was used to compare toxicity of mainstream smoke from experimental cigarettes containing different added levels of cocoa-derived ingredients. MATERIALS AND METHODS:Five cocoa-derived ingredients chocolate (CH), cocoa (COC), ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2010.542580
更新日期：2011-06-01 00:00:00
abstract：:Chronic exposure to chlorine gas has been shown to cause occupational asthma. Acute inhalation of chlorine is known to cause airway inflammation and induce airway nitric oxide formation. Exhaled nitric oxide may therefore be a marker of airway damage after chlorine gas exposure. After accidental chlorine gas exposure ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370701432157
更新日期：2007-08-01 00:00:00
abstract：:Measurement strategies as well as results from measurements at workplaces are presented. Measurements were performed in research laboratories as well as by companies producing small amounts of nanostructured materials. The work was done in the frame of a BAuA (Bundesanstalt für Arbeitsschutz und Arbeitsmedizin) resear...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370902962317
更新日期：2009-07-01 00:00:00
abstract：:Particle research has been historically closely connected to industrial activities or materials, such as coal, asbestos, man-made mineral fibers, and more recently ambient particulate matter (PM). It is the purpose of this review to combine insights and developments in particle toxicology with the historical context o...
journal_title：Inhalation toxicology
pub_type： 历史文章,杂志文章,评审
doi：10.1080/08958370252809086
更新日期：2002-03-01 00:00:00
abstract：:Regulatory guidelines are intended to provide recommendations on ways to achieve greater harmonization in the interpretation and application of technical procedures and requirements for product registration in order to reduce or obviate replication of the testing carried out during the research and development of new ...
journal_title：Inhalation toxicology
pub_type： 杂志文章,评审
doi：10.3109/08958378.2012.757400
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVE:There has been an increase in the popularity of waterpipe tobacco smoking (WTS) worldwide, especially in the younger population, including asthma patients. In this study, we investigated the effects of waterpipe smoking on airway inflammation, cytokine levels and oxidative stress markers in an antigen-driven ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2017.1280105
更新日期：2017-02-01 00:00:00
abstract：:Computational fluid dynamic modeling software has enabled microdosimetry patterns of inhaled toxins and toxicants to be predicted and visualized, and is being used in inhalation toxicology and risk assessment. These predicted microdosimetry patterns in airway structures are derived from predicted airflow patterns with...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370701260889
更新日期：2007-05-01 00:00:00
abstract：:Biodiesel made from the transesterification of plant- and animal-derived oils is an important alternative fuel source for diesel engines. Although numerous studies have reported health effects associated with petroleum diesel emissions, information on biodiesel emissions are more limited. To this end, a program at the...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2015.1076910
更新日期：2015-01-01 00:00:00
