Abstract:
:In order to evaluate the chronic effect of polymerized toner particles on the lung, inflammation- and fibrosis-related genes were analyzed and 8-hydroxydeoxyguanosine (8-OHdG) was examined by using the lung tissue of rats subjected to 24 months of toner inhalation exposure. Wistar female rats were divided into four groups (5 weeks old, 30 rats in each): the high concentration exposure group (16.3 +/- 0.6 mg/m(3)), the medium concentration exposure group (4.4 +/- 0.3 mg/m(3)), the low concentration exposure group (1.6 +/- 0.2 mg/m(3)), and the control group (clean air). The material used was black toner, and its aerodynamic diameter in the exposure chamber was 3.0 microm. The rats were exposed to the material for 24 months (6 hours/day, 5 days/week) and dissected after the exposure period. RNA was extracted from one lung and the gene expression related to inflammation and fibrosis. Matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase-2 (TIMP-2), and type I collagen were analyzed according to the ratio of each gene/beta-actin. Also, 8-OHdG level in the lung tissue was measured by HPLC with an electrochemical detector. Small fibrotic foci were found in the toner exposed groups; however, progressive or irreversible fibrosis was not found. The incidence of small fibrotic foci and cell aggregation increased in a dose-dependent manner. There were no significant differences of expression of MMP-2, TIMP-2, and type I collagen between the control group and each exposed group. Lung tumors did not develop in each group. A significant production of 8-OHdG was not observed in the toner exposed groups. In conclusion, toner produced by polymerization was not associated with evidence of carcinogenesis in this experiment.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Morimoto Y,Hirohashi M,Kasai T,Oyabu T,Ogami A,Myojo T,Murakami M,Nishi K,Kadoya C,Todoroki M,Yamamoto M,Kawai K,Kasai H,Tanaka Idoi
10.1080/08958370802641938subject
Has Abstractpub_date
2009-09-01 00:00:00pages
898-905issue
11eissn
0895-8378issn
1091-7691journal_volume
21pub_type
杂志文章abstract::It is important to conduct a risk assessment that includes hazard assessment and exposure assessment for the safe production and handling of newly developed nanomaterials. We conducted an inhalation study of a multi-wall carbon nanotube (MWCNT) as a hazard assessment. Male Wistar rats were exposed to well-dispersed MW...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.608096
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abstract::During the "Commonwealth Games" 2010 (CWG-2010) in Delhi, the Indian government has implemented an ambitious project "System of Air quality Forecasting And Research (SAFAR)" for monitoring and forecasting air-quality scenario. Using high-precision spatio-temporal measurements of criteria pollutants from the SAFAR netw...
journal_title:Inhalation toxicology
pub_type: 杂志文章
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journal_title:Inhalation toxicology
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doi:10.1080/08958370590922580
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journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701758304
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abstract::Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, the effect of airway irritation by synthetic amorphous silica (SAS) on respiratory allergy to trimellitic anhydride (TMA) was studied. Brown Norway (BN) rats were topically sensitized on...
journal_title:Inhalation toxicology
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doi:10.1080/08958370802105371
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journal_title:Inhalation toxicology
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doi:10.3109/08958378.2014.984881
更新日期:2015-01-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490264852
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journal_title:Inhalation toxicology
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doi:10.1080/08958370600743027
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journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
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abstract::In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
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journal_title:Inhalation toxicology
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doi:10.3109/08958378.2010.545841
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abstract::Endotoxin causes an inflammation at the bronchial and alveolar level. The inflammation-induced increase in permeability of the bronchoalveolar epithelial barrier is supposed to cause a leakage of pneumoproteins. Therefore, their concentrations are expected to increase in the bloodstream. This study aimed at examining ...
journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
pub_type: 历史文章,杂志文章,评审
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journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
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abstract::In order to conserve material that is available in limited quantities, "directed-flow" nose-only exposure systems have at times been run at flow rates close to the minute ventilation of the animal. Such low-flow-rate conditions can contribute to a decrease of test substance concentration in inhaled air; near the anima...
journal_title:Inhalation toxicology
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journal_title:Inhalation toxicology
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章
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journal_title:Inhalation toxicology
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更新日期:2011-06-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
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journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
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journal_title:Inhalation toxicology
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更新日期:2006-12-01 00:00:00