Abstract:
:Recurrent events, such as repeated hospital admissions for the same health outcome, occur frequently in environmental health studies. In this study, we conducted an analysis of data on repeated respiratory hospitalizations among the elderly in Vancouver, Canada, for the period of June 1, 1995, to March 31, 1999, using a new method proposed by (Dewanji and Moolgavkar 2000, 2002) for recurrent events, and compared it with some traditional methods. In particular, we assessed the impact of ambient gaseous (SO2, NO2, CO, and O3) and particulate pollutants (PM10, PM2.5, and PM10-2.5) as well as the coefficient of haze (CoH) on recurrent respiratory hospital admissions. Using the new procedure, significant associations were found between admissions and 3-day, 5-day, and 7-day moving averages of the ambient SO2 concentrations, with the strongest association observed at the 7-day lag (RR = 1.044, 95% CI: 1.018-1.070). We also found PM10-2.5 for 3-day and 5-day lag to be significant, with the strongest association at 5-day lag (RR = 1.020, 95% CI: 1.001-1.039). No significant associations with admission were found with current day exposure.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Fung KY,Khan S,Krewski D,Chen Ydoi
10.1080/08958370600904538subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1005-11issue
13eissn
0895-8378issn
1091-7691pii
V90550084627X308journal_volume
18pub_type
杂志文章abstract::Objectives: To (1) design and build a low-cost exposure chamber system for whole-body exposure of rodents to electronic cigarette aerosol, (2) provide detailed instructions with particular focus on automated e-cigarette activation, and (3) develop a simple mathematical model for aerosol levels in the exposure chamber....
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2019.1698678
更新日期:2019-01-01 00:00:00
abstract::Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, it was studied whether airway irritation by sulfur dioxide (SO(2)) would enhance respiratory allergic reactions to trimellitic anhydride (TMA), using a rat model. Brown Norway (BN) rats ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370902828468
更新日期:2010-02-01 00:00:00
abstract::In order to evaluate the chronic effect of polymerized toner particles on the lung, inflammation- and fibrosis-related genes were analyzed and 8-hydroxydeoxyguanosine (8-OHdG) was examined by using the lung tissue of rats subjected to 24 months of toner inhalation exposure. Wistar female rats were divided into four gr...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802641938
更新日期:2009-09-01 00:00:00
abstract::Introduction: Tobacco use is a major risk factor of cardiovascular diseases (CVD) and atherosclerosis in particular. The use of waterpipe smoking (WPS) is increasing due to the misperception that it is less harmful than cigarette smoking due to its flavor and the use of water as a filter. Thus, research that investiga...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2019.1606366
更新日期:2019-02-01 00:00:00
abstract::A method for inhalative exposure of minipigs to aerosols and gases has been developed. Minipigs are exposed via mask inhalation to the test substance using a computer-controlled exposure system that permits simultaneous exposure of groups of four animals in parallel to different controlled dose levels. We studied inha...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370150502476
更新日期:2001-03-01 00:00:00
abstract::Computational fluid dynamic modeling software has enabled microdosimetry patterns of inhaled toxins and toxicants to be predicted and visualized, and is being used in inhalation toxicology and risk assessment. These predicted microdosimetry patterns in airway structures are derived from predicted airflow patterns with...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701260889
更新日期:2007-05-01 00:00:00
abstract::Adult Sprague-Dawley (SD) male rats were exposed for a single 3 h period to air, ozone (O₃) or O₃) followed by tobacco smoke (O₃/TS). For pulmonary effects, bronchoalveolar lavage (BAL) cells and fluid were analyzed. Data revealed a significant increase in polymorphonuclear leukocytes (PMN), total protein and albumin ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.751143
更新日期:2013-01-01 00:00:00
abstract::Epidemiological studies of particulate matter (PM) using central area monitors have associated total PM mass, as well as certain individual components of PM, including sulfate, with adverse human health effects. However, some recent studies that used concentrated ambient particles (CAPs) or analyzed the effects of air...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370590885672
更新日期:2005-01-01 00:00:00
abstract::Microbial growth in moisture-damaged buildings has been associated with respiratory health effects, and the spores of the mycotoxin producing fungus Aspergillus versicolor are frequently present in the indoor air. To characterize the potential of these spores to cause harmful respiratory effects, mice were exposed via...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370290084908
更新日期:2002-12-01 00:00:00
abstract:CONTEXT:There have been no animal studies of the health effects of repeated inhalation of mixtures representing downwind pollution from coal combustion. Environmental exposures typically follow atmospheric processing and mixing with pollutants from other sources. OBJECTIVE:This was the fourth study by the National Env...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.572932
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:Previous studies have shown that air pollution exposure primes the body to heightened responses to everyday stressors of the cardiovascular system. The purpose of this study was to examine the utility of postprandial responses to a high carbohydrate oral load, a cardiometabolic stressor long used to predict c...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1809572
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:There has been an increase in the popularity of waterpipe tobacco smoking (WTS) worldwide, especially in the younger population, including asthma patients. In this study, we investigated the effects of waterpipe smoking on airway inflammation, cytokine levels and oxidative stress markers in an antigen-driven ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1280105
更新日期:2017-02-01 00:00:00
abstract::A number of Norwegian soldiers have reported health problems after live-fire training using the HK416 rifle. The objective of this study was to characterize gaseous and particulate emissions from three different types of ammunition, and record the health effects after exposure to emissions from live-firing. Fifty-five...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.970783
更新日期:2014-12-01 00:00:00
abstract::AKR/J mice were exposed to cigarette smoke (CS) and/or lipopolysaccharide (LPS) via inhalation for 3 wk and pulmonary responses were evaluated. The objective was to explore the feasibility of coexposing LPS with cigarette smoke under a subacute exposure, as a surrogate for viral or bacterial insults, that would mimic ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600985784
更新日期:2007-01-01 00:00:00
abstract::Pulmonary tissue injury and repair processes involve complex and coordinated cellular events such as necrosis, inflammation, cell growth/differentiation, apoptosis, and remodeling of extracellular matrix. These processes are regulated by expression of multiple mediator genes. Commercially available microarray blots an...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370050198566
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:Worldwide popularity of waterpipe tobacco smoking has increased, including in pregnant women. This study investigates the effect of prenatal waterpipe tobacco smoke (WTS) exposure on airway inflammation in a murine model of asthma of adult offspring mice. MATERIALS AND METHODS:Pregnant BALB/c mice were expos...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1385113
更新日期:2017-07-01 00:00:00
abstract::The intent of this article is to review the comparative nonneoplastic pathological responses (inflammation, fibrosis, and epithelial proliferation) of rats, hamsters, mice, and monkeys to low-toxicity dusts (TiO(2), carbon black, talc, coal-mine dust, and diesel particulate). The paucity of information on some of thes...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/089583700196563
更新日期:2000-01-01 00:00:00
abstract::Background: Allergies and smoking are common reasons for nasal mucosa inflammations, which in turn, cause nasal obstructions. Nevertheless, the impact of coexisting allergies and smoking on nasal mucosa inflammation has not been studied.Objectives: To study the impact of smoking with relation to allergies on nasal muc...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1777226
更新日期:2020-05-01 00:00:00
abstract::Oxygen radical generation due to surface radicals, inflammation, and iron release has been suggested as the mechanism of adverse effects of quartz, such as emphysema, fibrosis, and carcinogenic effects. Therefore, we measured iron release, acellular generation of hydroxyl radicals, and oxidative DNA damage and cytotox...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583799196628
更新日期:1999-12-01 00:00:00
abstract::Antisense oligonucleotides (ASOs) bind and facilitate degradation of RNA and inhibit protein expression in pathways not easily targeted with small molecules or antibodies. Interleukin (IL)-4 and IL-13 potentiate signaling through the shared IL-4 receptor-α (IL-4Rα) subunit of their receptors. ASO targeting of IL-4Rα m...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.907587
更新日期:2014-07-01 00:00:00
abstract::This study aimed to determine the association between home and vehicle exposure to environmental tobacco smoke (ETS), and chronic bronchitis based on data from 64,961 non-smokers aged 12 years and older who participated in the 2005 Canadian Community Health Survey (CCHS). The proportion of respondents who reported ETS...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802409567
更新日期:2009-02-01 00:00:00
abstract::Results from epidemiology studies have shown statistical associations between ambient air particulate matter (PM) concentrations and mortality/morbidity, particularly among susceptible subpopulations. Although the epidemiology of ambient air PM is compelling, there remains considerable uncertainty in PM risk assessmen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463230
更新日期:2000-01-01 00:00:00
abstract::The understanding of historical ambient asbestos concentrations is critical to exposure mapping and retrospective health impact studies involving asbestos related diseases. Two presentations at the University of Montana Center for Environmental Health Sciences Asbestos Conference (July 28, 2005) introduced novel metho...
journal_title:Inhalation toxicology
pub_type: 历史文章,杂志文章
doi:10.1080/08958370600835138
更新日期:2006-11-01 00:00:00
abstract::Because of the interest attendant to establishing an 8-h ozone (O(3)) federal air quality standard, acute pulmonary function responses to prolonged (6.6 to 8 h) O(3) exposure between 0.08 and 0. 24 ppm have been examined in chamber studies. Given time constraints for O(3) concentration changes in room-sized chambers a...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583700196167
更新日期:2000-04-01 00:00:00
abstract::Sulfur dioxide (SO2) is a common but important air pollutant. Micronuclei (MN) in the polychromatic erythrocytes (PCE) of mouse bone marrow and the ratio between organ and body weight of treatment mouse were determined and analyzed in vivo in order to study injury of sulfur dioxide inhalation on organs and germ plasm ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390226558
更新日期:2003-09-01 00:00:00
abstract:CONTEXT:Ambient particulate matter (PM) is associated with acute exacerbations of airflow obstruction. Additionally, elderly individuals are more susceptible to increased functional morbidity following acute PM exposure. OBJECTIVE:The purpose of this study is to determine the aging effects of PM exposure on the respon...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.731436
更新日期:2012-12-01 00:00:00
abstract::Recent studies have shown that air pollution is a risk factor for hospitalization for pneumonia. However, there is limited evidence to suggest what subpopulations are at greater risk from air pollution. This study was undertaken to examine the modifying effect of specific secondary diagnosis (including hypertension, d...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370902744855
更新日期:2009-11-01 00:00:00
abstract::This special issue describes the scientific progress and scientific review process to develop a safer cigarette. A peer-review panel, the ECLIPSE Expert Panel, was convened to critically review the potential health hazards of this new cigarette to a reference, conventional cigarette that bums tobacco. This new cigaret...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11720735
更新日期:2000-01-01 00:00:00
abstract::Cigarette smoke exposures in mice have been conducted under various exposure conditions using different strains as animal models of smoke-related diseases. We exposed cigarette smoke to two strains of mice [C57BL/6J (C57) and AKR/J (AKR)] under two different exposure regimens (1 h or 4 h/day) at equivalent daily expos...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.596851
更新日期:2011-08-01 00:00:00
abstract::We used inert melamin particles that are very well defined in size (diameters: 0.5, 1.9, 6.8 microm) to study the effects of ambient particles of <10 microm (PM(10)) on phagocytosis. Dose-response functions were found between the amount of added melamin particle mass and the toxicity. Fine particles (0.5 microm) were ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370252871005
更新日期:2002-04-01 00:00:00