Abstract：
:Adult Sprague-Dawley (SD) male rats were exposed for a single 3 h period to air, ozone (O₃) or O₃) followed by tobacco smoke (O₃/TS). For pulmonary effects, bronchoalveolar lavage (BAL) cells and fluid were analyzed. Data revealed a significant increase in polymorphonuclear leukocytes (PMN), total protein and albumin concentrations in the O₃ group, reflecting inflammatory and toxic responses. A subsequent exposure to TS attenuated PMN infiltration into the airspaces and their recovery in the BAL. A similar reduction was observed for BAL protein and albumin in the O₃/TS group, but it was not statistically significant. We also observed a significant increase in BAL total antioxidant capacity following O₃ exposure, suggesting development of protective mechanisms for oxidative stress damage from O₃. Exposure to TS attenuated the levels of total antioxidant capacity. Lung tissue protein analysis showed a significant reduction of extracellular superoxide dismutase (EC-SOD) in the O₃ or O₃/TS group and catalase in the O₃/TS group. TS further altered O₃-induced EC-SOD and catalase protein expression, but the reductions were not significant. For effects in the central nervous system (CNS), we measured striatal dopamine levels by HPLC with electrochemical detection. O₃ exposure produced a nonsignificant decrease in the striatal dopamine content. The effect was partially reversed in the O₃/TS group. Overall, the results show that the toxicity of O₃ in the lung is modulated by TS exposure, and the attenuating trend, though nonsignificant in many cases, is contrary to the synergistic toxicity predicted for TS and O₃, suggesting limited cross-tolerance following such exposures.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Bhoopalan V,Han SG,Shah MM,Thomas DM,Bhalla DKdoi
10.3109/08958378.2012.751143subject
Has Abstractpub_date
2013-01-01 00:00:00pages
21-8issue
1eissn
0895-8378issn
1091-7691journal_volume
25pub_type
杂志文章abstract：:The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carried out on 80 adult...
journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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abstract：:Diesel engine exhaust (DEE), a ubiquitous environmental pollutant, has been associated with adverse health effects. Revelation of cellular and molecular changes is critical for understanding environmental exposure-related diseases. Although the molecular-level effects of DEE exposure have been investigated, whether it...
journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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abstract：PURPOSE:This research describes a novel "minitower" dry powder delivery system for nose-only delivery of dry powder aerosols to spontaneously breathing rats. METHODS:The minitower system forces pressurized air through pre-filled capsules to deliver aerosolized drug to four nose ports; three of which house spontaneousl...
journal_title：Inhalation toxicology
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abstract：:This special issue describes the scientific progress and scientific review process to develop a safer cigarette. A peer-review panel, the ECLIPSE Expert Panel, was convened to critically review the potential health hazards of this new cigarette to a reference, conventional cigarette that bums tobacco. This new cigaret...
journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
pub_type： 杂志文章,评审
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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journal_title：Inhalation toxicology
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abstract：:The purpose of this exploratory study within the integrated subchronic inhalation exposure study (Lippmann et al., 2005) was to identify genes in heart and lung tissue that changed in expression level as a result of subchronic exposure to concentrated ambient particles (CAPs). Identification of CAPs exposure-related c...
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