Biopersistence of inhaled MWCNT in rat lungs in a 4-week well-characterized exposure.

abstract：INTRODUCTION:Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in diffe...

journal_title：Inhalation toxicology

authors： Fagundes LS,Fleck Ada S,Zanchi AC,Saldiva PH,Rhoden CR

更新日期：2015-01-01 00:00:00

abstract：:This article addresses results of two 13-wk inhalation toxicity studies in Wistar rats with aerosolized 1,6-hexamethylene diisocyanate (HDI) homopolymers using either the isocyanurate (HDI-IC) type or biuret (HDI-BT) type. Groups of 10 rats/sex/level were exposed nose-only to breathing zone concentrations of 0.5, 3.3,...

journal_title：Inhalation toxicology

authors： Pauluhn J,Mohr U

更新日期：2001-06-01 00:00:00

abstract：:NASA is planning to build a habitat on the Moon and use the Moon as a stepping stone to Mars. JSC-1, an Arizona volcanic ash that has mineral properties similar to those of lunar soil, is used to produce lunar environments for instrument and equipment testing. NASA is concerned about potential health risks to workers ...

journal_title：Inhalation toxicology

authors： Latch JN,Hamilton RF Jr,Holian A,James JT,Lam CW

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Numerous studies have found an association between transiently increased particulate matter air pollution and acute adverse cardiovascular health effects; however, the mechanisms underlying these effects are not clear. Translocation of ultra-fine ambient particulate matter has been proposed to play a key role...

journal_title：Inhalation toxicology

authors： Bai N,van Eeden SF

更新日期：2013-11-01 00:00:00

abstract：:The molecular bases for variability in air pollutant-induced pulmonary injury due to underlying cardiovascular (CVD) and/or metabolic diseases are unknown. We hypothesized that healthy and genetic CVD-prone rat models will exhibit exacerbated response to acute ozone exposure dependent on the type and severity of disea...

journal_title：Inhalation toxicology

authors： Kodavanti UP,Ledbetter AD,Thomas RF,Richards JE,Ward WO,Schladweiler MC,Costa DL

更新日期：2015-01-01 00:00:00

abstract：:A subchronic, nose-only inhalation study compared the effects of mainstream smoke from a 1R4F research cigarette to that of a 2R4F research cigarette. Male and female rats were exposed for 1 h/day, 5 days/wk, for 13 wk to mainstream smoke at 0, 0.06, 0.20, or 0.80 mg wet total particulate matter per liter of air. Clin...

journal_title：Inhalation toxicology

authors： Higuchi MA,Sagartz J,Shreve WK,Ayres PH

更新日期：2004-01-01 00:00:00

abstract：:The effect of prenatal exposure to diesel exhaust (DE) was investigated. Twenty pregnant ICR mice were exposed to DE at the particle concentration of 1.0 mg/m3, from d 2 until d 16 postcoitum. Male offspring were kept alive until 12 wk of age, and then male reproductive organ weight, daily sperm production (DSP), seru...

journal_title：Inhalation toxicology

authors： Ono N,Oshio S,Niwata Y,Yoshida S,Tsukue N,Sugawara I,Takano H,Takeda K

更新日期：2007-03-01 00:00:00

abstract：:The Toxicological Evaluation of Realistic Emissions Source Aerosols (TERESA) study was carried out at three US coal-fired power plants to investigate the potential toxicological effects of primary and photochemically aged (secondary) particles using in situ stack emissions. The exposure system designed successfully si...

journal_title：Inhalation toxicology

authors： Kang CM,Gupta T,Ruiz PA,Wolfson JM,Ferguson ST,Lawrence JE,Rohr AC,Godleski J,Koutrakis P

更新日期：2011-08-01 00:00:00

abstract：:This article addresses results from a single 4-h and repeated 1- and 4-wk inhalation exposure studies in Wistar rats with vapor and/or aerosol atmospheres of 4-ethoxyaniline (p-phenetidine). Groups of 10 rats/sex were exposed nose-only to mean analytical concentrations of 11.1, 86.2, and 882.6 mg p-phenetidine/m(3) us...

journal_title：Inhalation toxicology

authors： Pauluhn J,Mohr U

更新日期：2001-11-01 00:00:00

abstract：CONTEXT:Sulfur mustard exposure, as the most widely used chemical weapon, can lead to acute and long-term pulmonary complications via various pathways, such as triggering an imbalance between the oxidant and antioxidant system. Currently, there is no validated antidote, chemoprophylaxis and curative modality for pulmon...

journal_title：Inhalation toxicology

authors： Shohrati M,Karimzadeh I,Saburi A,Khalili H,Ghanei M

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:Due to some historical (and inaccurate) reports that asbestos might be present in some cosmetic talc products, questions are occasionally raised regarding the potential pleural mesothelioma risks associated with cosmetic talc products. Our objective was to determine the incidence of pleural mesothelioma of in...

journal_title：Inhalation toxicology

authors： Finley BL,Benson SM,Marsh GM

更新日期：2017-03-01 00:00:00

abstract：:Concurrent exposure to SO(2) and benzo(a)pyrene (B(a)P) resulted in an increased incidence of lung tumors in rodents compared to exposure to B(a)P alone. A synergistic effect on the expression of c-fos and c-jun between SO(2) and B(a)P was observed in lungs after SO(2) and B(a)P exposure. However, tumorigenesis occurs...

journal_title：Inhalation toxicology

authors： Qin G,Meng Z

更新日期：2010-03-01 00:00:00

abstract：:In the evaluation of particulate matter (PM) toxicity, one faces the challenge of identifying components that could be addressed as markers of toxicity. This study examines the use of statistical methods to determine which components present in the complex mixtures are related to toxic effects. The work is based on da...

journal_title：Inhalation toxicology

authors： Alfaro-Moreno E,Ponce-de-León S,Osornio-Vargas AR,García-Cuellar C,Martínez L,Rosas I

更新日期：2007-01-01 00:00:00

abstract：:Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial ...

journal_title：Inhalation toxicology

authors： Song MK,Kim DI,Lee K

更新日期：2019-01-01 00:00:00

abstract：:Objective: To develop a physiologically based pharmacokinetic (PBPK) model for chloroprene in the mouse, rat and human, relying only on in vitro data to estimate tissue metabolism rates and partitioning, and to apply the model to calculate an inhalation unit risk (IUR) for chloroprene.Materials and methods: Female B6C...

journal_title：Inhalation toxicology

authors： Clewell HJ 3rd,Campbell JL,Van Landingham C,Franzen A,Yoon M,Dodd DE,Andersen ME,Gentry PR

更新日期：2019-01-01 00:00:00

abstract：:Laboratory animals exposed to methyl iodide (MeI) have previously demonstrated lesions of the olfactory epithelium that were associated with local metabolism in the nasal tissues. Interactions of MeI in the nasal passage may, therefore, alter systemic toxicokinetics. The current study used unrestrained plethysmographs...

journal_title：Inhalation toxicology

authors： DeLorme MP,Himmelstein MW,Kemper RA,Kegelman TA,Gargas ML,Kinzell JH

更新日期：2009-05-01 00:00:00

abstract：:Washed human erythrocytes were incubated with titanium dioxide (TiO2) particles at 37 degrees C for 1 hr and hemolysis was determined by the percentage of hemoglobin released (optical density at 540 nm; OD540) from the cells. Effects of TiO2 on OD540 were corrected and dose-response curves were analyzed by the Hill pl...

journal_title：Inhalation toxicology

authors： Aisaka Y,Kawaguchi R,Watanabe S,Ikeda M,Igisu H

更新日期：2008-07-01 00:00:00

abstract：:Sexually mature male and female Gottingen minipigs were exposed to various concentrations of GB and GF vapor via whole-body inhalation exposures or to liquid GB or GF via intravenous or subcutaneous injections. Vapor inhalation exposures were for 10, 60 or 180 min. Maximum likelihood estimation was used to calculate t...

journal_title：Inhalation toxicology

authors： Hulet SW,Sommerville DR,Miller DB,Scotto JA,Muse WT,Burnett DC

更新日期：2014-02-01 00:00:00

abstract：:Regulatory guidelines are intended to provide recommendations on ways to achieve greater harmonization in the interpretation and application of technical procedures and requirements for product registration in order to reduce or obviate replication of the testing carried out during the research and development of new ...

journal_title：Inhalation toxicology

authors： Jones DR,Baldrick P

更新日期：2013-02-01 00:00:00

abstract：:Wollastonite is a naturally occurring calcium silicate (CaSiO(3)) that is produced in both powder and fibrous forms. It is a valuable industrial mineral used in plastics, ceramics, metallurgical applications, paint, and friction products. For some applications wollastonite serves as an asbestos replacement. To varying...

journal_title：Inhalation toxicology

authors： Maxim LD,McConnell EE

更新日期：2005-08-01 00:00:00

abstract：:In this article, we review and analyze different modes of exposure to ultrafine particles in order to assess particle-induced inflammatory responses and the underlying mechanisms in vitro and in vivo. Based on results from monocytic cells cultured under submerged conditions, we discuss (1) the impact of particle prope...

journal_title：Inhalation toxicology

authors： Maier KL,Alessandrini F,Beck-Speier I,Hofer TP,Diabaté S,Bitterle E,Stöger T,Jakob T,Behrendt H,Horsch M,Beckers J,Ziesenis A,Hültner L,Frankenberger M,Krauss-Etschmann S,Schulz H

更新日期：2008-02-01 00:00:00

abstract：:Objective: Ethanol is used as a solvent for flavoring chemicals in some electronic cigarette (e-cigarette) liquids (e-liquids). However, there are limited data available regarding the effects of inhalation of ethanol on blood alcohol concentration (BAC) during e-cigarette use. In this study, a modified physiologically...

journal_title：Inhalation toxicology

authors： More SL,Thornton SA,Maskrey JR,Sharma A,de Gandiaga E,Cheng TJ,Fung ES,Bernal AJ,Madl AK

更新日期：2020-01-01 00:00:00

abstract：:This article addresses the importance of blood pressure as a covariate in studies of long-term associations between air quality and mortality. We focus on a cohort of about 50,000 U.S. veterans who had been diagnosed as hypertensive at some time and whose survival rates were predicted by blood pressure (BP) and ambien...

journal_title：Inhalation toxicology

authors： Lipfert FW,Perry HM Jr,Miller JP,Baty JD,Wyzga RE,Carmody SE

更新日期：2003-04-25 00:00:00

abstract：CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...

journal_title：Inhalation toxicology

authors： Ramos-Bonilla JP,Breysse PN,Dominici F,Geyh A,Tankersley CG

更新日期：2010-03-01 00:00:00

abstract：:The effects of low-level ozone exposure (0.08 ppm) on pulmonary function in healthy young adults are well known; however, much less is known about the inflammatory and immunomodulatory effects of low-level ozone in the airways. Techniques such as induced sputum and flow cytometry make it possible to examine airways in...

journal_title：Inhalation toxicology

authors： Alexis NE,Lay JC,Hazucha M,Harris B,Hernandez ML,Bromberg PA,Kehrl H,Diaz-Sanchez D,Kim C,Devlin RB,Peden DB

更新日期：2010-06-01 00:00:00

abstract：:In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...

journal_title：Inhalation toxicology

authors： Stöber W

更新日期：1999-04-01 00:00:00

abstract：:The purpose of this study was to characterize the respiratory effects of single and repeated controlled exposures to clean warm humid and cold dry air in a new model of anesthetized, mechanically ventilated guinea pigs, and to compare findings with known effects in humans. Intratracheal air (T(tr)) and retrotracheal t...

journal_title：Inhalation toxicology

authors： Hälinen AI,Pennanen AS,Salonen RO

更新日期：2000-08-01 00:00:00

abstract：:The irritants acrolein, acetaldehyde, and acetic acid induce a rapid sensory nerve-mediated nasal vasodilatory response in the rat. The aim of the current study was to examine acute nasal sensory nerve-mediated acute responses to an irritant ester vapor, ethyl acrylate. For this purpose, the upper respiratory tract of...

journal_title：Inhalation toxicology

authors： Morris JB

更新日期：2002-06-01 00:00:00

abstract：:In order to evaluate the chronic effect of polymerized toner particles on the lung, inflammation- and fibrosis-related genes were analyzed and 8-hydroxydeoxyguanosine (8-OHdG) was examined by using the lung tissue of rats subjected to 24 months of toner inhalation exposure. Wistar female rats were divided into four gr...

journal_title：Inhalation toxicology

authors： Morimoto Y,Hirohashi M,Kasai T,Oyabu T,Ogami A,Myojo T,Murakami M,Nishi K,Kadoya C,Todoroki M,Yamamoto M,Kawai K,Kasai H,Tanaka I

更新日期：2009-09-01 00:00:00

abstract：:The purpose of this exploratory study within the integrated subchronic inhalation exposure study (Lippmann et al., 2005) was to identify genes in heart and lung tissue that changed in expression level as a result of subchronic exposure to concentrated ambient particles (CAPs). Identification of CAPs exposure-related c...

journal_title：Inhalation toxicology

authors： Gunnison A,Chen LC

更新日期：2005-04-01 00:00:00