Ambient air pollution alters heart rate regulation in aged mice.

abstract：CONTEXT:Air pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, the major organ that senses changes in arterial oxygen...

journal_title：Inhalation toxicology

authors： Perez CM,Hazari MS,Ledbetter AD,Haykal-Coates N,Carll AP,Cascio WE,Winsett DW,Costa DL,Farraj AK

更新日期：2015-01-01 00:00:00

abstract：:A combination of high fuel prices, bus maintenance costs, and the health and safety of school children, along with a consideration of federal and state regulations, prompted Medford Township school district in southern New Jersey to explore the use of alternative fuels, specifically biodiesel. The school district owns...

journal_title：Inhalation toxicology

authors： Biluck J Jr

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Due to some historical (and inaccurate) reports that asbestos might be present in some cosmetic talc products, questions are occasionally raised regarding the potential pleural mesothelioma risks associated with cosmetic talc products. Our objective was to determine the incidence of pleural mesothelioma of in...

journal_title：Inhalation toxicology

authors： Finley BL,Benson SM,Marsh GM

更新日期：2017-03-01 00:00:00

abstract：:The primary objective of this study was to correlate the emission of macro and nanoparticles released during the process of metal inert gas/metal active gas (MIG/MAG) of stainless steel with different gas mixtures. Using different gas mixtures with different heat inputs, it was possible to determine fume formation rat...

journal_title：Inhalation toxicology

authors： Pacheco RP,Gomes JF,Miranda RM,Quintino ML

更新日期：2017-05-01 00:00:00

abstract：:In order to evaluate the chronic effect of polymerized toner particles on the lung, inflammation- and fibrosis-related genes were analyzed and 8-hydroxydeoxyguanosine (8-OHdG) was examined by using the lung tissue of rats subjected to 24 months of toner inhalation exposure. Wistar female rats were divided into four gr...

journal_title：Inhalation toxicology

authors： Morimoto Y,Hirohashi M,Kasai T,Oyabu T,Ogami A,Myojo T,Murakami M,Nishi K,Kadoya C,Todoroki M,Yamamoto M,Kawai K,Kasai H,Tanaka I

更新日期：2009-09-01 00:00:00

abstract：:This article addresses results from a single 4-h and repeated 1- and 4-wk inhalation exposure studies in Wistar rats with vapor and/or aerosol atmospheres of 4-ethoxyaniline (p-phenetidine). Groups of 10 rats/sex were exposed nose-only to mean analytical concentrations of 11.1, 86.2, and 882.6 mg p-phenetidine/m(3) us...

journal_title：Inhalation toxicology

authors： Pauluhn J,Mohr U

更新日期：2001-11-01 00:00:00

abstract：:Continuous environmental or occupational exposure to airborne particulate pollution is believed to be a major hazard for human health. A technique to characterize their deposition and clearance from the lungs is fundamental to understand the underlying mechanisms behind their negative health effects. In this work, we ...

journal_title：Inhalation toxicology

authors： Sanchez-Crespo A,Klepczynska-Nyström A,Lundin A,Larsson BM,Svartengren M

更新日期：2011-02-01 00:00:00

abstract：:Epidemiological and experimental data suggest that obesity exacerbates the health effects of air pollutants such as ozone (O3). Maternal inactivity and calorically rich diets lead to offspring that show signs of obesity. Exacerbated O3 susceptibility of offspring could thus be manifested by maternal obesity. Thirty-da...

journal_title：Inhalation toxicology

authors： Gordon CJ,Phillips PM,Johnstone AFM,Schmid J,Schladweiler MC,Ledbetter A,Snow SJ,Kodavanti UP

更新日期：2017-05-01 00:00:00

abstract：:The Toxicological Evaluation of Realistic Emissions Source Aerosols (TERESA) study was carried out at three US coal-fired power plants to investigate the potential toxicological effects of primary and photochemically aged (secondary) particles using in situ stack emissions. The exposure system designed successfully si...

journal_title：Inhalation toxicology

authors： Kang CM,Gupta T,Ruiz PA,Wolfson JM,Ferguson ST,Lawrence JE,Rohr AC,Godleski J,Koutrakis P

更新日期：2011-08-01 00:00:00

abstract：:Increasing evidence suggests a role for a systemic pro-coagulant state in the pathogenesis of cardiac dysfunction subsequent to inhalation of airborne particulate matter (PM). We evaluated platelet activation, systemic cytokines and pulmonary gene expression in mice exposed to concentrated ambient particulate matter (...

journal_title：Inhalation toxicology

authors： Tablin F,den Hartigh LJ,Aung HH,Lame MW,Kleeman MJ,Ham W,Norris JW,Pombo M,Wilson DW

更新日期：2012-07-01 00:00:00

abstract：:Although the association between exposure to asbestos fibers and the development of lung cancer and mesothelioma has been well established in humans, the carcinogenic potential of other natural and man-made fibers/particles is not clear. Various in vitro genotoxicity studies have been employed to assess their in vivo ...

journal_title：Inhalation toxicology

authors： Hei TK,Xu A,Louie D,Zhao YL

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS:In order to identify a gr...

journal_title：Inhalation toxicology

authors： Świątkowska B,Szeszenia-Dąbrowska N

更新日期：2017-01-01 00:00:00

abstract：:The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carried out on 80 adult...

journal_title：Inhalation toxicology

authors： Emara AM,Abo El-Noor MM,Hassan NA,Wagih AA

更新日期：2010-02-01 00:00:00

abstract：:Propylene glycol mono-t-butyl ether (PGMBE) is a widely used solvent in industry and in consumer products, posing a potential for human exposure via inhalation or dermal routes. Toxicokinetic studies were conducted on F344/N rats and B6C3F1 mice of both sexes to evaluate single or repeated dose, species, and/or sex di...

journal_title：Inhalation toxicology

authors： Dill J,Fuciarelli A,Lee K,Mellinger K,Burka L,Roycroft J

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Increases in particulate matter less than 2.5 µm (PM(2.5)) in ambient air is linked to acute cardiovascular morbidity and mortality. Specific components and potential emission sources of PM(2.5) responsible for adverse health effects of cardiovascular function are unclear. METHODS:Spontaneously hypertensive...

journal_title：Inhalation toxicology

authors： Kamal AS,Rohr AC,Mukherjee B,Morishita M,Keeler GJ,Harkema JR,Wagner JG

更新日期：2011-06-01 00:00:00

abstract：:Epidemiological studies of particulate matter (PM) using central area monitors have associated total PM mass, as well as certain individual components of PM, including sulfate, with adverse human health effects. However, some recent studies that used concentrated ambient particles (CAPs) or analyzed the effects of air...

journal_title：Inhalation toxicology

authors： Grahame T,Schlesinger R

更新日期：2005-01-01 00:00:00

abstract：:Nasal efficiency for removing fine particles from inhaled air may be affected by variations in nasal structure associated with race. In 11 African American and 11 Caucasian adults (age 18-31 yr) we measured the fractional deposition (DF) of fine particles (1 and 2 mum mass median aerodynamic diameter) (MMAD) for oral ...

journal_title：Inhalation toxicology

authors： Bennett WD,Zeman KL

更新日期：2005-11-01 00:00:00

abstract：:Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, it was studied whether airway irritation by sulfur dioxide (SO(2)) would enhance respiratory allergic reactions to trimellitic anhydride (TMA), using a rat model. Brown Norway (BN) rats ...

journal_title：Inhalation toxicology

authors： Arts JH,Jacobs EJ,Kuper CF

更新日期：2010-02-01 00:00:00

abstract：:The lung toxicity of inhalable polymer materials is normally carried out by evaluation of the histopathology responses of rat lungs to repeat, nose-only, exposures of an inhalable aerosol of material in a 13-wk subchronic repeat dose toxicity study. The introduction of transcriptomics into toxicology has allowed the c...

journal_title：Inhalation toxicology

authors： Carthew P,Fletcher S,White A,Harries H,Weber K

更新日期：2006-04-01 00:00:00

abstract：:The authors have previously demonstrated that wildfire-derived coarse or fine particulate matter (PM) intratracheally instilled into lungs of mice induce a strong inflammatory response. In the current study, the authors demonstrate that wildfire PM simultaneously cause major increases in oxidative stress in the mouse ...

journal_title：Inhalation toxicology

authors： Wegesser TC,Franzi LM,Mitloehner FM,Eiguren-Fernandez A,Last JA

更新日期：2010-06-01 00:00:00

abstract：:The application of a proportional-integral-derivative (PID) control algorithm to an inhalation exposure system using a building automation system is described. Previous studies had utilized a control system in which concentration was monitored continuously and adjustments to the generator were made on a continuous bas...

journal_title：Inhalation toxicology

authors： Wong BA

更新日期：2003-07-01 00:00:00

abstract：:We assessed the effects of long-term inhalation of toner on the pathological changes and formation of 8-hydroxydeoxyguanosine (8-OH-Gua) in DNA in a rat model. Female Wistar rats (10 wk old) were divided evenly into a high concentration exposure group (H: 15.2 mg/m(3)), a low concentration exposure group (L: 5.5 mg/m(...

journal_title：Inhalation toxicology

authors： Morimoto Y,Kim H,Oyabu T,Hirohashi M,Nagatomo H,Ogami A,Yamato H,Obata Y,Kasai H,Higashi T,Tanaka I

更新日期：2005-12-01 00:00:00

abstract：:This 3-mo inhalation study investigated the biological effects of a special-purpose glass microfiber (E-glass microfiber), the stone wool fiber MMVF21, and a new high-temperature application fiber (calcium-magnesium-silicate fiber, CMS) in Wistar rats. Rats were exposed 6 h/day, 5 days/wk for 3 mo to fiber aerosol con...

journal_title：Inhalation toxicology

authors： Bellmann B,Muhle H,Creutzenberg O,Ernst H,Müller M,Bernstein DM,Riego Sintes JM

更新日期：2003-10-01 00:00:00

abstract：:In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitreous fibers, but it...

journal_title：Inhalation toxicology

authors： Rödelsperger K

更新日期：2004-10-01 00:00:00

abstract：:Recurrent events, such as repeated hospital admissions for the same health outcome, occur frequently in environmental health studies. In this study, we conducted an analysis of data on repeated respiratory hospitalizations among the elderly in Vancouver, Canada, for the period of June 1, 1995, to March 31, 1999, using...

journal_title：Inhalation toxicology

authors： Fung KY,Khan S,Krewski D,Chen Y

更新日期：2006-12-01 00:00:00

abstract：:In this article, we review and analyze different modes of exposure to ultrafine particles in order to assess particle-induced inflammatory responses and the underlying mechanisms in vitro and in vivo. Based on results from monocytic cells cultured under submerged conditions, we discuss (1) the impact of particle prope...

journal_title：Inhalation toxicology

authors： Maier KL,Alessandrini F,Beck-Speier I,Hofer TP,Diabaté S,Bitterle E,Stöger T,Jakob T,Behrendt H,Horsch M,Beckers J,Ziesenis A,Hültner L,Frankenberger M,Krauss-Etschmann S,Schulz H

更新日期：2008-02-01 00:00:00

abstract：:Background: While the role of lysosomal membrane permeabilization (LMP) in NP-induced inflammatory responses has been recognized, the underlying mechanism of LMP is still unclear. The assumption has been that zinc oxide (ZnO)-induced LMP is due to Zn2+; however, little is known about the role of ZnO nanoparticles (NP)...

journal_title：Inhalation toxicology

authors： Ziglari T,Anderson DS,Holian A

更新日期：2020-02-01 00:00:00

abstract：:Epidemiologic studies have provided strong evidence that episodic exposure to ambient particulate matter is associated with increases in morbidity and mortality. These adverse effects have been demonstrated at concentrations far below the National Ambient Air Quality Standard (NAAQS), and thus, the biological plausibi...

journal_title：Inhalation toxicology

authors： Gordon T,Gerber H,Fang CP,Chen LC

更新日期：1999-01-01 00:00:00

abstract：:A study was performed in Sprague-Dawley rats (Crl:CD BR) to differentiate between effects of hydrofluorocarbon 123 (HCFC-123) on the lactating dam or on the fetus using fostering and cross-fostering of the offspring. Pregnant and/or lactating dams without the pups present were exposed to the test substance (1000 ppm) ...

journal_title：Inhalation toxicology

authors： Buschmann J,Bartsch W,Dasenbrock C,Fuhst R,Pohlmann G,Preiss A,Berger-Preiss E

更新日期：2001-08-01 00:00:00

abstract：:Increased lung cancer incidence with workers at the production site of crude silicon carbide (SiC) using the Acheson process has been reported. Several agents derived from the process were discussed as causative factors. Recently concern had been expressed about the presence of cleavage fragments (CFs) in commercial p...

journal_title：Inhalation toxicology

authors： Bruch J,Rehn B,Duval-Arnould G,Efskind J,Röderer G,Sébastian P

更新日期：2014-04-01 00:00:00