Abstract：
:Concurrent exposure to SO(2) and benzo(a)pyrene (B(a)P) resulted in an increased incidence of lung tumors in rodents compared to exposure to B(a)P alone. A synergistic effect on the expression of c-fos and c-jun between SO(2) and B(a)P was observed in lungs after SO(2) and B(a)P exposure. However, tumorigenesis occurs by multiple events that may involve the activation of more than one oncogene, as well as the functional loss of the tumor suppressor gene. In order to further investigate the interactions between SO(2) and B(a)P, male Wistar rats were exposed via intratracheal instillation of B(a)P (3 mg) or SO(2) (56 mg/m(3)) inhalation, alone or together. The mRNA and protein levels of oncogenes (c-myc and H-ras) and tumor suppressor genes (p53, p16, and Rb) were analyzed in lungs by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot, respectively. The results showed that all treatments increased mRNA and protein expression levels of c-myc, H-ras, and p53, and reduced expression levels of p16 and Rb. In general, the combination of SO(2) and B(a)P was more effective in influencing these expression levels than either agent alone, except for H-ras expression. These findings indicate that multiple cell cycle regulatory proteins play key roles in the toxicity of SO(2) and B(a)P. It might involve the activation of c-fos, c-jun, c-myc, and p53. And the p16-Rb pathway might also participate in the progress. Elucidating the expression patterns of those factors after SO(2) and B(a)P exposure may be critical to understanding the mechanisms of SO(2) cocarcinogenesis and helpful for therapeutic intervention.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Qin G,Meng Zdoi
10.3109/08958370903341891subject
Has Abstractpub_date
2010-03-01 00:00:00pages
322-9issue
4eissn
0895-8378issn
1091-7691journal_volume
22pub_type
杂志文章abstract：:The aim of the present study was to investigate the effect of low-level concentrations, under the occupational acceptable limits, of toluene exposure and peptidoglycan (PGN) stimulation on Th1/Th2 immunity in infant mice. Pregnant BALB/c mice and their offspring were exposed to low-level toluene inhalation (0, 5, and ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370902798448
更新日期：2009-08-01 00:00:00
abstract：:The irritants acrolein, acetaldehyde, and acetic acid induce a rapid sensory nerve-mediated nasal vasodilatory response in the rat. The aim of the current study was to examine acute nasal sensory nerve-mediated acute responses to an irritant ester vapor, ethyl acrylate. For this purpose, the upper respiratory tract of...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370290084511
更新日期：2002-06-01 00:00:00
abstract：:Regulatory guidelines are intended to provide recommendations on ways to achieve greater harmonization in the interpretation and application of technical procedures and requirements for product registration in order to reduce or obviate replication of the testing carried out during the research and development of new ...
journal_title：Inhalation toxicology
pub_type： 杂志文章,评审
doi：10.3109/08958378.2012.757400
更新日期：2013-02-01 00:00:00
abstract：:Sulfur dioxide (SO2) is a common but important air pollutant. Micronuclei (MN) in the polychromatic erythrocytes (PCE) of mouse bone marrow and the ratio between organ and body weight of treatment mouse were determined and analyzed in vivo in order to study injury of sulfur dioxide inhalation on organs and germ plasm ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370390226558
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVE:The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS:In order to identify a gr...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2016.1272652
更新日期：2017-01-01 00:00:00
abstract：:Cigarette smoke exposures in mice have been conducted under various exposure conditions using different strains as animal models of smoke-related diseases. We exposed cigarette smoke to two strains of mice [C57BL/6J (C57) and AKR/J (AKR)] under two different exposure regimens (1 h or 4 h/day) at equivalent daily expos...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2011.596851
更新日期：2011-08-01 00:00:00
abstract：:Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2019.1707912
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:There has been an increase in the popularity of waterpipe tobacco smoking (WTS) worldwide, especially in the younger population, including asthma patients. In this study, we investigated the effects of waterpipe smoking on airway inflammation, cytokine levels and oxidative stress markers in an antigen-driven ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2017.1280105
更新日期：2017-02-01 00:00:00
abstract：:The effects of low-level ozone exposure (0.08 ppm) on pulmonary function in healthy young adults are well known; however, much less is known about the inflammatory and immunomodulatory effects of low-level ozone in the airways. Techniques such as induced sputum and flow cytometry make it possible to examine airways in...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958371003596587
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:Due to some historical (and inaccurate) reports that asbestos might be present in some cosmetic talc products, questions are occasionally raised regarding the potential pleural mesothelioma risks associated with cosmetic talc products. Our objective was to determine the incidence of pleural mesothelioma of in...
journal_title：Inhalation toxicology
pub_type： 杂志文章,评审
doi：10.1080/08958378.2017.1336187
更新日期：2017-03-01 00:00:00
abstract：:This study was designed to investigate effects of sulfur dioxide (SO(2)) and its derivatives (bisulfite and sulfite) on the rat blood pressure. The blood pressures of male Wistar rats exposed to SO(2) and its derivatives at various doses were measured. Findings were that: (1) with acute-one time exposure to SO(2) for ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370390215785
更新日期：2003-08-01 00:00:00
abstract：:Mexico City children are chronically exposed to significant concentrations of air pollutants and exhibit chronic respiratory-tract inflammation. Epidemiological, controlled human exposures, laboratory-based animal models, and in vitro/in vivo studies have shown that inflammatory, endothelial dysfunction, and endotheli...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370701864797
更新日期：2008-03-01 00:00:00
abstract：:The aim of this study was to investigate the potential cytotoxicity of solid lipid nanoparticles (SLN) loaded with sildenafil. The SLNs were tested as a new drug delivery system (DDS) for the inhalable treatment of pulmonary hypertension in human lungs. Solubility of sildenafil in SLN lipid matrix (30:70 phospholipid:...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2013.810315
更新日期：2013-08-01 00:00:00
abstract：:Hypersensitivity pneumonitis (HP) represents the immunologically mediated lung disease induced by repeated inhalations of a wide variety of certain finely dispersed organic antigens. In susceptible subjects, these inhalations provoke a hypersensitivity reaction characterized by intense inflammation of the terminal bro...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2013.827284
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Epidemiologic studies have linked inhalation of air pollutants such as ozone to cardiovascular mortality. Human exposure studies have shown that inhalation of ambient levels of ozone causes airway and systemic inflammation and an imbalance in sympathetic/parasympathetic tone. METHODS:To explore molecular me...
journal_title：Inhalation toxicology
pub_type： 杂志文章,meta分析
doi：10.1080/08958378.2017.1310333
更新日期：2017-02-01 00:00:00
abstract：:A study was performed in Sprague-Dawley rats (Crl:CD BR) to differentiate between effects of hydrofluorocarbon 123 (HCFC-123) on the lactating dam or on the fetus using fostering and cross-fostering of the offspring. Pregnant and/or lactating dams without the pups present were exposed to the test substance (1000 ppm) ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370126866
更新日期：2001-08-01 00:00:00
abstract：:In order to conserve material that is available in limited quantities, "directed-flow" nose-only exposure systems have at times been run at flow rates close to the minute ventilation of the animal. Such low-flow-rate conditions can contribute to a decrease of test substance concentration in inhaled air; near the anima...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370500282555
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:Dimethyl sulfide (DMS, CAS 75-18-3) is an industrial chemical. It is both an irritant and neurotoxicant that may be life-threatening because of accidental release. The effects of DMS on public health and associated public health response depend on the exposure concentration and duration. However, currently, p...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2018.1551444
更新日期：2018-01-01 00:00:00
abstract：:The aim of this study was to investigate the dose-related effects of dichlorvos inhalation on electrophysiological alterations of diaphragm and phrenic nerve and the changes in the histologic structure of respiratory system. This study was performed on 33 rats divided into 5 groups, inhaling 1, 2, 5, 10, and 15 microg...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/089583701753403999
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:Gastroesophageal reflux of bile acids plays an important role in the development of Barrett's esophagus (BE)-associated esophageal adenocarcinoma (EAC). Cigarette smoke has been demonstrated to exacerbate the effects of reflux and thus the initial stages of EAC carcinogenesis. To date, no in vivo studies hav...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2011.568977
更新日期：2011-04-01 00:00:00
abstract：OBJECTIVE:Numerous studies have found an association between transiently increased particulate matter air pollution and acute adverse cardiovascular health effects; however, the mechanisms underlying these effects are not clear. Translocation of ultra-fine ambient particulate matter has been proposed to play a key role...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2013.844749
更新日期：2013-11-01 00:00:00
abstract：:Nasal efficiency for removing fine particles from inhaled air may be affected by variations in nasal structure associated with race. In 11 African American and 11 Caucasian adults (age 18-31 yr) we measured the fractional deposition (DF) of fine particles (1 and 2 mum mass median aerodynamic diameter) (MMAD) for oral ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370500188984
更新日期：2005-11-01 00:00:00
abstract：:In the evaluation of particulate matter (PM) toxicity, one faces the challenge of identifying components that could be addressed as markers of toxicity. This study examines the use of statistical methods to determine which components present in the complex mixtures are related to toxic effects. The work is based on da...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370701492987
更新日期：2007-01-01 00:00:00
abstract：CONTEXT:Three heterocyclic nitrogen compounds, 2,3-diethylpyrazine (DEP), 2,3,5,6-tetramethylpyrazine (TMP), and 2-acetyl pyridine (AP), are naturally present in tobacco and are also added to tobacco as flavor ingredients. OBJECTIVE:A battery of tests was used to compare the toxicity of mainstream smoke from experimen...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2010.545841
更新日期：2011-06-01 00:00:00
abstract：:Epidemiology studies of populations living in areas with good air quality report correlations between levels of ambient particulate matter (PM) and mortality rates. These associations occur at low PM concentrations that are below current air quality standards. Can such concentrations cause mortality, given the toxicit...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370490442935
更新日期：2004-01-01 00:00:00
abstract：:Respiratory disturbances play a central role in chemical warfare nerve agent (CWNA) induced toxicity; they are the starting point of mass casualty and the major cause of death. We developed a microinstillation technique of inhalation exposure to nerve agent VX and assessed lung injury by biochemical analysis of the br...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370600602116
更新日期：2006-06-01 00:00:00
abstract：:The C9 alkylbenzenes, composed mostly of ethyltoluenes and trimethylbenzenes, comprise 75-90% of the naphtha fraction of crude oil. Occupational and environmental exposure to C9 alkylbenzenes occur via inhalation. We conducted short-term inhalation studies on the ethyltoluene isomers (2-, 3- or 4-) to select one isome...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2018.1430190
更新日期：2017-01-01 00:00:00
abstract：:Oxygen radical generation due to surface radicals, inflammation, and iron release has been suggested as the mechanism of adverse effects of quartz, such as emphysema, fibrosis, and carcinogenic effects. Therefore, we measured iron release, acellular generation of hydroxyl radicals, and oxidative DNA damage and cytotox...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/089583799196628
更新日期：1999-12-01 00:00:00
abstract：:With regard to genotoxicity testing and cancer risk assessment, particles and fibers form a rather specific group among all toxicants. First, the physicochemical behavior of fibrous and nonfibrous particles is usually very different from that of nonparticulate, chemical carcinogens. Reactive oxygen species (ROS) are b...
journal_title：Inhalation toxicology
pub_type： 杂志文章,评审
doi：10.1080/089583701753338631
更新日期：2002-01-01 00:00:00
abstract：:Recent studies have shown that air pollution is a risk factor for hospitalization for pneumonia. However, there is limited evidence to suggest what subpopulations are at greater risk from air pollution. This study was undertaken to examine the modifying effect of specific secondary diagnosis (including hypertension, d...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958370902744855
更新日期：2009-11-01 00:00:00
