Systemic inflammation, endothelial dysfunction, and activation in clinically healthy children exposed to air pollutants.

Abstract:

:Mexico City children are chronically exposed to significant concentrations of air pollutants and exhibit chronic respiratory-tract inflammation. Epidemiological, controlled human exposures, laboratory-based animal models, and in vitro/in vivo studies have shown that inflammatory, endothelial dysfunction, and endothelial damage mediators are upregulated upon exposure to particulate matter (PM). Endothelial dysfunction is a critical event in cardiovascular disease. The focus of this work was to investigate whether exposure to ambient air pollution including PM(2.5) produces systemic inflammation and endothelial injury in healthy children. We measured markers of endothelial activation, and inflammatory mediators in 52 children age 8.6+/-0.1 yr, residents of Mexico City (n: 28) or of Polotitlán (n: 24), a city with low levels of pollutants. Mexico City children had significant increases in inflammatory mediators and vasoconstrictors, including tumor necrosis factor (TNF)alpha, prostaglandin (PG) E2, C-reactive protein, interleukin-1beta, and endothelin-1. There was a significant anti-inflammatory response, and a downregulation of vascular adhesion molecule-1, intercellular adhesion molecule-1 and -2, and selectins sE and sL. Results from linear regression found TNF a positively associated with 24- and 48-h cumulative levels of PM(2.5), while the 7-d PM(2.5) value was negatively associated with the numbers of white blood cells in peripheral blood in highly exposed children. Systemic subclinical inflammation, increased endothelin- 1, and significant downregulation of soluble adhesion molecules are seen in Mexico City children. Children chronically exposed to fine PM above the standard could be at risk of developing cardiovascular diseases, atherosclerosis, stroke, and other systemic effects later in life.

journal_name

Inhal Toxicol

journal_title

Inhalation toxicology

authors

Calderón-Garcidueñas L,Villarreal-Calderon R,Valencia-Salazar G,Henríquez-Roldán C,Gutiérrez-Castrellón P,Torres-Jardón R,Osnaya-Brizuela N,Romero L,Torres-Jardón R,Solt A,Reed W

doi

10.1080/08958370701864797

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

499-506

issue

5

eissn

0895-8378

issn

1091-7691

pii

791762122

journal_volume

20

pub_type

杂志文章
  • Dosimetry of Particles: Critical Factors Having Risk Assessment Implications.

    abstract::Species differences in the handling of particles are topics of interest for setting ambient particulate matter standards as well as for studies involving the phenomenon of lung overload and the implications, if any, of such studies for workplace dust exposure standards. The dosimetry of inhaled particles differs among...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958378.2000.11463250

    authors: Miller FJ

    更新日期:2000-01-01 00:00:00

  • NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination.

    abstract::Multi-walled carbon nanotubes (MWCNT) have been reported to cause lung pathologies in multiple studies. However, the mechanism responsible for the bioactivity has not been determined. This study used nine different well-characterized MWCNT and examined the outcomes in vitro and in vivo. MWCNT, from a variety of source...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2012.745633

    authors: Hamilton RF Jr,Buford M,Xiang C,Wu N,Holian A

    更新日期:2012-12-01 00:00:00

  • Characterization of respiratory exposure to and effects of cold-air hyperventilation in guinea pigs.

    abstract::The purpose of this study was to characterize the respiratory effects of single and repeated controlled exposures to clean warm humid and cold dry air in a new model of anesthetized, mechanically ventilated guinea pigs, and to compare findings with known effects in humans. Intratracheal air (T(tr)) and retrotracheal t...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370050085129

    authors: Hälinen AI,Pennanen AS,Salonen RO

    更新日期:2000-08-01 00:00:00

  • Thioredoxin mediates remodeling factors of human bronchial epithelial cells upon interaction with house dust mite-stimulated eosinophils.

    abstract::Bronchial epithelial cells exposed to allergens typically secrete chemokines to recruit eosinophils. Persistent inflammation and repair responses result in airway remodeling and irreversible airflow limitation. House dust mite (HDM) is a common allergen causing allergic disorders. Thioredoxin (TRX) is a redox protein ...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370802368730

    authors: Chuang CY,Chang CH,Huang YL

    更新日期:2009-02-01 00:00:00

  • Direct contact with particulate matter increases oxidative stress in different brain structures.

    abstract:INTRODUCTION:Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in diffe...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2015.1060278

    authors: Fagundes LS,Fleck Ada S,Zanchi AC,Saldiva PH,Rhoden CR

    更新日期:2015-01-01 00:00:00

  • Glue (toluene) abuse: increased QT dispersion and relation with unexplained syncope.

    abstract::Exposure to toluene, one of the major components of glue, can lead to cardiac arrhythmias and sudden sniffing death syndrome. QT dispersion is a useful risk marker for cardiac arrhythmias and sudden cardiac death. The aim of this study was to investigate the effects of glue abuse on QT interval and QT dispersion. The ...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370701758304

    authors: Alper AT,Akyol A,Hasdemir H,Nurkalem Z,Güler O,Güvenç TS,Erdinler I,Cakmak N,Eksik A,Gürkan K

    更新日期:2008-01-01 00:00:00

  • Particle toxicology: from coal mining to nanotechnology.

    abstract::Particle research has been historically closely connected to industrial activities or materials, such as coal, asbestos, man-made mineral fibers, and more recently ambient particulate matter (PM). It is the purpose of this review to combine insights and developments in particle toxicology with the historical context o...

    journal_title:Inhalation toxicology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1080/08958370252809086

    authors: Borm PJ

    更新日期:2002-03-01 00:00:00

  • Biopersistence, fiber length, and cancer risk assessment for inhaled fibers.

    abstract::We briefly review the evidence that the carcinogenic risk posed by inhaled fibers depends principally on the lung burden of long fibers. We use a deposition clearance model to generate time-dependent lung burdens in rats of a dozen long fibers for various exposure concentrations. Together with a previously estimated p...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/089583701316941294

    authors: Moolgavkar SH,Brown RC,Turim J

    更新日期:2001-09-01 00:00:00

  • Toxicological comparisons of cigarettes containing different amounts of vanillin.

    abstract::Vanillin is a flavoring agent used in cigarettes. Previous toxicological examinations of the effects on the addition of vanillin to tobacco used mixtures with several other flavoring agents. In the present work, toxicological comparisons were made of experimental cigarettes containing no added vanillin against otherwi...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370701353205

    authors: Lemus R,Carmines EL,Van Miert E,Coggins CR,Anskeit E,Gerstenberg B,Meisgen TJ,Schramke H,Stabbert R,Völkel H,Terpstra PM

    更新日期:2007-06-01 00:00:00

  • A custom-built low-cost chamber for exposing rodents to e-cigarette aerosol: practical considerations.

    abstract::Objectives: To (1) design and build a low-cost exposure chamber system for whole-body exposure of rodents to electronic cigarette aerosol, (2) provide detailed instructions with particular focus on automated e-cigarette activation, and (3) develop a simple mathematical model for aerosol levels in the exposure chamber....

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958378.2019.1698678

    authors: Hilpert M,Ilievski V,Coady M,Andrade-Gutierrez M,Yan B,Chillrud SN,Navas-Acien A,Kleiman NJ

    更新日期:2019-01-01 00:00:00

  • Interaction of nanoparticles with the pulmonary surfactant system.

    abstract::Nano-sized particles (NSPs) have a diameter of less than 100 nm. When inhaled, they preferentially deposit in the deeper lung, where pulmonary surfactant covers the thin aqueous lining layer. Thus, pulmonary surfactant is the initial contact where NSPs impinge. This can lead to various consequences. For example, bindi...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章,评审

    doi:10.1080/08958370903005744

    authors: Schleh C,Hohlfeld JM

    更新日期:2009-07-01 00:00:00

  • The in vitro and in vivo investigation of a novel small chamber dry powder inhalation delivery system for preclinical dosing to rats.

    abstract:PURPOSE:This research describes a novel "minitower" dry powder delivery system for nose-only delivery of dry powder aerosols to spontaneously breathing rats. METHODS:The minitower system forces pressurized air through pre-filled capsules to deliver aerosolized drug to four nose ports; three of which house spontaneousl...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2015.1089959

    authors: Sellers S,Horodnik W,House A,Wylie J,Mauser P,Donovan B

    更新日期:2015-01-01 00:00:00

  • Prenatal exposure to diesel exhaust impairs mouse spermatogenesis.

    abstract::The effect of prenatal exposure to diesel exhaust (DE) was investigated. Twenty pregnant ICR mice were exposed to DE at the particle concentration of 1.0 mg/m3, from d 2 until d 16 postcoitum. Male offspring were kept alive until 12 wk of age, and then male reproductive organ weight, daily sperm production (DSP), seru...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370601069257

    authors: Ono N,Oshio S,Niwata Y,Yoshida S,Tsukue N,Sugawara I,Takano H,Takeda K

    更新日期:2007-03-01 00:00:00

  • Quantitative exposure matrix for asphalt fume, total particulate matter, and respirable crystalline silica among roofing and asphalt manufacturing workers.

    abstract::This paper summarizes available data on worker exposures to asphalt fume (soluble fraction), total particulate matter, and respirable crystalline silica (quartz) [hereinafter RCS] over a 30-year period in Owens Corning's asphalt production and roofing manufacturing plants. For the period 1977 through 2006, the air-mon...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2011.604107

    authors: Fayerweather WE,Trumbore DC,Johnson KA,Niebo RW,Maxim LD

    更新日期:2011-09-01 00:00:00

  • A single exposure to eucalyptus smoke sensitizes rats to the postprandial cardiovascular effects of a high carbohydrate oral load.

    abstract:OBJECTIVE:Previous studies have shown that air pollution exposure primes the body to heightened responses to everyday stressors of the cardiovascular system. The purpose of this study was to examine the utility of postprandial responses to a high carbohydrate oral load, a cardiometabolic stressor long used to predict c...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958378.2020.1809572

    authors: Martin BL,Thompson LC,Kim YH,Snow SJ,Schladweiler MC,Phillips P,Harmon M,King C,Richards J,George I,W Kyle Martin,Haykal-Coates N,Gilmour MI,Kodavanti UP,Hazari MS,Farraj AK

    更新日期:2020-07-01 00:00:00

  • Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. VI. Gene expression in heart and lung tissue.

    abstract::The purpose of this exploratory study within the integrated subchronic inhalation exposure study (Lippmann et al., 2005) was to identify genes in heart and lung tissue that changed in expression level as a result of subchronic exposure to concentrated ambient particles (CAPs). Identification of CAPs exposure-related c...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370590912851

    authors: Gunnison A,Chen LC

    更新日期:2005-04-01 00:00:00

  • Ultrafine particle deposition in humans during rest and exercise.

    abstract::Ultrafine particles (diameter < 100 nm) may be important in the health effects of air pollution, in part because of their predicted high respiratory deposition. However, there are few measurements of ultrafine particle deposition during spontaneous breathing. The fractional deposition for the total respiratory tract o...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370304468

    authors: Daigle CC,Chalupa DC,Gibb FR,Morrow PE,Oberdörster G,Utell MJ,Frampton MW

    更新日期:2003-05-01 00:00:00

  • A pulmonary rat gene array for screening altered expression profiles in air pollutant-induced lung injury.

    abstract::Pulmonary tissue injury and repair processes involve complex and coordinated cellular events such as necrosis, inflammation, cell growth/differentiation, apoptosis, and remodeling of extracellular matrix. These processes are regulated by expression of multiple mediator genes. Commercially available microarray blots an...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370050198566

    authors: Nadadur SS,Schladweiler MC,Kodavanti UP

    更新日期:2000-12-01 00:00:00

  • Toxicological investigations on the respirable fraction of silicon carbide grain products by the in vitro vector model.

    abstract::Increased lung cancer incidence with workers at the production site of crude silicon carbide (SiC) using the Acheson process has been reported. Several agents derived from the process were discussed as causative factors. Recently concern had been expressed about the presence of cleavage fragments (CFs) in commercial p...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2014.885099

    authors: Bruch J,Rehn B,Duval-Arnould G,Efskind J,Röderer G,Sébastian P

    更新日期:2014-04-01 00:00:00

  • Association of Inhalation Toxicologists' (AIT) review of regulatory aspects for inhalation toxicology studies.

    abstract::Regulatory guidelines are intended to provide recommendations on ways to achieve greater harmonization in the interpretation and application of technical procedures and requirements for product registration in order to reduce or obviate replication of the testing carried out during the research and development of new ...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章,评审

    doi:10.3109/08958378.2012.757400

    authors: Jones DR,Baldrick P

    更新日期:2013-02-01 00:00:00

  • Spores of Aspergillus versicolor isolated from indoor air of a moisture-damaged building provoke acute inflammation in mouse lungs.

    abstract::Microbial growth in moisture-damaged buildings has been associated with respiratory health effects, and the spores of the mycotoxin producing fungus Aspergillus versicolor are frequently present in the indoor air. To characterize the potential of these spores to cause harmful respiratory effects, mice were exposed via...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370290084908

    authors: Jussila J,Komulainen H,Kosma VM,Nevalainen A,Pelkonen J,Hirvonen MR

    更新日期:2002-12-01 00:00:00

  • Inhalation studies with the Göttingen minipig.

    abstract::A method for inhalative exposure of minipigs to aerosols and gases has been developed. Minipigs are exposed via mask inhalation to the test substance using a computer-controlled exposure system that permits simultaneous exposure of groups of four animals in parallel to different controlled dose levels. We studied inha...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370150502476

    authors: Koch W,Windt H,Walles M,Borlak J,Clausing P

    更新日期:2001-03-01 00:00:00

  • Variability in ozone-induced pulmonary injury and inflammation in healthy and cardiovascular-compromised rat models.

    abstract::The molecular bases for variability in air pollutant-induced pulmonary injury due to underlying cardiovascular (CVD) and/or metabolic diseases are unknown. We hypothesized that healthy and genetic CVD-prone rat models will exhibit exacerbated response to acute ozone exposure dependent on the type and severity of disea...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2014.954169

    authors: Kodavanti UP,Ledbetter AD,Thomas RF,Richards JE,Ward WO,Schladweiler MC,Costa DL

    更新日期:2015-01-01 00:00:00

  • A review of the toxicology and epidemiology of wollastonite.

    abstract::Wollastonite is a naturally occurring calcium silicate (CaSiO(3)) that is produced in both powder and fibrous forms. It is a valuable industrial mineral used in plastics, ceramics, metallurgical applications, paint, and friction products. For some applications wollastonite serves as an asbestos replacement. To varying...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章,评审

    doi:10.1080/08958370591002030

    authors: Maxim LD,McConnell EE

    更新日期:2005-08-01 00:00:00

  • Characterization of airborne particles generated from metal active gas welding process.

    abstract::This study is focused on the characterization of particles emitted in the metal active gas welding of carbon steel using mixture of Ar + CO2, and intends to analyze which are the main process parameters that influence the emission itself. It was found that the amount of emitted particles (measured by particle number a...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2014.897400

    authors: Guerreiro C,Gomes JF,Carvalho P,Santos TJ,Miranda RM,Albuquerque P

    更新日期:2014-05-01 00:00:00

  • Cardiomyopathy confers susceptibility to particulate matter-induced oxidative stress, vagal dominance, arrhythmia and pulmonary inflammation in heart failure-prone rats.

    abstract::Acute exposure to ambient fine particulate matter (PM2.5) is tied to cardiovascular morbidity and mortality, especially among those with prior cardiac injury. The mechanisms and pathophysiological events precipitating these outcomes remain poorly understood but may involve inflammation, oxidative stress, arrhythmia an...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2014.995387

    authors: Carll AP,Haykal-Coates N,Winsett DW,Hazari MS,Ledbetter AD,Richards JH,Cascio WE,Costa DL,Farraj AK

    更新日期:2015-02-01 00:00:00

  • In vitro and ex vivo toxicological testing of sildenafil-loaded solid lipid nanoparticles.

    abstract::The aim of this study was to investigate the potential cytotoxicity of solid lipid nanoparticles (SLN) loaded with sildenafil. The SLNs were tested as a new drug delivery system (DDS) for the inhalable treatment of pulmonary hypertension in human lungs. Solubility of sildenafil in SLN lipid matrix (30:70 phospholipid:...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.3109/08958378.2013.810315

    authors: Paranjpe M,Neuhaus V,Finke JH,Richter C,Gothsch T,Kwade A,Büttgenbach S,Braun A,Müller-Goymann CC

    更新日期:2013-08-01 00:00:00

  • Changes at global and site-specific DNA methylation of MLH1 gene promoter induced by waterpipe smoking in blood lymphocytes and oral epithelial cells.

    abstract::Objective: Cigarette tobacco smoking has been shown to cause cancer through different mechanisms that include epigenetic modulation of tumor-suppressor genes. In the present study, the association between global and MLH1 gene promoter methylation and waterpipe tobacco smoking was investigated. Materials and Methods: B...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958378.2020.1754972

    authors: Sabi SH,Khabour OF,Alzoubi KH,Cobb CO,Eissenberg T

    更新日期:2020-02-01 00:00:00

  • Biopersistence of graphite whiskers deposited in rat lungs by 4-week inhalation.

    abstract::Rats were exposed to a new graphite whisker for 4 wk by inhalation. Mass and fiber concentrations were 8.3 +/- 2.2 mg/m3 and 151.7 +/- 78.8 fibers (F)/ml, respectively, and mass median aerodynamic diameter was 3.0 micro m. Geometric mean sizes of the original whiskers were 0.86 micro m diameter and 6.8 micro m length....

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370304453

    authors: Ishimatsu S,Hori H,Oyabu T,Tanaka I

    更新日期:2003-01-01 00:00:00

  • Air pollution and postneonatal mortality in a tropical city: Kaohsiung, Taiwan.

    abstract::With growing evidence of the association between daily mortality and air pollution in adults, it is important to investigate whether infants are also susceptible to the adverse health effects of ambient air pollutants. The purpose of this study is to examine the relationship between air pollution and postneonatal mort...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章

    doi:10.1080/08958370500434214

    authors: Tsai SS,Chen CC,Hsieh HJ,Chang CC,Yang CY

    更新日期:2006-03-01 00:00:00