Abstract:
OBJECTIVE:The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS:In order to identify a group of individuals with the highest risk of lung cancer incidence based on lung function levels of FEV1% predicted value, we examined 6882 subjects enrolled in the health surveillance program for asbestos related diseases over the years 2000-2014. We found a total of 110 cases confirmed as primary lung cancer. RESULTS:Using Cox's proportional hazards model after adjustment for age, gender, number of cigarettes, duration of smoking and cumulative asbestos exposure, we estimated that compared with the subjects with FEV1 ≥90% pred, the HR of lung cancer was 1.40 (95%CI: 0.94-2.08) for the subjects with FEV1 less than 90% and 1.95 (HR = 1.86; 95%CI: 1.12-3.08) for those with FEV1 less than 70%. In addition, probability of the occurrence of lung cancer for FEV1 <90% of the predicted value was HR = 2.19 (95%CI: 1.04-4.61) in the subjects whose time since spirometry and cancer diagnosis was three years or less. CONCLUSIONS:The results strongly support the hypothesis that spirometry can identify patients at a risk of lung cancer development. Regular spirometry should be offered to all patients with a history of asbestos exposure, at least once every three years.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Świątkowska B,Szeszenia-Dąbrowska Ndoi
10.1080/08958378.2016.1272652subject
Has Abstractpub_date
2017-01-01 00:00:00pages
18-22issue
1eissn
0895-8378issn
1091-7691journal_volume
29pub_type
杂志文章abstract::Fine particulate matter (PM(2.5)) is associated with respiratory effects, and asthmatic children are especially sensitive. Preliminary evidence suggests that combustion-derived particles play an important role. Our objective was to evaluate effect estimates from different PM(2.5) exposure metrics in relation to airway...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370801903826
更新日期:2008-02-01 00:00:00
abstract::Although the association between exposure to asbestos fibers and the development of lung cancer and mesothelioma has been well established in humans, the carcinogenic potential of other natural and man-made fibers/particles is not clear. Various in vitro genotoxicity studies have been employed to assess their in vivo ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463207
更新日期:2000-01-01 00:00:00
abstract::We briefly review the evidence that the carcinogenic risk posed by inhaled fibers depends principally on the lung burden of long fibers. We use a deposition clearance model to generate time-dependent lung burdens in rats of a dozen long fibers for various exposure concentrations. Together with a previously estimated p...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583701316941294
更新日期:2001-09-01 00:00:00
abstract::Particle research has been historically closely connected to industrial activities or materials, such as coal, asbestos, man-made mineral fibers, and more recently ambient particulate matter (PM). It is the purpose of this review to combine insights and developments in particle toxicology with the historical context o...
journal_title:Inhalation toxicology
pub_type: 历史文章,杂志文章,评审
doi:10.1080/08958370252809086
更新日期:2002-03-01 00:00:00
abstract::In February 2006, an IARC Monographs Working Group reevaluated the carcinogenic hazards to humans of carbon black, titanium dioxide, and talc, which belong to the group of poorly soluble, low-toxicity particles. The review of the relevant literature and the evaluations by the Working Group will be published in Volume ...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370701497903
更新日期:2007-01-01 00:00:00
abstract::Species differences in the handling of particles are topics of interest for setting ambient particulate matter standards as well as for studies involving the phenomenon of lung overload and the implications, if any, of such studies for workplace dust exposure standards. The dosimetry of inhaled particles differs among...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463250
更新日期:2000-01-01 00:00:00
abstract::Epidemiology studies of populations living in areas with good air quality report correlations between levels of ambient particulate matter (PM) and mortality rates. These associations occur at low PM concentrations that are below current air quality standards. Can such concentrations cause mortality, given the toxicit...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490442935
更新日期:2004-01-01 00:00:00
abstract::Tire and road wear particles (TRWP) are a component of ambient particulate matter (PM) produced from the interaction of tires with the roadway. Inhalation of PM has been associated with cardiopulmonary morbidities and mortalities thought to stem from pulmonary inflammation. To determine whether TRWP may contribute to ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.730071
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Worldwide popularity of waterpipe tobacco smoking has increased, including in pregnant women. This study investigates the effect of prenatal waterpipe tobacco smoke (WTS) exposure on airway inflammation in a murine model of asthma of adult offspring mice. MATERIALS AND METHODS:Pregnant BALB/c mice were expos...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1385113
更新日期:2017-07-01 00:00:00
abstract::With regard to genotoxicity testing and cancer risk assessment, particles and fibers form a rather specific group among all toxicants. First, the physicochemical behavior of fibrous and nonfibrous particles is usually very different from that of nonparticulate, chemical carcinogens. Reactive oxygen species (ROS) are b...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/089583701753338631
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Increases in particulate matter less than 2.5 µm (PM(2.5)) in ambient air is linked to acute cardiovascular morbidity and mortality. Specific components and potential emission sources of PM(2.5) responsible for adverse health effects of cardiovascular function are unclear. METHODS:Spontaneously hypertensive...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.580387
更新日期:2011-06-01 00:00:00
abstract::This study investigated the surface chemistry of urban fine particles (PM(2.5)), and quantified the adsorbed and desorbed species after exposure to bronchoalveolar lavage fluid (BALF). Urban background and roadside PM(2.5) samples of different mass concentration and total weight were collected in triplicate in the Sou...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490443204
更新日期:2004-01-01 00:00:00
abstract::A number of Norwegian soldiers have reported health problems after live-fire training using the HK416 rifle. The objective of this study was to characterize gaseous and particulate emissions from three different types of ammunition, and record the health effects after exposure to emissions from live-firing. Fifty-five...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.970783
更新日期:2014-12-01 00:00:00
abstract::Bronchial epithelial cells exposed to allergens typically secrete chemokines to recruit eosinophils. Persistent inflammation and repair responses result in airway remodeling and irreversible airflow limitation. House dust mite (HDM) is a common allergen causing allergic disorders. Thioredoxin (TRX) is a redox protein ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802368730
更新日期:2009-02-01 00:00:00
abstract::A cross-sectional study on suberosis was conducted in the Champagne-Ardenne County, France, to determine the prevalence of respiratory symptoms, the level of pulmonary function, and the presence of precipitins against Penicillium frequentans. Thirteen of the 33 workers exposed to cork dust had respiratory symptoms exc...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390249120
更新日期:2003-12-01 00:00:00
abstract::Chronic exposure to chlorine gas has been shown to cause occupational asthma. Acute inhalation of chlorine is known to cause airway inflammation and induce airway nitric oxide formation. Exhaled nitric oxide may therefore be a marker of airway damage after chlorine gas exposure. After accidental chlorine gas exposure ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701432157
更新日期:2007-08-01 00:00:00
abstract::Biodiesel made from the transesterification of plant- and animal-derived oils is an important alternative fuel source for diesel engines. Although numerous studies have reported health effects associated with petroleum diesel emissions, information on biodiesel emissions are more limited. To this end, a program at the...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1076910
更新日期:2015-01-01 00:00:00
abstract::The authors have previously demonstrated that wildfire-derived coarse or fine particulate matter (PM) intratracheally instilled into lungs of mice induce a strong inflammatory response. In the current study, the authors demonstrate that wildfire PM simultaneously cause major increases in oxidative stress in the mouse ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370903571849
更新日期:2010-06-01 00:00:00
abstract::Measurement strategies as well as results from measurements at workplaces are presented. Measurements were performed in research laboratories as well as by companies producing small amounts of nanostructured materials. The work was done in the frame of a BAuA (Bundesanstalt für Arbeitsschutz und Arbeitsmedizin) resear...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370902962317
更新日期:2009-07-01 00:00:00
abstract::Most current deterministic computer dosimetry models use idealized dichotomous symmetrical infant, child, and adolescent tracheobronchial geometries for dosimetry predictions. These tracheobronchial geometries were derived from either the morphometric measurements of J. D. Mortensen and colleagues or those of R. F. Ph...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600748349
更新日期:2006-09-01 00:00:00
abstract::The lung toxicity of inhalable polymer materials is normally carried out by evaluation of the histopathology responses of rat lungs to repeat, nose-only, exposures of an inhalable aerosol of material in a 13-wk subchronic repeat dose toxicity study. The introduction of transcriptomics into toxicology has allowed the c...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370500444304
更新日期:2006-04-01 00:00:00
abstract::Hypersensitivity pneumonitis (HP) represents the immunologically mediated lung disease induced by repeated inhalations of a wide variety of certain finely dispersed organic antigens. In susceptible subjects, these inhalations provoke a hypersensitivity reaction characterized by intense inflammation of the terminal bro...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.827284
更新日期:2013-09-01 00:00:00
abstract::This study aims to investigate the negative effects of chronic exposure to isoflurane on spermatogenesis and explore the underlying mechanisms. Sixty male rats were randomly allocated to two groups: control group, receiving no treatment, and anesthesia group, administrated exposure to isoflurane (2 ppm) for 25 consecu...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1080772
更新日期:2015-01-01 00:00:00
abstract:CONTEXT:Cocoa-derived ingredients are used in cigarette tobacco. OBJECTIVE:A battery of tests was used to compare toxicity of mainstream smoke from experimental cigarettes containing different added levels of cocoa-derived ingredients. MATERIALS AND METHODS:Five cocoa-derived ingredients chocolate (CH), cocoa (COC), ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2010.542580
更新日期:2011-06-01 00:00:00
abstract::Background: Allergies and smoking are common reasons for nasal mucosa inflammations, which in turn, cause nasal obstructions. Nevertheless, the impact of coexisting allergies and smoking on nasal mucosa inflammation has not been studied.Objectives: To study the impact of smoking with relation to allergies on nasal muc...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1777226
更新日期:2020-05-01 00:00:00
abstract::Oxidative stress is thought to be the pathogenesis of pulmonary fibrosis induced by asbestos, and heme oxygenase-1 (HO-1) protects lung tissue against oxidative stress. We hypothesized that HO-1 is associated with oxidative lung injury caused by exposure to asbestos. This study was conducted to investigate the time co...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370590922580
更新日期:2005-05-01 00:00:00
abstract::Results from epidemiology studies have shown statistical associations between ambient air particulate matter (PM) concentrations and mortality/morbidity, particularly among susceptible subpopulations. Although the epidemiology of ambient air PM is compelling, there remains considerable uncertainty in PM risk assessmen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463230
更新日期:2000-01-01 00:00:00
abstract::Mexico City children are chronically exposed to significant concentrations of air pollutants and exhibit chronic respiratory-tract inflammation. Epidemiological, controlled human exposures, laboratory-based animal models, and in vitro/in vivo studies have shown that inflammatory, endothelial dysfunction, and endotheli...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701864797
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Gastroesophageal reflux of bile acids plays an important role in the development of Barrett's esophagus (BE)-associated esophageal adenocarcinoma (EAC). Cigarette smoke has been demonstrated to exacerbate the effects of reflux and thus the initial stages of EAC carcinogenesis. To date, no in vivo studies hav...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.568977
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:Rodents used in scientific research are typically housed in cages containing natural bedding materials. Despite extensive evidence of biological harm from inhaled particulate matter (PM), relatively little work has been performed to measure bedding-generated PM exposure in caged animals used in basic science...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2019.1694109
更新日期:2019-08-01 00:00:00