Abstract:
:A cross-sectional study on suberosis was conducted in the Champagne-Ardenne County, France, to determine the prevalence of respiratory symptoms, the level of pulmonary function, and the presence of precipitins against Penicillium frequentans. Thirteen of the 33 workers exposed to cork dust had respiratory symptoms excluding hypersensitivity pneumonitis. The respiratory symptoms were not correlated with tobacco habits or duration of exposure. The levels of pulmonary function were not significantly impaired. No precipitin arc against Penicillium frequentans was found in the sera of exposed workers. The varied symptomatology of suberosis may point to several different diseases, each with its own determining factor. In the present study, exposure to weak humidity and low level of cork dust were related to asthma and chronic bronchitis only, excluding hypersensitivity pneumonitis.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Deschamps F,Foudrinier F,Dherbecourt V,Mas P,Prevost E,Legrele AM,Bellier S,Toubas Ddoi
10.1080/08958370390249120subject
Has Abstractpub_date
2003-12-01 00:00:00pages
1479-86issue
14eissn
0895-8378issn
1091-7691pii
YCY0M78CY9NEARB2journal_volume
15pub_type
杂志文章abstract:PURPOSE:This research describes a novel "minitower" dry powder delivery system for nose-only delivery of dry powder aerosols to spontaneously breathing rats. METHODS:The minitower system forces pressurized air through pre-filled capsules to deliver aerosolized drug to four nose ports; three of which house spontaneousl...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1089959
更新日期:2015-01-01 00:00:00
abstract::This study was designed to investigate effects of sulfur dioxide (SO(2)) and its derivatives (bisulfite and sulfite) on the rat blood pressure. The blood pressures of male Wistar rats exposed to SO(2) and its derivatives at various doses were measured. Findings were that: (1) with acute-one time exposure to SO(2) for ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390215785
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:Numerous studies have found an association between transiently increased particulate matter air pollution and acute adverse cardiovascular health effects; however, the mechanisms underlying these effects are not clear. Translocation of ultra-fine ambient particulate matter has been proposed to play a key role...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.844749
更新日期:2013-11-01 00:00:00
abstract::Cell signaling by pathogenic minerals may initiate the transactivation of genes that are critical to carcinogenesis and fibroproliferative diseases of the lung and pleura. We have shown previously that stimulation of the mitogen-activated protein kinase (MAPK) cascade by asbestos fibers leads to phosphorylation events...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463240
更新日期:2000-01-01 00:00:00
abstract::Naphthalene (NA) was shown to be carcinogenic, causing respiratory epithelial adenoma in the nasal cavity of male F344 rats and olfactory epithelial neuroblastoma in female F344 rats at exposure concentrations of 10-60 ppm in a 2-year inhalation study conducted by the National Toxicology Program. To explore the exposu...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.636086
更新日期:2012-01-01 00:00:00
abstract::Recent studies have shown that air pollution is a risk factor for hospitalization for pneumonia. However, there is limited evidence to suggest what subpopulations are at greater risk from air pollution. This study was undertaken to examine the modifying effect of specific secondary diagnosis (including hypertension, d...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370902744855
更新日期:2009-11-01 00:00:00
abstract::The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carried out on 80 adult...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370902934894
更新日期:2010-02-01 00:00:00
abstract::Computational fluid dynamic modeling software has enabled microdosimetry patterns of inhaled toxins and toxicants to be predicted and visualized, and is being used in inhalation toxicology and risk assessment. These predicted microdosimetry patterns in airway structures are derived from predicted airflow patterns with...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701260889
更新日期:2007-05-01 00:00:00
abstract::Risk assessment of occupational exposure to nanomaterials is needed. Human data are limited, but quantitative data are available from rodent studies. To use these data in risk assessment, a scientifically reasonable approach for extrapolating the rodent data to humans is required. One approach is allometric adjustment...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600747887
更新日期:2006-09-01 00:00:00
abstract::This study is focused on the characterization of particles emitted in the metal active gas welding of carbon steel using mixture of Ar + CO2, and intends to analyze which are the main process parameters that influence the emission itself. It was found that the amount of emitted particles (measured by particle number a...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.897400
更新日期:2014-05-01 00:00:00
abstract::In 1997 The International Agency for Research on Cancer classified some exposures to crystalline silica as carcinogenic to humans. Such exposures were acknowledged to be very variable, and even in the same monograph it was admitted that coal dust, containing as much as 20% quartz, could not be classified. Clearly ther...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802136731
更新日期:2008-09-01 00:00:00
abstract::Results from epidemiology studies have shown statistical associations between ambient air particulate matter (PM) concentrations and mortality/morbidity, particularly among susceptible subpopulations. Although the epidemiology of ambient air PM is compelling, there remains considerable uncertainty in PM risk assessmen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463230
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in diffe...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1060278
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Worldwide popularity of waterpipe tobacco smoking has increased, including in pregnant women. This study investigates the effect of prenatal waterpipe tobacco smoke (WTS) exposure on airway inflammation in a murine model of asthma of adult offspring mice. MATERIALS AND METHODS:Pregnant BALB/c mice were expos...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1385113
更新日期:2017-07-01 00:00:00
abstract::In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583799197096
更新日期:1999-04-01 00:00:00
abstract::This article addresses results from a single 4-h and repeated 1- and 4-wk inhalation exposure studies in Wistar rats with vapor and/or aerosol atmospheres of 4-ethoxyaniline (p-phenetidine). Groups of 10 rats/sex were exposed nose-only to mean analytical concentrations of 11.1, 86.2, and 882.6 mg p-phenetidine/m(3) us...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583701753210371
更新日期:2001-11-01 00:00:00
abstract::This study aims to investigate the negative effects of chronic exposure to isoflurane on spermatogenesis and explore the underlying mechanisms. Sixty male rats were randomly allocated to two groups: control group, receiving no treatment, and anesthesia group, administrated exposure to isoflurane (2 ppm) for 25 consecu...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1080772
更新日期:2015-01-01 00:00:00
abstract::Acute exposure to ambient fine particulate matter (PM2.5) is tied to cardiovascular morbidity and mortality, especially among those with prior cardiac injury. The mechanisms and pathophysiological events precipitating these outcomes remain poorly understood but may involve inflammation, oxidative stress, arrhythmia an...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.995387
更新日期:2015-02-01 00:00:00
abstract:CONTEXT:High malaria burden has led to the increased use of insecticides in the tropics and subtropics. This study thus aimed at assessing the hematological effects alteration of pyrethroid insecticide exposure using the experimental animal model. OBJECTIVE:A commonly available Electric Mosquito-Repellent Liquid pyret...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.781251
更新日期:2013-04-01 00:00:00
abstract:CONTEXT:Three heterocyclic nitrogen compounds, 2,3-diethylpyrazine (DEP), 2,3,5,6-tetramethylpyrazine (TMP), and 2-acetyl pyridine (AP), are naturally present in tobacco and are also added to tobacco as flavor ingredients. OBJECTIVE:A battery of tests was used to compare the toxicity of mainstream smoke from experimen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2010.545841
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:This study aimed to investigate whether increased carboxyhemoglobin (COHB) levels and ECG changes, which associated with fatal ventricular dysrhythmias, including increased QT, P-wave and T peak (Tp)-Tend (Te) dispersion, can be detected after smoking narghile, which is a traditional method of smoking tobacco t...
journal_title:Inhalation toxicology
pub_type: 临床试验,杂志文章
doi:10.1080/08958378.2016.1224957
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:There has been an increase in the popularity of waterpipe tobacco smoking (WTS) worldwide, especially in the younger population, including asthma patients. In this study, we investigated the effects of waterpipe smoking on airway inflammation, cytokine levels and oxidative stress markers in an antigen-driven ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1280105
更新日期:2017-02-01 00:00:00
abstract::A number of Norwegian soldiers have reported health problems after live-fire training using the HK416 rifle. The objective of this study was to characterize gaseous and particulate emissions from three different types of ammunition, and record the health effects after exposure to emissions from live-firing. Fifty-five...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.970783
更新日期:2014-12-01 00:00:00
abstract::Concurrent exposure to SO(2) and benzo(a)pyrene (B(a)P) resulted in an increased incidence of lung tumors in rodents compared to exposure to B(a)P alone. A synergistic effect on the expression of c-fos and c-jun between SO(2) and B(a)P was observed in lungs after SO(2) and B(a)P exposure. However, tumorigenesis occurs...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370903341891
更新日期:2010-03-01 00:00:00
abstract::Airstream clearance (with units of volume/time) is the volumetric flow from which chemical would have to be completely removed to account for the net loss in the nose. Extraction is the proportion of airflow from which the chemical is completely removed. Over the past several years we have developed physiologically ba...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370151126284
更新日期:2001-05-01 00:00:00
abstract::The Toxicological Evaluation of Realistic Emissions Source Aerosols (TERESA) study was carried out at three US coal-fired power plants to investigate the potential toxicological effects of primary and photochemically aged (secondary) particles using in situ stack emissions. The exposure system designed successfully si...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958371003728040
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Epidemiologic studies have linked inhalation of air pollutants such as ozone to cardiovascular mortality. Human exposure studies have shown that inhalation of ambient levels of ozone causes airway and systemic inflammation and an imbalance in sympathetic/parasympathetic tone. METHODS:To explore molecular me...
journal_title:Inhalation toxicology
pub_type: 杂志文章,meta分析
doi:10.1080/08958378.2017.1310333
更新日期:2017-02-01 00:00:00
abstract::We examined the effect of breathing pattern on ozone reaction product content within the respiratory tract. Thirty-four anesthetized, male Wistar rats were exposed to oxygen-18 ((18)O)-labeled ozone at 1.0 ppm for 2 h using a dual-chamber, negative-pressure ventilation system. Frequency was set at 80 (n = 9), 120 (n =...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490264852
更新日期:2004-02-01 00:00:00
abstract::Laboratory studies involving intentional and highly controlled exposures to air pollutants among groups of human volunteers provide valuable information related to the potential health effects of pollutants regulated under the US Clean Air Act. These controlled human exposure studies often provide biological plausibil...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.3109/08958378.2010.539290
更新日期:2011-01-01 00:00:00
abstract::In order to evaluate the chronic effect of polymerized toner particles on the lung, inflammation- and fibrosis-related genes were analyzed and 8-hydroxydeoxyguanosine (8-OHdG) was examined by using the lung tissue of rats subjected to 24 months of toner inhalation exposure. Wistar female rats were divided into four gr...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802641938
更新日期:2009-09-01 00:00:00