Abstract:
:Epidemiology studies of populations living in areas with good air quality report correlations between levels of ambient particulate matter (PM) and mortality rates. These associations occur at low PM concentrations that are below current air quality standards. Can such concentrations cause mortality, given the toxicity of PM chemical constituents? We examined chemical-specific, dose-response data typically used in U.S. EPA human health risk assessments. These assessments rely on established, no-effect thresholds for noncancer health endpoints. We found that chemicals identified as constituents of ambient PM are present at concentrations considerably below the regulatory thresholds used in risk assessment (i.e., below the RfCs and RfDs that identify levels for which no adverse health effects are anticipated). From the perspective of risk assessment, exposure to the concentrations of chemicals in ambient PM (e.g., sulfate, nitrate, and elemental carbon) cannot be expected to cause death. Hence, the health effects attributed to ambient PM in "regulatory impact analyses" appear to be at odds with what would be predicted from a standard U.S. EPA health-risk assessment for PM chemicals. Four possible resolutions of this paradox are that (1) the mixtures of chemicals present in ambient PM are vastly more toxic than the sum of individual components, (2) small portions of the general population are vastly more sensitive to certain ambient PM chemicals than reflected in U.S. EPA toxicity factors, (3) the toxicity of ambient PM is unrelated to its chemical constituents, or (4) PM mass concentration is not the causal factor in the reported associations. The associations may arise because ambient PM concentrations (1) are a surrogate for unmeasured copollutants (e.g., HAPs), (2) covary with confounding factors that cannot be fully controlled (e.g., weather, demographics), or (3) covary with unmeasured (e.g., societal, behavioral, or stress) factors.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Valberg PAdoi
10.1080/08958370490442935subject
Has Abstractpub_date
2004-01-01 00:00:00pages
19-29eissn
0895-8378issn
1091-7691pii
0Q7QXD0F4F6TGFU2journal_volume
16 Suppl 1pub_type
杂志文章abstract::The Provisional Advisory Level (PAL) protocol was applied to estimate inhalation exposure limits for phosgene (CG). Three levels (PAL 1, PAL 2, and PAL 3), distinguished by severity of toxic effects, are developed for 24-hour, 30-day, 90-day, and 2-year durations of potential drinking water and inhalation exposures fo...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.3109/08958370903202820
更新日期:2009-12-01 00:00:00
abstract::Background: High-mobility group box 1 (HMGB1) protein plays an important pathogenic role in various diseases such as pulmonary fibrosis. However, the relationship between variation of HMGB1 gene and susceptibility to coal worker's pneumoconiosis (CWP) remains unclear. The objective of the study was to determine the as...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1764153
更新日期:2020-03-01 00:00:00
abstract:CONTEXT:Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body. OBJECTIVES:To describe the normal lung deposition and 1 week particle retention of indium-111 labeled UF carbo...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.708065
更新日期:2012-08-01 00:00:00
abstract::The World Health Organization identified urban outdoor air pollution as the eighth highest mortality risk factor in high-income countries. Exposure to ambient pollutants such as ozone (O3) increases the number of hospital admissions. O3 is a highly reactive gas that reacts with cells lining the airways, producing the ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.922648
更新日期:2014-07-01 00:00:00
abstract::Manganese (Mn) is ubiquitous in ambient air due to both industrial and crustal sources. It is also a component of the octane-enhancing fuel additive methylcyclopentadienyl manganese tricarbonyl (MMT). The combustion of MMT by the automobile engine results in the formation of Mn particulates including phosphate, sulfat...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370050138003
更新日期:2000-10-01 00:00:00
abstract::Methylhexahydrophthalic anhydride (MHHPA) is a reactive, low molecular weight chemical used in products such as plastics, paints, and electronic components. Exposure to MHHPA may lead to work-related airway diseases such as rhinitis, conjunctivitis, and asthma. Twelve subjects employed at a plant manufacturing electri...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802715997
更新日期:2009-10-01 00:00:00
abstract::A cross-sectional study on suberosis was conducted in the Champagne-Ardenne County, France, to determine the prevalence of respiratory symptoms, the level of pulmonary function, and the presence of precipitins against Penicillium frequentans. Thirteen of the 33 workers exposed to cork dust had respiratory symptoms exc...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390249120
更新日期:2003-12-01 00:00:00
abstract::In order to evaluate the chronic effect of polymerized toner particles on the lung, inflammation- and fibrosis-related genes were analyzed and 8-hydroxydeoxyguanosine (8-OHdG) was examined by using the lung tissue of rats subjected to 24 months of toner inhalation exposure. Wistar female rats were divided into four gr...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802641938
更新日期:2009-09-01 00:00:00
abstract::Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, it was studied whether airway irritation by sulfur dioxide (SO(2)) would enhance respiratory allergic reactions to trimellitic anhydride (TMA), using a rat model. Brown Norway (BN) rats ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370902828468
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Epidemiologic studies have linked inhalation of air pollutants such as ozone to cardiovascular mortality. Human exposure studies have shown that inhalation of ambient levels of ozone causes airway and systemic inflammation and an imbalance in sympathetic/parasympathetic tone. METHODS:To explore molecular me...
journal_title:Inhalation toxicology
pub_type: 杂志文章,meta分析
doi:10.1080/08958378.2017.1310333
更新日期:2017-02-01 00:00:00
abstract::Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2019.1707912
更新日期:2019-01-01 00:00:00
abstract::Studies have shown associations between acute ambient particulate matter (PM) levels and increases in morbidity and mortality from cardiovascular diseases. We have previously reported in 24 healthy adults that exposure to concentrated ambient particles plus ozone (CAP + O(3)) caused a mean decrease of 0.09 mm in brach...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490439489
更新日期:2004-06-01 00:00:00
abstract::An approach to identify causal components of complex air pollution mixtures was explored. Rats and mice were exposed by inhalation 6 h daily for 1 week or 6 months to dilutions of simulated downwind coal emissions, diesel and gasoline exhausts and wood smoke. Organ weights, hematology, serum chemistry, bronchoalveolar...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.920440
更新日期:2014-09-01 00:00:00
abstract::In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitreous fibers, but it...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370490505016
更新日期:2004-10-01 00:00:00
abstract::Laboratory animals exposed to methyl iodide (MeI) have previously demonstrated lesions of the olfactory epithelium that were associated with local metabolism in the nasal tissues. Interactions of MeI in the nasal passage may, therefore, alter systemic toxicokinetics. The current study used unrestrained plethysmographs...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802596926
更新日期:2009-05-01 00:00:00
abstract::The antibacterial effect of silver nanoparticles has resulted in their extensive application in health, electronic, and home products. However, while the population exposed to silver nanoparticles continues to increase with ever new applications, silver nanoparticles remain a controversial research area as regards the...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701874663
更新日期:2008-04-01 00:00:00
abstract::Oxygen radical generation due to surface radicals, inflammation, and iron release has been suggested as the mechanism of adverse effects of quartz, such as emphysema, fibrosis, and carcinogenic effects. Therefore, we measured iron release, acellular generation of hydroxyl radicals, and oxidative DNA damage and cytotox...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583799196628
更新日期:1999-12-01 00:00:00
abstract::Respiratory disturbances play a central role in chemical warfare nerve agent (CWNA) induced toxicity; they are the starting point of mass casualty and the major cause of death. We developed a microinstillation technique of inhalation exposure to nerve agent VX and assessed lung injury by biochemical analysis of the br...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600602116
更新日期:2006-06-01 00:00:00
abstract::The effect of prenatal exposure to diesel exhaust (DE) was investigated. Twenty pregnant ICR mice were exposed to DE at the particle concentration of 1.0 mg/m3, from d 2 until d 16 postcoitum. Male offspring were kept alive until 12 wk of age, and then male reproductive organ weight, daily sperm production (DSP), seru...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370601069257
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Nanoparticles are being rapidly assimilated into numerous research fields and consumer products. A concurrent increase in human exposure to such materials is expected. Magnetic nanoparticles (MNPs) possess unique and beneficial features, increasing their functionality and integrative potential. However, MNP ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.592869
更新日期:2011-08-01 00:00:00
abstract::Most current deterministic computer dosimetry models use idealized dichotomous symmetrical infant, child, and adolescent tracheobronchial geometries for dosimetry predictions. These tracheobronchial geometries were derived from either the morphometric measurements of J. D. Mortensen and colleagues or those of R. F. Ph...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600748349
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:Dimethyl sulfide (DMS, CAS 75-18-3) is an industrial chemical. It is both an irritant and neurotoxicant that may be life-threatening because of accidental release. The effects of DMS on public health and associated public health response depend on the exposure concentration and duration. However, currently, p...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2018.1551444
更新日期:2018-01-01 00:00:00
abstract::This study aimed to determine the association between home and vehicle exposure to environmental tobacco smoke (ETS), and chronic bronchitis based on data from 64,961 non-smokers aged 12 years and older who participated in the 2005 Canadian Community Health Survey (CCHS). The proportion of respondents who reported ETS...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802409567
更新日期:2009-02-01 00:00:00
abstract::In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583799197096
更新日期:1999-04-01 00:00:00
abstract::Acute lung injury (ALI) induced by phosgene increases risk of serious edema and mortality. Increased permeability of the microvascular endothelium is implicated in the progression of ALI, but the processing interaction and time course activity of the vascular regulators in exudation are still not understood. The main ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802015091
更新日期:2008-07-01 00:00:00
abstract::Introduction: Tobacco use is a major risk factor of cardiovascular diseases (CVD) and atherosclerosis in particular. The use of waterpipe smoking (WPS) is increasing due to the misperception that it is less harmful than cigarette smoking due to its flavor and the use of water as a filter. Thus, research that investiga...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2019.1606366
更新日期:2019-02-01 00:00:00
abstract::Background: Allergies and smoking are common reasons for nasal mucosa inflammations, which in turn, cause nasal obstructions. Nevertheless, the impact of coexisting allergies and smoking on nasal mucosa inflammation has not been studied.Objectives: To study the impact of smoking with relation to allergies on nasal muc...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1777226
更新日期:2020-05-01 00:00:00
abstract::Asthma rates have been increasing worldwide, and exposure to diesel exhaust particles (DEP) may be implicated in this increase. DEP may also play a role in the increased morbidity and mortality associated with ambient airborne particulate matter (PM) exposure. Two types of nasal responses have been reported for human ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600743027
更新日期:2006-08-01 00:00:00
abstract::Bronchial epithelial cells exposed to allergens typically secrete chemokines to recruit eosinophils. Persistent inflammation and repair responses result in airway remodeling and irreversible airflow limitation. House dust mite (HDM) is a common allergen causing allergic disorders. Thioredoxin (TRX) is a redox protein ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802368730
更新日期:2009-02-01 00:00:00
abstract::Ultrafine particles (diameter < 100 nm) may be important in the health effects of air pollution, in part because of their predicted high respiratory deposition. However, there are few measurements of ultrafine particle deposition during spontaneous breathing. The fractional deposition for the total respiratory tract o...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370304468
更新日期:2003-05-01 00:00:00