Abstract:
:Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, it was studied whether airway irritation by sulfur dioxide (SO(2)) would enhance respiratory allergic reactions to trimellitic anhydride (TMA), using a rat model. Brown Norway (BN) rats were topically sensitized, subsequently exposed for a single time or repeatedly to 300 ppm SO(2), and challenged by inhalation to a distinctly irritating or minimally irritating concentration of TMA after the (last) SO(2) exposure. Repeated exposure to SO(2) alone reduced breathing frequency during exposure, and caused epithelial alterations including hyperplasia and squamous metaplasia, and infiltration of polymorphonuclear inflammatory cells into nasal tissues, larynx, trachea, and bronchi/bronchioli. Histopathological changes were less prominent after 1 day of SO(2) exposure. Repeated pre-exposure to SO(2) reduced the number of TMA-induced apnoeas, in an SO(2) exposure duration-dependent manner. This effect of SO(2) on TMA-induced functional allergic reactions (apnoeas) was distinct only when the TMA challenge concentration was not too irritating itself. Repeated pre-exposure to SO(2) reduced TMA-induced laryngeal ulceration, goblet-cell hyperplasia, and inflammation in the lungs in most animals, regardless of the TMA challenge concentration. The SO(2)-induced replacement of normal respiratory epithelium by less sensitive, squamous epithelium may offer an explanation for the, unexpected, reduced allergic manifestation. However in a few animals, SO(2) appeared to facilitate TMA-induced irritation, probably due to incomplete protection. Overall, SO(2) exposure of TMA-sensitized rats reduced TMA-related allergic respiratory responses in most animals.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Arts JH,Jacobs EJ,Kuper CFdoi
10.3109/08958370902828468subject
Has Abstractpub_date
2010-02-01 00:00:00pages
179-91issue
3eissn
0895-8378issn
1091-7691journal_volume
22pub_type
杂志文章abstract::The effect of particles from road traffic and wood smoke on the innate immune response in the lung was studied in a lung challenge model with the intracellular bacterium Listeria monocytogenes. Female Balb/cA mice were instilled intratracheally with wood smoke particles, particles from road traffic collected during wi...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802590499
更新日期:2009-09-01 00:00:00
abstract::Ultrafine particles (diameter < 100 nm) may be important in the health effects of air pollution, in part because of their predicted high respiratory deposition. However, there are few measurements of ultrafine particle deposition during spontaneous breathing. The fractional deposition for the total respiratory tract o...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370304468
更新日期:2003-05-01 00:00:00
abstract::Crystalline silica has been classified as a human carcinogen, but there is still considerable controversy regarding its fibrogenic and carcinogenic potential. In the present study, we investigated the genotoxic potential of bentonite particles (diameter < 10 microm) with an a-quartz content of up to 6% and different c...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600563524
更新日期:2006-05-01 00:00:00
abstract::The Provisional Advisory Level (PAL) protocol was applied to estimate inhalation exposure limits for phosgene (CG). Three levels (PAL 1, PAL 2, and PAL 3), distinguished by severity of toxic effects, are developed for 24-hour, 30-day, 90-day, and 2-year durations of potential drinking water and inhalation exposures fo...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.3109/08958370903202820
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:Mucociliary clearance sustains a baseline functionality and an "on demand" capability to upregulate clearance upon irritant exposure involving mucus hypersecretion and accelerated ciliary beat frequency (CBF) modulated by nitric oxide (NO). This study characterized these elements as well as cellular and exoge...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1318985
更新日期:2017-02-01 00:00:00
abstract::Sexually mature male and female Gottingen minipigs were exposed to various concentrations of GB and GF vapor via whole-body inhalation exposures or to liquid GB or GF via intravenous or subcutaneous injections. Vapor inhalation exposures were for 10, 60 or 180 min. Maximum likelihood estimation was used to calculate t...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.872212
更新日期:2014-02-01 00:00:00
abstract::Most current deterministic computer dosimetry models use idealized dichotomous symmetrical infant, child, and adolescent tracheobronchial geometries for dosimetry predictions. These tracheobronchial geometries were derived from either the morphometric measurements of J. D. Mortensen and colleagues or those of R. F. Ph...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600748349
更新日期:2006-09-01 00:00:00
abstract::AKR/J mice were exposed to cigarette smoke (CS) and/or lipopolysaccharide (LPS) via inhalation for 3 wk and pulmonary responses were evaluated. The objective was to explore the feasibility of coexposing LPS with cigarette smoke under a subacute exposure, as a surrogate for viral or bacterial insults, that would mimic ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600985784
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS:In order to identify a gr...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2016.1272652
更新日期:2017-01-01 00:00:00
abstract::Wollastonite is a naturally occurring calcium silicate (CaSiO(3)) that is produced in both powder and fibrous forms. It is a valuable industrial mineral used in plastics, ceramics, metallurgical applications, paint, and friction products. For some applications wollastonite serves as an asbestos replacement. To varying...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/08958370591002030
更新日期:2005-08-01 00:00:00
abstract::Objectives: To (1) design and build a low-cost exposure chamber system for whole-body exposure of rodents to electronic cigarette aerosol, (2) provide detailed instructions with particular focus on automated e-cigarette activation, and (3) develop a simple mathematical model for aerosol levels in the exposure chamber....
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2019.1698678
更新日期:2019-01-01 00:00:00
abstract:CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370903349365
更新日期:2010-03-01 00:00:00
abstract::Particle research has been historically closely connected to industrial activities or materials, such as coal, asbestos, man-made mineral fibers, and more recently ambient particulate matter (PM). It is the purpose of this review to combine insights and developments in particle toxicology with the historical context o...
journal_title:Inhalation toxicology
pub_type: 历史文章,杂志文章,评审
doi:10.1080/08958370252809086
更新日期:2002-03-01 00:00:00
abstract::This study was designed to investigate effects of sulfur dioxide (SO(2)) and its derivatives (bisulfite and sulfite) on the rat blood pressure. The blood pressures of male Wistar rats exposed to SO(2) and its derivatives at various doses were measured. Findings were that: (1) with acute-one time exposure to SO(2) for ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390215785
更新日期:2003-08-01 00:00:00
abstract:INTRODUCTION:Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in diffe...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1060278
更新日期:2015-01-01 00:00:00
abstract::Mexico City children are chronically exposed to significant concentrations of air pollutants and exhibit chronic respiratory-tract inflammation. Epidemiological, controlled human exposures, laboratory-based animal models, and in vitro/in vivo studies have shown that inflammatory, endothelial dysfunction, and endotheli...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701864797
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Dimethyl sulfide (DMS, CAS 75-18-3) is an industrial chemical. It is both an irritant and neurotoxicant that may be life-threatening because of accidental release. The effects of DMS on public health and associated public health response depend on the exposure concentration and duration. However, currently, p...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2018.1551444
更新日期:2018-01-01 00:00:00
abstract::Information on nasal particle deposition is used in risk assessments for exposure to airborne particulate pollutants and for optimizing the delivery of therapeutic aerosols. Monkeys are commonly used to assess the therapeutic potential of inhaled substances and to a lesser extent the toxicity of inhaled xenobiotics. Y...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370500241270
更新日期:2005-12-15 00:00:00
abstract::Objectives: This follow-up study set out to evaluate the natural course and radiographic progression of silicosis among ceramic workers and describe the risk factors related with disease progression. Materials and methods: We retrospectively analyzed the data of ceramic workers with silicosis who were referred to our ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2019.1613459
更新日期:2019-02-01 00:00:00
abstract::This study assessed the association between ambient air pollution and daily elementary school absenteeism in Washoe County, NV, between 1996 and 1998. All 57 elementary schools in Washoe County in northern Nevada were included in the data set. There was a total of 27,793 student enrollments during this study period. T...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370050164626
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:There has been an increase in the popularity of waterpipe tobacco smoking (WTS) worldwide, especially in the younger population, including asthma patients. In this study, we investigated the effects of waterpipe smoking on airway inflammation, cytokine levels and oxidative stress markers in an antigen-driven ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1280105
更新日期:2017-02-01 00:00:00
abstract::Background: The correlation of physico-chemical properties with mechanisms of toxicity has been proposed as an approach to predict the toxic potential of the vast number of emerging nanomaterials. Although relationships have been established between properties and the acute pulmonary inflammation induced by nanomateri...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2019.1680775
更新日期:2019-07-01 00:00:00
abstract::Several pharmacokinetic studies on inhalation exposure to manganese (Mn) have already demonstrated that Mn readily accumulates in the olfactory and brain regions. However, a shortening of the magnetic resonance imaging (MRI) T1 relaxation time or high T1 signal intensity in specific sites of the brain, including the g...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701516108
更新日期:2007-09-01 00:00:00
abstract:CONTEXT:Three heterocyclic nitrogen compounds, 2,3-diethylpyrazine (DEP), 2,3,5,6-tetramethylpyrazine (TMP), and 2-acetyl pyridine (AP), are naturally present in tobacco and are also added to tobacco as flavor ingredients. OBJECTIVE:A battery of tests was used to compare the toxicity of mainstream smoke from experimen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2010.545841
更新日期:2011-06-01 00:00:00
abstract::With growing evidence of the association between daily mortality and air pollution in adults, it is important to investigate whether infants are also susceptible to the adverse health effects of ambient air pollutants. The purpose of this study is to examine the relationship between air pollution and postneonatal mort...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370500434214
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:The toxicity of multi-walled carbon nanotubes (MWCNT) may be related to the immune system. The objective of this study was to obtain information for immunotoxic mechanisms of MWCNT in situ. METHODS:Using whole-body inhalation, male and female rats were exposed to 0, 0.2, 1 or 5 mg MWCNT/m³ for 13 weeks. The...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.953275
更新日期:2014-10-01 00:00:00
abstract::This study aims to investigate the negative effects of chronic exposure to isoflurane on spermatogenesis and explore the underlying mechanisms. Sixty male rats were randomly allocated to two groups: control group, receiving no treatment, and anesthesia group, administrated exposure to isoflurane (2 ppm) for 25 consecu...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1080772
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Numerous studies have found an association between transiently increased particulate matter air pollution and acute adverse cardiovascular health effects; however, the mechanisms underlying these effects are not clear. Translocation of ultra-fine ambient particulate matter has been proposed to play a key role...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2013.844749
更新日期:2013-11-01 00:00:00
abstract::Oxygen radical generation due to surface radicals, inflammation, and iron release has been suggested as the mechanism of adverse effects of quartz, such as emphysema, fibrosis, and carcinogenic effects. Therefore, we measured iron release, acellular generation of hydroxyl radicals, and oxidative DNA damage and cytotox...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583799196628
更新日期:1999-12-01 00:00:00
abstract::The purpose of this work is to define a sample preparation protocol that allows inorganic fibers and particulate matter extracted from different biological samples to be characterized morphologically, crystallographically and chemically by transmission electron microscopy-energy dispersive spectroscopy (TEM-EDS). The ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2016.1175527
更新日期:2016-07-01 00:00:00