A custom-built low-cost chamber for exposing rodents to e-cigarette aerosol: practical considerations.

abstract：:Recent studies have shown that air pollution is a risk factor for hospitalization for pneumonia. However, there is limited evidence to suggest what subpopulations are at greater risk from air pollution. This study was undertaken to examine the modifying effect of specific secondary diagnosis (including hypertension, d...

journal_title：Inhalation toxicology

authors： Cheng MF,Tsai SS,Chiu HF,Sung FC,Wu TN,Yang CY

更新日期：2009-11-01 00:00:00

abstract：:Objective: Cigarette tobacco smoking has been shown to cause cancer through different mechanisms that include epigenetic modulation of tumor-suppressor genes. In the present study, the association between global and MLH1 gene promoter methylation and waterpipe tobacco smoking was investigated. Materials and Methods: B...

journal_title：Inhalation toxicology

authors： Sabi SH,Khabour OF,Alzoubi KH,Cobb CO,Eissenberg T

更新日期：2020-02-01 00:00:00

abstract：:Halomethanes (HMs) can be formed during the chlorination process to obtain drinking water. In liver cells, HMs had been shown to be mutagenic and carcinogenic; however, their bioactivation by CYP 2E1 and GSTT1 is required. Although inhalation is the most common pathway of exposure, reports on the toxic effects induced...

journal_title：Inhalation toxicology

authors： Nájera-Martínez M,García-Latorre EA,Reyes-Maldonado E,Domínguez-López ML,Vega-López A

更新日期：2012-09-01 00:00:00

abstract：CONTEXT:Sulfur mustard exposure, as the most widely used chemical weapon, can lead to acute and long-term pulmonary complications via various pathways, such as triggering an imbalance between the oxidant and antioxidant system. Currently, there is no validated antidote, chemoprophylaxis and curative modality for pulmon...

journal_title：Inhalation toxicology

authors： Shohrati M,Karimzadeh I,Saburi A,Khalili H,Ghanei M

更新日期：2014-08-01 00:00:00

abstract：CONTEXT:Three heterocyclic nitrogen compounds, 2,3-diethylpyrazine (DEP), 2,3,5,6-tetramethylpyrazine (TMP), and 2-acetyl pyridine (AP), are naturally present in tobacco and are also added to tobacco as flavor ingredients. OBJECTIVE:A battery of tests was used to compare the toxicity of mainstream smoke from experimen...

journal_title：Inhalation toxicology

authors： Coggins CR,Merski JA,Oldham MJ

更新日期：2011-06-01 00:00:00

abstract：:The purpose of the Enhanced Particulate Matter Surveillance Program was to provide scientifically founded information on the chemical and physical properties of dust collected over a period of approximately 1 year in Djibouti, Afghanistan (Bagram, Khowst), Qatar, United Arab Emirates, Iraq (Balad, Baghdad, Tallil, Tik...

journal_title：Inhalation toxicology

authors： Engelbrecht JP,McDonald EV,Gillies JA,Jayanty RK,Casuccio G,Gertler AW

更新日期：2009-02-01 00:00:00

abstract：:The Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) study involved withdrawal, aging, and atmospheric transformation of emissions of three coal-fired power plants. Toxicological evaluations were carried out in rats exposed to different emission scenarios with extensive exposure characteriza...

journal_title：Inhalation toxicology

authors： Coull BA,Wellenius GA,Gonzalez-Flecha B,Diaz E,Koutrakis P,Godleski JJ

更新日期：2011-08-01 00:00:00

abstract：:Sexually mature male and female Gottingen minipigs were exposed to various concentrations of GB and GF vapor via whole-body inhalation exposures or to liquid GB or GF via intravenous or subcutaneous injections. Vapor inhalation exposures were for 10, 60 or 180 min. Maximum likelihood estimation was used to calculate t...

journal_title：Inhalation toxicology

authors： Hulet SW,Sommerville DR,Miller DB,Scotto JA,Muse WT,Burnett DC

更新日期：2014-02-01 00:00:00

abstract：:This article addresses the importance of blood pressure as a covariate in studies of long-term associations between air quality and mortality. We focus on a cohort of about 50,000 U.S. veterans who had been diagnosed as hypertensive at some time and whose survival rates were predicted by blood pressure (BP) and ambien...

journal_title：Inhalation toxicology

authors： Lipfert FW,Perry HM Jr,Miller JP,Baty JD,Wyzga RE,Carmody SE

更新日期：2003-04-25 00:00:00

abstract：:Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, it was studied whether airway irritation by sulfur dioxide (SO(2)) would enhance respiratory allergic reactions to trimellitic anhydride (TMA), using a rat model. Brown Norway (BN) rats ...

journal_title：Inhalation toxicology

authors： Arts JH,Jacobs EJ,Kuper CF

更新日期：2010-02-01 00:00:00

abstract：:Background: High-mobility group box 1 (HMGB1) protein plays an important pathogenic role in various diseases such as pulmonary fibrosis. However, the relationship between variation of HMGB1 gene and susceptibility to coal worker's pneumoconiosis (CWP) remains unclear. The objective of the study was to determine the as...

journal_title：Inhalation toxicology

authors： Tang Y,Duan J,Wang Y,Yuan L

更新日期：2020-03-01 00:00:00

abstract：:Although the association between exposure to asbestos fibers and the development of lung cancer and mesothelioma has been well established in humans, the carcinogenic potential of other natural and man-made fibers/particles is not clear. Various in vitro genotoxicity studies have been employed to assess their in vivo ...

journal_title：Inhalation toxicology

authors： Hei TK,Xu A,Louie D,Zhao YL

更新日期：2000-01-01 00:00:00

abstract：:Increased levels of C-reactive protein (CRP) and heat-shock protein-70 (Hsp70) in plasma are known to be associated with an increased risk of cardiovascular disease. In this study we have investigated the effects of environmental air pollution particles (PM10) and ultrafine carbon black (ufCB) on the expression of CRP...

journal_title：Inhalation toxicology

authors： Ramage L,Guy K

更新日期：2004-06-01 00:00:00

abstract：:Epidemiological studies suggest that diabetics may be more susceptible to the adverse health effects from exposure to high ambient concentrations of ozone, the primary oxidant gas in photochemical smog. While increased morbidity and mortality from ozone inhalation has been linked to disruption of normal cardiovascular...

journal_title：Inhalation toxicology

authors： Ying Z,Allen K,Zhong J,Chen M,Williams KM,Wagner JG,Lewandowski R,Sun Q,Rajagopalan S,Harkema JR

更新日期：2016-01-01 00:00:00

abstract：:An approach to identify causal components of complex air pollution mixtures was explored. Rats and mice were exposed by inhalation 6 h daily for 1 week or 6 months to dilutions of simulated downwind coal emissions, diesel and gasoline exhausts and wood smoke. Organ weights, hematology, serum chemistry, bronchoalveolar...

journal_title：Inhalation toxicology

authors： Mauderly JL,Seilkop SK

更新日期：2014-09-01 00:00:00

abstract：:This study was designed to investigate effects of sulfur dioxide (SO(2)) and its derivatives (bisulfite and sulfite) on the rat blood pressure. The blood pressures of male Wistar rats exposed to SO(2) and its derivatives at various doses were measured. Findings were that: (1) with acute-one time exposure to SO(2) for ...

journal_title：Inhalation toxicology

authors： Meng Z,Geng H,Bai J,Yan G

更新日期：2003-08-01 00:00:00

abstract：:Antisense oligonucleotides (ASOs) bind and facilitate degradation of RNA and inhibit protein expression in pathways not easily targeted with small molecules or antibodies. Interleukin (IL)-4 and IL-13 potentiate signaling through the shared IL-4 receptor-α (IL-4Rα) subunit of their receptors. ASO targeting of IL-4Rα m...

journal_title：Inhalation toxicology

authors： Fey RA,Templin MV,McDonald JD,Yu RZ,Hutt JA,Gigliotti AP,Henry SP,Reed MD

更新日期：2014-07-01 00:00:00

abstract：:Epidemiologic studies have provided strong evidence that episodic exposure to ambient particulate matter is associated with increases in morbidity and mortality. These adverse effects have been demonstrated at concentrations far below the National Ambient Air Quality Standard (NAAQS), and thus, the biological plausibi...

journal_title：Inhalation toxicology

authors： Gordon T,Gerber H,Fang CP,Chen LC

更新日期：1999-01-01 00:00:00

abstract：:Measurement strategies as well as results from measurements at workplaces are presented. Measurements were performed in research laboratories as well as by companies producing small amounts of nanostructured materials. The work was done in the frame of a BAuA (Bundesanstalt für Arbeitsschutz und Arbeitsmedizin) resear...

journal_title：Inhalation toxicology

authors： Plitzko S

更新日期：2009-07-01 00:00:00

abstract：:Tire and road wear particles (TRWP) are a component of ambient particulate matter (PM) produced from the interaction of tires with the roadway. Inhalation of PM has been associated with cardiopulmonary morbidities and mortalities thought to stem from pulmonary inflammation. To determine whether TRWP may contribute to ...

journal_title：Inhalation toxicology

authors： Kreider ML,Doyle-Eisele M,Russell RG,McDonald JD,Panko JM

更新日期：2012-11-01 00:00:00

abstract：CONTEXT:Sulfur mustard (SM) causes skin blistering and long-term pulmonary dysfunction. Its adverse effects have been studied in battlefield-exposed humans, but lack of knowledge regarding confounding factors makes interpretation challenging. Animal studies are critical to understanding mechanisms, but differences betw...

journal_title：Inhalation toxicology

authors： Seagrave J,Weber WM,Grotendorst GR

更新日期：2010-09-01 00:00:00

abstract：:The Toxicological Evaluation of Realistic Emissions Source Aerosols (TERESA) study was carried out at three US coal-fired power plants to investigate the potential toxicological effects of primary and photochemically aged (secondary) particles using in situ stack emissions. The exposure system designed successfully si...

journal_title：Inhalation toxicology

authors： Kang CM,Gupta T,Ruiz PA,Wolfson JM,Ferguson ST,Lawrence JE,Rohr AC,Godleski J,Koutrakis P

更新日期：2011-08-01 00:00:00

abstract：:A cross-sectional study on suberosis was conducted in the Champagne-Ardenne County, France, to determine the prevalence of respiratory symptoms, the level of pulmonary function, and the presence of precipitins against Penicillium frequentans. Thirteen of the 33 workers exposed to cork dust had respiratory symptoms exc...

journal_title：Inhalation toxicology

authors： Deschamps F,Foudrinier F,Dherbecourt V,Mas P,Prevost E,Legrele AM,Bellier S,Toubas D

更新日期：2003-12-01 00:00:00

abstract：:Airstream clearance (with units of volume/time) is the volumetric flow from which chemical would have to be completely removed to account for the net loss in the nose. Extraction is the proportion of airflow from which the chemical is completely removed. Over the past several years we have developed physiologically ba...

journal_title：Inhalation toxicology

authors： Andersen ME,Sarangapani R

更新日期：2001-05-01 00:00:00

abstract：:Endotoxin causes an inflammation at the bronchial and alveolar level. The inflammation-induced increase in permeability of the bronchoalveolar epithelial barrier is supposed to cause a leakage of pneumoproteins. Therefore, their concentrations are expected to increase in the bloodstream. This study aimed at examining ...

journal_title：Inhalation toxicology

authors： Widmeier S,Bernard A,Tschopp A,Jeggli S,Dumont X,Hilfiker S,Oppliger A,Hotz P

更新日期：2007-04-01 00:00:00

abstract：:Recurrent events, such as repeated hospital admissions for the same health outcome, occur frequently in environmental health studies. In this study, we conducted an analysis of data on repeated respiratory hospitalizations among the elderly in Vancouver, Canada, for the period of June 1, 1995, to March 31, 1999, using...

journal_title：Inhalation toxicology

authors： Fung KY,Khan S,Krewski D,Chen Y

更新日期：2006-12-01 00:00:00

abstract：:We used inert melamin particles that are very well defined in size (diameters: 0.5, 1.9, 6.8 microm) to study the effects of ambient particles of <10 microm (PM(10)) on phagocytosis. Dose-response functions were found between the amount of added melamin particle mass and the toxicity. Fine particles (0.5 microm) were ...

journal_title：Inhalation toxicology

authors： Monn C,Fendt R,Koller T

更新日期：2002-04-01 00:00:00

abstract：:Laboratory studies involving intentional and highly controlled exposures to air pollutants among groups of human volunteers provide valuable information related to the potential health effects of pollutants regulated under the US Clean Air Act. These controlled human exposure studies often provide biological plausibil...

journal_title：Inhalation toxicology

authors： Johns DO,Linn WS

更新日期：2011-01-01 00:00:00

abstract：:It is well documented that inhalation of sulfur mustard causes injury of the respiratory system. While all of the reports and surveys thoroughly document long-term pulmonary effects after significant exposure to mustard, there is no direct evidence that addresses the issue of long-term respiratory effects in individua...

journal_title：Inhalation toxicology

authors： Ghanei M,Fathi H,Mohammad MM,Aslani J,Nematizadeh F

更新日期：2004-07-01 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNT) have been reported to cause lung pathologies in multiple studies. However, the mechanism responsible for the bioactivity has not been determined. This study used nine different well-characterized MWCNT and examined the outcomes in vitro and in vivo. MWCNT, from a variety of source...

journal_title：Inhalation toxicology

authors： Hamilton RF Jr,Buford M,Xiang C,Wu N,Holian A

更新日期：2012-12-01 00:00:00