Particles from wood smoke and road traffic differently affect the innate immune system of the lung.

abstract：:Increasing evidence suggests a role for a systemic pro-coagulant state in the pathogenesis of cardiac dysfunction subsequent to inhalation of airborne particulate matter (PM). We evaluated platelet activation, systemic cytokines and pulmonary gene expression in mice exposed to concentrated ambient particulate matter (...

journal_title：Inhalation toxicology

authors： Tablin F,den Hartigh LJ,Aung HH,Lame MW,Kleeman MJ,Ham W,Norris JW,Pombo M,Wilson DW

更新日期：2012-07-01 00:00:00

abstract：:Inhalation exposure systems are necessary tools for determining the dose-response relationship of inhaled toxicants under a variety of exposure conditions. The objective of this project was to develop an automated computer controlled system to expose small laboratory animals to precise concentrations of airborne multi...

journal_title：Inhalation toxicology

authors： McKinney W,Chen B,Frazer D

更新日期：2009-10-01 00:00:00

abstract：:Wistar rats were exposed for 24 mo to diesel emissions containing a low (0.2 ppm, 0.21 mg/m(3)), medium (1.04 ppm, 1.18 mg/m(3)), or high (2.96 ppm, 3.05 mg/m(3)) concentration of NO(2) and particles, or diesel emissions containing a medium (1.12 ppm, 0.01 mg/m(3)) concentration of NO(2) without particles. At 6-mo int...

journal_title：Inhalation toxicology

authors： Kato A,Nagai A,Kagawa J

更新日期：2000-06-01 00:00:00

abstract：:Epidemiological studies have reported increased morbidity in human populations following inhalation of elevated levels of urban particulate matter. These responses are especially prevalent in populations with chronic obstructive pulmonary diseases, including chronic bronchitis. Toxicological studies have reported alte...

journal_title：Inhalation toxicology

authors： Clarke RW,Catalano PJ,Koutrakis P,Murthy GG,Sioutas C,Paulauskis J,Coull B,Ferguson S,Godleski JJ

更新日期：1999-08-01 00:00:00

abstract：:Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, the effect of airway irritation by synthetic amorphous silica (SAS) on respiratory allergy to trimellitic anhydride (TMA) was studied. Brown Norway (BN) rats were topically sensitized on...

journal_title：Inhalation toxicology

authors： Arts JH,Schijf MA,Kuper CF

更新日期：2008-08-01 00:00:00

abstract：:Risk assessment of occupational exposure to nanomaterials is needed. Human data are limited, but quantitative data are available from rodent studies. To use these data in risk assessment, a scientifically reasonable approach for extrapolating the rodent data to humans is required. One approach is allometric adjustment...

journal_title：Inhalation toxicology

authors： Kuempel ED,Tran CL,Castranova V,Bailer AJ

更新日期：2006-09-01 00:00:00

abstract：:Epidemiological studies suggest that diabetics may be more susceptible to the adverse health effects from exposure to high ambient concentrations of ozone, the primary oxidant gas in photochemical smog. While increased morbidity and mortality from ozone inhalation has been linked to disruption of normal cardiovascular...

journal_title：Inhalation toxicology

authors： Ying Z,Allen K,Zhong J,Chen M,Williams KM,Wagner JG,Lewandowski R,Sun Q,Rajagopalan S,Harkema JR

更新日期：2016-01-01 00:00:00

abstract：:Halomethanes (HMs) can be formed during the chlorination process to obtain drinking water. In liver cells, HMs had been shown to be mutagenic and carcinogenic; however, their bioactivation by CYP 2E1 and GSTT1 is required. Although inhalation is the most common pathway of exposure, reports on the toxic effects induced...

journal_title：Inhalation toxicology

authors： Nájera-Martínez M,García-Latorre EA,Reyes-Maldonado E,Domínguez-López ML,Vega-López A

更新日期：2012-09-01 00:00:00

abstract：:Cellulose fibers, along with many other organic fibers, are durable. Therefore, if inhaled, they have the potential to persist within the lung, and may then cause disease. Here we report the effects of injecting high-purity cellulose fibers into the abdominal cavity of rats. A respirable fraction of cellulose fiber wa...

journal_title：Inhalation toxicology

authors： Cullen RT,Miller BG,Clark S,Davis JM

更新日期：2002-07-01 00:00:00

abstract：:A study was performed in Sprague-Dawley rats (Crl:CD BR) to differentiate between effects of hydrofluorocarbon 123 (HCFC-123) on the lactating dam or on the fetus using fostering and cross-fostering of the offspring. Pregnant and/or lactating dams without the pups present were exposed to the test substance (1000 ppm) ...

journal_title：Inhalation toxicology

authors： Buschmann J,Bartsch W,Dasenbrock C,Fuhst R,Pohlmann G,Preiss A,Berger-Preiss E

更新日期：2001-08-01 00:00:00

abstract：:The irritants acrolein, acetaldehyde, and acetic acid induce a rapid sensory nerve-mediated nasal vasodilatory response in the rat. The aim of the current study was to examine acute nasal sensory nerve-mediated acute responses to an irritant ester vapor, ethyl acrylate. For this purpose, the upper respiratory tract of...

journal_title：Inhalation toxicology

authors： Morris JB

更新日期：2002-06-01 00:00:00

abstract：:Background: While the role of lysosomal membrane permeabilization (LMP) in NP-induced inflammatory responses has been recognized, the underlying mechanism of LMP is still unclear. The assumption has been that zinc oxide (ZnO)-induced LMP is due to Zn2+; however, little is known about the role of ZnO nanoparticles (NP)...

journal_title：Inhalation toxicology

authors： Ziglari T,Anderson DS,Holian A

更新日期：2020-02-01 00:00:00

abstract：:Background: Allergies and smoking are common reasons for nasal mucosa inflammations, which in turn, cause nasal obstructions. Nevertheless, the impact of coexisting allergies and smoking on nasal mucosa inflammation has not been studied.Objectives: To study the impact of smoking with relation to allergies on nasal muc...

journal_title：Inhalation toxicology

authors： Warman M,Tiomkin E,Huszar M,Halperin D,Asher I,Cohen O

更新日期：2020-05-01 00:00:00

abstract：:A combination of high fuel prices, bus maintenance costs, and the health and safety of school children, along with a consideration of federal and state regulations, prompted Medford Township school district in southern New Jersey to explore the use of alternative fuels, specifically biodiesel. The school district owns...

journal_title：Inhalation toxicology

authors： Biluck J Jr

更新日期：2007-09-01 00:00:00

abstract：:Nasal efficiency for removing fine particles from inhaled air may be affected by variations in nasal structure associated with race. In 11 African American and 11 Caucasian adults (age 18-31 yr) we measured the fractional deposition (DF) of fine particles (1 and 2 mum mass median aerodynamic diameter) (MMAD) for oral ...

journal_title：Inhalation toxicology

authors： Bennett WD,Zeman KL

更新日期：2005-11-01 00:00:00

abstract：:The Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) study involved withdrawal, aging, and atmospheric transformation of emissions of three coal-fired power plants. Toxicological evaluations were carried out in rats exposed to different emission scenarios with extensive exposure characteriza...

journal_title：Inhalation toxicology

authors： Coull BA,Wellenius GA,Gonzalez-Flecha B,Diaz E,Koutrakis P,Godleski JJ

更新日期：2011-08-01 00:00:00

abstract：:Introduction: Tobacco use is a major risk factor of cardiovascular diseases (CVD) and atherosclerosis in particular. The use of waterpipe smoking (WPS) is increasing due to the misperception that it is less harmful than cigarette smoking due to its flavor and the use of water as a filter. Thus, research that investiga...

journal_title：Inhalation toxicology

authors： Rababa'h AM,Bsoul RW,Alkhatatbeh MJ,Alzoubi KH,Khabour OF

更新日期：2019-02-01 00:00:00

abstract：:Ultrafine particles (diameter < 100 nm) may be important in the health effects of air pollution, in part because of their predicted high respiratory deposition. However, there are few measurements of ultrafine particle deposition during spontaneous breathing. The fractional deposition for the total respiratory tract o...

journal_title：Inhalation toxicology

authors： Daigle CC,Chalupa DC,Gibb FR,Morrow PE,Oberdörster G,Utell MJ,Frampton MW

更新日期：2003-05-01 00:00:00

abstract：:Laboratory studies involving intentional and highly controlled exposures to air pollutants among groups of human volunteers provide valuable information related to the potential health effects of pollutants regulated under the US Clean Air Act. These controlled human exposure studies often provide biological plausibil...

journal_title：Inhalation toxicology

authors： Johns DO,Linn WS

更新日期：2011-01-01 00:00:00

abstract：:Sulfur dioxide (SO2) is a common but important air pollutant. Micronuclei (MN) in the polychromatic erythrocytes (PCE) of mouse bone marrow and the ratio between organ and body weight of treatment mouse were determined and analyzed in vivo in order to study injury of sulfur dioxide inhalation on organs and germ plasm ...

journal_title：Inhalation toxicology

authors： Ruan A,Min H,Meng Z,Lü Z

更新日期：2003-09-01 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNT) have been reported to cause lung pathologies in multiple studies. However, the mechanism responsible for the bioactivity has not been determined. This study used nine different well-characterized MWCNT and examined the outcomes in vitro and in vivo. MWCNT, from a variety of source...

journal_title：Inhalation toxicology

authors： Hamilton RF Jr,Buford M,Xiang C,Wu N,Holian A

更新日期：2012-12-01 00:00:00

abstract：CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...

journal_title：Inhalation toxicology

authors： Ramos-Bonilla JP,Breysse PN,Dominici F,Geyh A,Tankersley CG

更新日期：2010-03-01 00:00:00

abstract：:Results from epidemiology studies have shown statistical associations between ambient air particulate matter (PM) concentrations and mortality/morbidity, particularly among susceptible subpopulations. Although the epidemiology of ambient air PM is compelling, there remains considerable uncertainty in PM risk assessmen...

journal_title：Inhalation toxicology

authors： Dreher KL

更新日期：2000-01-01 00:00:00

abstract：:Although the association between exposure to asbestos fibers and the development of lung cancer and mesothelioma has been well established in humans, the carcinogenic potential of other natural and man-made fibers/particles is not clear. Various in vitro genotoxicity studies have been employed to assess their in vivo ...

journal_title：Inhalation toxicology

authors： Hei TK,Xu A,Louie D,Zhao YL

更新日期：2000-01-01 00:00:00

abstract：:This study assessed the association between ambient air pollution and daily elementary school absenteeism in Washoe County, NV, between 1996 and 1998. All 57 elementary schools in Washoe County in northern Nevada were included in the data set. There was a total of 27,793 student enrollments during this study period. T...

journal_title：Inhalation toxicology

authors： Chen L,Jennison BL,Yang W,Omaye ST

更新日期：2000-11-01 00:00:00

abstract：:Increased levels of C-reactive protein (CRP) and heat-shock protein-70 (Hsp70) in plasma are known to be associated with an increased risk of cardiovascular disease. In this study we have investigated the effects of environmental air pollution particles (PM10) and ultrafine carbon black (ufCB) on the expression of CRP...

journal_title：Inhalation toxicology

authors： Ramage L,Guy K

更新日期：2004-06-01 00:00:00

abstract：:Objectives: To (1) design and build a low-cost exposure chamber system for whole-body exposure of rodents to electronic cigarette aerosol, (2) provide detailed instructions with particular focus on automated e-cigarette activation, and (3) develop a simple mathematical model for aerosol levels in the exposure chamber....

journal_title：Inhalation toxicology

authors： Hilpert M,Ilievski V,Coady M,Andrade-Gutierrez M,Yan B,Chillrud SN,Navas-Acien A,Kleiman NJ

更新日期：2019-01-01 00:00:00

abstract：:Sulfur dioxide (SO2) is a ubiquitous air pollutant, present in low concentrations in the urban air and in higher concentrations in the working environment. In this study, we investigated the effects of inhaled SO2 on the O-dealkylase of pentoxyresorufin (PROD) and p-nitrophenol hydroxylases (p-NP) activities and mRNA ...

journal_title：Inhalation toxicology

authors： Qin G,Meng Z

更新日期：2006-07-01 00:00:00

abstract：:The lung toxicity of inhalable polymer materials is normally carried out by evaluation of the histopathology responses of rat lungs to repeat, nose-only, exposures of an inhalable aerosol of material in a 13-wk subchronic repeat dose toxicity study. The introduction of transcriptomics into toxicology has allowed the c...

journal_title：Inhalation toxicology

authors： Carthew P,Fletcher S,White A,Harries H,Weber K

更新日期：2006-04-01 00:00:00

abstract：:The effect of prenatal exposure to diesel exhaust (DE) was investigated. Twenty pregnant ICR mice were exposed to DE at the particle concentration of 1.0 mg/m3, from d 2 until d 16 postcoitum. Male offspring were kept alive until 12 wk of age, and then male reproductive organ weight, daily sperm production (DSP), seru...

journal_title：Inhalation toxicology

authors： Ono N,Oshio S,Niwata Y,Yoshida S,Tsukue N,Sugawara I,Takano H,Takeda K

更新日期：2007-03-01 00:00:00