Abstract:
:Increased levels of C-reactive protein (CRP) and heat-shock protein-70 (Hsp70) in plasma are known to be associated with an increased risk of cardiovascular disease. In this study we have investigated the effects of environmental air pollution particles (PM10) and ultrafine carbon black (ufCB) on the expression of CRP and Hsp70 in the lung epithelial cell line, A549. After treatment with PM10 or ufCB the cells were found to have increased expression of CRP and Hsp70 localized in both the cell cytoplasm and nucleus. Analysis of the cell supernatants revealed that CRP and Hsp70 were present, suggesting secretion of both proteins in response to the particulate treatment. To investigate if the expression of CRP and Hsp70 was the result of free radical production, cells were treated with ufCB in the presence of antioxidants (NAL and Trolox). This revealed that antioxidants reduced the amount of CRP and Hsp70 secreted from the cells. These findings suggest that CRP and Hsp70 may be secreted from the lung epithelium as a result of oxidative stress and have important effects on the inflammatory response associated with inhalation of particulate matter.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Ramage L,Guy Kdoi
10.1080/08958370490439614subject
Has Abstractpub_date
2004-06-01 00:00:00pages
447-52issue
6-7eissn
0895-8378issn
1091-7691pii
MCGF41NTJG3EE253journal_volume
16pub_type
杂志文章abstract:CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370903349365
更新日期:2010-03-01 00:00:00
abstract::The purpose of this study was to characterize the respiratory effects of single and repeated controlled exposures to clean warm humid and cold dry air in a new model of anesthetized, mechanically ventilated guinea pigs, and to compare findings with known effects in humans. Intratracheal air (T(tr)) and retrotracheal t...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370050085129
更新日期:2000-08-01 00:00:00
abstract::Epidemiological and experimental data suggest that obesity exacerbates the health effects of air pollutants such as ozone (O3). Maternal inactivity and calorically rich diets lead to offspring that show signs of obesity. Exacerbated O3 susceptibility of offspring could thus be manifested by maternal obesity. Thirty-da...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1342719
更新日期:2017-05-01 00:00:00
abstract::Chronic bronchitis is a significant cause of morbidity and mortality. Chronic irritation of the conducting airways by inhaled substances, most importantly cigarette smoke, air pollution, and occupational exposures, is thought to be a key factor in the pathogenesis of chronic bronchitis. Microbial infections have been ...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/089583700750019549
更新日期:2000-01-01 00:00:00
abstract::The Provisional Advisory Level (PAL) protocol was applied to estimate inhalation exposure limits for phosgene (CG). Three levels (PAL 1, PAL 2, and PAL 3), distinguished by severity of toxic effects, are developed for 24-hour, 30-day, 90-day, and 2-year durations of potential drinking water and inhalation exposures fo...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.3109/08958370903202820
更新日期:2009-12-01 00:00:00
abstract::The use of methylcyclopentadienyl manganese tricarbonyl (MMT) in unleaded gasoline has given rise to numerous debates on the potential public health risk associated with manganese emissions. In fact, combustion products are mainly Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. Our research group did sever...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490277245
更新日期:2004-04-01 00:00:00
abstract:CONTEXT:Eleven carbohydrates and natural product ingredients were added individually to experimental cigarettes. OBJECTIVE:A battery of tests was used to compare toxicity of mainstream smoke from these experimental cigarettes to matched control cigarettes without test ingredients. MATERIALS AND METHODS:Smoke fraction...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.545085
更新日期:2011-06-01 00:00:00
abstract::Halomethanes (HMs) can be formed during the chlorination process to obtain drinking water. In liver cells, HMs had been shown to be mutagenic and carcinogenic; however, their bioactivation by CYP 2E1 and GSTT1 is required. Although inhalation is the most common pathway of exposure, reports on the toxic effects induced...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.716871
更新日期:2012-09-01 00:00:00
abstract::Acute exposure to ambient fine particulate matter (PM2.5) is tied to cardiovascular morbidity and mortality, especially among those with prior cardiac injury. The mechanisms and pathophysiological events precipitating these outcomes remain poorly understood but may involve inflammation, oxidative stress, arrhythmia an...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.995387
更新日期:2015-02-01 00:00:00
abstract::The effect of particles from road traffic and wood smoke on the innate immune response in the lung was studied in a lung challenge model with the intracellular bacterium Listeria monocytogenes. Female Balb/cA mice were instilled intratracheally with wood smoke particles, particles from road traffic collected during wi...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802590499
更新日期:2009-09-01 00:00:00
abstract::Results from epidemiology studies have shown statistical associations between ambient air particulate matter (PM) concentrations and mortality/morbidity, particularly among susceptible subpopulations. Although the epidemiology of ambient air PM is compelling, there remains considerable uncertainty in PM risk assessmen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2000.11463230
更新日期:2000-01-01 00:00:00
abstract::Information on nasal particle deposition is used in risk assessments for exposure to airborne particulate pollutants and for optimizing the delivery of therapeutic aerosols. Monkeys are commonly used to assess the therapeutic potential of inhaled substances and to a lesser extent the toxicity of inhaled xenobiotics. Y...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370500241270
更新日期:2005-12-15 00:00:00
abstract::We used inert melamin particles that are very well defined in size (diameters: 0.5, 1.9, 6.8 microm) to study the effects of ambient particles of <10 microm (PM(10)) on phagocytosis. Dose-response functions were found between the amount of added melamin particle mass and the toxicity. Fine particles (0.5 microm) were ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370252871005
更新日期:2002-04-01 00:00:00
abstract:CONTEXT:Three heterocyclic nitrogen compounds, 2,3-diethylpyrazine (DEP), 2,3,5,6-tetramethylpyrazine (TMP), and 2-acetyl pyridine (AP), are naturally present in tobacco and are also added to tobacco as flavor ingredients. OBJECTIVE:A battery of tests was used to compare the toxicity of mainstream smoke from experimen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2010.545841
更新日期:2011-06-01 00:00:00
abstract::The antibacterial effect of silver nanoparticles has resulted in their extensive application in health, electronic, and home products. However, while the population exposed to silver nanoparticles continues to increase with ever new applications, silver nanoparticles remain a controversial research area as regards the...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701874663
更新日期:2008-04-01 00:00:00
abstract::The intent of this article is to review the comparative nonneoplastic pathological responses (inflammation, fibrosis, and epithelial proliferation) of rats, hamsters, mice, and monkeys to low-toxicity dusts (TiO(2), carbon black, talc, coal-mine dust, and diesel particulate). The paucity of information on some of thes...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/089583700196563
更新日期:2000-01-01 00:00:00
abstract::Studies have shown associations between acute ambient particulate matter (PM) levels and increases in morbidity and mortality from cardiovascular diseases. We have previously reported in 24 healthy adults that exposure to concentrated ambient particles plus ozone (CAP + O(3)) caused a mean decrease of 0.09 mm in brach...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490439489
更新日期:2004-06-01 00:00:00
abstract::Endotoxin causes an inflammation at the bronchial and alveolar level. The inflammation-induced increase in permeability of the bronchoalveolar epithelial barrier is supposed to cause a leakage of pneumoproteins. Therefore, their concentrations are expected to increase in the bloodstream. This study aimed at examining ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370601144456
更新日期:2007-04-01 00:00:00
abstract::NASA is planning to build a habitat on the Moon and use the Moon as a stepping stone to Mars. JSC-1, an Arizona volcanic ash that has mineral properties similar to those of lunar soil, is used to produce lunar environments for instrument and equipment testing. NASA is concerned about potential health risks to workers ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701821219
更新日期:2008-01-01 00:00:00
abstract::With regard to genotoxicity testing and cancer risk assessment, particles and fibers form a rather specific group among all toxicants. First, the physicochemical behavior of fibrous and nonfibrous particles is usually very different from that of nonparticulate, chemical carcinogens. Reactive oxygen species (ROS) are b...
journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
doi:10.1080/089583701753338631
更新日期:2002-01-01 00:00:00
abstract::Computational fluid dynamic modeling software has enabled microdosimetry patterns of inhaled toxins and toxicants to be predicted and visualized, and is being used in inhalation toxicology and risk assessment. These predicted microdosimetry patterns in airway structures are derived from predicted airflow patterns with...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701260889
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:The toxicity of multi-walled carbon nanotubes (MWCNT) may be related to the immune system. The objective of this study was to obtain information for immunotoxic mechanisms of MWCNT in situ. METHODS:Using whole-body inhalation, male and female rats were exposed to 0, 0.2, 1 or 5 mg MWCNT/m³ for 13 weeks. The...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.953275
更新日期:2014-10-01 00:00:00
abstract::The aim of the present study was to investigate the effect of low-level concentrations, under the occupational acceptable limits, of toluene exposure and peptidoglycan (PGN) stimulation on Th1/Th2 immunity in infant mice. Pregnant BALB/c mice and their offspring were exposed to low-level toluene inhalation (0, 5, and ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370902798448
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Animal studies on refractory ceramic fiber (RCF) have led to the suggestion that RCF might resemble asbestos in carcinogenicity. Human data are available to test this hypothesis. METHODS:We compared the occurrence of lung cancer and mesothelioma in 605 men engaged in the manufacture of RCF and followed sinc...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.683892
更新日期:2012-06-01 00:00:00
abstract::The effect of prenatal exposure to diesel exhaust (DE) was investigated. Twenty pregnant ICR mice were exposed to DE at the particle concentration of 1.0 mg/m3, from d 2 until d 16 postcoitum. Male offspring were kept alive until 12 wk of age, and then male reproductive organ weight, daily sperm production (DSP), seru...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370601069257
更新日期:2007-03-01 00:00:00
abstract::Continuous environmental or occupational exposure to airborne particulate pollution is believed to be a major hazard for human health. A technique to characterize their deposition and clearance from the lungs is fundamental to understand the underlying mechanisms behind their negative health effects. In this work, we ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2010.549856
更新日期:2011-02-01 00:00:00
abstract::We briefly review the evidence that the carcinogenic risk posed by inhaled fibers depends principally on the lung burden of long fibers. We use a deposition clearance model to generate time-dependent lung burdens in rats of a dozen long fibers for various exposure concentrations. Together with a previously estimated p...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/089583701316941294
更新日期:2001-09-01 00:00:00
abstract::A number of Norwegian soldiers have reported health problems after live-fire training using the HK416 rifle. The objective of this study was to characterize gaseous and particulate emissions from three different types of ammunition, and record the health effects after exposure to emissions from live-firing. Fifty-five...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.970783
更新日期:2014-12-01 00:00:00
abstract::Airstream clearance (with units of volume/time) is the volumetric flow from which chemical would have to be completely removed to account for the net loss in the nose. Extraction is the proportion of airflow from which the chemical is completely removed. Over the past several years we have developed physiologically ba...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370151126284
更新日期:2001-05-01 00:00:00
abstract::An approach to identify causal components of complex air pollution mixtures was explored. Rats and mice were exposed by inhalation 6 h daily for 1 week or 6 months to dilutions of simulated downwind coal emissions, diesel and gasoline exhausts and wood smoke. Organ weights, hematology, serum chemistry, bronchoalveolar...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.920440
更新日期:2014-09-01 00:00:00