Ambient PM(10) extracts inhibit phagocytosis of defined inert model particles by alveolar macrophages.

abstract：PURPOSE:This research describes a novel "minitower" dry powder delivery system for nose-only delivery of dry powder aerosols to spontaneously breathing rats. METHODS:The minitower system forces pressurized air through pre-filled capsules to deliver aerosolized drug to four nose ports; three of which house spontaneousl...

journal_title：Inhalation toxicology

authors： Sellers S,Horodnik W,House A,Wylie J,Mauser P,Donovan B

更新日期：2015-01-01 00:00:00

abstract：:We briefly review the evidence that the carcinogenic risk posed by inhaled fibers depends principally on the lung burden of long fibers. We use a deposition clearance model to generate time-dependent lung burdens in rats of a dozen long fibers for various exposure concentrations. Together with a previously estimated p...

journal_title：Inhalation toxicology

authors： Moolgavkar SH,Brown RC,Turim J

更新日期：2001-09-01 00:00:00

abstract：:The aim of this study was to investigate the dose-related effects of dichlorvos inhalation on electrophysiological alterations of diaphragm and phrenic nerve and the changes in the histologic structure of respiratory system. This study was performed on 33 rats divided into 5 groups, inhaling 1, 2, 5, 10, and 15 microg...

journal_title：Inhalation toxicology

authors： Atiş S,Cömelekoğlu U,Coşkun B,Ozge A,Ersöz G,Talas D

更新日期：2002-02-01 00:00:00

abstract：:Laboratory studies involving intentional and highly controlled exposures to air pollutants among groups of human volunteers provide valuable information related to the potential health effects of pollutants regulated under the US Clean Air Act. These controlled human exposure studies often provide biological plausibil...

journal_title：Inhalation toxicology

authors： Johns DO,Linn WS

更新日期：2011-01-01 00:00:00

abstract：:Regulatory guidelines are intended to provide recommendations on ways to achieve greater harmonization in the interpretation and application of technical procedures and requirements for product registration in order to reduce or obviate replication of the testing carried out during the research and development of new ...

journal_title：Inhalation toxicology

authors： Jones DR,Baldrick P

更新日期：2013-02-01 00:00:00

abstract：:Antisense oligonucleotides (ASOs) bind and facilitate degradation of RNA and inhibit protein expression in pathways not easily targeted with small molecules or antibodies. Interleukin (IL)-4 and IL-13 potentiate signaling through the shared IL-4 receptor-α (IL-4Rα) subunit of their receptors. ASO targeting of IL-4Rα m...

journal_title：Inhalation toxicology

authors： Fey RA,Templin MV,McDonald JD,Yu RZ,Hutt JA,Gigliotti AP,Henry SP,Reed MD

更新日期：2014-07-01 00:00:00

abstract：:Crystalline silica has been classified as a human carcinogen, but there is still considerable controversy regarding its fibrogenic and carcinogenic potential. In the present study, we investigated the genotoxic potential of bentonite particles (diameter < 10 microm) with an a-quartz content of up to 6% and different c...

journal_title：Inhalation toxicology

authors： Geh S,Shi T,Shokouhi B,Schins RP,Armbruster L,Rettenmeier AW,Dopp E

更新日期：2006-05-01 00:00:00

abstract：:Studies have shown associations between acute ambient particulate matter (PM) levels and increases in morbidity and mortality from cardiovascular diseases. We have previously reported in 24 healthy adults that exposure to concentrated ambient particles plus ozone (CAP + O(3)) caused a mean decrease of 0.09 mm in brach...

journal_title：Inhalation toxicology

authors： Urch B,Brook JR,Wasserstein D,Brook RD,Rajagopalan S,Corey P,Silverman F

更新日期：2004-06-01 00:00:00

abstract：:Wistar rats were exposed for 24 mo to diesel emissions containing a low (0.2 ppm, 0.21 mg/m(3)), medium (1.04 ppm, 1.18 mg/m(3)), or high (2.96 ppm, 3.05 mg/m(3)) concentration of NO(2) and particles, or diesel emissions containing a medium (1.12 ppm, 0.01 mg/m(3)) concentration of NO(2) without particles. At 6-mo int...

journal_title：Inhalation toxicology

authors： Kato A,Nagai A,Kagawa J

更新日期：2000-06-01 00:00:00

abstract：:This special issue describes the scientific progress and scientific review process to develop a safer cigarette. A peer-review panel, the ECLIPSE Expert Panel, was convened to critically review the potential health hazards of this new cigarette to a reference, conventional cigarette that bums tobacco. This new cigaret...

journal_title：Inhalation toxicology

authors： ECLIPSE Expert Panel.

更新日期：2000-01-01 00:00:00

abstract：:Particle research has been historically closely connected to industrial activities or materials, such as coal, asbestos, man-made mineral fibers, and more recently ambient particulate matter (PM). It is the purpose of this review to combine insights and developments in particle toxicology with the historical context o...

journal_title：Inhalation toxicology

authors： Borm PJ

更新日期：2002-03-01 00:00:00

abstract：:In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...

journal_title：Inhalation toxicology

authors： Stöber W

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS:In order to identify a gr...

journal_title：Inhalation toxicology

authors： Świątkowska B,Szeszenia-Dąbrowska N

更新日期：2017-01-01 00:00:00

abstract：:Bronchial epithelial cells exposed to allergens typically secrete chemokines to recruit eosinophils. Persistent inflammation and repair responses result in airway remodeling and irreversible airflow limitation. House dust mite (HDM) is a common allergen causing allergic disorders. Thioredoxin (TRX) is a redox protein ...

journal_title：Inhalation toxicology

authors： Chuang CY,Chang CH,Huang YL

更新日期：2009-02-01 00:00:00

abstract：CONTEXT:Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body. OBJECTIVES:To describe the normal lung deposition and 1 week particle retention of indium-111 labeled UF carbo...

journal_title：Inhalation toxicology

authors： Klepczyńska-Nyström A,Sanchez-Crespo A,Andersson M,Falk R,Lundin A,Larsson BM,Svartengren M

更新日期：2012-08-01 00:00:00

abstract：:To elucidate dose-response and other effects of diesel particles in guinea pigs chronically exposed to diesel exhaust, various biomarkers for chronic obstructive lung diseases were studied using bronchoalveolar lavage (BAL) fluid and blood specimens. Guinea pigs were exposed 16 h/day, 6 days/wk, for 6, 12, 18, or 24 m...

journal_title：Inhalation toxicology

authors： Ishihara Y,Kagawa J

更新日期：2002-10-01 00:00:00

abstract：:A cross-sectional study on suberosis was conducted in the Champagne-Ardenne County, France, to determine the prevalence of respiratory symptoms, the level of pulmonary function, and the presence of precipitins against Penicillium frequentans. Thirteen of the 33 workers exposed to cork dust had respiratory symptoms exc...

journal_title：Inhalation toxicology

authors： Deschamps F,Foudrinier F,Dherbecourt V,Mas P,Prevost E,Legrele AM,Bellier S,Toubas D

更新日期：2003-12-01 00:00:00

abstract：CONTEXT:Sulfur mustard (SM) causes skin blistering and long-term pulmonary dysfunction. Its adverse effects have been studied in battlefield-exposed humans, but lack of knowledge regarding confounding factors makes interpretation challenging. Animal studies are critical to understanding mechanisms, but differences betw...

journal_title：Inhalation toxicology

authors： Seagrave J,Weber WM,Grotendorst GR

更新日期：2010-09-01 00:00:00

abstract：:Epidemiology studies of populations living in areas with good air quality report correlations between levels of ambient particulate matter (PM) and mortality rates. These associations occur at low PM concentrations that are below current air quality standards. Can such concentrations cause mortality, given the toxicit...

journal_title：Inhalation toxicology

authors： Valberg PA

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The toxicity of multi-walled carbon nanotubes (MWCNT) may be related to the immune system. The objective of this study was to obtain information for immunotoxic mechanisms of MWCNT in situ. METHODS:Using whole-body inhalation, male and female rats were exposed to 0, 0.2, 1 or 5 mg MWCNT/m³ for 13 weeks. The...

journal_title：Inhalation toxicology

authors： Kido T,Tsunoda M,Kasai T,Sasaki T,Umeda Y,Senoh H,Yanagisawa H,Asakura M,Aizawa Y,Fukushima S

更新日期：2014-10-01 00:00:00

abstract：:This study assessed the association between ambient air pollution and daily elementary school absenteeism in Washoe County, NV, between 1996 and 1998. All 57 elementary schools in Washoe County in northern Nevada were included in the data set. There was a total of 27,793 student enrollments during this study period. T...

journal_title：Inhalation toxicology

authors： Chen L,Jennison BL,Yang W,Omaye ST

更新日期：2000-11-01 00:00:00

abstract：:Computational fluid dynamic modeling software has enabled microdosimetry patterns of inhaled toxins and toxicants to be predicted and visualized, and is being used in inhalation toxicology and risk assessment. These predicted microdosimetry patterns in airway structures are derived from predicted airflow patterns with...

journal_title：Inhalation toxicology

authors： Robinson RJ,Snyder P,Oldham MJ

更新日期：2007-05-01 00:00:00

abstract：:Methylhexahydrophthalic anhydride (MHHPA) is a reactive, low molecular weight chemical used in products such as plastics, paints, and electronic components. Exposure to MHHPA may lead to work-related airway diseases such as rhinitis, conjunctivitis, and asthma. Twelve subjects employed at a plant manufacturing electri...

journal_title：Inhalation toxicology

authors： Jeppsson MC,Lindh CH,Kristiansson MH,Nielsen J,Jönsson BA

更新日期：2009-10-01 00:00:00

abstract：:It is well documented that inhalation of sulfur mustard causes injury of the respiratory system. While all of the reports and surveys thoroughly document long-term pulmonary effects after significant exposure to mustard, there is no direct evidence that addresses the issue of long-term respiratory effects in individua...

journal_title：Inhalation toxicology

authors： Ghanei M,Fathi H,Mohammad MM,Aslani J,Nematizadeh F

更新日期：2004-07-01 00:00:00

abstract：:Exposure to toluene, one of the major components of glue, can lead to cardiac arrhythmias and sudden sniffing death syndrome. QT dispersion is a useful risk marker for cardiac arrhythmias and sudden cardiac death. The aim of this study was to investigate the effects of glue abuse on QT interval and QT dispersion. The ...

journal_title：Inhalation toxicology

authors： Alper AT,Akyol A,Hasdemir H,Nurkalem Z,Güler O,Güvenç TS,Erdinler I,Cakmak N,Eksik A,Gürkan K

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Due to some historical (and inaccurate) reports that asbestos might be present in some cosmetic talc products, questions are occasionally raised regarding the potential pleural mesothelioma risks associated with cosmetic talc products. Our objective was to determine the incidence of pleural mesothelioma of in...

journal_title：Inhalation toxicology

authors： Finley BL,Benson SM,Marsh GM

更新日期：2017-03-01 00:00:00

abstract：:The primary objective of this study was to correlate the emission of macro and nanoparticles released during the process of metal inert gas/metal active gas (MIG/MAG) of stainless steel with different gas mixtures. Using different gas mixtures with different heat inputs, it was possible to determine fume formation rat...

journal_title：Inhalation toxicology

authors： Pacheco RP,Gomes JF,Miranda RM,Quintino ML

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Worldwide popularity of waterpipe tobacco smoking has increased, including in pregnant women. This study investigates the effect of prenatal waterpipe tobacco smoke (WTS) exposure on airway inflammation in a murine model of asthma of adult offspring mice. MATERIALS AND METHODS:Pregnant BALB/c mice were expos...

journal_title：Inhalation toxicology

authors： Al-Sawalha NA,Al-Bo'ul HF,Alzoubi KH,Khabour OF,Thanawala VJ

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Nanoparticles are being rapidly assimilated into numerous research fields and consumer products. A concurrent increase in human exposure to such materials is expected. Magnetic nanoparticles (MNPs) possess unique and beneficial features, increasing their functionality and integrative potential. However, MNP ...

journal_title：Inhalation toxicology

authors： Baber O,Jang M,Barber D,Powers K

更新日期：2011-08-01 00:00:00

abstract：:Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial ...

journal_title：Inhalation toxicology

authors： Song MK,Kim DI,Lee K

更新日期：2019-01-01 00:00:00