Abstract:
:Objective: Humidifier-disinfectant-induced lung injury is a new syndrome associated with a high mortality rate and characterized by severe hypersensitivity pneumonitis, acute interstitial pneumonia, or acute respiratory distress syndrome. Polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial agent, is a major component associated with severe lung injury. In-depth studies are needed to determine how PHMG-P affects pathogenesis at the molecular level. Therefore, in this study, we analyzed short-term (4 weeks) and long-term (10 weeks) PHMG-P-exposure-specific gene-expression patterns in rats to improve our understanding of time-dependent changes in fibrosis.Materials and methods: Gene-expression profiles were analyzed in rat lung tissues using DNA microarrays and bioinformatics tools.Results: Clustering analysis of gene-expression data showed different gene-alteration patterns in the short- and long-term exposure groups and higher sensitivity to gene-expression changes in the long-term exposure group than in the short-term exposure group. Supervised analysis revealed 34 short-term and 335 long-term exposure-specific genes, and functional analysis revealed that short-term exposure-specific genes were involved in PHMG-P-induced initial inflammatory responses, whereas long-term exposure-specific genes were involved in PHMG-P-related induction of chronic lung fibrosis.Conclusion: The results of transcriptomic analysis were consistent with lung histopathology results. These findings indicated that exposure-time-specific changes in gene expression closely reflected time-dependent pathological changes in PHMG-P-induced lung injury.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Song MK,Kim DI,Lee Kdoi
10.1080/08958378.2019.1707912subject
Has Abstractpub_date
2019-01-01 00:00:00pages
457-467issue
13-14eissn
0895-8378issn
1091-7691journal_volume
31pub_type
杂志文章abstract:CONTEXT:Ambient particulate matter (PM) is associated with acute exacerbations of airflow obstruction. Additionally, elderly individuals are more susceptible to increased functional morbidity following acute PM exposure. OBJECTIVE:The purpose of this study is to determine the aging effects of PM exposure on the respon...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.731436
更新日期:2012-12-01 00:00:00
abstract::The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carried out on 80 adult...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370902934894
更新日期:2010-02-01 00:00:00
abstract::Endotoxin causes an inflammation at the bronchial and alveolar level. The inflammation-induced increase in permeability of the bronchoalveolar epithelial barrier is supposed to cause a leakage of pneumoproteins. Therefore, their concentrations are expected to increase in the bloodstream. This study aimed at examining ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370601144456
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abstract:CONTEXT:Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body. OBJECTIVES:To describe the normal lung deposition and 1 week particle retention of indium-111 labeled UF carbo...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.708065
更新日期:2012-08-01 00:00:00
abstract::This study investigated the effects of particulate matter (PM) with aerodynamic diameter 0.02-1 microm (noted as PM1) inhalation during exercise on conduit artery and microvascular function. Inhalation of internal combustion-derived PM is associated with cardiovascular mortality and morbidity. Direct action of PM on t...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370601051727
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Increases in particulate matter less than 2.5 µm (PM(2.5)) in ambient air is linked to acute cardiovascular morbidity and mortality. Specific components and potential emission sources of PM(2.5) responsible for adverse health effects of cardiovascular function are unclear. METHODS:Spontaneously hypertensive...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.580387
更新日期:2011-06-01 00:00:00
abstract::This article addresses results of two 13-wk inhalation toxicity studies in Wistar rats with aerosolized 1,6-hexamethylene diisocyanate (HDI) homopolymers using either the isocyanurate (HDI-IC) type or biuret (HDI-BT) type. Groups of 10 rats/sex/level were exposed nose-only to breathing zone concentrations of 0.5, 3.3,...
journal_title:Inhalation toxicology
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doi:10.1080/08958370118600
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abstract:CONTEXT:Air pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, the major organ that senses changes in arterial oxygen...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.984881
更新日期:2015-01-01 00:00:00
abstract::The lung toxicity of inhalable polymer materials is normally carried out by evaluation of the histopathology responses of rat lungs to repeat, nose-only, exposures of an inhalable aerosol of material in a 13-wk subchronic repeat dose toxicity study. The introduction of transcriptomics into toxicology has allowed the c...
journal_title:Inhalation toxicology
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doi:10.1080/08958370500444304
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abstract::This study was designed to investigate effects of sulfur dioxide (SO(2)) and its derivatives (bisulfite and sulfite) on the rat blood pressure. The blood pressures of male Wistar rats exposed to SO(2) and its derivatives at various doses were measured. Findings were that: (1) with acute-one time exposure to SO(2) for ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390215785
更新日期:2003-08-01 00:00:00
abstract::Diesel engine exhaust (DEE), a ubiquitous environmental pollutant, has been associated with adverse health effects. Revelation of cellular and molecular changes is critical for understanding environmental exposure-related diseases. Although the molecular-level effects of DEE exposure have been investigated, whether it...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2016.1162233
更新日期:2016-01-01 00:00:00
abstract::Vanillin is a flavoring agent used in cigarettes. Previous toxicological examinations of the effects on the addition of vanillin to tobacco used mixtures with several other flavoring agents. In the present work, toxicological comparisons were made of experimental cigarettes containing no added vanillin against otherwi...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370701353205
更新日期:2007-06-01 00:00:00
abstract::Methylhexahydrophthalic anhydride (MHHPA) is a reactive, low molecular weight chemical used in products such as plastics, paints, and electronic components. Exposure to MHHPA may lead to work-related airway diseases such as rhinitis, conjunctivitis, and asthma. Twelve subjects employed at a plant manufacturing electri...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802715997
更新日期:2009-10-01 00:00:00
abstract::The World Health Organization identified urban outdoor air pollution as the eighth highest mortality risk factor in high-income countries. Exposure to ambient pollutants such as ozone (O3) increases the number of hospital admissions. O3 is a highly reactive gas that reacts with cells lining the airways, producing the ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2014.922648
更新日期:2014-07-01 00:00:00
abstract::This 3-mo inhalation study investigated the biological effects of a special-purpose glass microfiber (E-glass microfiber), the stone wool fiber MMVF21, and a new high-temperature application fiber (calcium-magnesium-silicate fiber, CMS) in Wistar rats. Rats were exposed 6 h/day, 5 days/wk for 3 mo to fiber aerosol con...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390229843
更新日期:2003-10-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2020.1809572
更新日期:2020-07-01 00:00:00
abstract::Oxidative stress is thought to be the pathogenesis of pulmonary fibrosis induced by asbestos, and heme oxygenase-1 (HO-1) protects lung tissue against oxidative stress. We hypothesized that HO-1 is associated with oxidative lung injury caused by exposure to asbestos. This study was conducted to investigate the time co...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370590922580
更新日期:2005-05-01 00:00:00
abstract:CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958370903349365
更新日期:2010-03-01 00:00:00
abstract::This study aimed to determine the association between home and vehicle exposure to environmental tobacco smoke (ETS), and chronic bronchitis based on data from 64,961 non-smokers aged 12 years and older who participated in the 2005 Canadian Community Health Survey (CCHS). The proportion of respondents who reported ETS...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802409567
更新日期:2009-02-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370390249120
更新日期:2003-12-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958378.2017.1342719
更新日期:2017-05-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2011.604107
更新日期:2011-09-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2012.697926
更新日期:2012-08-01 00:00:00
abstract::Elastolysis, collagenolysis and gelatinolysis are essential in the pathogenesis of tobacco smoke-induced emphysema; however, these activities have been scantily studied in emphysema secondary to woodsmoke. The aim of this study was to analyze elastolysis, collagenolysis and gelatinolysis, MMP-1, MMP-2, and MMP-9 expre...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370802419145
更新日期:2009-02-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.3109/08958378.2015.1060278
更新日期:2015-01-01 00:00:00
abstract::Sulfur dioxide (SO2) is a ubiquitous air pollutant, present in low concentrations in the urban air and in higher concentrations in the working environment. In this study, we investigated the effects of inhaled SO2 on the O-dealkylase of pentoxyresorufin (PROD) and p-nitrophenol hydroxylases (p-NP) activities and mRNA ...
journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370600686341
更新日期:2006-07-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章
doi:10.1080/08958370490264852
更新日期:2004-02-01 00:00:00
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journal_title:Inhalation toxicology
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更新日期:2019-01-01 00:00:00
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journal_title:Inhalation toxicology
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
abstract::Cell signaling by pathogenic minerals may initiate the transactivation of genes that are critical to carcinogenesis and fibroproliferative diseases of the lung and pleura. We have shown previously that stimulation of the mitogen-activated protein kinase (MAPK) cascade by asbestos fibers leads to phosphorylation events...
journal_title:Inhalation toxicology
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doi:10.1080/08958378.2000.11463240
更新日期:2000-01-01 00:00:00