The in vitro and in vivo investigation of a novel small chamber dry powder inhalation delivery system for preclinical dosing to rats.

abstract：:Washed human erythrocytes were incubated with titanium dioxide (TiO2) particles at 37 degrees C for 1 hr and hemolysis was determined by the percentage of hemoglobin released (optical density at 540 nm; OD540) from the cells. Effects of TiO2 on OD540 were corrected and dose-response curves were analyzed by the Hill pl...

journal_title：Inhalation toxicology

authors： Aisaka Y,Kawaguchi R,Watanabe S,Ikeda M,Igisu H

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The toxicity of multi-walled carbon nanotubes (MWCNT) may be related to the immune system. The objective of this study was to obtain information for immunotoxic mechanisms of MWCNT in situ. METHODS:Using whole-body inhalation, male and female rats were exposed to 0, 0.2, 1 or 5 mg MWCNT/m³ for 13 weeks. The...

journal_title：Inhalation toxicology

authors： Kido T,Tsunoda M,Kasai T,Sasaki T,Umeda Y,Senoh H,Yanagisawa H,Asakura M,Aizawa Y,Fukushima S

更新日期：2014-10-01 00:00:00

abstract：:This article addresses results of two 13-wk inhalation toxicity studies in Wistar rats with aerosolized 1,6-hexamethylene diisocyanate (HDI) homopolymers using either the isocyanurate (HDI-IC) type or biuret (HDI-BT) type. Groups of 10 rats/sex/level were exposed nose-only to breathing zone concentrations of 0.5, 3.3,...

journal_title：Inhalation toxicology

authors： Pauluhn J,Mohr U

更新日期：2001-06-01 00:00:00

abstract：INTRODUCTION:Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in diffe...

journal_title：Inhalation toxicology

authors： Fagundes LS,Fleck Ada S,Zanchi AC,Saldiva PH,Rhoden CR

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:This study aimed to investigate whether increased carboxyhemoglobin (COHB) levels and ECG changes, which associated with fatal ventricular dysrhythmias, including increased QT, P-wave and T peak (Tp)-Tend (Te) dispersion, can be detected after smoking narghile, which is a traditional method of smoking tobacco t...

journal_title：Inhalation toxicology

authors： Yıldırım F,Çevik Y,Emektar E,Çorbacıoğlu ŞK,Katırcı Y

更新日期：2016-10-01 00:00:00

abstract：:Airstream clearance (with units of volume/time) is the volumetric flow from which chemical would have to be completely removed to account for the net loss in the nose. Extraction is the proportion of airflow from which the chemical is completely removed. Over the past several years we have developed physiologically ba...

journal_title：Inhalation toxicology

authors： Andersen ME,Sarangapani R

更新日期：2001-05-01 00:00:00

abstract：:Sexually mature male and female Gottingen minipigs were exposed to various concentrations of GB and GF vapor via whole-body inhalation exposures or to liquid GB or GF via intravenous or subcutaneous injections. Vapor inhalation exposures were for 10, 60 or 180 min. Maximum likelihood estimation was used to calculate t...

journal_title：Inhalation toxicology

authors： Hulet SW,Sommerville DR,Miller DB,Scotto JA,Muse WT,Burnett DC

更新日期：2014-02-01 00:00:00

abstract：:A method for inhalative exposure of minipigs to aerosols and gases has been developed. Minipigs are exposed via mask inhalation to the test substance using a computer-controlled exposure system that permits simultaneous exposure of groups of four animals in parallel to different controlled dose levels. We studied inha...

journal_title：Inhalation toxicology

authors： Koch W,Windt H,Walles M,Borlak J,Clausing P

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Animal studies on refractory ceramic fiber (RCF) have led to the suggestion that RCF might resemble asbestos in carcinogenicity. Human data are available to test this hypothesis. METHODS:We compared the occurrence of lung cancer and mesothelioma in 605 men engaged in the manufacture of RCF and followed sinc...

journal_title：Inhalation toxicology

authors： Walker AM,Maxim LD,Utell MJ

更新日期：2012-06-01 00:00:00

abstract：:Cellulose fibers, along with many other organic fibers, are durable. Therefore, if inhaled, they have the potential to persist within the lung, and may then cause disease. Here we report the effects of injecting high-purity cellulose fibers into the abdominal cavity of rats. A respirable fraction of cellulose fiber wa...

journal_title：Inhalation toxicology

authors： Cullen RT,Miller BG,Clark S,Davis JM

更新日期：2002-07-01 00:00:00

abstract：:The lung toxicity of inhalable polymer materials is normally carried out by evaluation of the histopathology responses of rat lungs to repeat, nose-only, exposures of an inhalable aerosol of material in a 13-wk subchronic repeat dose toxicity study. The introduction of transcriptomics into toxicology has allowed the c...

journal_title：Inhalation toxicology

authors： Carthew P,Fletcher S,White A,Harries H,Weber K

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:Worldwide popularity of waterpipe tobacco smoking has increased, including in pregnant women. This study investigates the effect of prenatal waterpipe tobacco smoke (WTS) exposure on airway inflammation in a murine model of asthma of adult offspring mice. MATERIALS AND METHODS:Pregnant BALB/c mice were expos...

journal_title：Inhalation toxicology

authors： Al-Sawalha NA,Al-Bo'ul HF,Alzoubi KH,Khabour OF,Thanawala VJ

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Epidemiologic studies have linked inhalation of air pollutants such as ozone to cardiovascular mortality. Human exposure studies have shown that inhalation of ambient levels of ozone causes airway and systemic inflammation and an imbalance in sympathetic/parasympathetic tone. METHODS:To explore molecular me...

journal_title：Inhalation toxicology

authors： Tham A,Lullo D,Dalton S,Zeng S,van Koeverden I,Arjomandi M

更新日期：2017-02-01 00:00:00

abstract：:Increasing evidence suggests a role for a systemic pro-coagulant state in the pathogenesis of cardiac dysfunction subsequent to inhalation of airborne particulate matter (PM). We evaluated platelet activation, systemic cytokines and pulmonary gene expression in mice exposed to concentrated ambient particulate matter (...

journal_title：Inhalation toxicology

authors： Tablin F,den Hartigh LJ,Aung HH,Lame MW,Kleeman MJ,Ham W,Norris JW,Pombo M,Wilson DW

更新日期：2012-07-01 00:00:00

abstract：:Acute exposure to ambient fine particulate matter (PM2.5) is tied to cardiovascular morbidity and mortality, especially among those with prior cardiac injury. The mechanisms and pathophysiological events precipitating these outcomes remain poorly understood but may involve inflammation, oxidative stress, arrhythmia an...

journal_title：Inhalation toxicology

authors： Carll AP,Haykal-Coates N,Winsett DW,Hazari MS,Ledbetter AD,Richards JH,Cascio WE,Costa DL,Farraj AK

更新日期：2015-02-01 00:00:00

abstract：:A cross-sectional study on suberosis was conducted in the Champagne-Ardenne County, France, to determine the prevalence of respiratory symptoms, the level of pulmonary function, and the presence of precipitins against Penicillium frequentans. Thirteen of the 33 workers exposed to cork dust had respiratory symptoms exc...

journal_title：Inhalation toxicology

authors： Deschamps F,Foudrinier F,Dherbecourt V,Mas P,Prevost E,Legrele AM,Bellier S,Toubas D

更新日期：2003-12-01 00:00:00

abstract：:Crystalline silica has been classified as a human carcinogen, but there is still considerable controversy regarding its fibrogenic and carcinogenic potential. In the present study, we investigated the genotoxic potential of bentonite particles (diameter < 10 microm) with an a-quartz content of up to 6% and different c...

journal_title：Inhalation toxicology

authors： Geh S,Shi T,Shokouhi B,Schins RP,Armbruster L,Rettenmeier AW,Dopp E

更新日期：2006-05-01 00:00:00

abstract：:The aim of this study was to investigate the dose-related effects of dichlorvos inhalation on electrophysiological alterations of diaphragm and phrenic nerve and the changes in the histologic structure of respiratory system. This study was performed on 33 rats divided into 5 groups, inhaling 1, 2, 5, 10, and 15 microg...

journal_title：Inhalation toxicology

authors： Atiş S,Cömelekoğlu U,Coşkun B,Ozge A,Ersöz G,Talas D

更新日期：2002-02-01 00:00:00

abstract：:Microbial growth in moisture-damaged buildings has been associated with respiratory health effects, and the spores of the mycotoxin producing fungus Aspergillus versicolor are frequently present in the indoor air. To characterize the potential of these spores to cause harmful respiratory effects, mice were exposed via...

journal_title：Inhalation toxicology

authors： Jussila J,Komulainen H,Kosma VM,Nevalainen A,Pelkonen J,Hirvonen MR

更新日期：2002-12-01 00:00:00

abstract：:Most current deterministic computer dosimetry models use idealized dichotomous symmetrical infant, child, and adolescent tracheobronchial geometries for dosimetry predictions. These tracheobronchial geometries were derived from either the morphometric measurements of J. D. Mortensen and colleagues or those of R. F. Ph...

journal_title：Inhalation toxicology

authors： Oldham MJ,Robinson RJ

更新日期：2006-09-01 00:00:00

abstract：:In Germany in 2006 a series of rapidly developing and sometimes severe cases of pulmonary health impairment were observed after normal use of the "Magic Nano Glass & Ceramic" spray and "Magic Nano Bath" spray. In contrast, the previously marketed "Magic Nano" pump spray product (handheld trigger device without propell...

journal_title：Inhalation toxicology

authors： Pauluhn J,Hahn A,Spielmann H

更新日期：2008-11-01 00:00:00

abstract：:The effects of low-level ozone exposure (0.08 ppm) on pulmonary function in healthy young adults are well known; however, much less is known about the inflammatory and immunomodulatory effects of low-level ozone in the airways. Techniques such as induced sputum and flow cytometry make it possible to examine airways in...

journal_title：Inhalation toxicology

authors： Alexis NE,Lay JC,Hazucha M,Harris B,Hernandez ML,Bromberg PA,Kehrl H,Diaz-Sanchez D,Kim C,Devlin RB,Peden DB

更新日期：2010-06-01 00:00:00

abstract：:The intent of this article is to review the comparative nonneoplastic pathological responses (inflammation, fibrosis, and epithelial proliferation) of rats, hamsters, mice, and monkeys to low-toxicity dusts (TiO(2), carbon black, talc, coal-mine dust, and diesel particulate). The paucity of information on some of thes...

journal_title：Inhalation toxicology

authors： Donaldson K

更新日期：2000-01-01 00:00:00

abstract：:This study was undertaken to determine whether there was an association between fine particles (PM₂.₅) levels and hospital admissions for congestive heart failure (CHF) in Taipei, Taiwan. Hospital admissions for CHF and ambient air pollution data for Taipei were obtained for the period 2006-2010. The relative risk of ...

journal_title：Inhalation toxicology

authors： Hsieh YL,Tsai SS,Yang CY

更新日期：2013-07-01 00:00:00

abstract：:The Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) study involved withdrawal, aging, and atmospheric transformation of emissions of three coal-fired power plants. Toxicological evaluations were carried out in rats exposed to different emission scenarios with extensive exposure characteriza...

journal_title：Inhalation toxicology

authors： Coull BA,Wellenius GA,Gonzalez-Flecha B,Diaz E,Koutrakis P,Godleski JJ

更新日期：2011-08-01 00:00:00

abstract：CONTEXT:Air pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, the major organ that senses changes in arterial oxygen...

journal_title：Inhalation toxicology

authors： Perez CM,Hazari MS,Ledbetter AD,Haykal-Coates N,Carll AP,Cascio WE,Winsett DW,Costa DL,Farraj AK

更新日期：2015-01-01 00:00:00

abstract：:Asthma rates have been increasing worldwide, and exposure to diesel exhaust particles (DEP) may be implicated in this increase. DEP may also play a role in the increased morbidity and mortality associated with ambient airborne particulate matter (PM) exposure. Two types of nasal responses have been reported for human ...

journal_title：Inhalation toxicology

authors： Kongerud J,Madden MC,Hazucha M,Peden D

更新日期：2006-08-01 00:00:00

abstract：:The effect of prenatal exposure to diesel exhaust (DE) was investigated. Twenty pregnant ICR mice were exposed to DE at the particle concentration of 1.0 mg/m3, from d 2 until d 16 postcoitum. Male offspring were kept alive until 12 wk of age, and then male reproductive organ weight, daily sperm production (DSP), seru...

journal_title：Inhalation toxicology

authors： Ono N,Oshio S,Niwata Y,Yoshida S,Tsukue N,Sugawara I,Takano H,Takeda K

更新日期：2007-03-01 00:00:00

abstract：:The C9 alkylbenzenes, composed mostly of ethyltoluenes and trimethylbenzenes, comprise 75-90% of the naphtha fraction of crude oil. Occupational and environmental exposure to C9 alkylbenzenes occur via inhalation. We conducted short-term inhalation studies on the ethyltoluene isomers (2-, 3- or 4-) to select one isome...

journal_title：Inhalation toxicology

authors： Roberts GK,Willson CJ,Olivera DS,Malarkey DE,Morgan DL

更新日期：2017-01-01 00:00:00

abstract：:Information on nasal particle deposition is used in risk assessments for exposure to airborne particulate pollutants and for optimizing the delivery of therapeutic aerosols. Monkeys are commonly used to assess the therapeutic potential of inhaled substances and to a lesser extent the toxicity of inhaled xenobiotics. Y...

journal_title：Inhalation toxicology

authors： Kelly JT,Asgharian B,Wong BA

更新日期：2005-12-15 00:00:00