Are airborne refractory ceramic fibers similar to asbestos in their carcinogenicity?

abstract：:It is well documented that inhalation of sulfur mustard causes injury of the respiratory system. While all of the reports and surveys thoroughly document long-term pulmonary effects after significant exposure to mustard, there is no direct evidence that addresses the issue of long-term respiratory effects in individua...

journal_title：Inhalation toxicology

authors： Ghanei M,Fathi H,Mohammad MM,Aslani J,Nematizadeh F

更新日期：2004-07-01 00:00:00

abstract：:Diagnosis of an exposure to airborne toxicants can be problematic. Phosgene is used widely in industry for the production of many synthetic products, such as polyfoam rubber, plastics, and dyes. Although nearly 100% of the gas is consumed during processing, there is the potential problem of accidental or even intentio...

journal_title：Inhalation toxicology

authors： Sciuto AM,Clapp DL,Hess ZA,Moran TS

更新日期：2003-06-01 00:00:00

abstract：:This study investigated the effects of particulate matter (PM) with aerodynamic diameter 0.02-1 microm (noted as PM1) inhalation during exercise on conduit artery and microvascular function. Inhalation of internal combustion-derived PM is associated with cardiovascular mortality and morbidity. Direct action of PM on t...

journal_title：Inhalation toxicology

authors： Rundell KW,Hoffman JR,Caviston R,Bulbulian R,Hollenbach AM

更新日期：2007-02-01 00:00:00

abstract：:We briefly review the evidence that the carcinogenic risk posed by inhaled fibers depends principally on the lung burden of long fibers. We use a deposition clearance model to generate time-dependent lung burdens in rats of a dozen long fibers for various exposure concentrations. Together with a previously estimated p...

journal_title：Inhalation toxicology

authors： Moolgavkar SH,Brown RC,Turim J

更新日期：2001-09-01 00:00:00

abstract：:The irritants acrolein, acetaldehyde, and acetic acid induce a rapid sensory nerve-mediated nasal vasodilatory response in the rat. The aim of the current study was to examine acute nasal sensory nerve-mediated acute responses to an irritant ester vapor, ethyl acrylate. For this purpose, the upper respiratory tract of...

journal_title：Inhalation toxicology

authors： Morris JB

更新日期：2002-06-01 00:00:00

abstract：:In order to conserve material that is available in limited quantities, "directed-flow" nose-only exposure systems have at times been run at flow rates close to the minute ventilation of the animal. Such low-flow-rate conditions can contribute to a decrease of test substance concentration in inhaled air; near the anima...

journal_title：Inhalation toxicology

authors： Moss OR,James RA,Asgharian B

更新日期：2006-01-01 00:00:00

abstract：:Objectives: This follow-up study set out to evaluate the natural course and radiographic progression of silicosis among ceramic workers and describe the risk factors related with disease progression. Materials and methods: We retrospectively analyzed the data of ceramic workers with silicosis who were referred to our ...

journal_title：Inhalation toxicology

authors： Karataş M,Gündüzöz M,Büyükşekerci M,Özakıncı OG,Nadir Öziş T

更新日期：2019-02-01 00:00:00

abstract：:Oxidative stress is thought to be the pathogenesis of pulmonary fibrosis induced by asbestos, and heme oxygenase-1 (HO-1) protects lung tissue against oxidative stress. We hypothesized that HO-1 is associated with oxidative lung injury caused by exposure to asbestos. This study was conducted to investigate the time co...

journal_title：Inhalation toxicology

authors： Nagatomo H,Morimoto Y,Oyabu T,Hirohashi M,Ogami A,Yamato H,Kuroda K,Higashi T,Tanaka I

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:There has been an increase in the popularity of waterpipe tobacco smoking (WTS) worldwide, especially in the younger population, including asthma patients. In this study, we investigated the effects of waterpipe smoking on airway inflammation, cytokine levels and oxidative stress markers in an antigen-driven ...

journal_title：Inhalation toxicology

authors： Al-Sawalha NA,Migdadi AM,Alzoubi KH,Khabour OF,Qinna NA

更新日期：2017-02-01 00:00:00

abstract：:Acute exposure to ambient fine particulate matter (PM2.5) is tied to cardiovascular morbidity and mortality, especially among those with prior cardiac injury. The mechanisms and pathophysiological events precipitating these outcomes remain poorly understood but may involve inflammation, oxidative stress, arrhythmia an...

journal_title：Inhalation toxicology

authors： Carll AP,Haykal-Coates N,Winsett DW,Hazari MS,Ledbetter AD,Richards JH,Cascio WE,Costa DL,Farraj AK

更新日期：2015-02-01 00:00:00

abstract：:The purpose of this exploratory study within the integrated subchronic inhalation exposure study (Lippmann et al., 2005) was to identify genes in heart and lung tissue that changed in expression level as a result of subchronic exposure to concentrated ambient particles (CAPs). Identification of CAPs exposure-related c...

journal_title：Inhalation toxicology

authors： Gunnison A,Chen LC

更新日期：2005-04-01 00:00:00

abstract：:Epidemiological studies of particulate matter (PM) using central area monitors have associated total PM mass, as well as certain individual components of PM, including sulfate, with adverse human health effects. However, some recent studies that used concentrated ambient particles (CAPs) or analyzed the effects of air...

journal_title：Inhalation toxicology

authors： Grahame T,Schlesinger R

更新日期：2005-01-01 00:00:00

abstract：:Wollastonite is a naturally occurring calcium silicate (CaSiO(3)) that is produced in both powder and fibrous forms. It is a valuable industrial mineral used in plastics, ceramics, metallurgical applications, paint, and friction products. For some applications wollastonite serves as an asbestos replacement. To varying...

journal_title：Inhalation toxicology

authors： Maxim LD,McConnell EE

更新日期：2005-08-01 00:00:00

abstract：:Recurrent events, such as repeated hospital admissions for the same health outcome, occur frequently in environmental health studies. In this study, we conducted an analysis of data on repeated respiratory hospitalizations among the elderly in Vancouver, Canada, for the period of June 1, 1995, to March 31, 1999, using...

journal_title：Inhalation toxicology

authors： Fung KY,Khan S,Krewski D,Chen Y

更新日期：2006-12-01 00:00:00

abstract：:Coal mine dust's possible carcinogenicity has recently drawn attention because of the IARC review of quartz, some new epidemiological data in German coal miners, and findings on other poorly soluble, nontoxic dusts in the rat. The aim of this study was to investigate persistent inflammation and tumor response in the r...

journal_title：Inhalation toxicology

authors： Borm PJ,Höhr D,Steinfartz Y,Zeitträger I,Albrecht C

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Gastroesophageal reflux of bile acids plays an important role in the development of Barrett's esophagus (BE)-associated esophageal adenocarcinoma (EAC). Cigarette smoke has been demonstrated to exacerbate the effects of reflux and thus the initial stages of EAC carcinogenesis. To date, no in vivo studies hav...

journal_title：Inhalation toxicology

authors： Aiyer HS,Li Y,Harper N,Myers SR,Martin RC

更新日期：2011-04-01 00:00:00

abstract：:Wistar rats were exposed for 24 mo to diesel emissions containing a low (0.2 ppm, 0.21 mg/m(3)), medium (1.04 ppm, 1.18 mg/m(3)), or high (2.96 ppm, 3.05 mg/m(3)) concentration of NO(2) and particles, or diesel emissions containing a medium (1.12 ppm, 0.01 mg/m(3)) concentration of NO(2) without particles. At 6-mo int...

journal_title：Inhalation toxicology

authors： Kato A,Nagai A,Kagawa J

更新日期：2000-06-01 00:00:00

abstract：:Epidemiological and experimental data suggest that obesity exacerbates the health effects of air pollutants such as ozone (O3). Maternal inactivity and calorically rich diets lead to offspring that show signs of obesity. Exacerbated O3 susceptibility of offspring could thus be manifested by maternal obesity. Thirty-da...

journal_title：Inhalation toxicology

authors： Gordon CJ,Phillips PM,Johnstone AFM,Schmid J,Schladweiler MC,Ledbetter A,Snow SJ,Kodavanti UP

更新日期：2017-05-01 00:00:00

abstract：:Laboratory studies involving intentional and highly controlled exposures to air pollutants among groups of human volunteers provide valuable information related to the potential health effects of pollutants regulated under the US Clean Air Act. These controlled human exposure studies often provide biological plausibil...

journal_title：Inhalation toxicology

authors： Johns DO,Linn WS

更新日期：2011-01-01 00:00:00

abstract：:This special issue describes the scientific progress and scientific review process to develop a safer cigarette. A peer-review panel, the ECLIPSE Expert Panel, was convened to critically review the potential health hazards of this new cigarette to a reference, conventional cigarette that bums tobacco. This new cigaret...

journal_title：Inhalation toxicology

authors： ECLIPSE Expert Panel.

更新日期：2000-01-01 00:00:00

abstract：:This paper summarizes available data on worker exposures to asphalt fume (soluble fraction), total particulate matter, and respirable crystalline silica (quartz) [hereinafter RCS] over a 30-year period in Owens Corning's asphalt production and roofing manufacturing plants. For the period 1977 through 2006, the air-mon...

journal_title：Inhalation toxicology

authors： Fayerweather WE,Trumbore DC,Johnson KA,Niebo RW,Maxim LD

更新日期：2011-09-01 00:00:00

abstract：:Airstream clearance (with units of volume/time) is the volumetric flow from which chemical would have to be completely removed to account for the net loss in the nose. Extraction is the proportion of airflow from which the chemical is completely removed. Over the past several years we have developed physiologically ba...

journal_title：Inhalation toxicology

authors： Andersen ME,Sarangapani R

更新日期：2001-05-01 00:00:00

abstract：CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...

journal_title：Inhalation toxicology

authors： Ramos-Bonilla JP,Breysse PN,Dominici F,Geyh A,Tankersley CG

更新日期：2010-03-01 00:00:00

abstract：:Mexico City children are chronically exposed to significant concentrations of air pollutants and exhibit chronic respiratory-tract inflammation. Epidemiological, controlled human exposures, laboratory-based animal models, and in vitro/in vivo studies have shown that inflammatory, endothelial dysfunction, and endotheli...

journal_title：Inhalation toxicology

authors： Calderón-Garcidueñas L,Villarreal-Calderon R,Valencia-Salazar G,Henríquez-Roldán C,Gutiérrez-Castrellón P,Torres-Jardón R,Osnaya-Brizuela N,Romero L,Torres-Jardón R,Solt A,Reed W

更新日期：2008-03-01 00:00:00

abstract：:The aim of this study was to investigate the dose-related effects of dichlorvos inhalation on electrophysiological alterations of diaphragm and phrenic nerve and the changes in the histologic structure of respiratory system. This study was performed on 33 rats divided into 5 groups, inhaling 1, 2, 5, 10, and 15 microg...

journal_title：Inhalation toxicology

authors： Atiş S,Cömelekoğlu U,Coşkun B,Ozge A,Ersöz G,Talas D

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:This research describes a novel "minitower" dry powder delivery system for nose-only delivery of dry powder aerosols to spontaneously breathing rats. METHODS:The minitower system forces pressurized air through pre-filled capsules to deliver aerosolized drug to four nose ports; three of which house spontaneousl...

journal_title：Inhalation toxicology

authors： Sellers S,Horodnik W,House A,Wylie J,Mauser P,Donovan B

更新日期：2015-01-01 00:00:00

abstract：:Tire and road wear particles (TRWP) are a component of ambient particulate matter (PM) produced from the interaction of tires with the roadway. Inhalation of PM has been associated with cardiopulmonary morbidities and mortalities thought to stem from pulmonary inflammation. To determine whether TRWP may contribute to ...

journal_title：Inhalation toxicology

authors： Kreider ML,Doyle-Eisele M,Russell RG,McDonald JD,Panko JM

更新日期：2012-11-01 00:00:00

abstract：:Acute lung injury (ALI) induced by phosgene increases risk of serious edema and mortality. Increased permeability of the microvascular endothelium is implicated in the progression of ALI, but the processing interaction and time course activity of the vascular regulators in exudation are still not understood. The main ...

journal_title：Inhalation toxicology

authors： Zhang XD,Hai CX,Cai FL,Liang X,Liu R,Chen HL,Qin XJ,Feng AJ

更新日期：2008-07-01 00:00:00

abstract：:NASA is planning to build a habitat on the Moon and use the Moon as a stepping stone to Mars. JSC-1, an Arizona volcanic ash that has mineral properties similar to those of lunar soil, is used to produce lunar environments for instrument and equipment testing. NASA is concerned about potential health risks to workers ...

journal_title：Inhalation toxicology

authors： Latch JN,Hamilton RF Jr,Holian A,James JT,Lam CW

更新日期：2008-01-01 00:00:00

abstract：:Exposure to toluene, one of the major components of glue, can lead to cardiac arrhythmias and sudden sniffing death syndrome. QT dispersion is a useful risk marker for cardiac arrhythmias and sudden cardiac death. The aim of this study was to investigate the effects of glue abuse on QT interval and QT dispersion. The ...

journal_title：Inhalation toxicology

authors： Alper AT,Akyol A,Hasdemir H,Nurkalem Z,Güler O,Güvenç TS,Erdinler I,Cakmak N,Eksik A,Gürkan K

更新日期：2008-01-01 00:00:00