Influence of exhaled air on inhalation exposure delivered through a directed-flow nose-only exposure system.

abstract：PURPOSE:This research describes a novel "minitower" dry powder delivery system for nose-only delivery of dry powder aerosols to spontaneously breathing rats. METHODS:The minitower system forces pressurized air through pre-filled capsules to deliver aerosolized drug to four nose ports; three of which house spontaneousl...

journal_title：Inhalation toxicology

authors： Sellers S,Horodnik W,House A,Wylie J,Mauser P,Donovan B

更新日期：2015-01-01 00:00:00

abstract：:Exposure to toluene, one of the major components of glue, can lead to cardiac arrhythmias and sudden sniffing death syndrome. QT dispersion is a useful risk marker for cardiac arrhythmias and sudden cardiac death. The aim of this study was to investigate the effects of glue abuse on QT interval and QT dispersion. The ...

journal_title：Inhalation toxicology

authors： Alper AT,Akyol A,Hasdemir H,Nurkalem Z,Güler O,Güvenç TS,Erdinler I,Cakmak N,Eksik A,Gürkan K

更新日期：2008-01-01 00:00:00

abstract：:Methylhexahydrophthalic anhydride (MHHPA) is a reactive, low molecular weight chemical used in products such as plastics, paints, and electronic components. Exposure to MHHPA may lead to work-related airway diseases such as rhinitis, conjunctivitis, and asthma. Twelve subjects employed at a plant manufacturing electri...

journal_title：Inhalation toxicology

authors： Jeppsson MC,Lindh CH,Kristiansson MH,Nielsen J,Jönsson BA

更新日期：2009-10-01 00:00:00

abstract：:Epidemiological studies of particulate matter (PM) using central area monitors have associated total PM mass, as well as certain individual components of PM, including sulfate, with adverse human health effects. However, some recent studies that used concentrated ambient particles (CAPs) or analyzed the effects of air...

journal_title：Inhalation toxicology

authors： Grahame T,Schlesinger R

更新日期：2005-01-01 00:00:00

abstract：:Introduction: Tobacco use is a major risk factor of cardiovascular diseases (CVD) and atherosclerosis in particular. The use of waterpipe smoking (WPS) is increasing due to the misperception that it is less harmful than cigarette smoking due to its flavor and the use of water as a filter. Thus, research that investiga...

journal_title：Inhalation toxicology

authors： Rababa'h AM,Bsoul RW,Alkhatatbeh MJ,Alzoubi KH,Khabour OF

更新日期：2019-02-01 00:00:00

abstract：:Information on nasal particle deposition is used in risk assessments for exposure to airborne particulate pollutants and for optimizing the delivery of therapeutic aerosols. Monkeys are commonly used to assess the therapeutic potential of inhaled substances and to a lesser extent the toxicity of inhaled xenobiotics. Y...

journal_title：Inhalation toxicology

authors： Kelly JT,Asgharian B,Wong BA

更新日期：2005-12-15 00:00:00

abstract：:Ultrafine particles (diameter < 100 nm) may be important in the health effects of air pollution, in part because of their predicted high respiratory deposition. However, there are few measurements of ultrafine particle deposition during spontaneous breathing. The fractional deposition for the total respiratory tract o...

journal_title：Inhalation toxicology

authors： Daigle CC,Chalupa DC,Gibb FR,Morrow PE,Oberdörster G,Utell MJ,Frampton MW

更新日期：2003-05-01 00:00:00

abstract：:The authors have previously demonstrated that wildfire-derived coarse or fine particulate matter (PM) intratracheally instilled into lungs of mice induce a strong inflammatory response. In the current study, the authors demonstrate that wildfire PM simultaneously cause major increases in oxidative stress in the mouse ...

journal_title：Inhalation toxicology

authors： Wegesser TC,Franzi LM,Mitloehner FM,Eiguren-Fernandez A,Last JA

更新日期：2010-06-01 00:00:00

abstract：:The effects of low-level ozone exposure (0.08 ppm) on pulmonary function in healthy young adults are well known; however, much less is known about the inflammatory and immunomodulatory effects of low-level ozone in the airways. Techniques such as induced sputum and flow cytometry make it possible to examine airways in...

journal_title：Inhalation toxicology

authors： Alexis NE,Lay JC,Hazucha M,Harris B,Hernandez ML,Bromberg PA,Kehrl H,Diaz-Sanchez D,Kim C,Devlin RB,Peden DB

更新日期：2010-06-01 00:00:00

abstract：:This study was undertaken to determine whether there was an association between fine particles (PM₂.₅) levels and hospital admissions for congestive heart failure (CHF) in Taipei, Taiwan. Hospital admissions for CHF and ambient air pollution data for Taipei were obtained for the period 2006-2010. The relative risk of ...

journal_title：Inhalation toxicology

authors： Hsieh YL,Tsai SS,Yang CY

更新日期：2013-07-01 00:00:00

abstract：:The Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) study involved withdrawal, aging, and atmospheric transformation of emissions of three coal-fired power plants. Toxicological evaluations were carried out in rats exposed to different emission scenarios with extensive exposure characteriza...

journal_title：Inhalation toxicology

authors： Coull BA,Wellenius GA,Gonzalez-Flecha B,Diaz E,Koutrakis P,Godleski JJ

更新日期：2011-08-01 00:00:00

abstract：CONTEXT:Heart rate alterations associated with exposure to particulate matter (PM) and gaseous pollutants have been observed in epidemiological studies and animal experiments. Nevertheless, the time-lag of these associations is still unclear. OBJECTIVE:Determine the association at different time-lags between the compl...

journal_title：Inhalation toxicology

authors： Ramos-Bonilla JP,Breysse PN,Dominici F,Geyh A,Tankersley CG

更新日期：2010-03-01 00:00:00

abstract：:Chronic exposure to chlorine gas has been shown to cause occupational asthma. Acute inhalation of chlorine is known to cause airway inflammation and induce airway nitric oxide formation. Exhaled nitric oxide may therefore be a marker of airway damage after chlorine gas exposure. After accidental chlorine gas exposure ...

journal_title：Inhalation toxicology

authors： Grasemann H,Tschiedel E,Groch M,Klepper J,Ratjen F

更新日期：2007-08-01 00:00:00

abstract：:Antisense oligonucleotides (ASOs) bind and facilitate degradation of RNA and inhibit protein expression in pathways not easily targeted with small molecules or antibodies. Interleukin (IL)-4 and IL-13 potentiate signaling through the shared IL-4 receptor-α (IL-4Rα) subunit of their receptors. ASO targeting of IL-4Rα m...

journal_title：Inhalation toxicology

authors： Fey RA,Templin MV,McDonald JD,Yu RZ,Hutt JA,Gigliotti AP,Henry SP,Reed MD

更新日期：2014-07-01 00:00:00

abstract：:Epidemiological studies have shown an association between microbial growth in buildings and increased risk of respiratory symptoms and disease related to inflammatory reactions in the inhabitants96. The current study examined the affects of growth conditions of Streptomyces anulatus, isolated from indoor air of a mold...

journal_title：Inhalation toxicology

authors： Hirvonen MR,Suutari M,Ruotsalainen M,Lignell U,Nevalainen A

更新日期：2001-01-01 00:00:00

abstract：:We examined the effect of breathing pattern on ozone reaction product content within the respiratory tract. Thirty-four anesthetized, male Wistar rats were exposed to oxygen-18 ((18)O)-labeled ozone at 1.0 ppm for 2 h using a dual-chamber, negative-pressure ventilation system. Frequency was set at 80 (n = 9), 120 (n =...

journal_title：Inhalation toxicology

authors： Alfaro MF,Putney L,Tarkington BK,Hatch GE,Hyde DM,Schelegle ES

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Nanoparticles are being rapidly assimilated into numerous research fields and consumer products. A concurrent increase in human exposure to such materials is expected. Magnetic nanoparticles (MNPs) possess unique and beneficial features, increasing their functionality and integrative potential. However, MNP ...

journal_title：Inhalation toxicology

authors： Baber O,Jang M,Barber D,Powers K

更新日期：2011-08-01 00:00:00

abstract：CONTEXT:There have been no animal studies of the health effects of repeated inhalation of mixtures representing downwind pollution from coal combustion. Environmental exposures typically follow atmospheric processing and mixing with pollutants from other sources. OBJECTIVE:This was the fourth study by the National Env...

journal_title：Inhalation toxicology

authors： Mauderly JL,Barrett EG,Gigliotti AP,McDonald JD,Reed MD,Seagrave J,Mitchell LA,Seilkop SK

更新日期：2011-05-01 00:00:00

abstract：:Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, it was studied whether airway irritation by sulfur dioxide (SO(2)) would enhance respiratory allergic reactions to trimellitic anhydride (TMA), using a rat model. Brown Norway (BN) rats ...

journal_title：Inhalation toxicology

authors： Arts JH,Jacobs EJ,Kuper CF

更新日期：2010-02-01 00:00:00

abstract：:The Toxicological Evaluation of Realistic Emissions Source Aerosols (TERESA) study was carried out at three US coal-fired power plants to investigate the potential toxicological effects of primary and photochemically aged (secondary) particles using in situ stack emissions. The exposure system designed successfully si...

journal_title：Inhalation toxicology

authors： Kang CM,Gupta T,Ruiz PA,Wolfson JM,Ferguson ST,Lawrence JE,Rohr AC,Godleski J,Koutrakis P

更新日期：2011-08-01 00:00:00

abstract：:In the evaluation of particulate matter (PM) toxicity, one faces the challenge of identifying components that could be addressed as markers of toxicity. This study examines the use of statistical methods to determine which components present in the complex mixtures are related to toxic effects. The work is based on da...

journal_title：Inhalation toxicology

authors： Alfaro-Moreno E,Ponce-de-León S,Osornio-Vargas AR,García-Cuellar C,Martínez L,Rosas I

更新日期：2007-01-01 00:00:00

abstract：:In recent years, a physiology-oriented multicompartmental kinetics (POCK) model was developed to simulate pulmonary retention data of biopersistent, noncytotoxic aerosols in long-term inhalation exposures of rats. Experimental data were successfully simulated for submicrometer-sized aerosols like carbon black, diesel ...

journal_title：Inhalation toxicology

authors： Stöber W

更新日期：1999-04-01 00:00:00

abstract：CONTEXT:Particulate air pollution, for example, from ultrafine (UF) particles, has negative health effects. However, there is still limited knowledge regarding the fate of inhaled particles in the human body. OBJECTIVES:To describe the normal lung deposition and 1 week particle retention of indium-111 labeled UF carbo...

journal_title：Inhalation toxicology

authors： Klepczyńska-Nyström A,Sanchez-Crespo A,Andersson M,Falk R,Lundin A,Larsson BM,Svartengren M

更新日期：2012-08-01 00:00:00

abstract：:To elucidate dose-response and other effects of diesel particles in guinea pigs chronically exposed to diesel exhaust, various biomarkers for chronic obstructive lung diseases were studied using bronchoalveolar lavage (BAL) fluid and blood specimens. Guinea pigs were exposed 16 h/day, 6 days/wk, for 6, 12, 18, or 24 m...

journal_title：Inhalation toxicology

authors： Ishihara Y,Kagawa J

更新日期：2002-10-01 00:00:00

abstract：:An approach to identify causal components of complex air pollution mixtures was explored. Rats and mice were exposed by inhalation 6 h daily for 1 week or 6 months to dilutions of simulated downwind coal emissions, diesel and gasoline exhausts and wood smoke. Organ weights, hematology, serum chemistry, bronchoalveolar...

journal_title：Inhalation toxicology

authors： Mauderly JL,Seilkop SK

更新日期：2014-09-01 00:00:00

abstract：:Recent studies have shown that air pollution is a risk factor for hospitalization for pneumonia. However, there is limited evidence to suggest what subpopulations are at greater risk from air pollution. This study was undertaken to examine the modifying effect of specific secondary diagnosis (including hypertension, d...

journal_title：Inhalation toxicology

authors： Cheng MF,Tsai SS,Chiu HF,Sung FC,Wu TN,Yang CY

更新日期：2009-11-01 00:00:00

abstract：:Acute carbon monoxide (CO) poisoning may cause cardiotoxicity. The natriuretic peptides, including atrial natriuretic peptide, brain natriuretic peptide (BNP), N-BNP, and NT-proBNP (N-terminal pro brain natriuretic peptide), are endogenous cardiac hormones that may be secreted upon myocardial stress. The aim of this s...

journal_title：Inhalation toxicology

authors： Davutoglu V,Gunay N,Kocoglu H,Gunay NE,Yildirim C,Cavdar M,Tarakcioglu M

更新日期：2006-02-01 00:00:00

abstract：:Minimally invasive approaches to detect/predict target organ toxicity have significant practical applications in occupational toxicology. The potential application of peripheral blood transcriptomics as a practical approach to study the mechanisms of silica-induced pulmonary toxicity was investigated. Rats were expose...

journal_title：Inhalation toxicology

authors： Sellamuthu R,Umbright C,Roberts JR,Chapman R,Young SH,Richardson D,Cumpston J,McKinney W,Chen BT,Frazer D,Li S,Kashon M,Joseph P

更新日期：2012-08-01 00:00:00

abstract：:Halomethanes (HMs) can be formed during the chlorination process to obtain drinking water. In liver cells, HMs had been shown to be mutagenic and carcinogenic; however, their bioactivation by CYP 2E1 and GSTT1 is required. Although inhalation is the most common pathway of exposure, reports on the toxic effects induced...

journal_title：Inhalation toxicology

authors： Nájera-Martínez M,García-Latorre EA,Reyes-Maldonado E,Domínguez-López ML,Vega-López A

更新日期：2012-09-01 00:00:00

abstract：:Recurrent events, such as repeated hospital admissions for the same health outcome, occur frequently in environmental health studies. In this study, we conducted an analysis of data on repeated respiratory hospitalizations among the elderly in Vancouver, Canada, for the period of June 1, 1995, to March 31, 1999, using...

journal_title：Inhalation toxicology

authors： Fung KY,Khan S,Krewski D,Chen Y

更新日期：2006-12-01 00:00:00