Abstract：
:This study investigated the effects of particulate matter (PM) with aerodynamic diameter 0.02-1 microm (noted as PM1) inhalation during exercise on conduit artery and microvascular function. Inhalation of internal combustion-derived PM is associated with cardiovascular mortality and morbidity. Direct action of PM on the vascular endothelium is likely, as a substantial fraction of ultrafine PM translocates from the alveoli to the circulatory system. Sixteen intercollegiate athletes performed 30 min of exercise while inhaling low or high PM1. Flow-mediated brachial artery dilation (FMD) using high-resolution ultrasonography with simultaneous measurements of forearm oxygen kinetics using near infrared spectrophotometry (NIRS) was done before and after exercise. Basal brachial artery vasoconstriction was found after high PM1 exercise (4.0%, 4.66 +/- 0.609 to 4.47 +/- 0.625 mm diameter; p = .0002), but not after low PM1 exercise (-0.3%, 4.66 +/- 0.626 to 4.68 +/- 0.613 mm diameter). FMD was impaired after high PM1 exercise (6.8 +/- 3.58% for preexercise FMD and 0.30 +/- 2.74% for postexercise FMD, p = .0001), but not after low PM1 exercise (6.6 +/- 4.04% for preexercise FMD and 4.89 +/- 4.42% for postexercise FMD). Reduction in forearm muscle reperfusion estimated by reoxygenation slope-to-baseline after 4 min cuff ischemia was observed for high PM1 exercise (55% vs. 3%, p = .0006); no difference was noted for low PM1 exercise. Brachial artery FMD was significantly correlated to muscle reoxygenation slope-to-baseline (r = .50, p = .005). Acute inhalation of high [PM1] typical of urban environments impairs both systemic conduit artery function and microcirculation. The observed decrease reoxygenation slope-to-baseline after cuff release is consistent with reduced blood flow in the muscle microvasculature.
journal_name
Inhal Toxicoljournal_title
Inhalation toxicologyauthors
Rundell KW,Hoffman JR,Caviston R,Bulbulian R,Hollenbach AMdoi
10.1080/08958370601051727subject
Has Abstractpub_date
2007-02-01 00:00:00pages
133-40issue
2eissn
0895-8378issn
1091-7691pii
N843560814P71523journal_volume
19pub_type
杂志文章abstract：:Increasing evidence suggests a role for a systemic pro-coagulant state in the pathogenesis of cardiac dysfunction subsequent to inhalation of airborne particulate matter (PM). We evaluated platelet activation, systemic cytokines and pulmonary gene expression in mice exposed to concentrated ambient particulate matter (...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2012.695815
更新日期：2012-07-01 00:00:00
abstract：:Inhalation exposure systems are necessary tools for determining the dose-response relationship of inhaled toxicants under a variety of exposure conditions. The objective of this project was to develop an automated computer controlled system to expose small laboratory animals to precise concentrations of airborne multi...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802712713
更新日期：2009-10-01 00:00:00
abstract：:The aim of the present study was to investigate the effect of low-level concentrations, under the occupational acceptable limits, of toluene exposure and peptidoglycan (PGN) stimulation on Th1/Th2 immunity in infant mice. Pregnant BALB/c mice and their offspring were exposed to low-level toluene inhalation (0, 5, and ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370902798448
更新日期：2009-08-01 00:00:00
abstract：:The application of a proportional-integral-derivative (PID) control algorithm to an inhalation exposure system using a building automation system is described. Previous studies had utilized a control system in which concentration was monitored continuously and adjustments to the generator were made on a continuous bas...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370390217819
更新日期：2003-07-01 00:00:00
abstract：:Respiratory disturbances play a central role in chemical warfare nerve agent (CWNA) induced toxicity; they are the starting point of mass casualty and the major cause of death. We developed a microinstillation technique of inhalation exposure to nerve agent VX and assessed lung injury by biochemical analysis of the br...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370600602116
更新日期：2006-06-01 00:00:00
abstract：:This study was undertaken to determine whether there was an association between fine particles (PM₂.₅) levels and hospital admissions for congestive heart failure (CHF) in Taipei, Taiwan. Hospital admissions for CHF and ambient air pollution data for Taipei were obtained for the period 2006-2010. The relative risk of ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2013.804609
更新日期：2013-07-01 00:00:00
abstract：:Oxidative stress is thought to be the pathogenesis of pulmonary fibrosis induced by asbestos, and heme oxygenase-1 (HO-1) protects lung tissue against oxidative stress. We hypothesized that HO-1 is associated with oxidative lung injury caused by exposure to asbestos. This study was conducted to investigate the time co...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370590922580
更新日期：2005-05-01 00:00:00
abstract：:In 1997 The International Agency for Research on Cancer classified some exposures to crystalline silica as carcinogenic to humans. Such exposures were acknowledged to be very variable, and even in the same monograph it was admitted that coal dust, containing as much as 20% quartz, could not be classified. Clearly ther...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802136731
更新日期：2008-09-01 00:00:00
abstract：:Sulfur dioxide (SO2) is a ubiquitous air pollutant, present in low concentrations in the urban air and in higher concentrations in the working environment. In this study, we investigated the effects of inhaled SO2 on the O-dealkylase of pentoxyresorufin (PROD) and p-nitrophenol hydroxylases (p-NP) activities and mRNA ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370600686341
更新日期：2006-07-01 00:00:00
abstract：:The immune and hematological systems can be a target for environmental contaminants with potential adverse effects, so the purpose of this study is to provide documentation on immunotoxicity and hematotoxicity of tetrachloroethylene, which is widely used in dry cleaning in Egypt. This study was carried out on 80 adult...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958370902934894
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Gastroesophageal reflux of bile acids plays an important role in the development of Barrett's esophagus (BE)-associated esophageal adenocarcinoma (EAC). Cigarette smoke has been demonstrated to exacerbate the effects of reflux and thus the initial stages of EAC carcinogenesis. To date, no in vivo studies hav...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2011.568977
更新日期：2011-04-01 00:00:00
abstract：:Epidemiological and experimental data suggest that obesity exacerbates the health effects of air pollutants such as ozone (O3). Maternal inactivity and calorically rich diets lead to offspring that show signs of obesity. Exacerbated O3 susceptibility of offspring could thus be manifested by maternal obesity. Thirty-da...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2017.1342719
更新日期：2017-05-01 00:00:00
abstract：:The authors have previously demonstrated that wildfire-derived coarse or fine particulate matter (PM) intratracheally instilled into lungs of mice induce a strong inflammatory response. In the current study, the authors demonstrate that wildfire PM simultaneously cause major increases in oxidative stress in the mouse ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958370903571849
更新日期：2010-06-01 00:00:00
abstract：:The effects of low-level ozone exposure (0.08 ppm) on pulmonary function in healthy young adults are well known; however, much less is known about the inflammatory and immunomodulatory effects of low-level ozone in the airways. Techniques such as induced sputum and flow cytometry make it possible to examine airways in...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958371003596587
更新日期：2010-06-01 00:00:00
abstract：:Epidemiologic studies of air pollution require accurate exposure assessments at unmonitored locations in order to minimize exposure misclassification. One approach gaining considerable interest is the land-use regression (LUR) model. Generally, the LUR model has been utilized to characterize air pollution exposure and...
journal_title：Inhalation toxicology
pub_type： 杂志文章,评审
doi：10.1080/08958370701495998
更新日期：2007-01-01 00:00:00
abstract：:Adult Sprague-Dawley (SD) male rats were exposed for a single 3 h period to air, ozone (O₃) or O₃) followed by tobacco smoke (O₃/TS). For pulmonary effects, bronchoalveolar lavage (BAL) cells and fluid were analyzed. Data revealed a significant increase in polymorphonuclear leukocytes (PMN), total protein and albumin ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2012.751143
更新日期：2013-01-01 00:00:00
abstract：:Diagnosis of an exposure to airborne toxicants can be problematic. Phosgene is used widely in industry for the production of many synthetic products, such as polyfoam rubber, plastics, and dyes. Although nearly 100% of the gas is consumed during processing, there is the potential problem of accidental or even intentio...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370390197254
更新日期：2003-06-01 00:00:00
abstract：OBJECTIVE:Previous studies have shown that air pollution exposure primes the body to heightened responses to everyday stressors of the cardiovascular system. The purpose of this study was to examine the utility of postprandial responses to a high carbohydrate oral load, a cardiometabolic stressor long used to predict c...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2020.1809572
更新日期：2020-07-01 00:00:00
abstract：:This study is focused on the characterization of particles emitted in the metal active gas welding of carbon steel using mixture of Ar + CO2, and intends to analyze which are the main process parameters that influence the emission itself. It was found that the amount of emitted particles (measured by particle number a...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2014.897400
更新日期：2014-05-01 00:00:00
abstract：:Measurement strategies as well as results from measurements at workplaces are presented. Measurements were performed in research laboratories as well as by companies producing small amounts of nanostructured materials. The work was done in the frame of a BAuA (Bundesanstalt für Arbeitsschutz und Arbeitsmedizin) resear...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370902962317
更新日期：2009-07-01 00:00:00
abstract：:Continuous environmental or occupational exposure to airborne particulate pollution is believed to be a major hazard for human health. A technique to characterize their deposition and clearance from the lungs is fundamental to understand the underlying mechanisms behind their negative health effects. In this work, we ...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2010.549856
更新日期：2011-02-01 00:00:00
abstract：:A low-cutoff, high-volume conventional impactor has been designed. This sampler uses a slit-shaped acceleration jet and operates at 1100 L/min. The impaction substrate is polyurethane foam (PUF). The impactor collection efficiency was characterized using polydisperse particles, and the 50% size cutoff point was 0.12 ¡...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2000.11463198
更新日期：2000-01-01 00:00:00
abstract：:Laboratory animals exposed to methyl iodide (MeI) have previously demonstrated lesions of the olfactory epithelium that were associated with local metabolism in the nasal tissues. Interactions of MeI in the nasal passage may, therefore, alter systemic toxicokinetics. The current study used unrestrained plethysmographs...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802596926
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:Dimethyl sulfide (DMS, CAS 75-18-3) is an industrial chemical. It is both an irritant and neurotoxicant that may be life-threatening because of accidental release. The effects of DMS on public health and associated public health response depend on the exposure concentration and duration. However, currently, p...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2018.1551444
更新日期：2018-01-01 00:00:00
abstract：:The purpose of the Enhanced Particulate Matter Surveillance Program was to provide scientifically founded information on the chemical and physical properties of dust collected over a period of approximately 1 year in Djibouti, Afghanistan (Bagram, Khowst), Qatar, United Arab Emirates, Iraq (Balad, Baghdad, Tallil, Tik...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958370802464273
更新日期：2009-02-01 00:00:00
abstract：:Halomethanes (HMs) can be formed during the chlorination process to obtain drinking water. In liver cells, HMs had been shown to be mutagenic and carcinogenic; however, their bioactivation by CYP 2E1 and GSTT1 is required. Although inhalation is the most common pathway of exposure, reports on the toxic effects induced...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2012.716871
更新日期：2012-09-01 00:00:00
abstract：:Species differences in the handling of particles are topics of interest for setting ambient particulate matter standards as well as for studies involving the phenomenon of lung overload and the implications, if any, of such studies for workplace dust exposure standards. The dosimetry of inhaled particles differs among...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.1080/08958378.2000.11463250
更新日期：2000-01-01 00:00:00
abstract：:During the "Commonwealth Games" 2010 (CWG-2010) in Delhi, the Indian government has implemented an ambitious project "System of Air quality Forecasting And Research (SAFAR)" for monitoring and forecasting air-quality scenario. Using high-precision spatio-temporal measurements of criteria pollutants from the SAFAR netw...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958378.2013.788103
更新日期：2013-05-01 00:00:00
abstract：:In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitreous fibers, but it...
journal_title：Inhalation toxicology
pub_type： 杂志文章,评审
doi：10.1080/08958370490505016
更新日期：2004-10-01 00:00:00
abstract：:The Toxicological Evaluation of Realistic Emissions Source Aerosols (TERESA) study was carried out at three US coal-fired power plants to investigate the potential toxicological effects of primary and photochemically aged (secondary) particles using in situ stack emissions. The exposure system designed successfully si...
journal_title：Inhalation toxicology
pub_type： 杂志文章
doi：10.3109/08958371003728040
更新日期：2011-08-01 00:00:00
