Effect of sulfur dioxide inhalation on CYP2B1/2 and CYP2E1 in rat liver and lung.


:Sulfur dioxide (SO2) is a ubiquitous air pollutant, present in low concentrations in the urban air and in higher concentrations in the working environment. In this study, we investigated the effects of inhaled SO2 on the O-dealkylase of pentoxyresorufin (PROD) and p-nitrophenol hydroxylases (p-NP) activities and mRNA levels of CYP2B1/2 and CYP2E1 in the lung and liver of Wistar rats. Male Wistar rats were housed in exposure chambers and treated with 14.11 +/- 1.53, 28.36 +/- 2.12, and 56.25 +/- 4.28 mg/m3 SO2 for 6 h/day for 7 days, while control rats were exposed to filtered air in the same condition. The mRNAs of CYP2B1/2 and -2E1 were analyzed in livers and lungs by using reverse-transcription polymerase chain reaction (RT-PCR). Our results showed that the PROD activities and mRNA of CYP2B1/2 were decreased in livers and lungs of rats exposed to SO2. The p-NP activities and mRNA of CYP2E1 were decreased in lungs but not in livers of rats exposed to SO2. Total liver microsomal cytochrome P-450 (CYP) contents were diminished in SO2-exposed rats. These results lead to two conclusions: (1) SO2 exposure can suppress CYP2B1/2 and CYP2E1 in lungs and CYP2B1/2 in livers of rats, thus modifying the liver and lung toxication/detoxication potential, and (2) the total liver microsomal CYP contents were diminished, although the activity and mRNA expression of CYP2E1 in rat livers were not affected by SO2 exposure.


Inhal Toxicol


Inhalation toxicology


Qin G,Meng Z




Has Abstract


2006-07-01 00:00:00














  • A centrifugal particle concentrator for use in inhalation toxicology.

    abstract::Epidemiologic studies have provided strong evidence that episodic exposure to ambient particulate matter is associated with increases in morbidity and mortality. These adverse effects have been demonstrated at concentrations far below the National Ambient Air Quality Standard (NAAQS), and thus, the biological plausibi...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Gordon T,Gerber H,Fang CP,Chen LC

    更新日期:1999-01-01 00:00:00

  • The role of N-acetylcysteine in the management of acute and chronic pulmonary complications of sulfur mustard: a literature review.

    abstract:CONTEXT:Sulfur mustard exposure, as the most widely used chemical weapon, can lead to acute and long-term pulmonary complications via various pathways, such as triggering an imbalance between the oxidant and antioxidant system. Currently, there is no validated antidote, chemoprophylaxis and curative modality for pulmon...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章,评审


    authors: Shohrati M,Karimzadeh I,Saburi A,Khalili H,Ghanei M

    更新日期:2014-08-01 00:00:00

  • The negative effects of chronic exposure to isoflurane on spermatogenesis via breaking the hypothalamus-pituitary-gonadal equilibrium.

    abstract::This study aims to investigate the negative effects of chronic exposure to isoflurane on spermatogenesis and explore the underlying mechanisms. Sixty male rats were randomly allocated to two groups: control group, receiving no treatment, and anesthesia group, administrated exposure to isoflurane (2 ppm) for 25 consecu...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Ding Y,Yu J,Qu P,Ma P,Yu Z

    更新日期:2015-01-01 00:00:00

  • Inhalation of ultrafine and fine particulate matter disrupts systemic vascular function.

    abstract::This study investigated the effects of particulate matter (PM) with aerodynamic diameter 0.02-1 microm (noted as PM1) inhalation during exercise on conduit artery and microvascular function. Inhalation of internal combustion-derived PM is associated with cardiovascular mortality and morbidity. Direct action of PM on t...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Rundell KW,Hoffman JR,Caviston R,Bulbulian R,Hollenbach AM

    更新日期:2007-02-01 00:00:00

  • Effect of prenatal waterpipe tobacco smoke on airway inflammation in murine model of asthma of adult offspring mice.

    abstract:OBJECTIVE:Worldwide popularity of waterpipe tobacco smoking has increased, including in pregnant women. This study investigates the effect of prenatal waterpipe tobacco smoke (WTS) exposure on airway inflammation in a murine model of asthma of adult offspring mice. MATERIALS AND METHODS:Pregnant BALB/c mice were expos...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Al-Sawalha NA,Al-Bo'ul HF,Alzoubi KH,Khabour OF,Thanawala VJ

    更新日期:2017-07-01 00:00:00

  • Assessments of population exposure to environmental pollutants using air quality measurements during Commonwealth Games-2010.

    abstract::During the "Commonwealth Games" 2010 (CWG-2010) in Delhi, the Indian government has implemented an ambitious project "System of Air quality Forecasting And Research (SAFAR)" for monitoring and forecasting air-quality scenario. Using high-precision spatio-temporal measurements of criteria pollutants from the SAFAR netw...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Chate D,Beig G,Satpute T,Sahu SK,Ali K,Parkhi N,Ghude S

    更新日期:2013-05-01 00:00:00

  • Hemolysis caused by titanium dioxide particles.

    abstract::Washed human erythrocytes were incubated with titanium dioxide (TiO2) particles at 37 degrees C for 1 hr and hemolysis was determined by the percentage of hemoglobin released (optical density at 540 nm; OD540) from the cells. Effects of TiO2 on OD540 were corrected and dose-response curves were analyzed by the Hill pl...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Aisaka Y,Kawaguchi R,Watanabe S,Ikeda M,Igisu H

    更新日期:2008-07-01 00:00:00

  • Urban PM2.5 surface chemistry and interactions with bronchoalveolar lavage fluid.

    abstract::This study investigated the surface chemistry of urban fine particles (PM(2.5)), and quantified the adsorbed and desorbed species after exposure to bronchoalveolar lavage fluid (BALF). Urban background and roadside PM(2.5) samples of different mass concentration and total weight were collected in triplicate in the Sou...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Kendall M,Guntern J,Lockyer NP,Jones FH,Hutton BM,Lippmann M,Tetley TD

    更新日期:2004-01-01 00:00:00

  • Effect of growth medium on potential of Streptomyces Anulatus spores to induce inflammatory responses and cytotoxicity in RAW264.7 macrophages.

    abstract::Epidemiological studies have shown an association between microbial growth in buildings and increased risk of respiratory symptoms and disease related to inflammatory reactions in the inhabitants96. The current study examined the affects of growth conditions of Streptomyces anulatus, isolated from indoor air of a mold...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Hirvonen MR,Suutari M,Ruotsalainen M,Lignell U,Nevalainen A

    更新日期:2001-01-01 00:00:00

  • NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination.

    abstract::Multi-walled carbon nanotubes (MWCNT) have been reported to cause lung pathologies in multiple studies. However, the mechanism responsible for the bioactivity has not been determined. This study used nine different well-characterized MWCNT and examined the outcomes in vitro and in vivo. MWCNT, from a variety of source...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Hamilton RF Jr,Buford M,Xiang C,Wu N,Holian A

    更新日期:2012-12-01 00:00:00

  • Comparison of sarin and cyclosarin toxicity by subcutaneous, intravenous and inhalation exposure in Gottingen minipigs.

    abstract::Sexually mature male and female Gottingen minipigs were exposed to various concentrations of GB and GF vapor via whole-body inhalation exposures or to liquid GB or GF via intravenous or subcutaneous injections. Vapor inhalation exposures were for 10, 60 or 180 min. Maximum likelihood estimation was used to calculate t...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Hulet SW,Sommerville DR,Miller DB,Scotto JA,Muse WT,Burnett DC

    更新日期:2014-02-01 00:00:00

  • Calculated deposition in growing tracheobronchial airways: effect of growth-rate assumptions.

    abstract::Most current deterministic computer dosimetry models use idealized dichotomous symmetrical infant, child, and adolescent tracheobronchial geometries for dosimetry predictions. These tracheobronchial geometries were derived from either the morphometric measurements of J. D. Mortensen and colleagues or those of R. F. Ph...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Oldham MJ,Robinson RJ

    更新日期:2006-09-01 00:00:00

  • Generation and characterization of diesel engine combustion emissions from petroleum diesel and soybean biodiesel fuels and application for inhalation exposure studies.

    abstract::Biodiesel made from the transesterification of plant- and animal-derived oils is an important alternative fuel source for diesel engines. Although numerous studies have reported health effects associated with petroleum diesel emissions, information on biodiesel emissions are more limited. To this end, a program at the...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Mutlu E,Nash DG,King C,Krantz TQ,Preston WT,Kooter IM,Higuchi M,DeMarini D,Linak WP,Gilmour MI

    更新日期:2015-01-01 00:00:00

  • A custom-built low-cost chamber for exposing rodents to e-cigarette aerosol: practical considerations.

    abstract::Objectives: To (1) design and build a low-cost exposure chamber system for whole-body exposure of rodents to electronic cigarette aerosol, (2) provide detailed instructions with particular focus on automated e-cigarette activation, and (3) develop a simple mathematical model for aerosol levels in the exposure chamber....

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Hilpert M,Ilievski V,Coady M,Andrade-Gutierrez M,Yan B,Chillrud SN,Navas-Acien A,Kleiman NJ

    更新日期:2019-01-01 00:00:00

  • Cosmetic talc as a risk factor for pleural mesothelioma: a weight of evidence evaluation of the epidemiology.

    abstract:OBJECTIVE:Due to some historical (and inaccurate) reports that asbestos might be present in some cosmetic talc products, questions are occasionally raised regarding the potential pleural mesothelioma risks associated with cosmetic talc products. Our objective was to determine the incidence of pleural mesothelioma of in...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章,评审


    authors: Finley BL,Benson SM,Marsh GM

    更新日期:2017-03-01 00:00:00

  • Respiratory diseases in French cork workers.

    abstract::A cross-sectional study on suberosis was conducted in the Champagne-Ardenne County, France, to determine the prevalence of respiratory symptoms, the level of pulmonary function, and the presence of precipitins against Penicillium frequentans. Thirteen of the 33 workers exposed to cork dust had respiratory symptoms exc...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Deschamps F,Foudrinier F,Dherbecourt V,Mas P,Prevost E,Legrele AM,Bellier S,Toubas D

    更新日期:2003-12-01 00:00:00

  • Physical and chemical characterization of mn phosphate/sulfate mixture used in an inhalation toxicology study.

    abstract::The use of methylcyclopentadienyl manganese tricarbonyl (MMT) in unleaded gasoline has given rise to numerous debates on the potential public health risk associated with manganese emissions. In fact, combustion products are mainly Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. Our research group did sever...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Beaupré LA,Salehi F,Zayed J,Plamondon P,L'Espérance G

    更新日期:2004-04-01 00:00:00

  • Spirometry: a predictor of lung cancer among asbestos workers.

    abstract:OBJECTIVE:The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS:In order to identify a gr...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Świątkowska B,Szeszenia-Dąbrowska N

    更新日期:2017-01-01 00:00:00

  • Nasal epithelial lesions in F344 rats following a 90-day inhalation exposure to naphthalene.

    abstract::Naphthalene (NA) was shown to be carcinogenic, causing respiratory epithelial adenoma in the nasal cavity of male F344 rats and olfactory epithelial neuroblastoma in female F344 rats at exposure concentrations of 10-60 ppm in a 2-year inhalation study conducted by the National Toxicology Program. To explore the exposu...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Dodd DE,Wong BA,Gross EA,Miller RA

    更新日期:2012-01-01 00:00:00

  • Systemic inflammation, endothelial dysfunction, and activation in clinically healthy children exposed to air pollutants.

    abstract::Mexico City children are chronically exposed to significant concentrations of air pollutants and exhibit chronic respiratory-tract inflammation. Epidemiological, controlled human exposures, laboratory-based animal models, and in vitro/in vivo studies have shown that inflammatory, endothelial dysfunction, and endotheli...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Calderón-Garcidueñas L,Villarreal-Calderon R,Valencia-Salazar G,Henríquez-Roldán C,Gutiérrez-Castrellón P,Torres-Jardón R,Osnaya-Brizuela N,Romero L,Torres-Jardón R,Solt A,Reed W

    更新日期:2008-03-01 00:00:00

  • Effect of rapid shallow breathing on the distribution of 18O-labeled ozone reaction product in the respiratory tract of the rat.

    abstract::We examined the effect of breathing pattern on ozone reaction product content within the respiratory tract. Thirty-four anesthetized, male Wistar rats were exposed to oxygen-18 ((18)O)-labeled ozone at 1.0 ppm for 2 h using a dual-chamber, negative-pressure ventilation system. Frequency was set at 80 (n = 9), 120 (n =...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Alfaro MF,Putney L,Tarkington BK,Hatch GE,Hyde DM,Schelegle ES

    更新日期:2004-02-01 00:00:00

  • Waterpipe tobacco smoke distresses cardiovascular biomarkers in mice: alterations in protein expression of metalloproteinases, endothelin and myeloperoxidase.

    abstract::Introduction: Tobacco use is a major risk factor of cardiovascular diseases (CVD) and atherosclerosis in particular. The use of waterpipe smoking (WPS) is increasing due to the misperception that it is less harmful than cigarette smoking due to its flavor and the use of water as a filter. Thus, research that investiga...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Rababa'h AM,Bsoul RW,Alkhatatbeh MJ,Alzoubi KH,Khabour OF

    更新日期:2019-02-01 00:00:00

  • Toxicological investigations on the respirable fraction of silicon carbide grain products by the in vitro vector model.

    abstract::Increased lung cancer incidence with workers at the production site of crude silicon carbide (SiC) using the Acheson process has been reported. Several agents derived from the process were discussed as causative factors. Recently concern had been expressed about the presence of cleavage fragments (CFs) in commercial p...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Bruch J,Rehn B,Duval-Arnould G,Efskind J,Röderer G,Sébastian P

    更新日期:2014-04-01 00:00:00

  • Toxicological comparisons of cigarettes containing different amounts of vanillin.

    abstract::Vanillin is a flavoring agent used in cigarettes. Previous toxicological examinations of the effects on the addition of vanillin to tobacco used mixtures with several other flavoring agents. In the present work, toxicological comparisons were made of experimental cigarettes containing no added vanillin against otherwi...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Lemus R,Carmines EL,Van Miert E,Coggins CR,Anskeit E,Gerstenberg B,Meisgen TJ,Schramke H,Stabbert R,Völkel H,Terpstra PM

    更新日期:2007-06-01 00:00:00

  • Particle toxicology: from coal mining to nanotechnology.

    abstract::Particle research has been historically closely connected to industrial activities or materials, such as coal, asbestos, man-made mineral fibers, and more recently ambient particulate matter (PM). It is the purpose of this review to combine insights and developments in particle toxicology with the historical context o...

    journal_title:Inhalation toxicology

    pub_type: 历史文章,杂志文章,评审


    authors: Borm PJ

    更新日期:2002-03-01 00:00:00

  • Radiological progression and lung function decrements among silica-exposed ceramic workers: a longitudinal study.

    abstract::Objectives: This follow-up study set out to evaluate the natural course and radiographic progression of silicosis among ceramic workers and describe the risk factors related with disease progression. Materials and methods: We retrospectively analyzed the data of ceramic workers with silicosis who were referred to our ...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Karataş M,Gündüzöz M,Büyükşekerci M,Özakıncı OG,Nadir Öziş T

    更新日期:2019-02-01 00:00:00

  • Concentration-time extrapolation of short-term inhalation exposure levels: dimethyl sulfide, a case study using a chemical-specific toxic load exponent.

    abstract:OBJECTIVE:Dimethyl sulfide (DMS, CAS 75-18-3) is an industrial chemical. It is both an irritant and neurotoxicant that may be life-threatening because of accidental release. The effects of DMS on public health and associated public health response depend on the exposure concentration and duration. However, currently, p...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Demchuk E,Ball SL,Le SL,Prussia AJ

    更新日期:2018-01-01 00:00:00

  • Lung antioxidant and cytokine responses to coarse and fine particulate matter from the great California wildfires of 2008.

    abstract::The authors have previously demonstrated that wildfire-derived coarse or fine particulate matter (PM) intratracheally instilled into lungs of mice induce a strong inflammatory response. In the current study, the authors demonstrate that wildfire PM simultaneously cause major increases in oxidative stress in the mouse ...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Wegesser TC,Franzi LM,Mitloehner FM,Eiguren-Fernandez A,Last JA

    更新日期:2010-06-01 00:00:00

  • Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.

    abstract::Objective: To develop a physiologically based pharmacokinetic (PBPK) model for chloroprene in the mouse, rat and human, relying only on in vitro data to estimate tissue metabolism rates and partitioning, and to apply the model to calculate an inhalation unit risk (IUR) for chloroprene.Materials and methods: Female B6C...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Clewell HJ 3rd,Campbell JL,Van Landingham C,Franzen A,Yoon M,Dodd DE,Andersen ME,Gentry PR

    更新日期:2019-01-01 00:00:00

  • Morphological changes in rat lung after long-term exposure to diesel emissions.

    abstract::Wistar rats were exposed for 24 mo to diesel emissions containing a low (0.2 ppm, 0.21 mg/m(3)), medium (1.04 ppm, 1.18 mg/m(3)), or high (2.96 ppm, 3.05 mg/m(3)) concentration of NO(2) and particles, or diesel emissions containing a medium (1.12 ppm, 0.01 mg/m(3)) concentration of NO(2) without particles. At 6-mo int...

    journal_title:Inhalation toxicology

    pub_type: 杂志文章


    authors: Kato A,Nagai A,Kagawa J

    更新日期:2000-06-01 00:00:00